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Lesion Of Cholinergic Neurons In Nucleus Basalis Enhances Response To General Anesthetics, Leung L. Stan

Physiology and Pharmacology Publications

Acetylcholine in the brain has been associated with consciousness and general anesthesia effects. We tested the hypothesis that the integrity of the nucleus basalis magnocellularis (NBM) affects the response to general anesthetics. Cholinergic neurons in NBM were selectively lesioned by bilateral infusion of 192IgG-saporin in adult, male Long–Evans rats, and control rats were infused with saline. Depletion of choline-acetyltransferase (ChAT)-immunoreactive cells in the NBM and decrease in optical density of acetylcholinesterase (AChE) staining in the frontal and visual cortices confirmed a significant decrease in NBM cholinergic neurons in lesioned as compared to control rats. AChE staining in the hippocampus and …

Negative Associations Between Corpus Callosum Midsagittal Area And Iq In A Representative Sample Of Healthy Children And Adolescents., Hooman Ganjavi, John D Lewis, Pierre Bellec, Penny A Macdonald, Deborah P Waber, Alan C Evans, Sherif Karama, The Brain Development Cooperative Group

Brain and Mind Institute Researchers' Publications

Documented associations between corpus callosum size and cognitive ability have heretofore been inconsistent potentially owing to differences in sample characteristics, differing methodologies in measuring CC size, or the use of absolute versus relative measures. We investigated the relationship between CC size and intelligence quotient (IQ) in the NIH MRI Study of Normal Brain Development sample, a large cohort of healthy children and adolescents (aged six to 18, n = 198) recruited to be representative of the US population. CC midsagittal area was measured using an automated system that partitioned the CC into 25 subregions. IQ was measured using the Wechsler …

False Recall In The Deese–Roediger–Mcdermott Paradigm: The Roles Of Gist And Associative Strength, David R. Cann, Ken Mcrae, Albert N. Katz

Psychology Publications

Theories of false memories, particularly in the Deese–Roediger–McDermott (DRM) paradigm, focus on word association strength and gist. Backward associative strength (BAS) is a strong predictor of false recall in this paradigm. However, other than being defined as a measure of association between studied list words and falsely recalled nonpresented critical words, there is little understanding of this variable. In Experiment 1, we used a knowledge-type taxonomy to classify the semantic relations in DRM stimuli. These knowledge types predicted false-recall probability, as well as BAS itself, with the most important being situation features, synonyms, and taxonomic relations. In three subsequent experiments, …

Measuring Cognitive Errors: Initial Development Of The Cognitive Distortions Scale (Cds), Roger Covin, David J. A. Dozois, Avital Ogniewicz, Pamela M. Seeds

Psychology Publications

The ability to assess and correct biases in thinking is central to cognitive-behavioral therapy. Although measures of cognitive distortions exist, no measure comprehensively assesses the cognitive errors that are typically cited in the literature. The development and initial validation of the Cognitive Distortions Scale (CDS), a questionnaire that measures the tendency to make 10 cognitive distortions (e.g., mindreading, catastrophizing, all-or-nothing thinking) as they occur in interpersonal and achievement domains, is described. Across two studies, undergraduate students (n = 318) completed the CDS and other clinically relevant measures. The CDS and its two subscales appear to exhibit good psychometric properties; …

‘Contextualizing And Critiquing The Fantastic Prosumer: Power, Alienation And Hegemony’, Edward Comor

FIMS Publications

Abstract The ‘prosumer’ has emerged to become a central figure in contemporary culture. Through the melding of production with consumption, both mainstream and progressive analysts conceptualize prosumption to be a liberating, empowering and, for some, a prospectively revolutionary institution. In this article, these fantastic associations are critically assessed using an approach that situates prosumption activities, including contemporary online applications often referred to as ‘cocreation’, in three social-historical contexts: capitalism as a political economy dominated by mediated abstractions; capitalist society as a hierarchical order; and alienation as a pervasive norm. Among other conclusions, we find that prosumption (particularly its Web 2.0 …

Paper Tigers: Rethinking The Relationship Between Copyright And Scholarly Publishing, Alissa Centivany

FIMS Publications

Discontent is growing in academia over the practices of the proprietary scholarly publishing industry. Scholars and universities criticize the expensive subscription fees, restrictive access policies, and copyright assignment requirements of many journals. These practices seem fundamentally unfair given that the industries’ two main inputs - articles and peer-review - are provided to it free of charge. Furthermore, while many publishers continue to enjoy substantial profit margins, many elite university libraries have been forced to triage their collections, choosing between purchasing monographs or subscribing to journals, or in some cases, doing away with “non-essential” materials altogether. The situation is even more …

The Politics Of Not Knowing: The Disappearing Act Of An Education In Music, Cathy Benedict, Patrick K. Schmidt

Music Education Publications

No abstract provided.

Gender And Physiological Effects In Connecting Disgust To Political Preferences, Amanda Friesen, Carly M. Jacobs

Political Science Publications

Sensitivity to disgust predicts social attitudes, but this relationship can shift depending on gender and whether response to disgust is measured through surveys or physiological tests. We are interested in exploring the relationship between gender, political preferences, and different measures of disgust. Methods We systematically evaluate these interrelationships by comparing self-reported disgust sensitivity and changes in skin conductance while viewing disgusting images, accounting for gender and attitudes toward gay marriage. Results We find that although there is no physiological difference between genders, opponents of gay marriage conform to gender-role expectations in self-reports, with women reporting higher levels of disgust than …

A Graduate Degree In Library Or Information Science Is Required, But Not Sufficient, To Enter The Profession, Nazi Torabi

Western Libraries Publications

No abstract provided.

Public Librarians With The Highest Retention Rate Are More Likely To Choose Their Entire Career Path In Public Libraries, Nazi Torabi

Western Libraries Publications

No abstract provided.

Bf3·Oet2 Catalyzed Reaction Of Donor-Acceptor Cyclobutanes With Terminal Alkynes: Single Step Access To 2,3-Dihydrooxepines, Ben P Machin, Brian L Pagenkopf

Chemistry Publications

In the presence of BF3˙OEt2 cyclobutane-1,1-diesters undergo a reaction with terminal alkynes to quickly access dihydro­oxepines.

An Empirical Study Of Open Source Software Usability – The Industrial Perspective, Arif Raza, Luiz Fernando Capretz, Faheem Ahmed

Electrical and Computer Engineering Publications

Recent years have seen a sharp increase in the use of open source projects by common novice users; Open Source Software (OSS) is thus no longer a reserved arena for software developers and computer gurus. Although user-centered designs are gaining popularity in OSS, usability is still not considered one of the prime objectives in many design scenarios. This paper analyzes industry users’ perception of usability factors, including understandability, learnability, operability, and attractiveness on OSS usability. The research model of this empirical study establishes the relationship between the key usability factors and OSS usability from industrial perspective. In order to conduct …

Federated Critical Infrastructure Simulators: Towards Ontologies For Support Of Collaboration, Katarina Grolinger, Miriam Am Capretz, Adam Shypanski, Gagandeep S. Gill

Electrical and Computer Engineering Publications

Our society relies greatly on a variety of critical infrastructures (CI), such as power system networks, water distribution, oil and natural gas systems, telecommunication networks and others. Interdependency between those systems is high and may result in cascading failures spanning different infrastructures. Behavior of each CI can be observed and analyzed through the use of domain simulators, but this does not account for their interdependency. To explore CI interdependencies, domain simulators need to be integrated in a federation where they can collaborate.

This paper explores three different simulators: the EPANET water distribution simulator, the PSCAD power system simulator and the …

A Unit Test Approach For Database Schema Evolution, Katarina Grolinger, Miriam A M Capretz

Electrical and Computer Engineering Publications

Context: The constant changes in today’s business requirements demand continuous database revisions. Hence, database structures, not unlike software applications, deteriorate during their lifespan and thus require refactoring in order to achieve a longer life span. Although unit tests support changes to application programs and refactoring, there is currently a lack of testing strategies for database schema evolution.

Objective: This work examines the challenges for database schema evolution and explores the possibility of using various testing strategies to assist with schema evolution. Specifically, the work proposes a novel unit test approach for the application code that accesses databases with the objective …