Digital Commons Network^™

Annual Report 2017, European Central Bank (Ecb)

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No abstract provided.

Our Mission 2017 - How We Regulate Financial Services, Financial Conduct Authority (Fca)

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No abstract provided.

Korea Deposit Insurance Corporation Annual Report 2017, Korea Deposit Insurance Corporation (Kdic)

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No abstract provided.

Evaluating The Utility Of Spect/Ct Imaging Of Angiosome Perfusion In Diabetic Patients With Critical Limb Ischemia, Jessica Buckley

Yale Medicine Thesis Digital Library

EVALUATING THE UTILITY OF SPECT/CT IMAGING OF ANGIOSOME PERFUSION IN DIABETIC PATIENTS WITH CRITICAL LIMB ISCHEMIA.

Jessica L. Buckley, Albert J. Sinusas, Mitchel R. Stacy. Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT.

Impaired lower extremity perfusion is a hallmark of peripheral arterial disease (PAD) and is particularly problematic in diabetic patients, who suffer from high rates of PAD, ulceration, and lower extremity amputation. The ability to non-invasively detect deficits in microvascular perfusion within vascular territories, or angiosomes, of the feet may provide information related to tissue viability and guide therapeutic interventions. …

Demethylation Therapy As A Novel Treatment For Human Papilloma Virus-Associated Head And Neck Cancer, Michael Hajek

Yale Medicine Thesis Digital Library

5-azacytidine (5-aza) and its structural analog 5-aza-2’-deoxycytidine (decitabine) are demethylating agents currently used to treat myelodysplastic syndrome and acute myeloid leukemia. In addition to demethylating DNA, they are known to cause DNA damage and activate DNA damage response pathways, but our mechanistic understanding of these processes is incomplete. Given the unique epigenetic profile of human papilloma virus-associated (HPV+) head and neck squamous cell carcinoma (HNSCC), we sought to develop demethylation therapy as a novel, targeted treatment for this subset of cancer that has less morbidity than current treatments. We wanted to characterize the DNA damage and describe the mechanism of …

Novel Application Of Untargeted Metabolomics To Diseases Of Neurosurgical Significance, Alex Yang Lu

Yale Medicine Thesis Digital Library

Metabolomics, an emerging technique to study hundreds of small-molecule metabolites simultaneously, has been seldom applied to diseases of neurosurgical significance. We utilized metabolomics to explore two distinct questions: 1. to identify global metabolic changes and metabolite predictors of long-term outcome in aneurysmal subarachnoid hemorrhage (SAH) patients, 2. to identify differential metabolites profiles of radiation necrosis vs. recurrent tumor of metastatic brain lesions post-Gamma Knife radiosurgery. The first study applied gas chromatography time-of-flight mass spectrometry (GC-TOF) to cerebrospinal fluid samples collected from 15 high-grade aSAH patients (modified Fisher grades 3 and 4). Analysis was performed at two time points; metabolite levels …

The Evolution Of Restraint In American Psychiatry, Danilo Alejandro Rojas-Velasquez

Yale Medicine Thesis Digital Library

History/Social Science:

The Evolution of Restraint in American Psychiatry

Author: Danilo Rojas-Velasquez

In psychiatry, restraint generally refers to direct methods such as mechanical restraints or the use of drugs. Despite psychiatrists’ best efforts to utilize restraint judiciously, many patients still view it as the field’s defining feature, especially on inpatient units with involuntary commitment, medications against will, and locked doors. This essay is an attempt to understand the pervasiveness of restraint in psychiatry. It uses changes in the practices of restraint to examine the growth of the field over time. To accomplish this, the paper identifies three distinct regimes of …

Predicting Response To Anti-Pd-1 Immunotherapy In Metastatic Melanoma, James William Smithy

Yale Medicine Thesis Digital Library

Predictive biomarkers for antibodies against programmed death 1 (PD-1) remain a major unmet need in metastatic melanoma. Thus, we evaluated three alternative tissue- and blood based markers biomarkers for response to anti-PD-1 therapy. First, pre-treatment melanoma samples were assayed for expression of: 1) IRF-1, a PD-L1 transcription factor, as a proxy for a tumor’s capacity to express PD-L1, and 2) an immune activation panel consisting of CD3, Ki67, and Granzyme B to distinguish immune-active and immune-quiescent tumors. Additionally, we conducted pilot studies to determine the feasibility of measuring soluble PD-L1 in the plasma of cancer patients.

For tissue-based assays, samples …

Data Assimilation For Initialization Of Seasonal Forecasts, Magdalena A. Balmaseda

Journal of Marine Research

This article reviews the requirements for a data assimilation system from the perspective of initializing seasonal forecasts. It provides a historical perspective of the developments in ocean data assimilation and ocean observing systems. It also discusses the differences between state estimation and initialization, and presents a brief assessment of different initialization strategies. The value of assimilating ocean data to estimate the ocean state and to initialize seasonal forecasts is demonstrated. However, it is also shown that the assumption of unbiased models in conventional data assimilation methods is not suitable for the production of long temporal records of ocean initial states. …

Medicine@Yale January/February 2017 Volume 13, Issue 1, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Of A Healthy Constitution: Socialized Medicine Between The Triumphs Of Social Security And Medicare, Sarah D. Kim

Kaplan Senior Essay Prize for Use of Library Special Collections

In January 1937, Thomas Thacher, a former solicitor general of the United States under President Hoover, gave a talk at the annual meeting of the American Academy of Medicine. He attacked socialized medicine as a “fallacy” that would “blanket the country without regard to local conditions and individuals.” He also expressed doubts about the constitutionality of socialized medicine under the proposed system of compulsory health insurance, adding that states had no power to enforce funding for it. (Funding for such insurance would entail a sliding scale of costs between those in the upper and middle-income brackets, or to take money …

Influence And Effectiveness In The Years Of Upheaval: Winston Lord And The Policy Planning Staff From 1973 To 1977, Max L.B. Cook

Harvey M. Applebaum ’59 Award

This two-semester senior essay submitted in completion of the History major at Yale University focuses broadly on the formation of U.S. long-term foreign policy in the Cold War period. More specifically, it analyzes the influence of the State Department’s Policy Planning Staff (S/P) and its Director Winston Lord (YC ’59) from 1973 to 1977 on the decision-making and policy formulation of Secretary of State Henry Kissinger. In this period, the S/P took the lead on cross-agency issues, linked operational policy decisions with established long-term U.S. strategic principles, and in some issue areas directly defined U.S. policy on behalf of Secretary …

What Exactly Is Market Integrity? An Analysis Of One Of The Core Objectives Of Securities Regulation, Janet Austin

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No abstract provided.

Federal Open Market Committee Rules And Authorizations (January 2017), Federal Reserve System: Board Of Governors: Federal Open Market Committee (Fomc)

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No abstract provided.

Annual Report Of The State Audit Office Of The Republic Of Latvia 2016, Republic Of Latvia: State Audit Office

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No abstract provided.

2016 Annual Report, Bank Of Mongolia (Mongolbank)

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No abstract provided.

Annual Report 2016, Dexia

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No abstract provided.

The Factors Affecting The Profitability Of Banks: The Case Of Latvia, Kristina Bojāre, Inna Romānova

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No abstract provided.

Danish Marketing Practices Act, Danish Parliament

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No abstract provided.

State Capture: The Case Of The Republic Of Moldova, Transparency International Moldova, Adept, Legal Resources Center From Moldova, Institute For Development And Social Initiatives

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No abstract provided.

Annual Report 2016, Société Fédérale De Participations Et D’Investissement (Sfpi)

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No abstract provided.

Annual Report 2016, Dexia Group N.V./S.A.

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No abstract provided.

Frequently Asked Questions About Covered Bonds, Morrison And Foerster Llp

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No abstract provided.

Of A Healthy Constitution: Socialized Medicine Between The Triumphs Of Social Security And Medicare, Sarah D. Kim

Harvey M. Applebaum ’59 Award

No abstract provided.

Kissinger’S Strategy In The Iraqi Kurdish Rebellion Of 1972-75: False Start Or Foundation Of American-Kurdish Partnership?, Jonathan C. Esty

Harvey M. Applebaum ’59 Award

No abstract provided.

Longitudinal Assessment Of Blood Brain Barrier Disruption In Primary Hiv Infection And Effect Of Cart Therapy, Elham Rahimy

Yale Medicine Thesis Digital Library

Abnormal blood brain barrier (BBB) permeability has been implicated in the neuropathogenesis of chronic HIV infection. As neurocognitive impairment can persist despite effective combination antiretroviral therapy (cART), it is possible that irreversible central nervous system (CNS) processes are initiated in early infection, before cART is typically initiated. We analyzed the natural history of BBB permeability in primary HIV infection (PHI), and the effects of cART initiated during this period. CSF:Serum albumin quotient (QAlb), a marker of BBB permeability, was measured in longitudinal observational studies of PHI. We analyzed trajectories of QAlb pre- and post-cART using mixed-effects models, and associations between …

Prioritizing Primary Prevention Strategies For Cardiovascular Disease At The Clinic Population Level, Giulio Cesare Rottaro Castejon

Yale Medicine Thesis Digital Library

Cardiovascular Disease remains the number one cause of mortality in the United States with atherosclerotic cardiovascular disease (ASCVD) being a major component. Lifestyle interventions remain the first line treatment for the prevention of ASCVD, and clinic- based interventions effectively improve rates of healthy lifestyle choices. However, these programs require additional resources and there is currently no guidance for clinic directors to understand what lifestyle intervention(s) have the highest value for their unique population. We propose a novel application of the 10-year ASCVD risk calculator to a clinic patient cohort, thereby acting as a tool for providers and administrators to develop …

Identifying Barriers To Implementing Guidelines For Monitoring Metabolic Syndrome In Patients Prescribed Second-Generation Antipsychotics In Incarcerated Populations, Carol-Ann Margaret Cenac

Yale School of Nursing Digital Theses

Individuals with serious mental illness (SMI) have increased rates of cardiovascular disease (CVD) and mortality. Also, the evidence indicates that second-generation antipsychotics (SGAs, a conventional treatment) increase the risk of metabolic syndrome (MetS) often leading to weight gain, cardiovascular disease (CVD) and type 2 diabetes (DM 2). U. S. correctional institutions, faced with increased rates of mental illness in its population, are confronted with the need to assure adequate monitoring for its patients treated with SGAs. This paper reviews guidelines for monitoring incarcerated patients to ensure early intervention that can improve clinical outcomes. Characteristics of the incarcerated population and institution-related …

Identifying Barriers To Implementing Guidelines For Monitoring Metabolic Syndrome In Patients Prescribed Second-Generation Antipsychotics In Incarcerated Populations, Carol-Ann Margaret Cenac

Yale School of Nursing Digital Theses

Individuals with serious mental illness (SMI) have increased rates of cardiovascular disease (CVD) and mortality. Also, the evidence indicates that second-generation antipsychotics (SGAs, a conventional treatment) increase the risk of metabolic syndrome (MetS) often leading to weight gain, cardiovascular disease (CVD) and type 2 diabetes (DM 2). U. S. correctional institutions, faced with increased rates of mental illness in its population, are confronted with the need to assure adequate monitoring for its patients treated with SGAs. This paper reviews guidelines for monitoring incarcerated patients to ensure early intervention that can improve clinical outcomes. Characteristics of the incarcerated population and institution-related …

The Ebola Experience: Media Lessons For Nurse Leaders, Elizabeth Leary

Yale School of Nursing Digital Theses

Background: In October, 2014 the nursing profession gained unprecedented media attention when two nurses became infected with the Ebola virus, and another nurse who cared for Ebola patients defied two gubernatorial quarantine orders. Nurses have traditionally received little media attention, and the nursing profession was largely unprepared for the intense media scrutiny which occurred during the Ebola crisis.

Purpose: For decades nursing scholars have called for a new media image for the nursing profession, yet most of the nursing literature has focused on the profession’s poor media image rather than effective media communication techniques. The purpose of this paper is …