Digital Commons Network^™

Towards An Image-Based Indicator For Pad Classification And Localization, Christina Gillmann, Johh H. Matsuura, Hans Hagen, Thomas Wischgoll

Computer Science and Engineering Faculty Publications

Peripheral Artery Disease (PAD) is an often occurring problem caused by narrowed veins. With this type of disease, mostly the legs receive an insufficient supply of blood to sustain their functions. This can result in an amputation of extremities or strokes. In order to quantify the risks, doctors onsult a classification table which is based on the pain response of a patient. This classification is subjective and does not indicate the exact origin of the PAD symptoms. Resulting from this, complications can occur unprompted. We present the first results for an image-based indicator assisting medical doctors in estimating the stage …

Ontology Design Patterns For Winston’S Taxonomy Of Part-Whole Relations, Cogan Shimizu, Pascal Hitzler, Clare Paul

Computer Science and Engineering Faculty Publications

While the formal modeling of part-whole relationships has been of interest, and studied, in many fields including ontology modeling, as of yet there has been no dedicated ontology design pattern which goes beyond the modeling of an absolute minimum. We correct this by providing two patterns based on Winston's landmark paper, "A Taxonomy of Part-Whole Relations".

Towards A Comprehensive Modular Ontology Ide And Tool Suite, Cogan Shimizu

Computer Science and Engineering Faculty Publications

Published ontologies frequently fall short of their promises to enable knowledge sharing and reuse. This may be due to too strong or too weak ontological commitments; one way to prevent this is to en- gineer the ontology to be modular, thus allowing users to more easily adapt ontologies to their own individual use-cases. In order to enable this engineering paradigm, there is a distinct need for developing more supporting tools and infrastructure. This increased support can be im- mediately impactful in a number of ways: Guides engineers through best practices and promote ontology design pattern discovery, sharing, and reuse. To …

Towards A Pattern-Based Ontology For Chemical Laboratory Procedures, Cogan Shimizu, Leah Mcewen, Quinn Hirt

Computer Science and Engineering Faculty Publications

There is an increasing expectation in the academic sector for chemistry researchers to conduct risk assessment during experimental planning. However, information concerning laboratory scale chemical reactivity hazards can be difficult to parse despite ongoing efforts to compile from reported incidents. Laboratory procedures do not always directly flag possible incompatibilities among constituents or other process factors. In this paper, we present a pattern-based ontology for capturing multiple factors involved in laboratory procedures, including chemical properties, states, conditions, actions, and associated hazard classifications.

Hst 1100 Ii Western Civilizations To 1500 Core General Education Assessment, 2017-2018, College Of Liberal Arts, Wright State University

Core General Education Assessments - All

This report assesses Wright State University's course HST 1100, II Western Civilizations to 1500, as part of the institution’s ongoing general education Core assessment plan.

Element 3 Unoc Letter To Chairs Core General Education Assessment, 2017-2018, Wright State Core Oversight Committee, Wright State University

Core General Education Assessments - All

The UNOC Letter to Chairs for Element 3 - Interdisciplinary Global Studies as part of the institution’s ongoing general education Core assessment plan.

Metrics For Evaluating Quality Of Embeddings For Ontological Concepts, Faisal Alshargi, Saeedeh Shekarpour, Tommaso Soru, Amit P. Sheth

Kno.e.sis Publications

Although there is an emerging trend towards generating embeddings for primarily unstructured data and, recently, for structured data, no systematic suite for measuring the quality of embeddings has been proposed yet. This deficiency is further sensed with respect to embeddings generated for structured data because there are no concrete evaluation metrics measuring the quality of the encoded structure as well as semantic patterns in the embedding space. In this paper, we introduce a framework containing three distinct tasks concerned with the individual aspects of ontological concepts: (i) the categorization aspect, (ii) the hierarchical aspect, and (iii) the relational aspect. Then, …

Lead In Tap Water From The City Of Dayton, Ohio, Kayla Marie Haman

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Lead (Pb) in public tap water is a national health concern and is the main pathway of human exposure to Pb. The City of Dayton has verified Pb pipelines and homes with Pb plumbing; thus, residents are at risk to Pb leaching into their tap water. I sampled water from 130 residential and 24 public water taps and measured Pb and copper (Cu). Five percent of samples exceeded the action level for Pb (> 15 [micro]g/L) and none exceeded the action level for Cu. The City of Dayton's lead pipeline map identifies potential Pb exposure from Pb distribution pipes. However, …

In Vitro Assessment Of The Effects Of Valvular Stenosis On Aorta Hemodynamics And Left Ventricular Function, Ashish Madan

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Calcific aortic stenosis (CAS) is the most common valvular heart disease and is associated with aortopathy and ventricular dysfunction. Hemodynamic alterations due CAS could affect the aorta lining (endothelium), that is in direct contact with the blood, triggering adverse biological responses that may possibly cause aortic dilation and dissection. Also, CAS could impose excessive ventricular load leading to ventricular wall thickening, thus putting an individual at a higher risk of heart attack or stroke. These pathophysiological effects of CAS are highly dependent on the degree of calcification. However, the impact of CAS development on aorta flow and left ventricular workload …

A Lc-Ms/Ms-Based Method For The Multiplex Detection Of 24 Fentanyl Analogs And Metabolites In Whole Blood At Sub Ng Ml-1 Concentrations, Kraig Edward Strayer

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The United States and numerous other countries worldwide are currently experiencing a public health crisis due to the abuse of illicitly manufactured fentanyl (IMF) and its analogues. This manuscript describes the development of a liquid chromatography-tandem mass spectrometry-based method for the multiplex detection of N = 24 IMF analogues and metabolites in whole blood at concentrations as low as 0.1-0.5 ng mL-1. These available IMFs were fentanyl, norfentanyl, furanyl norfentanyl, remifentanil acid, butyryl norfentanyl, remifentanil, acetyl fentanyl, alfentanil, AH-7921, U-47700, acetyl fentanyl 4-methylphenethyl, acrylfentanyl, para-methoxyfentanyl, despropionyl fentanyl (4-ANPP), furanyl fentanyl, despropionyl para-fluorofentanyl, carfentanil, (±)-cis-3-methyl fentanyl, butyryl fentanyl, isobutyryl fentanyl, sufentanil, …

Chaotic Based Self-Synchronization For Rf Steganography Radar/Communication Waveform, Michael A. Gonnella

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In this project, we continue previous CSR project entitled RF Steganography based Joint Radar/Communication Waveform Design to develop a bio-inspired secure low probability detection (LPD) radio frequency (RF) waveform that can serve multiple purposes simultaneously. Previously, we have developed an RF steganography based RF waveform to conceal a secure digital communication within a linear frequency modulated (LFM) chirp radar signal. By exploiting novel reduced phase shift keying modulation and variable symbol duration, the new waveform is resistant to time domain analysis, frequency domain analysis and cyclostationary analysis. However, to demodulate the hidden communication message, the intended receiver has to know …

Gender Fairness Within The Force Concept Inventory, Adrienne L. Traxler, Rachel Henderson, John Stewart, Gay Stewart, Alexis Papak, Rebecca Lindell

Physics Faculty Publications

Research on the test structure of the Force Concept Inventory (FCI) has largely ignored gender, and research on FCI gender effects (often reported as “gender gaps”) has seldom interrogated the structure of the test. These rarely crossed streams of research leave open the possibility that the FCI may not be structurally valid across genders, particularly since many reported results come from calculus-based courses where 75% or more of the students are men. We examine the FCI considering both psychometrics and gender disaggregation (while acknowledging this as a binary simplification), and find several problematic questions whose removal decreases the apparent gender …

The Extension Newsletter, Issue 96, Winter 2018, Wright State University Retirees Association

The Extension Newsletter

An eight page newsletter from the Wright State University's Retirees Association.

Caregiver Assessment Using Smart Gaming Technology: A Preliminary Approach, Garrett Goodman, Tanvi Banerjee, William Romine, Cogan Shimizu, Jennifer Hughes

Computer Science and Engineering Faculty Publications

As pre-diagnostic technologies are becoming increasingly accessible, using them to improve the quality of care available to dementia patients and their caregivers is of increasing interest. Specifically, we aim to develop a tool for non- invasively assessing task performance in a simple gaming application. To address this, we have developed Caregiver Assessment using Smart Technology (CAST), a mobile application that personalizes a traditional word scramble game. Its core functionality uses a Fuzzy Inference System (FIS) optimized via a Genetic Algorithm (GA) to provide customized performance measures for each user of the system. With CAST, we match the relative level of …

Regulation Of The Motor Output Of The Spinal Cord: Burst Firing Generation And Sensorimotor Integration, Amr A. Mahrous

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Spinal motoneurons are the final common path for motor signals. Thus, the firing activity recorded from spinal motoneurons or their axons in the ventral roots represents the motor output of the nervous system. This dissertation investigates two major phenomena that help generate and shape the neuronal motor output. Specialized groups of spinal neurons called central pattern generators (CPGs) are capable of orchestrating rhythmic bursting activity without involvement of the brain. This activity underlies stereotyped movements such as locomotion. If known, the ionic mechanisms responsible for generating this activity can offer new pharmacological interventions to restore walking in paralyzed patients with …

Structure-Property Relationships In Paes Prepared From 2-(2,4-Difluorophenyl)Benzoxazole Derivatives, Amy Slaybaugh

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The synthesis of N-heterocycle functionalized poly(arylene ether)s, derived from 2-(2,4-difluorophenyl)benzoxazole, was explored. The platform monomer, 2-(2,4-difluorophenyl)benzoxazole (3), was prepared in one-step and characterized using NMR spectroscopy and elemental analysis. The “pre” approach involved introducing a carbazole moiety, using a copper catalyzed C-N coupling reaction, while the “post” approach required conversion of monomer 3 to the corresponding poly(arylene ether)s (PAE)s first, then performing the C-N coupling reaction. Both “pre” and “post” approaches utilized bisphenol-A (BPA) and 4,4’-difluorophenylsulfone (DPS) as comonomers as well as 4,4’-dihydroxydiphenyl ether (DPE) and 4,4’difluorotriphenylphosphine oxide (dfTPPO). All of the materials had sufficient molecular weights (Mn) to allow …

The Great Potential Of Redox Active Ligands: Applications In Cancer Research And Redox Active Catalysis, Meredith Miles

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Metal N-heterocyclic carbene (NHC) complexes have recently gained much popularity due to their tunable, steric, and electronic properties. Applications for such versatile molecules include organocatalysis, olefin metathesis, sundry cyclization reactions, and materials chemistry. Redox active NHCs are of special interest due to their ability to alter the electronic properties of the metal centers they are ligated to. In the first chapter, Au(I)-NHC complexes were synthesized and tested for biological activity in human cancer cell lines. Increasing reactive oxygen species (ROS) in cellular systems has proven to be a successful pathway for treating cancer. The redox active group in this case …

Characterization And Design Of Voltage-Mode Controlled Full-Bridge Dc/Dc Converter With Current Limit, Nathaniel R. Smith

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Advancements in Direct Current (DC) electrical power systems have enabled new functionality in many, varied applications. Discrete power semiconductor devices are increasing in efficiency, switching frequency, and power density, resulting in greater usage of DC power management and distribution methods, including DC/DC conversion. DC distribution lacks inherent capability to safely and effectively break fault current, particularly in mobile solutions, where larger and slower electromechanical switching devices are not optimal or feasible. One solution is to design a low-energy breaking point into a switching power supply. Simpler converter designs, with a lower number of switching devices, have been modeled and can …

Experimental Validation Of The Generalized Harvey-Shack Surface Scatter Theory, Kevin T. Nattinger

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The Generalized Harvey-Shack (GHS) surface scatter theory claims to predict the scatter from rough surfaces over a wide domain of validity but has not been widely implemented or tested. The focus of this research is to provide a documented implementation and experimental validation of the GHS theory for the prediction of the bidirectional reflectance distribution function (BRDF) from real rough surfaces. First, the GHS theory was developed for the MATLAB software and the details of its implementation and application to experimental comparison are discussed. Next, a BRDF measurement system was designed, built, and validated. The BRDF of the Spectralon reflectance …

Big Data And The Commoditization Of Analytics: Engaging First-Year Business Students With Analytics, Amir Hassan Zadeh, Shu Schiller, Kevin Duffy, Jonathan Williams

Management Information Systems Faculty Publications

The age of data analytics requires "data scientists” across a wide range of business disciplines with deep knowledge of how to manage and analyze vast amounts of data to support decision-making. As a result, new analytical tools are being taught in the Management Information Systems (MIS) or business analytics (BA) programs to foster students’ development of this critical competency. Three waves of analytics tools are considered froman experiential perspective including how to introduce analytics to first-year business students using an advanced data analytics software package with multiple techniques and data flow interface. SAS Enterprise Miner is used to teach technical …

The Response Of Unpolarized Macrophages (Raw 264.7)/Keratinocytes (Pam-212) Monolayer And Co-Culture System To Herpes Simplex Virus Type 1 (Hsv-1) Replication During The Infection., Fahad Mohammed Alradi

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Keratinocytes and neurons cells are the main target for Herpes Simplex Virus Type 1 (HSV-1) invasion. Moreover, keratinocytes are the most abundant cell types in the epidermis layer in the skin. Therefore, they are the first cells to encounter HSV-1 in the primary infection. Next, the virus reaches the nerve endings and is transferred to neuronal cells as a result from the primary infection. In between these two events, innate immune cells including monocytes and macrophages response is activated and recruited to the infection site. In this study, keratinocytes (PAM-212) and murine macrophage (RAW 264.7) cell lines were utilized to …

Virus Production And Cell Viability Of Hsv-1-Infected Murine Keratinocytes (Hel-30) Co-Cultured With Murine Macrophages (Raw 264.7), Barry Graffagna

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Keratinocytes are the most abundant type of cell in the outer layer of skin, the epidermis, and provide barrier against pathogens from invading. However, Herpes Simplex Virus Type 1 (HSV-1) targets these keratinocytes for infection, and later infects neurons to establish lifelong latency. The keratinocytes stimulate the innate immune system to engage and to destroy the virus. Among the cells of the innate immune system to respond to the viral invasion is the macrophage. In this study, RAW 264.7 macrophage and HEL-30 keratinocyte monolayers were challenged in vitro with HSV-1 at a multiplicity of infection (MOI) of 0.1 to investigate …

Synthesis Of 5-Methyl-3-Phenyl-1,3,4-Oxadiazol-2(3h)-One Derivatives By Electrophilic Aromatic Substitution, Amanda Solis Conde

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An important research element in the Turnbull laboratory has been the one-pot synthesis of 5-methyl-3-phenyl-1,3,4-oxadiazol-2(3H)-one from sydnone. The present study reexamined the reaction of 5-methyl-3-phenyl-1,3,4-oxadiazol-2(3H)-one with electrophiles and optimized methods for synthesis of oxadiazolinone derivatives. Further the oxadiazolinone derivatives were reacted with electrophiles to better comprehend the donating ability of the oxadiazolinone ring system in general with the expectation that the oxadiazolinone ring system is a slightly donating system. Additionally, when the structure assignment of the oxadiazolinone derivative was ambiguous, the corresponding oxadiazolinone or it’s isomer was synthesized from the appropriate sydnone to validate or refute the suggested structure. The …

"What's Ur Type?" Contextualized Classification Of User Types In Marijuana-Related Communications Using Compositional Multiview Embedding, Ugur Kursuncu, Manas Gaur, Usha Lokala, Anurag Illendula, Krishnaprasad Thirunarayan, Raminta Daniulaityte, Amit P. Sheth, Budak Arpinar

Kno.e.sis Publications

With 93% of pro-marijuana population in US favoring legalization of medical marijuana, high expectations of a greater return for Marijuana stocks, and public actively sharing information about medical, recreational and business aspects related to marijuana, it is no surprise that marijuana culture is thriving on Twitter. After the legalization of marijuana for recreational and medical purposes in 29 states, there has been a dramatic increase in the volume of drug-related communication on Twitter. Specifically, Twitter accounts have been established for promotional and informational purposes, some prominent among them being American Ganja, Medical Marijuana Exchange, and Cannabis Now. Identification and characterization …

Personalized Prediction Of Suicide Risk For Web-Based Intervention, Amanuel Alambo, Manas Gaur, Ugur Kursuncu, Krishnaprasad Thirunarayan, Jeremiah Schumm, Jyotishman Pathak, Amit P. Sheth

Kno.e.sis Publications

Across the United States, suicide is the second leading cause of death for people aged between 15 and 34, and younger people are more prone to mental health problems, suicidal thoughts, and behaviors. For instance, 80% of patients with Borderline Personality Disorder have suicide-related behaviors, and between 4-9% of them commit suicide. Moreover, the social stigma associated with mental health issues and suicide deter patients from sharing their experiences directly with others. In such a situation, social media that provides a free and open forum for voluntary expression can provide insights into suicide ideation and self-destructive behavior.

Reddit is a …

Feasibility Of Recording Sleep Quality And Sleep Duration Using Fitbit In Children With Asthma, Amit Sheth, Hong Y. Yip, Utkarshani Jaimini, Dipesh Kadariya, Vaikunth Sridharan, Revathy Venkataramanan, Tanvi Banerjee, Krishnaprasad Thirunarayan, Maninder Kalra

Kno.e.sis Publications

Sleep disorders are common in children with asthma and are increasingly implicated in poor asthma control. Smart wearables such as the Fitbit wristband allow monitoring of users’ sleep duration and quality in their natural surroundings. However, the utility and efficacy of using such wearable devices to monitor sleep in pediatric patients with asthma have not been well-established. Thus, the objective of this study is to demonstrate the feasibility of recording sleep quality and sleep duration using Fitbit in children with asthma.

Khealth Digital Personalized Healthcare Technology For Pediatric Asthma, Utkarshani Jaimini, Hong Y. Yip, Revathy Venkataramanan, Dipesh Kadariya, Vaikunth Sridharan, Tanvi Banerjee, Krishnaprasad Thirunarayan, Maninder Kalra, Amit Sheth

Kno.e.sis Publications

Episodic:Traditional Clinician Centric Healthcare

Questions to be answered:

1.Can we reduce the number of asthma attacks through continuous monitoring of the patient's health condition?

2.Can we predict the asthma attack based on the data collected from the patient?

3.Can we predict the asthma vulnerability score for a patient?

4.Can we predict the asthma severity level of a patient?

5.Can we understand the casual relationship between the asthma symptom and the possible factors responsible for it?

Personalized Health Knowledge Graph, Amelia Gyrard, Manas Gaur, Saeedeh Shekarpour, Krishnaprasad Thirunarayan, Amit Sheth

Kno.e.sis Publications

Our current health applications do not adequately take into account contextual and personalized knowledge about patients. In order to design “Personalized Coach for Healthcare” applications to manage chronic diseases, there is a need to create a Personalized Healthcare Knowledge Graph (PHKG) that takes into consideration a patient’s health condition (personalized knowledge) and enriches that with contextualized knowledge from environmental sensors and Web of Data (e.g., symptoms and treatments for diseases). To develop PHKG, aggregating knowledge from various heterogeneous sources such as the Internet of Things (IoT) devices, clinical notes, and Electronic Medical Records (EMRs) is necessary. In this paper, we …

Conduct Disorder In Times Of Crisis In The Eastern Mediterranean Region, Ruaa A. Al-Juboori

Master of Public Health Program Student Publications

Background: The Eastern Mediterranean Region (EMR), comprising of 22 countries, has a high burden of conduct disorder (CD) and has the largest burden of displaced populations. Violence and displacement increase the need for mental health services.

Methods: Using descriptive study design, 2015 global CD burden (disability-adjusted life years DALYs per 100,000 populations) was compared to the EMR burden. Across 25 years (1990-2015) trend of CD in 22 EMR countries was graphed and compared with the global CD burden. Association of CD with a) Corruption Perception Index; b) Global Peace Index; c) Human Development Index was assessed using correlation analysis. CD …

Investigating Problems With Mathematical Proof Skills, Samantha Collier

The University Honors Program

This research paper is focused on identifying and exploring problems that high school students have with the mathematical proof process. The study described in this report was designed to answer the question, do students who tend to struggle with mathematical proofs also struggle with understanding what is known and unknown in a proof, making assumptions about figures, and understanding mathematical converses? To answer these questions, students at three Dayton area high schools completed tasks relating to proofs and converse statements as well as a questionnaire. Contrary to the initial hypothesis, students who were perceived to have greater proof abilities did …