Digital Commons Network^™

Erk3 As A Braf-Regulated Tumor Suppressor Is A New Potential Cancer Target In Melanoma, Minyi Chen

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Melanoma is the highest mortality rate skin cancer and the sixth most common cancer in the U.S..[1, 2] Arising from melanocytes, melanoma is known for frequent mutation of BRAF to its constitutive activation state BRAFV600E, thus over-activating its downstream MAPK targets ERK1/2 and contributing to melanoma progression.[3, 4, 5] ERK3, a less studied MAPK family protein which contributes to promoting lung, breast, cervical, head and neck (HNC) cancer metastasis, has also shown a correlation with upregulation of BRAF.[6, 7, 8, 9] However, the BRAF-ERK3 regulatory mechanism and the function of ERK3 in melanoma are still unclear. Here, we first elucidate …

Engineering Inpatient Discharges: Disposition Prediction And Day-Of-Discharge Planning, Nicholas A. Ballester

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Inpatient discharge planning is a critical decision point in patient care, with implications for the efficiency of the inpatient unit as well as other units of the acute care hospital. Inefficient discharge planning can cause patient boarding (waiting for beds) in the upstream units. While this is a poignant and well-known problem in healthcare, very little quantitative research exists that proposes approaches to alleviate it. To address this issue, we apply Systems Engineering methods with focus on three key challenges in inpatient discharge planning. First, to aid inpatient care providers in predicting discharge disposition (home vs. non-home) within 24-hours of …

Urinary Metabolomics To Detect Polycystic Kidney Disease At Early Stage, Amnah Mahmoud Obidan

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Urinary metabolomics abilities in detection of biological effects (i.e., toxicity, disease) is compounded by high background variability. Previously, we showed mild kidney dysfunction was detectable under the stress imposed by furosemide (diuretic). Here we tested whether furosemide (FUR) can enhance the sensitivity to detect autosomal dominant polycystic kidney disease (ADPKD) at an early stage. ADPKD is one of the most common inherited renal disorders and is characterized by the growth of numerous cysts in the kidneys. Urinary metabolomics analyses, using nuclear magnetic resonance (NMR) spectroscopy, were conducted in control (WT) and diseased mice (RC) at 7 and 24 weeks of …

Development Of Computer Program For Wind Resource Assessment, Rotor Design And Rotor Performance, Valentina Jami

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People understand and have seen that renewable energy has many advantages over conventional energy sources. Because of these advantages, more and more emphasis has been given to generating electrical energy with renewable sources. Among the many renewable and conventional ways currently available for a society to generate electrical power, wind turbines are one of the cheapest ways of doing this. The main objective of this thesis work is to develop a computer program that assesses the wind resource at a given location, designs a wind turbine rotor for optimum power capture for one wind speed, and analyzes the performance of …

2015-16 First Destination Survey - Wright State University, Office Of Institutional Research, Wright State University

Post-Graduation Outcomes

The First Destination Survey was administered to students during the first year after graduation from Wright State University. The survey was emailed to all students who graduated between July 1, 2015, and June 30, 2016 (Summer 2015, Fall 2015, and Spring 2016). All data are self-reported by the respondent at the time of the survey completion. Included in the report are degrees earned by college, salary, job location, industry, and job function.

Synaptic Up-Scaling Preserves Motor Circuit Output After Chronic, Natural Inactivity, Joseph Michael Santin, Mauricio Vallejo, Lynn K. Hartzler

Biological Sciences Faculty Publications

Neural systems use homeostatic plasticity to maintain normal brain functions and to prevent abnormal activity. Surprisingly, homeostatic mechanisms that regulate circuit output have mainly been demonstrated during artificial and/or pathological perturbations. Natural, physiological scenarios that activate these stabilizing mechanisms in neural networks of mature animals remain elusive. To establish the extent to which a naturally inactive circuit engages mechanisms of homeostatic plasticity, we utilized the respiratory motor circuit in bullfrogs that normally remains inactive for several months during the winter. We found that inactive respiratory motoneurons exhibit a classic form of homeostatic plasticity, up-scaling of AMPA-glutamate receptors. Up-scaling increased the …

A High-Dimensional Data Quality Metric Using Pareto Optimality, Tobias Post, Thomas Wischgoll, Bernd Hamann, Hans Hagen

Computer Science and Engineering Faculty Publications

The representation of data quality within established high-dimensional data visualization techniques such as scatterplots and parallel coordinates is still an open problem. This work offers a scale-invariant measure based on Pareto optimality that is able to indicate the quality of data points with respect to the Pareto front. In cases where datasets contain noise or parameters that cannot easily be expressed or evaluated mathematically, the presented measure provides a visual encoding of the environment of a Pareto front to enable an enhanced visual inspection.

Cloud Point Extraction In Conjunction With Tangential Flow Filtration (Cpe-Tff) For The Enhanced Separation Of Silver Nanoparticles And Silver Ions From Aqueous Colloids And Biological Matrices, Md Ali Akbar

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The extensive use of silver nanoparticles (AgNPs) in consumer products and research is accompanied by their inevitable release into the environment. While the environmental fate of AgNPs is still under investigation, most in vitro and in vivo studies agree that the main toxicity of AgNPs is directly related to the release of Ag+ ions from AgNPs. In this study, cloud point extraction (CPE) was combined with tangential flow filtration (TFF) for the enhanced separation of AgNPs and Ag+ from aqueous colloids and biological matrices. The feasibility of the CPE-TFF method was demonstrated on four colloidal (borohydride-, PVP-, citrate-capped and uncapped …

Association Of Gut Luminal Metabolites And Allergic Responses, Ghaith Mohammed Fallata

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Allergy is a global health problem, affecting more than 40% of the world population. Allergy is often associated with a dysregulation of the immune system that becomes overactive against allergens. Several genes are known to be important for the proper homeostasis of the immune system in the epithelial tissues, and the loss of function of genes such as IKKß or SOX9 impacts the interaction between external stimuli and the host. Many of the allergic responses are triggered through the regulatory cascade governed by transcriptional factor NF-κB. Regulation of NF-κB activity is complex, involves several alternative routes, and is also influenced …

Computational And Experimental Investigations Concerning Rare Gas And Dpal Lasers And A Relaxation Kinetics Investigation Of The Br2 + 2no = 2brno Equilibrium, Joel R. Schmitz

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This research contains four different research projects, the first an educational project introducing hydrogen bromide and deuterium bromide (HBr/DBr) and carbon monoxide (CO) as viable options for infrared vibration-rotation spectroscopy at 0.125 cm^-1 or 0.5 cm^-1 resolution in the teaching laboratory. The second project involved determining the spectral shifts of lanthanide fibers for diode-pumped alkali laser (DPAL) applications. Spectral shifts of lanthanides were determined using UV-VIS-NIR absorbance spectroscopy and laser-induced fluorescence (LIF). The third project entailed computing Ar* atomic energy levels and the potential energy curves of Ar*+He laser systems arising from 3p⁵4s¹ and 3p …

Smart Ev Charging For Improved Sustainable Mobility, Ashutosh Shivakumar

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The landscape of energy generation and utilization is witnessing an unprecedented change. We are at the threshold of a major shift in electricity generation from utilization of conventional sources of energy like coal to sustainable and renewable sources of energy like solar and wind. On the other hand, electricity consumption, especially in the field of transportation, due to advancements in the field of battery research and exponential technologies like vehicle telematics, is seeing a shift from carbon based to Lithium based fuel. Encouraged by 1. Decrease in the cost of Li – ion based batteries 2. Breakthroughs in battery chemistry …

Upstream Sources Inhibit Benthic Phosphorus Fluxes In The Lower Great Miami River, Southwest Ohio, Kortney Mullen

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Human activities have increased nutrient loadings to aquatic ecosystems during the past century. During low river flow in late summer and early fall, excessive concentrations of phosphorus (P) are present in the Lower Great Miami River (LGMR) and contribute to its eutrophication. Although wastewater treatment plants are suspected of being major point sources of P to the LGMR during low river flow, riverbed sediment has not been examined as an additional potential source of P. Benthic P fluxes were measured at 11 representative locations along the LGMR during late summer and early fall of 2015. Sediment and overlying water sampled …

A Study Of Alkali-Resistant Materials For Use In Atomic Physics Based Systems, Aaron Thomas Fletcher

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Due to shortcomings in emerging alkali-based atomic physics based systems, a need to investigate alkali resistant materials has arisen. There is interest in alkali based systems such as atomic clocks and diode pumped alkali laser (DPAL) systems. In the case of atomic clocks and DPALs, alkali metal vapor, such as Rb, is the active part of the systems. The alkali vapor is confined in some manner of housing, but the transmission of electromagnetic radiation is required in the cells. This requires the incorporation of windows into the cell. The current window material, however, have been shown to degrade over time, …

06. Sas Program Files For Design And Analysis Of Experiments, Angela Dean, Dan Voss, Danel Draguljic

Design and Analysis of Experiments

SAS program files for use with Design and Analysis of Experiments.

08. R Program Files For Design And Analysis Of Experiments, Angela Dean, Dan Voss, Danel Draguljic

Design and Analysis of Experiments

R program files for use with Design and Analysis of Experiments.

07. Sas Data Files For Design And Analysis Of Experiments, Angela Dean, Dan Voss, Danel Draguljic

Design and Analysis of Experiments

SAS Data files for use with Design and Analysis of Experiments.

A Semantics-Based Measure Of Emoji Similarity, Sanjaya Wijeratne, Lakshika Balasuriya, Amit Sheth, Derek Doran

Kno.e.sis Publications

Emoji have grown to become one of the most important forms of communication on the web. With its widespread use, measuring the similarity of emoji has become an important problem for contemporary text processing since it lies at the heart of sentiment analysis, search, and interface design tasks. This paper presents a comprehensive analysis of the semantic similarity of emoji through embedding models that are learned over machine-readable emoji meanings in the EmojiNet knowledge base. Using emoji descriptions, emoji sense labels and emoji sense definitions, and with different training corpora obtained from Twitter and Google News, we develop and test …

Identifying Depressive Disorder In The Twitter Population, Goonmeet Bajaj, Amir Hossein Yazdavar, Krishnaprasad Thirunarayan, Amit Sheth

Kno.e.sis Publications

Depression is a highly prevalent public health challenge and a major cause of disability across the globe.

• Annually 6.7% of Americans (that is, more than 16 million).
• Traditional approaches to curb depression involve survey·based methods via phone or online questionnaires.
• Large temporal gaps and cognitive bias.

Social media provides a method for learning users' feelings, emotions, behaviors, and decisions in real-time.

Flexibility Of Projective-Planar Embeddings, John Maharry, Neil Robertson, Vaidy Sivaraman, Dan Slilaty

Mathematics and Statistics Faculty Publications

Given two embeddings σ1 and σ2 of a labeled nonplanar graph in the projective plane, we give a collection of maneuvers on projective-planar embeddings that can be used to take σ1 to σ2

Wright State University Fact Sheet, 2016-2017, Office Of Institutional Research & Effectiveness, Wright State University

Wright State University Fact Sheets

The Wright State University Fact Sheet showcasing numbers and statistics for Wright State University including demographics, funding, programs, and employment for the 2016-2017 academic year.

Diffusion Maps And Transfer Subspace Learning, Olga L. Mendoza-Schrock

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Transfer Subspace Learning has recently gained popularity for its ability to perform cross-dataset and cross-domain object recognition. The ability to leverage existing data without the need for additional data collections is attractive for Aided Target Recognition applications. For Aided Target Recognition (or object assessment) applications, Transfer Subspace Learning is particularly useful, as it enables the incorporation of sparse and dynamically collected data into existing systems that utilize large databases. In this dissertation, Manifold Learning and Transfer Subspace Learning are combined to create new Aided Target Recognition systems capable of achieving high target recognition rates for cross-dataset conditions and cross-domain applications. …

Effects Of Myrrh On Hsv-1 Using Plaque Assay, Badrieah Mohammad Alamri

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Herpes simplex virus type 1 (HSV-1) is a highly infective human pathogen which infects a wide range of population in North America and worldwide. HSV-1 infection has two phases, lytic and latent. Recurrence of HSV-1 is a major challenge to clinicians to control the infection especially in immune depleted individuals. Acyclovir (ACV) is an antiviral drug used to treat HSV-1 infection. Low solubility of ACV in water, mutation of viral thymidine kinase, and mutation of viral DNA polymerase are major problems that cause usage limitations of ACV. Myrrh has been used as an analgesic and anti-inflammatory natural product in middle …

Survey Of A Neotropical Anuran Assemblage (Pacaya-Samiria Reserve, Peru), Eric Woebbe

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The Pacaya-Samiria National Reserve of Peru is one of the largest protected areas of the Amazon rainforest, yet it has hosted only a few studies of frogs and toads (anurans). The primary goals of my study are: 1) To conduct an inventory of the local anuran species, 2) to quantify richness among habitats, 3) to compare differences in beta diversity across a river versus a continuous landscape, and 4) to compare difference in body size between nocturnal and diurnal individuals. After eight weeks of daytime and nighttime surveys during the dry season, a total of 601 individuals were identified across …

Settings Protection Add-On: A User-Interactive Browser Extension To Prevent The Exploitation Of Preferences, Venkata Naga Siva Seelam

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The abuse of browser preferences is a significant application security issue, despite numerous protections against automated software changing these preferences. Browser hijackers modify user’s desired preferences by injecting malicious software into the browser. Users are not aware of these modifications, and the unwanted changes can annoy the user and circumvent security preferences. Reverting these changes is not easy, and users often have to go through complicated sequences of steps to restore their preferences to the previous values. Tasks to resolve this issue include uninstalling and re-installing the browser, resetting browser preferences, and installing malware removal tools. This thesis describes a …

Exploiting Alignments In Linked Data For Compression And Query Answering, Amit Krishna Joshi

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Linked data has experienced accelerated growth in recent years due to its interlinking ability across disparate sources, made possible via machine-processable RDF data. Today, a large number of organizations, including governments and news providers, publish data in RDF format, inviting developers to build useful applications through reuse and integration of structured data. This has led to tremendous increase in the amount of RDF data on the web. Although the growth of RDF data can be viewed as a positive sign for semantic web initiatives, it causes performance bottlenecks for RDF data management systems that store and provide access to data. …

When Words Are Worse Than Bullets: A Study Of Corruption As An Unintended Consequence Of Threats Of Sanctions, Aleksei Balanov

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This research contributes to the debates on the efficacy of economic sanctions as a tool of international diplomacy. It focuses on corruption, one of the potential unintended consequences of sanctions. Using multiple regression on a custom cross-sectional time series dataset of more than a thousand observations, this research finds the correlation between threats of sanctions and level of corruption statistically significant. The model suggests each new round of threats translates into a 1.25% increase in corruption for relatively clean states and a 5% increase for already corrupt states. The resulting policy implications are examined in this thesis.

Bistatic Sar Polar Format Image Formation: Distortion Correction And Scene Size Limits, Davin Mao

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The polar format algorithm (PFA) for bistatic synthetic aperture radar (SAR) image formation offers the compromise between image quality and computational complexity afforded by PFA, while enabling the geometric flexibility of a bistatic collection scenario. The use of the far-field approximation (FFA), which enables the use of the two-dimensional (2D) fast Fourier transform (FFT) in PFA, introduces spatially-varying distortion and defocus effects causing geometric warping and blurring in the resulting image. In this thesis, the residual phase errors due to the FFA are analyzed by decomposing the residual phase errors in the time dimension into their constant, linear, and quadratic …

Synthesis Of 4-Iodo-3-(2-Iodoaryl) And 4-Bromo-3-(2-Bromoaryl) Sydnones And Their Reactions With Sodium Sulfite, Sodium Borohydride, And Iodine Monochloride, Kyle Jacob Liddy

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One goal of the Turnbull research group has been the synthesis of dihalogenated arylsydnones; i.e. sydnones with halogen substitution on the sydnone ring itself, as well as at the position on the aryl ring ortho to the sydnone. Further, it has been of interest to explore the reactivity of these compounds, once obtained. The present study examined the synthesis of 4-iodo-3-(2-iodoaryl)-, or "diiodo", and 4-bromo-3-(2-bromoaryl)-, or "dibromo", sydnones and the reactions of these compounds with Na2SO3 (sodium sulfite) and NaBH4 (sodium borohydride) to create a better understanding of the reactivity of diiodo and dibromo arylsydnones in general. Additionally, the reactivity …

An Engage Or Retreat Differential Game With Two Targets, Bikash Shrestha

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This thesis develops the equilibrium solution for a two-target engage or retreat differential game. In this game, the attacking player is modeled as a massless particle moving with simple motion about an infinite, obstacle-free plane. The opposing player, referred to as the defender, is tasked with the protection of two high-value targets. The mobile attacker must choose to either engage one of the high-value targets or retreat across a predefined boundary. Simultaneously, the defensive player must choose whether to minimize or maximize the attacker's integral utility in an effort to persuade the attacker to choose retreat from certain initial conditions. …

Global And Cultural Studies, Ronald G. Helms Ph.D.

Books Authored by Wright State Faculty/Staff

No abstract provided.