Digital Commons Network^™

Clinical Care Of Masters Athletes: A Health Needs Assessment, Princess A. Ulona

Electronic Thesis and Dissertation Repository

Little is known about the current state of clinical care that Masters Athletes (MAs) receive, their perceptions, and whether they meet their health needs. A 22-item online health needs assessment (HNA) survey was conducted to investigate the characteristics of clinical care received by MAs and determine their perceived health needs. 80 MAs completed our survey. In assessing three key categories of care, less than 40% of MAs reported receiving Pre-Participation Evaluation (PPE), Medical Monitoring, and Injury Management as part of their standard routine care. Dissatisfied MAs reported unmet needs due to a lack of educated clinicians, lack of accessibility to …

Social Capital Associates With Better Cognitive Health, Oral Health And Epigenetic Age Deceleration: Findings From The Canadian Longitudinal Study On Aging., Aileen Liang, Noha Gomaa

Department of Medicine Publications

Background: Social exposures are linked to an array of health outcomes, especially around aging. In this study, we examined the association of social capital, defined as social relationships and networks, with clinical and biological outcomes including cognitive health, oral inflammation, and epigenetic aging. Methods: We used data from the Canadian Longitudinal Study on Aging (CLSA) (n =1,479; aged 45–85 years), categorizing social capital as structural and cognitive capital. Oral inflammation was determined as the presence of gum bleeding. Epigenetic aging was computed as the difference between chronological age and DNA methylation age. We constructed multivariable regression models adjusted for covariates …

The Impact Of Access To Oral Health Care On Inadequate Oral Health And Multimorbidity, Luis Limo

Electronic Thesis and Dissertation Repository

The connection between oral health and other non-communicable chronic conditions—commonly referred in the dental literature as the oral-systemic health connection—emphasizes the role of oral health care on both oral diseases and chronic conditions, particularly in vulnerable populations like the elderly. This thesis comprises 2 studies: the first is a systematic review on the impact of oral health care interventions, as an indicator of access to oral health care, on chronic conditions of which their co-existence would result in multimorbidity; the second study is a cross-sectional investigation of the associations between oral health, access to oral health care, and multimorbidity among …

Examining Age-Related Enhancement Of Multisensory Gain: The Role Of Sensory Decline And Inverse Effectiveness, Laura C. Schneeberger

Electronic Thesis and Dissertation Repository

Older adults experience a greater benefit from multisensory integration than their younger counterparts, but it is unclear why. One hypothesis is that age-related sensory decline weakens unisensory stimulus effectiveness, producing a boost in multisensory gain through inverse effectiveness. Many previous studies present stimuli at the same intensity for both younger and older adults (i.e., stimulus-matched), as opposed to accounting for each participant’s unique perceptual ability (i.e., perception-matched). This makes it difficult to discern the source of age-related differences in multisensory gain. Through a combination of stimulus-matched and perception-matched tasks, I found that older adults exhibit enhanced multisensory gain at low …

Investigating The Roles Of The Dorsal And Ventral Striatum In Humor Comprehension And Appreciation Throughout Health, Aging, And Parkinson’S Disease, Maggie Prenger

Electronic Thesis and Dissertation Repository

Humor processing is thought to involve two distinct components. The first, humor comprehension, involves detecting and resolving incongruities that are present within a humorous stimulus. This is related to cognitive processes such as ambiguity resolution, response inhibition, working memory, and cognitive flexibility, functions that are mediated in part by the dorsal portion of the striatum (DS). Humor appreciation, on the other hand, refers to the subjective amusement and mirth that one experiences in response to a joke. This is related to reward processing, which implicates the ventral portion of the striatum (VS). Across three separate studies, we investigated the involvement …

The Effect Of Postural Perturbations On Cardiovascular And Skeletal Muscle Function In Healthy Adults, Patrick Siedlecki

Electronic Thesis and Dissertation Repository

Maintenance of standing balance is vital to daily living. Traditionally, perspectives on maintaining balance are achieved through the study of visual, vestibular and somatosensory inputs on motor outputs. While evidence suggests cardiovascular regulation also functions to assist postural control during orthostatic stress, how the cardiovascular system responds to postural perturbations is not well established. This dissertation includes four studies that investigated the effects of postural perturbations on the cardiovascular system and skeletal muscle responses in healthy adults. All of the studies involved exposing standing participants to surface-translation perturbations at different velocities, with known or unknown timing, and occurred while spontaneously …

The Role Of The Hippocampus In Pattern Separation And Statistical Learning, Helena Shizhe Wang

Electronic Thesis and Dissertation Repository

It has been theorized that pattern separation and statistical learning implicate two separate circuitries within the hippocampus, one that involves the dentate gyrus subregion and one that does not, respectively. Here, we tested whether the two processes are dissociable computations that rely on separate neural pathways by examining the effect of healthy aging (Chapter 2) and dentate gyrus lesion (Chapter 3) on participants’ ability to differentiate similar trisyllabic words and extract trisyllabic words from a continuous speech stream. Neither healthy aging nor dentate gyrus damage affected the implicit expression of statistical learning, but they both impaired pattern separation and the …

Changes In Audiovisual Integration In Aging, Alyssa S. Lynn

Undergraduate Student Research Internships Conference

The proposed study will examine changes in audiovisual integration between younger and older adults. Audiovisual integration enables us to associate and bind related auditory and visual information and experience it as a single percept (Spence, 2007). Being able to properly integrate is crucial in our everyday lives. When perceiving speech, audiovisual integration binds visual information from lip movements with auditory information from the speaker's utterances so that speech can be perceived multimodally. With age, our auditory and visual sensory acuity tends to decline with audiovisual integration being impacted as a result (Brooks et al., 2018; Mahoney et al., 2011). We …

Functional Neuroimaging Techniques To Examine Falls And Cognition In Older Adults: A Systematic Review, Tia M. Seleem, Raphael Gabiazon

Undergraduate Student Research Internships Conference

Falls in older adults have been attributed to impaired cognition. There is potential for neuroimaging techniques to understand the biological components that are involved in the cognitive processes pertaining to falls. Therefore, the purpose of this systematic review was to analyze how functional neuroimaging can be used to examine the relationship between falls and cognition among older adults. The following five electronic databases were selected to identify peer-reviewed articles in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses: 1) Medline (via OVID), 2) PsycINFO (via OVID), 3) CINAHL (via EBSCO), 4) EMBASE (via OVID), and 5) Pubmed. …

The Coping Strategies Of Older Adults With Age Related Vision Loss (Arvl) – A Narrative Account, Zakara J. Stampp

Electronic Thesis and Dissertation Repository

The goal of this study was to share the stories of older adults with age-related vision loss (ARVL) and how they have coped to maintain meaningful occupational engagement. Grounded in a constructivist paradigm, data collection and analysis were guided by the narrative inquiry methodology. The participants consisted of six older adults aged 60 or older, diagnosed with one of the following ARVL conditions: macular degeneration, diabetic retinopathy, and/or glaucoma. Participants were recruited from vision loss non-profit organizations such as the Canadian National Institute for the Blind (CNIB) and the Alliance for Equity of Blind Canadians (AEBC). One older adult was …

Hypophosphorylated Prb Knock-In Mice Exhibit Hallmarks Of Aging And Vitamin C-Preventable Diabetes, Zhe Jiang, Huiqin Li, Stephanie A. Schroer, Veronique Voisin, Young Jun Ju, Marek Pacal, Natalie Erdmann, Wei Shi, Philip E.D. Chung, Tao Deng, Nien Jung Chen, Giovanni Ciavarra, Alessandro Datti, Tak W. Mak, Lea Harrington, Frederick A. Dick, Gary D. Bader, Rod Bremner, Minna Woo, Eldad Zacksenhaus

Paediatrics Publications

Despite extensive analysis of pRB phosphorylation in vitro, how this modification influences development and homeostasis in vivo is unclear. Here, we show that homozygous Rb∆K4 and Rb∆K7 knock-in mice, in which either four or all seven phosphorylation sites in the C-terminal region of pRb, respectively, have been abolished by Ser/Thr-to-Ala substitutions, undergo normal embryogenesis and early development, notwithstanding suppressed phosphorylation of additional upstream sites. Whereas Rb∆K4 mice exhibit telomere attrition but no other abnormalities, Rb∆K7 mice are smaller and display additional hallmarks of premature aging including infertility, kyphosis, and diabetes, indicating an accumulative effect of blocking pRb phosphorylation. Diabetes in …

Nursing Homes And Loneliness Among Older Adults In The United States, Camila Iciaszczyk

MA Research Paper

Many studies have revealed that older adults experience varying rates of loneliness depending on their living arrangements, yet few have been measured in nursing homes. I assess rates of loneliness among aging adults across different living arrangements, including nursing homes. Analyzing nationally representative longitudinal survey data from the United States, I observe older adults in all living arrangements and whether the transition into nursing homes is linked with increased rates of loneliness. Findings indicate that older adults living in nursing homes are at a 3.0 higher odds of experiencing loneliness compared to those living independently. When controlling for demographic and …

The Effects Of Resistance Training On Cognition And Brain Health In Older Adults At Risk For Diabetes: A Pilot Feasibility Study, Joyla Furlano

Electronic Thesis and Dissertation Repository

Type 2 diabetes is associated with neurocognitive deficits and increased risk for dementia, with high prevalence of diabetes occurring in old age. There are many known risk factors for diabetes, including physical inactivity, obesity, and prediabetes. Studies show that individuals who are at risk for diabetes (i.e., have one or more risk factors) already experience some brain deficits seen in diabetes. One way to combat these deficits is aerobic exercise; however, the effects of resistance exercise in this population are relatively unknown. The objectives of this thesis were to report on the current evidence of brain deficits in prediabetes, and …

Neural Markers Of Musical Memory In Young And Older Adults, Avital Sternin

Electronic Thesis and Dissertation Repository

Memory for music can be preserved in the presence of neurodegenerative disorders even when other memories are forgotten. However, understanding how the brain remembers music has proven difficult despite decades of research. The central goal of this thesis was to elucidate the neural correlates of musical memory by exploring how the presence of language and music information affect the way young and older adults remember music. To that end, I 1) used a controlled training paradigm to familiarize participants with novel stimuli that manipulated the presence of language and music, and 2) collected functional magnetic resonance imaging data to compare …

Cortical Responses To The Amplitude Envelopes Of Sounds Change With Age, Vanessa C. Irsik, Ala Almanaseer, Ingrid S. Johnsrude, Björn Herrmann

Brain and Mind Institute Researchers' Publications

Many older listeners have difficulty understanding speech in noise, when cues to speech-sound identity are less redundant. The amplitude envelope of speech fluctuates dramatically over time, and features such as the rate of amplitude change at onsets (attack) and offsets (decay), signal critical information about the identity of speech sounds. Aging is also thought to be accompanied by increases in cortical excitability, which may differentially alter sensitivity to envelope dynamics. Here, we recorded electroencephalography in younger and older human adults (of both sexes) to investigate how aging affects neural synchronization to 4 Hz amplitude-modulated noises with different envelope shapes (ramped: …

Development Of A Standardized Histopathology Scoring System Using Machine Learning Algorithms For Intervertebral Disc Degeneration In The Mouse Model—An Ors Spine Section Initiative, Itzel Paola Melgoza, Srish S. Chenna, Steven Tessier, Yejia Zhang, Simon Y. Tang, Takashi Ohnishi, Emanuel José Novais, Geoffrey J. Kerr, Sarthak Mohanty, Vivian Tam, Wilson C.W. Chan, Chao Ming Zhou, Ying Zhang, Victor Y. Leung, Angela K. Brice, Cheryle A. Séguin, Danny Chan, Nam Vo, Makarand V. Risbud, Chitra L. Dahia

Paediatrics Publications

Mice have been increasingly used as preclinical model to elucidate mechanisms and test therapeutics for treating intervertebral disc degeneration (IDD). Several intervertebral disc (IVD) histological scoring systems have been proposed, but none exists that reliably quantitate mouse disc pathologies. Here, we report a new robust quantitative mouse IVD histopathological scoring system developed by building consensus from the spine community analyses of previous scoring systems and features noted on different mouse models of IDD. The new scoring system analyzes 14 key histopathological features from nucleus pulposus (NP), annulus fibrosus (AF), endplate (EP), and AF/NP/EP interface regions. Each feature is categorized and …

Protein Misfolding Toxicity And Inclusion Formation In Cellular Models Of Neurodegeneration, Sonja E. Di Gregorio

Electronic Thesis and Dissertation Repository

Protein misfolding characterizes most neurodegenerative diseases. Protein misfolding is the conversion of specific proteins from their normal, often soluble, and native three-dimensional conformation into an aberrant, often insoluble, non-functional conformation. Protein inclusions and aggregates are among the major pathological hallmarks of protein misfolding associated with many neurodegenerative diseases. Yet, the role of aggregates and inclusions is not clearly defined and heavily debated. This study utilizes powerful genetic approaches in yeast and verification in mammalian neuronal cell lines to address the misfolding and toxicity of three proteins, the Rho Guanine Nucleotide Exchange Factor (RGNEF), Matrin3, which are involved in amyotrophic lateral …

The Benefits Of High-Intensity Interval Training On Cognition And Blood Pressure In Older Adults With Hypertension And Subjective Cognitive Decline: Results From The Heart & Mind Study, Narlon C. Boa Sorte Silva, Andrea F.M. Petrella, Nathan Christopher, Catherine F.S. Marriott, Dawn P. Gill, Adrian M. Owen, Robert J. Petrella

Brain and Mind Institute Researchers' Publications

Background: The impact of exercise on cognition in older adults with hypertension and subjective cognitive decline (SCD) is unclear. Objectives: We determined the influence of high-intensity interval training (HIIT) combined with mind-motor training on cognition and systolic blood pressure (BP) in older adults with hypertension and SCD. Methods: We randomized 128 community-dwelling older adults [age mean (SD): 71.1 (6.7), 47.7% females] with history of hypertension and SCD to either HIIT or a moderate-intensity continuous training (MCT) group. Both groups received 15 min of mind-motor training followed by 45 min of either HIIT or MCT. Participants exercised in total 60 min/day, …

Cognition Across The Lifespan: Investigating Age, Sex, And Other Sociodemographic Influences, Emily S. Nichols, Conor J. Wild, Adrian M. Owen, Andrea Soddu

Brain and Mind Institute Researchers' Publications

Maintaining cognitive health across the lifespan has been the focus of a multi-billion-dollar industry. In order to guide treatment and interventions, a clear understanding of the way that proficiency in different cognitive domains develops and declines in both sexes across the lifespan is necessary. Additionally, there are sex differences in a range of other factors, including psychiatric illnesses such as anxiety, depression, and substance use, that are also known to affect cognition, although the scale of this interaction is unknown. Our objective was to assess differences in cognitive function across the lifespan in men and women in a large, representative …

The Process Of Creating And Disseminating Exercise Programs By Physical Therapists For Older Adults With Chronic Back Pain, Melissa E. Hay, Denise M. Connelly

Physical Therapy Publications

Objective: The purpose of this study was to enhance the understanding of the process that physical therapists undertake when creating and disseminating exercise programs for older adults with chronic backpain. Methods: Constructivist grounded theory methodology was used as an accessible mode of researching pragmatic clinical practices. Physical therapists from outpatient, ambulatory care clinic settings participated in in-depth, individual interviews (n = 9) and in-clinic observations (n = 5). Data collection and analysis were iterative processes. Codes were generated based on recurrent themes, and constant comparative analysis was used to compare data. Analysis and data collection were concluded when theoretical sufficiency …

Intersectional Social Inequalities And Cognitive Functioning Among Community-Dwelling Older Adults In England: A Decomposition Analysis Of The Mediating Role Of Loneliness, Chantel Walwyn

Electronic Thesis and Dissertation Repository

Normative cognitive decline is an emerging public health issue for older adult populations. It is necessary that we take an intersectional approach to examining heterogeneity in cognitive health outcomes. Using complex longitudinal survey data from the English Longitudinal Study of Ageing (ELSA), multiple linear regression models were used to examine the relationship between intersectional group membership based on age, education, and sex, and change in cognitive functioning domains (memory function, and executive function) over an 8-year period. Three-way decomposition analysis was also used to examine the mediating effect of loneliness on the association between intersectional group membership and the change …

Comparing Neuromuscular System Function In Healthy And Mobility-Impaired Older Females, Neal B. Mckinnon

Electronic Thesis and Dissertation Repository

Objectives: The objective of this thesis was to evaluate and compare neuromuscular system function in a group of young, healthy old and mobility-impaired older females (gait speed less than 1m/s) in an attempt to identify which neuromuscular factors contribute most to the loss of mobility and functional performance with age.

Methods: The ankle dorsiflexor and knee extensor muscles were used as a model in these studies. First, in Chapter 2 quantitative electromyography (EMG) was used to evaluate motor unit (MU) numbers, properties and the fidelity of the neuromuscular junction. Next, Chapter 3 conducted magnetic resonance imaging (MRI) to examine contractile …

The Effect Of Mtor Inhibitor Rapamycin On A Dietary Drosophila Melanogaster Model Of Calcium Oxalate Nephrolithiasis, Michael T. Pignanelli

Electronic Thesis and Dissertation Repository

Impaired cellular tolerance of reactive oxygen species (ROS) has been suggested as a common mechanistic link associated with aging in both metabolic syndrome and nephrolithiasis. The mechanistic (mammalian) target of rapamycin (mTOR) activity is characteristic of metabolic syndrome. When nutrients are abundant, mTOR is active. Conversely, fasting inhibits mTOR. Metabolic syndrome is correlated with an increased risk of self-reported or imaging findings of nephrolithiasis. At the individual level, patients with a higher BMI have an increased prevalence of recurrent symptomatic nephrolithiasis, 24-hour urinary excretion of oxalate, sodium, uric acid, calcium, and phosphorous as well as lower pH. Calcium oxalate crystals …

Energy Access And Extreme Heat Events: A Case Study Of Seniors In Ottawa, Ontario, Samantha N. Doris

Electronic Thesis and Dissertation Repository

Energy poverty, or not having access to sufficient energy to meet one’s needs, is a serious problem in Canada and around the world. While the current literature on energy poverty largely focuses on the experiences of people utilizing energy services to stay warm during cold winter temperatures, little is known about experiences of energy poverty during summertime heat. This gap is especially urgent since current climate models suggest that cities are likely to experience extreme heat conditions more frequently in the future. This research investigates how people use energy services, such as air conditioning and fans, among other strategies to …

Social Isolation: Do Helpers Help Ward It Off?, Kirsten Young Brown

MA Research Paper

Social isolation is particularly relevant among elderly individuals who are more likely to need care and help with their physical and living needs. Little is known about whether receiving help correlates with social isolation in older adults living at home as often there is no focus from caregivers and helpers on older adults' social needs. Using data from the 2018 US National Health and Aging Trends Study, a sample of adults aged 65 plus on Medicare/Medicaid (N=4,321), I examine the relationship between social isolation and help. I estimate ordinary least squares regression models to test the association between receiving help …

Lactate Dehydrogenase Expression Modulates Longevity And Neurodegeneration In Drosophila Melanogaster, Dani M. Long, Ariel Frame, Patrick N. Reardon, Robert C. Cumming, David A. Hendrix, Doris Kretzschmar, Jadwiga M. Giebultowicz

Paediatrics Publications

Lactate dehydrogenase (LDH) catalyzes the conversion of glycolysis-derived pyruvate to lactate. Lactate has been shown to play key roles in brain energetics and memory formation. However, lactate levels are elevated in aging and Alzheimer's disease patients, and it is not clear whether lactate plays protective or detrimental roles in these contexts. Here we show that Ldh transcript levels are elevated and cycle with diurnal rhythm in the heads of aged flies and this is associated with increased LDH protein, enzyme activity, and lactate concentrations. To understand the biological significance of increased Ldh gene expression, we genetically manipulated Ldh levels in …

Feasibility Of Dual-Task Gait Assessment And Association With Cognitive Impairment Subtypes In A Memory Clinic Setting, Stephanie Cullen

Electronic Thesis and Dissertation Repository

The objectives of this thesis were 1) to assess feasibility and practicality of gait performance to help differentiate cognitive diagnoses, 2) to assess differences in gait speed and dual-task gait cost across the cognitive spectrum, and 3) to determine if poor baseline gait performance is associated with future cognitive decline, all within a clinical setting. Patients at the Aging Brain and Memory Clinic completed gait assessment, consisting of a usual gait trial and three dual-task gait trials, in addition to cognitive and clinical assessments. Patients who had two clinic visits during the study period were also included in a longitudinal …

Bilingualism Affords No General Cognitive Advantages: A Population Study Of Executive Function In 11,000 People, Emily S. Nichols, Conor J. Wild, Bobby Stojanoski, Michael E. Battista, Adrian M. Owen

Brain and Mind Institute Researchers' Publications

Whether acquiring a second language affords any general advantages to executive function has been a matter of fierce scientific debate for decades. If being bilingual does have benefits over and above the broader social, employment, and lifestyle gains that are available to speakers of a second language, then it should manifest as a cognitive advantage in the general population of bilinguals. We assessed 11,041 participants on a broad battery of 12 executive tasks whose functional and neural properties have been well described. Bilinguals showed an advantage over monolinguals on only one test (whereas monolinguals performed better on four tests), and …

Regulation Of Endoplasmic Reticulum Stress In Saccharomyces Cerevisiae, Sarah R. Chadwick

Electronic Thesis and Dissertation Repository

The budding yeast Saccharomyces cerevisiae has been used extensively to uncover the genetic mechanisms that control basic cellular processes, including survival, maintenance, and response to stressors. One metric of yeast survival is chronological lifespan (CLS), which is the amount of time non-dividing yeast cells can survive at stationary phase. Variations in CLS following genetic alteration are used to understand the function of specific genes and pathways in cellular aging. Many factors contribute to aging, including accumulation of toxic misfolded secretory proteins in the endoplasmic reticulum (ER stress), to which the cell responds through activation of ER stress signaling pathways, such …

The Relationship Between Theory Of Mind And Executive Function: Are They Two Facets Of The Same Process Or Two Distinct Processes?, Isu Cho

Electronic Thesis and Dissertation Repository

This dissertation examines the relationship between Theory of Mind (ToM) and Executive Function (EF). There has been debate on whether ToM and EF are two facets of the same process or are two distinct processes. Distinguishing between these possibilities empirically is challenging because the two abilities have similar developmental timetables and ToM tasks typically place high demands on EF, with the consequence that ToM and EF performance measures may be artificially correlated. Three experiments explored the nature of this relationship. Experiments 1 and 2 tested whether socio-cultural factors known to influence individual differences in EF (i.e., bilingualism, country-of-origin) extend to …