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Articles 1 - 6 of 6
Full-Text Articles in Entire DC Network
The Effect Of Postural Perturbations On Cardiovascular And Skeletal Muscle Function In Healthy Adults, Patrick Siedlecki
The Effect Of Postural Perturbations On Cardiovascular And Skeletal Muscle Function In Healthy Adults, Patrick Siedlecki
Electronic Thesis and Dissertation Repository
Maintenance of standing balance is vital to daily living. Traditionally, perspectives on maintaining balance are achieved through the study of visual, vestibular and somatosensory inputs on motor outputs. While evidence suggests cardiovascular regulation also functions to assist postural control during orthostatic stress, how the cardiovascular system responds to postural perturbations is not well established. This dissertation includes four studies that investigated the effects of postural perturbations on the cardiovascular system and skeletal muscle responses in healthy adults. All of the studies involved exposing standing participants to surface-translation perturbations at different velocities, with known or unknown timing, and occurred while spontaneously …
The Role Of The Hippocampus In Pattern Separation And Statistical Learning, Helena Shizhe Wang
The Role Of The Hippocampus In Pattern Separation And Statistical Learning, Helena Shizhe Wang
Electronic Thesis and Dissertation Repository
It has been theorized that pattern separation and statistical learning implicate two separate circuitries within the hippocampus, one that involves the dentate gyrus subregion and one that does not, respectively. Here, we tested whether the two processes are dissociable computations that rely on separate neural pathways by examining the effect of healthy aging (Chapter 2) and dentate gyrus lesion (Chapter 3) on participants’ ability to differentiate similar trisyllabic words and extract trisyllabic words from a continuous speech stream. Neither healthy aging nor dentate gyrus damage affected the implicit expression of statistical learning, but they both impaired pattern separation and the …
Changes In Audiovisual Integration In Aging, Alyssa S. Lynn
Changes In Audiovisual Integration In Aging, Alyssa S. Lynn
Undergraduate Student Research Internships Conference
The proposed study will examine changes in audiovisual integration between younger and older adults. Audiovisual integration enables us to associate and bind related auditory and visual information and experience it as a single percept (Spence, 2007). Being able to properly integrate is crucial in our everyday lives. When perceiving speech, audiovisual integration binds visual information from lip movements with auditory information from the speaker's utterances so that speech can be perceived multimodally. With age, our auditory and visual sensory acuity tends to decline with audiovisual integration being impacted as a result (Brooks et al., 2018; Mahoney et al., 2011). We …
Functional Neuroimaging Techniques To Examine Falls And Cognition In Older Adults: A Systematic Review, Tia M. Seleem, Raphael Gabiazon
Functional Neuroimaging Techniques To Examine Falls And Cognition In Older Adults: A Systematic Review, Tia M. Seleem, Raphael Gabiazon
Undergraduate Student Research Internships Conference
Falls in older adults have been attributed to impaired cognition. There is potential for neuroimaging techniques to understand the biological components that are involved in the cognitive processes pertaining to falls. Therefore, the purpose of this systematic review was to analyze how functional neuroimaging can be used to examine the relationship between falls and cognition among older adults. The following five electronic databases were selected to identify peer-reviewed articles in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses: 1) Medline (via OVID), 2) PsycINFO (via OVID), 3) CINAHL (via EBSCO), 4) EMBASE (via OVID), and 5) Pubmed. …
The Coping Strategies Of Older Adults With Age Related Vision Loss (Arvl) – A Narrative Account, Zakara J. Stampp
The Coping Strategies Of Older Adults With Age Related Vision Loss (Arvl) – A Narrative Account, Zakara J. Stampp
Electronic Thesis and Dissertation Repository
The goal of this study was to share the stories of older adults with age-related vision loss (ARVL) and how they have coped to maintain meaningful occupational engagement. Grounded in a constructivist paradigm, data collection and analysis were guided by the narrative inquiry methodology. The participants consisted of six older adults aged 60 or older, diagnosed with one of the following ARVL conditions: macular degeneration, diabetic retinopathy, and/or glaucoma. Participants were recruited from vision loss non-profit organizations such as the Canadian National Institute for the Blind (CNIB) and the Alliance for Equity of Blind Canadians (AEBC). One older adult was …
Hypophosphorylated Prb Knock-In Mice Exhibit Hallmarks Of Aging And Vitamin C-Preventable Diabetes, Zhe Jiang, Huiqin Li, Stephanie A. Schroer, Veronique Voisin, Young Jun Ju, Marek Pacal, Natalie Erdmann, Wei Shi, Philip E.D. Chung, Tao Deng, Nien Jung Chen, Giovanni Ciavarra, Alessandro Datti, Tak W. Mak, Lea Harrington, Frederick A. Dick, Gary D. Bader, Rod Bremner, Minna Woo, Eldad Zacksenhaus
Hypophosphorylated Prb Knock-In Mice Exhibit Hallmarks Of Aging And Vitamin C-Preventable Diabetes, Zhe Jiang, Huiqin Li, Stephanie A. Schroer, Veronique Voisin, Young Jun Ju, Marek Pacal, Natalie Erdmann, Wei Shi, Philip E.D. Chung, Tao Deng, Nien Jung Chen, Giovanni Ciavarra, Alessandro Datti, Tak W. Mak, Lea Harrington, Frederick A. Dick, Gary D. Bader, Rod Bremner, Minna Woo, Eldad Zacksenhaus
Paediatrics Publications
Despite extensive analysis of pRB phosphorylation in vitro, how this modification influences development and homeostasis in vivo is unclear. Here, we show that homozygous Rb∆K4 and Rb∆K7 knock-in mice, in which either four or all seven phosphorylation sites in the C-terminal region of pRb, respectively, have been abolished by Ser/Thr-to-Ala substitutions, undergo normal embryogenesis and early development, notwithstanding suppressed phosphorylation of additional upstream sites. Whereas Rb∆K4 mice exhibit telomere attrition but no other abnormalities, Rb∆K7 mice are smaller and display additional hallmarks of premature aging including infertility, kyphosis, and diabetes, indicating an accumulative effect of blocking pRb phosphorylation. Diabetes in …