Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

West Virginia University

Discipline
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 1951 - 1980 of 4525

Full-Text Articles in Entire DC Network

Amphibian Metamorphosis In Created And Natural Wetlands, Lauren A. Mcpherson Jan 2015

Amphibian Metamorphosis In Created And Natural Wetlands, Lauren A. Mcpherson

Graduate Theses, Dissertations, and Problem Reports (ETD)

Functional assessment of created wetlands is an important factor in monitoring the success of wetland mitigation projects. Determining the ability of a created wetland to replace lost wildlife habitat and to support productive wildlife populations should be a priority in the assessment of created wetland success. We used a mesocosm design featuring water collected from 3 created wetlands and 3 natural wetlands in West Virginia to evaluate how the water quality from the 2 wetland types were able to support metamorphosis in larval spring peepers (Pseudacris crucifer) and wood frogs ( Rana sylvatica). Spring peepers displayed similar metamorphosis rates in …

Go to article

Development And Evaluation Of An Objective Method For Forensic Examination Of Human Head Hairs Using Texture-Based Image Analysis, Allyce S. Mcwhorter Jan 2015

Development And Evaluation Of An Objective Method For Forensic Examination Of Human Head Hairs Using Texture-Based Image Analysis, Allyce S. Mcwhorter

Graduate Theses, Dissertations, and Problem Reports (ETD)

In response to criticism of traditional forensic methods of human head hair examination, the goal of this study was to develop and evaluate an objective method using texture-based image analysis. 120 individuals, including 20 from six different maternal groups, were sampled and their hairs evaluated using the developed method. Different variables were evaluated to develop the most efficient method to increase intra/inter ratio, as well as the percentage of well-classified hairs. The variables included different microscope systems, objective lenses, number of hairs examined per individual, hair shaft regions, focus methods, and normalization filter techniques. Statistical analyses included one-way analysis of …

Go to article

Sexual Assault On The College Campus: A Partial Test Of Male Peer Support Theory, Falak Ojjeh Jan 2015

Sexual Assault On The College Campus: A Partial Test Of Male Peer Support Theory, Falak Ojjeh

Graduate Theses, Dissertations, and Problem Reports (ETD)

Researchers have identified a number of variables that influence sexual assault on college campuses; peer influence being one of them. According to the sexual assault literature, more than a quarter of victims of sexual assault report their offender was a fraternity member. Additionally, the literature shows that in many sexual assault cases, both the victim and the offender were intoxicated. In applying Walter DeKeseredy's theory of Male Peer Support -- all-male groups that legitimate women abuse -- to on-campus fraternity organizations, this study examines the link is between the drinking and rape cultures promoted by fraternities, specifically, the use of …

Go to article

A Phenomenological Study Of Living With Excess Facial Hair For African-American Women, Courtney M. Pate Jan 2015

A Phenomenological Study Of Living With Excess Facial Hair For African-American Women, Courtney M. Pate

Graduate Theses, Dissertations, and Problem Reports (ETD)

Excess facial hair is a characteristic of hirsutism. Excess facial hair can alter a woman's presentation of self in living day-to-day. Research is sparse in the realm of studying women who do not suffer from polycystic ovarian syndrome, who have excess facial hair. Women of varying racial backgrounds are also underrepresented in the current literature. The purpose of this study was to explore the structure of meaning of living with excess facial hair for African-American women. The stories of eight women were gathered and analyzed using van Manen's phenomenological approach and middle range story theory. As a result of this …

Go to article

Effect Of Time Of Pgf2alpha Application On Reproductive Outcome In Ewes, Callayn Danae Paul Jan 2015

Effect Of Time Of Pgf2alpha Application On Reproductive Outcome In Ewes, Callayn Danae Paul

Graduate Theses, Dissertations, and Problem Reports (ETD)

Traditionally, prostaglandin F2alpha (PGF2alpha) has been included in short-term progesterone-based estrous synchronization (STPBES) protocols but its inclusion has been associated with a reduction in fertility at the synchronized estrus. Also, previous studies have shown that there are differences in the endocrine status and follicular dynamics of ewes at different stages of the estrous cycle, although effects have not been sufficiently evaluated regarding the reproductive outcomes when luteolysis is induced on different days of the cycle. To evaluate the effect of time of application of PGF2alpha relative to the progesterone treatment on fertility, ewes (N=442) from 4 farms located in WV …

Go to article

Evaluation Of An Evidence-Based Breastfeeding Education Program For Pediatric And Women's Health Care Providers, Family Practice Residents, Medical Students, And Physician Assistant Students, Alissa Terry Parker Jan 2015

Evaluation Of An Evidence-Based Breastfeeding Education Program For Pediatric And Women's Health Care Providers, Family Practice Residents, Medical Students, And Physician Assistant Students, Alissa Terry Parker

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background.;Every year approximately {dollar}13 billion are spent and an estimated 900 infant lives are lost in the United States as a result of infants not exclusively receiving breast milk for the first six months of life. Many health care providers lack knowledge and supportive skills regarding basic breastfeeding management. However, the results of several research studies indicate that health care providers who provide support and who are knowledgeable in breastfeeding management can improve the breastfeeding rates of the maternal-infant dyads that they serve. An evidence-based breastfeeding educational program can significantly increase the breastfeeding knowledge and attitudes of health care providers.;Objectives.;The …

Go to article

Kriging-Based Design Of Experiments For Multi-Source Exposure-Response Studies In Nanotoxicology, Ying Pei Jan 2015

Kriging-Based Design Of Experiments For Multi-Source Exposure-Response Studies In Nanotoxicology, Ying Pei

Graduate Theses, Dissertations, and Problem Reports (ETD)

One of the major challenges with toxicology studies of nanomaterials (NMs), compared to traditional materials or chemicals, lies in the large NM variety (or sources) caused by their various physico-chemical properties. How to efficiently design multi-source biological experiments for the toxicity characterization of NMs in terms of their exposure-response profiles? This work intends to address this question by a two-stage experimental design procedure, which is developed based on the statistical model, stochastic kriging with qualitative factors (SKQ). With a given experimental budget, the SKQ-based design method aims at achieving the highest-quality SKQ, which synergistically models the exposure-response data from multiple …

Go to article

Role Of Stem-Like Cells In Carbon Nanotube-Induced Pulmonary Fibrosis, Amruta Manke Jan 2015

Role Of Stem-Like Cells In Carbon Nanotube-Induced Pulmonary Fibrosis, Amruta Manke

Graduate Theses, Dissertations, and Problem Reports (ETD)

Recent studies have shown that pulmonary exposure to (CNT) results in rapid and progressive interstitial lung fibrosis in animals without causing persistent lung inflammation, which is normally associated with other known fibrogenic agents. This unusual fibrogenic effect of CNT raises important health issues since the exposure could result in deadly and incurable lung fibrosis. Accumulating evidence indicates the fibrogenic potential of carbon nanotubes, however, the underlying mechanism remains poorly addressed. Recent studies have demonstrated the pathogenic role of mesenchymal stem cells in pulmonary fibrosis that differentiate into myofibroblasts and contribute to disease progression. Understanding the molecular/cellular basis of these fibrosis-associated …

Go to article

Role Of Multi-Site Phosphorylation In Regulation Of E(Spl) M8 Activity During Drosophila Neurogenesis, Mohna Bandyopadhyay Jan 2015

Role Of Multi-Site Phosphorylation In Regulation Of E(Spl) M8 Activity During Drosophila Neurogenesis, Mohna Bandyopadhyay

Graduate Theses, Dissertations, and Problem Reports (ETD)

Notch signaling is an evolutionarily conserved pathway that regulates cell-fate determination at various stages of development in invertebrate and vertebrate species. The Notch pathway mediates juxtacrine signaling through a process termed as lateral inhibition by which two equipotent cells adopt distinct cell fates. The functions of Notch have been exceptionally well analyzed during neurogenesis in Drosophila, particularly during eye and mechanosensory bristle morphogenesis. At the onset of neurogenesis, proneural bHLH activators encoded by atonal (ato) or the achaete-scute complex (ASC) is expressed in groups of cells, called proneural clusters (PNCs) in the eye and the bristle tissue respectively. From each …

Go to article

A Journey In Magic And Realism Performing The Role Of Titania From William Shakespeare's "A Midsummer Night's Dream", Mya Brown Jan 2015

A Journey In Magic And Realism Performing The Role Of Titania From William Shakespeare's "A Midsummer Night's Dream", Mya Brown

Graduate Theses, Dissertations, and Problem Reports (ETD)

This document consists of a detailed account of my process in developing my thesis role and the pedagogical experiences which have contributed to my artistry. The purpose of this thesis role was to allow exploration of the character Titania, from William Shakespeare's A Midsummer Night's Dream. Titania was an interesting character to portray due to the fact that I had previously performed this role. My study consisted of applying acting methodology to Shakespeare's play in order to realistically present a fresh characterization of the role. A detailed interpretation of the text along with the engagement of my imagination provided the …

Go to article

The Modeling And Stability Analysis Of Humans Balancing An Inverted Pendulum, Yaohui Ding Jan 2015

The Modeling And Stability Analysis Of Humans Balancing An Inverted Pendulum, Yaohui Ding

Graduate Theses, Dissertations, and Problem Reports (ETD)

The control of an inverted pendulum is a classical problem in dynamics and control theory. Without active control, the inverted pendulum by itself is inherently unstable, thus serving as an ideal platform for control algorithms design and testing. This study utilizes an inverted pendulum setup to investigate the characteristics of manual control in executing a single-axial compensatory task. An inverted pendulum with sliding base on a single-axial rail was built for this purpose. Human subjects were asked to stabilize the pendulum by sliding the base on the rail. To mathematically quantify the characteristics of human manual control, a quasi-linear lead-lag …

Go to article

A Novel Computational System For Identification Of Biological Processes From Multi-Dimensional High-Throughput Genomic Data, Julian Marshall Dymacek Jan 2015

A Novel Computational System For Identification Of Biological Processes From Multi-Dimensional High-Throughput Genomic Data, Julian Marshall Dymacek

Graduate Theses, Dissertations, and Problem Reports (ETD)

Identifying potential toxicity signaling pathways could guide future animal studies and support human risk assessment and intervention efforts. This thesis describes a novel computational approach for identifying biological processes and pathways that are significantly associated with a disease pathology from time series, dose response, gene expression data.;Our system employs a novel constrained non-negative matrix factorization algorithm and Monte Carlo Markov chain simulation to identify underlying patterns in mRNA gene expression data. Quantitative pathology can be used as a pattern constraint. The found patterns can be thought of as functions that influence a gene's expression. Using a database of curated gene …

Go to article

The Keyboard Works Of Alex Shapiro, Elizabeth Mary Etnoyer Jan 2015

The Keyboard Works Of Alex Shapiro, Elizabeth Mary Etnoyer

Graduate Theses, Dissertations, and Problem Reports (ETD)

This project serves as a broad introduction to the keyboard works of American composer Alex Shapiro (1962-present), with primary focus on her works for solo piano. Ms. Shapiro has developed a well-established reputation as a serious and innovative composer, writing both acoustic and electroacoustic music for a variety of musical genres including instrumental solo and chamber music, as well as music for large ensembles. Shapiro's writing is often influenced by extramusical ideas, such as her solo piano piece Luvina (2007), a work based on the short story with that name by Mexican author Juan Rulfo. With scores that often include …

Go to article

Investigations Of Pasteuria And The Root-Lesion Nematode Pratylenchus Penetrans In Soils Collected From Certified Organic Farms In The Mid-Atlantic United States, Tiara Nicole King Jan 2015

Investigations Of Pasteuria And The Root-Lesion Nematode Pratylenchus Penetrans In Soils Collected From Certified Organic Farms In The Mid-Atlantic United States, Tiara Nicole King

Graduate Theses, Dissertations, and Problem Reports (ETD)

Occurrence of lesion nematodes and Pasteuria, an obligate bacterial parasite, was surveyed in 34 soils collected from certified organic farms in the Mid-Atlantic United States. Pasteuria endospores were observed on Pratylenchus crenatus in six of 22 soils. Population density of Pratylenchus in soils lacking signs of Pasteuria correlated positively with soil pH, cation exchange capacity, and concentration of phosphorus pentoxide and calcium. Pasteuria was detected on Pratylenchus in nematode suppressive soils at the West Virginia University Organic Research Farm. Interactions between Pasteuria and Pratylenchus penetrans were studied in two laboratory bench-top experiments. Soil treatment effects on reproduction of Pratylenchus penetrans …

Go to article

Improving Wellbore Cement Performance Through The Application Of Nano-Materials For Oil And Gas Integrity, Benjamin J. Kleiner Jan 2015

Improving Wellbore Cement Performance Through The Application Of Nano-Materials For Oil And Gas Integrity, Benjamin J. Kleiner

Graduate Theses, Dissertations, and Problem Reports (ETD)

It is the ultimate goal that the application of nano-materials in wellbore cement enhance not only the integrity of the cement, but also the public view of the petroleum industry. Wellbore integrity should be a paramount concern of all petroleum companies due to the potential severity of the consequences if integrity is not maintained. Ecosystems, animal and plant life, and even human life are at great risk if wellbore integrity fails. It is this fact that the motivation for this thesis is based upon. Nano silica is the nano-particle under investigation for this thesis. Furthermore, wellbore integrity will be improved …

Go to article

Spatial And Temporal Distribution Of Hemlock Woolly Adelgid (Hemiptera: Adelgidae) Ovisac And Its Associations With The Environment, Sunghoon Baek Jan 2015

Spatial And Temporal Distribution Of Hemlock Woolly Adelgid (Hemiptera: Adelgidae) Ovisac And Its Associations With The Environment, Sunghoon Baek

Graduate Theses, Dissertations, and Problem Reports (ETD)

Eastern hemlock, Tsuga canadensis (Pinales: Pinaceae) is an important tree species in eastern North America ecosystems. During the past 65 years, eastern hemlock stands have been threatened by the hemlock woolly adelgid, Adelges tsugae Annand (Hemiptera: Adelgidae). The goal of this research was to determine the spatial and temporal distribution of A. tsugae populations. First, the appropriate sample unit for A. tsugae was determined based on within-branch and -tree distribution of A. tsugae. The results of this study showed that A. tsugae ovisacs were more frequently found at the tip of a branch and no significant (P > 0.05) differences in …

Go to article

Identification Of A Critical Gene In The Dihydroergot Alkaloid Pathway, Yulia Bilovol Jan 2015

Identification Of A Critical Gene In The Dihydroergot Alkaloid Pathway, Yulia Bilovol

Graduate Theses, Dissertations, and Problem Reports (ETD)

Ergot alkaloids, bioactive compounds produced by some species of fungi, have had significant impacts on agriculture and medicine. Claviceps purpurea and Epichloe spp. are ergot alkaloid producers associated with agricultural commodities and negatively affect humans and grazing animals, respectively. Another ergot alkaloid-producing fungus called Aspergillus fumigatus is ubiquitous in the environment; infections arising after inhaling the spores may kill immunocompromised persons. Ergot alkaloids and their derivatives are utilized by the pharmaceutical industry for the development of drugs. Some of these drugs are derived from lysergic acid, whereas others are derived from dihydrolysergic acid. Lysergic acid derivatives have vasoconstrictive properties and …

Go to article

Phylogenetic Relationships Among Arbuscular Mycorrhizal Fungal Species In The Deeply Rooted Archaeosporales (Glomeromycota), Robert J. Bills Jan 2015

Phylogenetic Relationships Among Arbuscular Mycorrhizal Fungal Species In The Deeply Rooted Archaeosporales (Glomeromycota), Robert J. Bills

Graduate Theses, Dissertations, and Problem Reports (ETD)

Arbuscular mycorrhizal fungi (AMF) in the phylum Glomeromycota are globally distributed biotrophic fungi that form symbiotic associations with a majority of terrestrial plants. Their global beneficial role in plant and soil ecology warrants a better understanding of their evolutionary history and taxonomic relationships. This project focused on species relationships in two deeply rooted families Ambisporaceae and Archaeosporaceae. In one study, analysis of morphology and 28S ribosomal DNA (LSU) sequences resulted in two major changes that redefined Ambispora to include only species that were dimorphic for both acaulosporoid and glomoid spore types. First, species described as producing only glomoid spores (Am. …

Go to article

Evolution Of A Disintegrin And Metalloproteinase Gene Family In Vertebrates, Shashwati Bhattacharya Jan 2015

Evolution Of A Disintegrin And Metalloproteinase Gene Family In Vertebrates, Shashwati Bhattacharya

Graduate Theses, Dissertations, and Problem Reports (ETD)

A disintegrin and metalloproteinases (ADAMs) are a family of transmembrane proteins which have diverse functions in various tissues. They play important roles in cellular and developmental processes and are present in various species. ADAMs are classified according to their expression in tissues into the somatic ADAMs (sADAMs) and the testicular ADAMs (tADAMs). The sADAMs are expressed in somatic tissues, and the testicular ADAMs (tADAMs) are expressed predominantly in the testis. The tADAMs are further classified into Group I and Group II, based on the absence or presence of introns. The mechanism of evolution of the tADAMs was unknown. Using bioinformatics …

Go to article

Kruppel-Like Factor 4 (Klf4) Regulates Protumorigenic Signaling In Triple-Negative Breast Cancer (Tnbc) Cells, Sriganesh B. Sharma Jan 2015

Kruppel-Like Factor 4 (Klf4) Regulates Protumorigenic Signaling In Triple-Negative Breast Cancer (Tnbc) Cells, Sriganesh B. Sharma

Graduate Theses, Dissertations, and Problem Reports (ETD)

The zinc-finger pluripotency factor Kruppel-like factor 4 (KLF4) exerts context dependent roles in the maintenance of tissue homeostasis and the pathobiology of many malignancies, including breast cancer. Despite the multitude of studies focused on the role of KLF4 across these contexts, the signaling programs that are regulated by this factor in breast cancer cells remain unclear. In this dissertation we deliniate three KLF4-dependent protumorigenic signaling axes that endow triple-negative breast cancer (TNBC) cells with enhanced capacity to resist cell stress.;In the first study (Chapter 2), we found that KLF4 promotes the expression of two microRNAs (miRs), miR-206 and miR-21 (miR-206/21), …

Go to article

Evaluating Changes In Knowledge, Beliefs, And Behaviors Associated With Hpv Following An Educational Intervention Among Women, Crystal Sheaves Jan 2015

Evaluating Changes In Knowledge, Beliefs, And Behaviors Associated With Hpv Following An Educational Intervention Among Women, Crystal Sheaves

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Prevalence of HPV is estimated to be 10-15% Americans. HPV is recognized as the causative agent in 99.7% of all cervical cancers. In 2006, a vaccine was released to prevent specific types of HPV that cause cervical cancer. Despite demonstrated vaccine safety and efficacy, vaccine rates are still low at less than 20% among women 18-26 years old. Vaccine uptake may be impacted by women's HPV knowledge and beliefs.;Aims: The purpose of this study was to evaluate changes in women's knowledge, beliefs, and behaviors associated with HPV following an educational intervention study. Specifically, the study was designed to evaluate …

Go to article

Transformation Of A Pre-Algebra Developmental Mathematics Course That Led To The Redesign Of The Developmental Mathematics Program At A Rural Community College, Mary Beth Angeline Jan 2015

Transformation Of A Pre-Algebra Developmental Mathematics Course That Led To The Redesign Of The Developmental Mathematics Program At A Rural Community College, Mary Beth Angeline

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation documents the redesign of a developmental mathematics program at a rural community college and compares the course pass rates between the redesigned courses and the traditional lecture-based courses. A design and developmental methodology was used to chronicle changes to outcomes, learning environment, instructor role, and curricular practices over four course offerings that occurred over three semesters. Effectiveness of these changes was used to continually make corrections to the course structure, and make a case to expand the redesign of the course to the entire developmental mathematics program.

Go to article

On The Evolution Of Organizational Governance: Divided Governance And Survival In The Long Run, Roger D. Congleton Dec 2014

On The Evolution Of Organizational Governance: Divided Governance And Survival In The Long Run, Roger D. Congleton

Economics Faculty Working Papers Series

This paper analyzes the formation, refinement, and evolution of organizational decisionmaking processes, e.g. organizational governments. In doing so, it develops a framework for analyzing a broad cross section of private and non-private formal organizations. Formal organizations are all founded, e.g. they have a beginning. As a consequence, decisionmaking authority within an organization is often initially distributed in a manner that provides their founders (formeteurs) with substantial control over their organizations. However, that control is rarely, if ever, complete, because formeteurs have interests that can often be advanced by trading and/or delegating authority to others in exchange for services and other …

Go to article

Lights Out In The Bakken: A Review And Analysis Of Flaring Regulation And Its Potential Effects On North Dakota Shale Oil Production, Monika U. Ehrman Dec 2014

Lights Out In The Bakken: A Review And Analysis Of Flaring Regulation And Its Potential Effects On North Dakota Shale Oil Production, Monika U. Ehrman

West Virginia Law Review

No abstract provided.

Go to article

The Influence Of White-Tailed Deer On Plant Communities In West Virginia And Stakeholder Attitudes Toward Deer Management With Respect To Plant Conservation, Kelley Lynne Flaherty Dec 2014

The Influence Of White-Tailed Deer On Plant Communities In West Virginia And Stakeholder Attitudes Toward Deer Management With Respect To Plant Conservation, Kelley Lynne Flaherty

Graduate Theses, Dissertations, and Problem Reports (ETD)

White-tailed deer (Odocoileus virginianus) may impact plant species by reducing individual survival or reduce reproductive potential by feeding on flowering parts or seeds. Herbivory may benefit plant populations by increasing dispersal of seeds. The combination of these factors may influence the composition of native plant communities. The recovery of deer populations from near extirpation was seen as a wildlife management success story. However, the maintenance of abnormally high deer density levels over many years may have taken a toll on plant communities. Some biologists now question whether or not white-tailed deer could be considered overabundant in some parts of their …

Go to article

Synergistic Inhibition Of Cyclooxygenases And Monoacylglycerol Lipase In Neuropathic Pain, Molly S. Crowe Dec 2014

Synergistic Inhibition Of Cyclooxygenases And Monoacylglycerol Lipase In Neuropathic Pain, Molly S. Crowe

Graduate Theses, Dissertations, and Problem Reports (ETD)

Neuropathic pain is caused by altered nerve function that often presents as allodynia, which is the painful perception of typically non-noxious stimuli. Neuropathic pain is commonly treated with GABA analogues, steroids, or non-steroidal anti-inflammatory drugs (NSAIDs). NSAIDs inhibit one or more cyclooxygenase (COX) enzymes and are effective, commonly used analgesics that have relatively fewer side effects than other treatments. However, chronic cyclooxygenase inhibition also causes gastrointestinal inflammation and increased risk of cardiac events. Like NSAIDs, cannabinoids have analgesic and anti-inflammatory properties and reduce neuropathic pain in preclinical models. The present study investigated the analgesic effects of inhibiting both monoacylglycerol lipase …

Go to article

The Conservative-Libertarian Turn In First Amendment Jurisprudence, Steven J. Heyman Sep 2014

The Conservative-Libertarian Turn In First Amendment Jurisprudence, Steven J. Heyman

West Virginia Law Review

No abstract provided.

Go to article

The Prohibition Of Moonshine: A Consumer Protection Analysis Of Raw Milk In Interstate Commerce, Whitney R. Morgan Sep 2014

The Prohibition Of Moonshine: A Consumer Protection Analysis Of Raw Milk In Interstate Commerce, Whitney R. Morgan

West Virginia Law Review

No abstract provided.

Go to article

Explicit Disclosure In Retail Communication: Impact Of Undetermined Social Network Site Relationships On Branded Identity, Hannah R. Gnegy Aug 2014

Explicit Disclosure In Retail Communication: Impact Of Undetermined Social Network Site Relationships On Branded Identity, Hannah R. Gnegy

Graduate Theses, Dissertations, and Problem Reports (ETD)

One of the most impactful technologies to emerge from Web 2.0 developments has been the social network site. In traditional models of branded identity, it is assumed that there is a distinction made between the retailer and consumer (de Chernatony, 1999; Kapferer, 2008). However, social network sites allow for the formation of undetermined relationships in which the underlying role of a party may be unknown.;As social network sites continue to shape retail practices, a gap in knowledge exists regarding how models of branded identity need to be modified to meet the demands of these undetermined social network site relationships. Through …

Go to article

The Effect Of Allopurinol And Inosine Administration On Xanthine Oxidoreductase Gene Expression, Mitochondrial Respiration, And Inflammation In Broiler Chickens, Tabatha Settle Aug 2014

The Effect Of Allopurinol And Inosine Administration On Xanthine Oxidoreductase Gene Expression, Mitochondrial Respiration, And Inflammation In Broiler Chickens, Tabatha Settle

Graduate Theses, Dissertations, and Problem Reports (ETD)

Birds have a remarkable longevity for their body size despite an increased body temperature, higher metabolic rate, and increased blood glucose concentrations. Theoretically, birds should sustain a much higher degree of oxidative damage yet do not, in part due to the powerful antioxidant, uric acid. As the end-product of purine degradation, uric acid is generated in the xanthine/hypoxanthine reactions catalyzed by xanthine oxiodreductase (XOR). In the first study, inosine, a purine precursor, was fed to 3 groups of 5 birds: Group 1 was fed 0 (control), Group 2, 0.6 mols inosine/kg feed (INO) and Group 3, INO treatment plus 50 …

Go to article

First Prev Next Last