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Word-Finding Difficulties: Exploring Tip-Of-The-Tongue States In Young And Old Adults, Allison J. Partridge
Word-Finding Difficulties: Exploring Tip-Of-The-Tongue States In Young And Old Adults, Allison J. Partridge
Electronic Thesis and Dissertation Repository
A Tip-of-the-Tongue (TOT) occurs when you are trying to think of a specific word but lack the ability to bring it to mind. The present study examined implicit learning processes operating under errorful (20-second delay) or errorless (0-second delay) learning conditions in TOT states. Participants included 15 young (20-30 years) and 15 old (65-88 years) adults who were tested twice a week for four weeks on a definition-word pair task. For young participants, results indicated that a TOT was more likely and older participants were more likely to indicate they did not know the word on a consecutive session after …
Electromechanical Delay Of The Dorsiflexors In Young And Old Women, In H. Choi
Electromechanical Delay Of The Dorsiflexors In Young And Old Women, In H. Choi
Electronic Thesis and Dissertation Repository
PURPOSE: The aim of the current study was to examine the effect on electromechanical delay (EMD) in the dorsiflexors of young and old women during maximal isometric voluntary and electrically evoked contractions, and after a bout of lengthening contractions. METHODS: Nine young (25.1±1.3 years) and nine old (68.3±6.1 years) women performed baseline isometric contractions with evoked twitches followed by a series of dynamic lengthening contractions using a Biodex multi-joint dynamometer. Maximal isometric voluntary and evoked contractions were measured to assess EMD. Time points were recorded at baseline, mid-point of the intervention, post-task termination, and during recovery at 0.5, 2, 10, …
Aging And Obesity Models In Osteoarthritis, Sara Ohora
Aging And Obesity Models In Osteoarthritis, Sara Ohora
Electronic Thesis and Dissertation Repository
Osteoarthritis (OA) is a degenerative joint disease whose exact mechanisms are not well understood, but aging and obesity are common risk factors. To determine the role of transforming growth factor-alpha (TGFα) in obesity-associated OA, Tgfa null and control mice on control and high fat diets were compared. In addition, spontaneous OA was investigated in aging C57BL/6J mice. Quantitative magnetic resonance was used to assess body composition in the obesity model, while gait analysis, histological staining and OARSI scoring were used to determine OA in both models. Mice on high fat diet developed no OA, but Tgfa null mice weighed significantly …
The Chromatin Remodeling Protein Atrx In Development And Maintenance Of Mouse Skeletal Tissues, Lauren A. Solomon
The Chromatin Remodeling Protein Atrx In Development And Maintenance Of Mouse Skeletal Tissues, Lauren A. Solomon
Electronic Thesis and Dissertation Repository
Alpha-thalassemia X-linked mental retardation (ATR-X) syndrome is a rare genetic disorder associated with severe developmental delay, mental retardation and craniofacial dysmorphism. This syndrome is caused by mutations in the ATRX gene which encodes a member of the SWI/SNF family of chromatin remodeling proteins. ATR-X patients exhibit dwarfism and skeletal defects, including hand and foot deformities. I hypothesized that the skeletal deformities in ATR-X syndrome are due to a direct role of ATRX in the development of the skeleton. My objective was to characterise skeletal phenotypes observed in three animal models conditionally deficient for ATRX in different skeletal tissues. Mice lacking …
Return To Work After Retirement: Contributing Factors And Health Implications, Jason Settels
Return To Work After Retirement: Contributing Factors And Health Implications, Jason Settels
Electronic Thesis and Dissertation Repository
An issue of mounting importance in many industrialized nations, including Canada, is that of population aging. Because of fears that this trend could result in labour force shortages, many national governments and international organizations have encouraged policies aimed at prolonging the working life. This thesis builds on work that has been done to identify factors relevant to the likelihood of involvement in post-retirement work by examining how interactions among various demographic variables impact this likelihood. Furthermore, we investigated how post-retirement work is related to three measures of health and well-being. As well as confirming results obtained by others, we have …
Subcellular Analysis Of The Disulfide Proteome In P66shc Expressing Nerve Cells, Tyler Cann
Subcellular Analysis Of The Disulfide Proteome In P66shc Expressing Nerve Cells, Tyler Cann
Electronic Thesis and Dissertation Repository
The longevity associated protein p66Shc has been suggested to regulate organismal lifespan through initiation of apoptotic pathways. Following stress-induced translocation into the mitochondria, p66Shc promotes increased reactive oxygen species (ROS) production and triggers poorly defined downstream signaling events that lead to decreased cell viability. Protein disulfide bonding has recently emerged as aROSdependent post-translational modification that regulates protein function and signaling processes. Using the mouse hippocampal HT-22 cell line, I sought to determine the changes in the disulfide proteome associated with p66Shc mediatedROSproduction. Through Redox 2D-SDSPAGEanalysis of mitochondrial and cytosolic extracts, redox sensitive proteins altered by p66Shc mediatedROSformation were identified. Of …