Digital Commons Network^™

Overseen And Overlooked: Knowledge Production And Care In Public Health Surveillance, Krzysztof Wojciech Chwala

Public Health Theses

At the beginning of the COVID-19 pandemic, contact tracing was implemented as a public health measure to prevent the further spread of disease. In this thesis, I analyze contact tracing as a case study of public health surveillance. I argue that public health does not sufficiently study the social components and consequences of its surveillant activities, and as a result is hyperopic; it sees health-related phenomena at a distance with clarity, but has not brought its own logics under view. To remedy this, I utilize perspectives from the field of surveillance studies, which studies surveillance as social and cultural phenomena. …

Determining Polymorphisms In Tnf Production As They Relate To Infection With Ebov, Nirvana K. Dominguez Singh

Public Health Theses

This is a theoretical proposal done as an intellectual exercise. The purpose of this project is to practice and familiarize oneself with the process of applying for a grant from the National Institute of Health to conduct research on human subjects. This proposed study plans to sequence blood samples from infected individuals, exposed and uninfected individuals, and unexposed individuals from the 2018 outbreak in the Democratic Republic of Congo to determine the presence of polymorphisms in TNF production as they relate to Ebolavirus infection. It is hypothesized that certain polymorphisms in the regulation and production of TNF that cause a …

Global Routine Immunization Policies For Refugees, Jad A. Elharake

Public Health Theses

BackgroundIn 2020, approximately 26 million refugees resettled in a new country—fleeing their homes due to conflict, persecution, violence, and human rights violations. Refugees often migrate from developing countries with limited access to adequate health care, routine immunizations, and public health resources. Because of low immunization coverage and potentially underlying health conditions, including stress, trauma, overcrowding during transit, poor hygiene and sanitation services, and malnutrition, refugees face a greater risk of contracting vaccine-preventable diseases (VPDs). This presents a key public health challenge and ethical imperative to serve the health needs of refugees resettling each year.

ObjectiveThe purpose of our study was …

How Knowledge, Perception, And Identity Influence Covid-19-Related Concerns In The Built Environment, Abigail Ginader

Public Health Theses

Background: There is increasing research exploring how different diverse and intersecting identities based on race, gender, ability/disability, sexual orientation, and age interact with space to influence an individual’s inclusiveness and comfort in a space. This is particularly salient in the context of COVID-19 which has shown large health inequities and increased risk for certain vulnerable subgroups (e.g., older individuals, individuals of color).Objective: To assess end users’ perception of COVID-19 safety in the built environment of museums. Methods: A cross-sectional study design was used. An electronic survey was distributed between January and February 2021. Repeated measures ANOVA, multivariate Poisson regression, and …

The Impact Of Covid-19 On Backyard Poultry-Associated Salmonella In Connecticut, Laura Kasper

Public Health Theses

Introduction: Salmonellosis is the second leading bacterial foodborne illness in the United States, and is mainly characterized by symptoms of gastroenteritis and their consequences in afflicted individuals. Salmonella accounts for 1.35 million infections, 26,500 hospitalizations and 420 deaths in the United States every year. Live poultry act as a reservoir of Salmonella and causes an annual national outbreak. There has yet to be a published study on the impact of COVID-19 lockdowns on the incidence of Salmonella and on the percentage of cases tied to the national poultry outbreak. Methods: Active public health surveillance of Salmonella in Connecticut is conducted …

An Exploration Of Race Differences In Network Exposures To Mass Incarceration, Jessica Lee

Public Health Theses

A growing literature suggests that mass incarceration impacts not only the individual who is incarcerated, but also their partners, family members, and children. However, few studies have examined race differences in network exposure to mass incarceration. This study explores associations between race and various measures of network exposure to incarceration: relationships, interactions with the criminal legal system, and housing. We draw on data from the 2017-2018 baseline survey from the Justice, Housing, and Health Study. Descriptive statistics show that Black respondents are more likely to experience each event we examined compared to whites, except for parental incarceration and receiving threats …

Public Health And Natural Gas Policy In Connecticut, Cheyenne Liberti

Public Health Theses

Due to its adverse impacts on public health via contributions to global climate change and emissions of toxic substances throughout the life cycle, natural gas use should be eliminated as quickly as possible in Connecticut. This project aims to 1) identify the policies and programs concerning all stages of the natural gas life cycle, in and affecting Connecticut; 2) evaluate the capacity of these policies and programs to mitigate public health hazards, promote environmental justice, and achieve rapid elimination of natural gas use; and 3) recommend policy and program alternatives that would accomplish these goals in a more timely manner. …

Analyzing The Restriction Of Mass Gatherings And School Closures/Reopening In China And Iran During The Covid-19 Pandemic With A Public Health Ethics Framework, Esther Luo

Public Health Theses

The COVID-19 pandemic has undoubtedly elevated the status of public health. Concurrently, public health ethics has been brought to the forefront of the field and its practices in several ways. Over the past year, SARS-CoV-2 has affected nearly every country. In both high and low resource settings, policymakers turned to public health to ease the tension placed on health care systems by COVID-19. Governments implemented measures ranging from lockdown orders to mask mandates, all with the primary goal of curbing the spread of SARS-CoV-2. The effectiveness of these interventions has become a salient topic in public health research, and much …

Determinants For Approval And Reimbursement Of Orphan Products In China, Wenlan Mao

Public Health Theses

Rare disease definition varies among countries/regions. China has published The First National List of Rare Diseases, including 121 kinds of rare diseases in 2018. It was the first time that China has defined rare diseases officially. China has also started releasing a range of encouraging regulations regarding orphan drug development and approval in recent years. Nevertheless, the FDA has introduced Orphan Drug Act in the 1980s, Japan has launched a government-led support initiative in the 1990s, and the European Parliament has adopted the Orphan Regulation in 2000. Among the 121 rare diseases, 58 of them have approved treatments in the …

Co-Distribution Of Ambient Light At Night And Incidence Of Human Cancers And Covid-19, Yidan Meng

Public Health Theses

Introduction and BackgroundThere are increasing concerns about the effects of artificial lights on human health, including hormone-related disease and immune functions. In January 2020, the outbreak of COVID-19 disrupted everyone’s life, and people who infected have various severity. Thus, we want to analyze whether people exposed to different ambient light at night (LAN) levels make them more susceptible to COVID-19 for our summer research. Besides the effects of LAN on immune functions, we also discussed the association of LAN and multiple cancers in seven states of Northeastern U.S. We used similar statistical and geographic analysis methods and separate them into …

Impact Of Health Care Access On Delayed Or Missed Adolescent Vaccinations For Tdap, Meningococcal, And Hpv Vaccines Among U.S. Adolescents, Nis-Teen 2018, Maura Iko Nakahata

Public Health Theses

Background: Adolescent vaccination coverage varies considerably between Tdap, meningococcal, and HPV vaccines. While evidence suggests that health care access affects vaccination coverage, evidence does not explain whether access drives delayed or no vaccination. This study evaluates whether measures of health care access are associated with delayed vaccination or not being vaccinated by age 17 years for Tdap, meningococcal, and HPV vaccines when controlling for sociodemographic factors as proxies for vaccine hesitancy. The secondary objective assesses whether health care access measures had consistent associations across the different vaccines. Methods: Using current ACIP recommendations, ‘on-time’, ‘delayed’, and ‘missed’ status by age 17 …

Impact Of Covid-19 On Participants Of A Fruit And Vegetable Program, Christabelle Ong

Public Health Theses

Objective: To investigate the impact of COVID-19 on the participants of a multi-city fruit and vegetable incentive program.Design: A six-month cohort study was conducted. Pre-program and post-program data were collected using an online survey platform. Setting: Eight cities across the United States. Participants: A total of 822 individuals were recruited through local site partners to participate in a fruit and vegetable incentive program (n=822; 79.4% women, 20.6% men; median age: 57 years old). Intervention: Participants received $50 monthly fruit and vegetable vouchers, a sneaker gift card or gift basket, and access to a weight loss app. Main Outcome Measures: The …

The Role Of Histone Demethylase Kdm6a In Mouse Coronavirus Infection, Sonam Patel

Public Health Theses

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of acute respiratory coronavirus disease 2019 (COVID-19), a disease that erupted into a global pandemic in March of 2020.2 Recently, a genome wide CRISPR screen was performed on SARS-lineage coronaviruses and two additional recombinant viruses; the screen revealed host genes essential to coronavirus pathogenesis and entry.7 The screen identified KDM6A, a histone demethylase, as an important pro-viral gene.7 Building upon this observation, in this thesis, I explore the role of Kdm6a in murine hepatitis virus (MHV), a type of mouse coronavirus. MHV is the prototypical model for studying SARS-CoV-2 …

An Agenda-Setting Report: Biome Monitoring For Human Health, Peter Roumeliotis

Public Health Theses

In light of the COVID-19 pandemic and the increasing frequency with which zoonotic diseases of pandemic potential have emerged in recent decades, it is vital to seek new methods of preventing disease outbreaks before they occur. Novel information age technologies have the potential to change the game for infectious disease outbreak monitoring. This paper addresses the overall opportunity that exists for biome surveillance as a means for health monitoring, particularly the way that the domains of technological and biological sciences can unite to prevent the next pandemic before it gets a chance to take hold. This report outlines the numerous …

Determining The Relationship Between Sars-Cov-2 Infection And Streptococcus Pneumoniae In Clinical Saliva Samples, Anne Watkins

Public Health Theses

Background. Streptococcus pneumoniae is a commonly found upper respiratory tract colonizer that can progress to more severe disease forms such as pneumonia. Interactions with respiratory viruses other than SARS-CoV-2 have been previously identified such that S. pneumoniae may sometimes enhance disease or occur as a secondary or co-infection. With the recent emergence of SARS-CoV-2 there is limited data available describing this specific pathogen relationship that could play a role in the breadth and severity of the pandemic. Methods. Inpatients and healthcare workers testing positive for SARS-CoV-2 March 2020-August 2020 were tested for S. pneumoniae through saliva culture enrichment and RT-qPCR …

Vector-Host Interactions Of Culex Pipiens Mosquitoes And Their Role In Arbovirus Transmission In The Mid-Atlantic United States, Karen Jane Yuan

Public Health Theses

As the primary vector for the West Nile virus in the United States, members of the Culex pipiens complex have caused illnesses and deaths in the human population since its discovery in 1937. The potential contribution of Cx. pipiens to transmission and enzootic amplification of WNV can be influenced by multiple aspects, including their interactions with various vertebrate hosts as an important factor. By using blood meal analysis and virus testing, this study further investigated the role of Cx. pipiens in WNV transmission and amplification. With 91% of blood meals identified from avian species, birds remain the most frequent source …

A Model Of Crisis Management, Fei Li, Jidong Zhou

Cowles Foundation Discussion Papers

We propose a model of how multiple societies respond to a common crisis. A government faces a “damned-either-way” policy-making dilemma: aggressive intervention contains the crisis, but the resulting good outcome makes people skeptical of the costly response; light intervention worsens the crisis and causes the government to be faulted for not doing enough. This dilemma can be mitigated for the society that encounters the crisis first if another society faces the same crisis afterward. Our model predicts that the later society does not necessarily perform better despite having more information, while the earlier society might benefit from a dynamic counterfactual …

The Effects Of Monetary Expansion And The Covid-19 Economic Crisis, Daehee Jeong

Documents

No abstract provided.

Urgent Actions Needed To Better Ensure An Effective Federal Response, United States: Government Accountability Office (Gao)

Documents

No abstract provided.

Rewritten Heroes Act Lops $800 Million Off First Proposal, But Unlikely To Proceed, Sean Fulmer, Corey Runkel

Documents

No abstract provided.

Chemsex Screening And Intervention Training For Urban Primary Care Providers, Jona Tanguay

Yale School of Medicine Physician Associate Program Theses

Chemsex, defined as the use of drugs before or during sex to enhance and facilitate the experience, is increasingly prevalent in urban populations of men who have sex with men. Chemsex is associated with higher risks of sexually transmitted infections including HIV, and it has negative effects on mental health and productivity. However, chemsex is under- or un-addressed in most primary care practices, and chemsex users rarely present to specialists in addiction medicine. We hypothesize that an integrative, multimodal training program for urban primary care providers in chemsex identification and harm reduction will increase the proportion of male patients screened …

Measuring Movement And Social Contact With Smartphone Data: A Real-Time Application To Covid-19, Victor Couture, Jonathan L. Dingel, Allison Green, Jessie Handbury, Kevin R. Williams

Cowles Foundation Discussion Papers

Tracking human activity in real time and at fine spatial scale is particularly valuable during episodes such as the COVID-19 pandemic. In this paper, we discuss the suitability of smartphone data for quantifying movement and social contact. We show that these data cover broad sections of the US population and exhibit movement patterns similar to conventional survey data. We develop and make publicly available a location exposure index that summarizes county-to-county movements and a device exposure index that quantifies social contact within venues. We use these indices to document how pandemic-induced reductions in activity vary across people and places.

Pse Reopens Trading Floor, Philippine Stock Exchange, Inc. (Pse)

Documents

No abstract provided.

Pse To Reopen Trading Floor On June 1, Philippine Stock Exchange, Inc. (Pse)

Documents

No abstract provided.

Towards Health Equity In Connecticut: The Role Of Social Inequality And The Impact Of Covid-19, Kelly Davila, Mark Abraham, Camille Seaberry

Reports

In January 2020, the first confirmed case of COVID-19 was reported in the United States, with Connecticut recording its first case by March 8. As of the time of writing, tens of thousands of Connecticut residents have tested positive for the illness, and thousands have died, with the true number of affected individuals likely being much higher. Early data indicate that Black, Latino, and Indigenous communities are experiencing disproportionately higher rates of infection and serious complications. In Connecticut, Black and Latino individuals have died at higher age-adjusted rates than white individuals, and nursing home residents account for more than half …

Promoting Pre-Exposure Prophylaxis Among People Who Inject Drugs Accessing Syringe Exchange Programs, Elena Sullivan

Yale School of Medicine Physician Associate Program Theses

People who inject drugs are at increased risk of acquiring HIV and accounted for 10% of all new diagnoses in 2018. Pre-exposure prophylaxis has been shown to reduce HIV acquisition among at-risk populations, including people who inject drugs. However, pre-exposure prophylaxis is underutilized by people who inject drugs due to limited knowledge about its existence and purpose. The objective of this study is to determine the effectiveness of a patient navigation intervention in increasing initiation of pre-exposure prophylaxis among people who inject drugs. Specifically, we will carry out a randomized controlled study to compare the rates of pre-exposure prophylaxis initiation …

Multinational Organizations’ Efforts To Assist Countries Through Covid-19 Crisis, Aidan Lawson, Manuel Leon Hoyos, June Rhee

Documents

No abstract provided.

Minutes Of The Monetary Policy Meeting On March 16, 2020, Bank Of Japan/Central Bank Of Japan

Documents

No abstract provided.

Hospital-Acquired Infection Outcomes Under A Patient-Centered Hand Hygiene Initiative, Nina Fiellin

Yale School of Medicine Physician Associate Program Theses

Hospital-acquired infections are common and represent the most frequent adverse event in healthcare delivery. Hand hygiene has been identified as the most effective intervention to prevent the spread of hospital-acquired infections. Although patients have been identified as vectors, the role of increased patient hand hygiene in the reduction of hospital-acquired infections has not been determined. We propose that the addition of a patient-centered hand hygiene intervention among hospitalized adult patients on general medicine floors will result in a 30% reduction in acquisition of hospital-acquired infections over the time period of 18-months in comparison to the standard of care focused on …

Liposomal Amphotericin B And Flucytosine Versus Micafungin In Treatment Of Candida Endocarditis, Anton Matthew Yanker

Yale School of Medicine Physician Associate Program Theses

Candida endocarditis is a life-threatening, opportunistic fungal infection of the endocardium. The mortality rate of Candida endocarditis is approximately 50% and has been increasing in incidence over recent years. Historically, amphotericin B and flucytosine has been considered the standard of treatment for candida endocarditis, but is limited by safety concerns of amphotericin B, primarily nephrotoxicity and hepatotoxicity. Echinocandins, such as micafungin, have demonstrated similar efficacy in other forms of invasive candidiasis with better safety profiles, but there have been no large-scale or direct comparison trials. In this review, we summarize existing data between micafungin, an echinocandin, vs. amphotericin B and …