Digital Commons Network^™

Regional Industry Cluster Analysis For The Potomac Highlands In West Virginia, Jing Chen, Randall Jackson

Regional Research Institute Resource Documents

No abstract provided.

The Relationship Between Dietary Quality And Mental Health In A Young Adult Appalachian College Population, Rachel Anne Wattick

Capstones and Honors Theses

To investigate the relationship between dietary quality and mental health status of young adults in an Appalachia college setting we 1) assessed the overall dietary quality of students 2) assessed the frequency of depression and anxiety symptoms of students and 3) assessed the relationship between these factors and food insecurity of students. A cross-sectional design was used in a large, Appalachian college population in fall 2017. Survey items included the Dietary Screener Questionnaire (DSQ), experience of depression or anxiety symptoms over the past 30 days, and the US Adult Food Security Survey Module, demographic variables and BMI. Participant responses (n=1956) …

Permeability Changes And Effect Of Chemotherapy In Brain Adjacent To Tumor In An Experimental Model Of Metastatic Brain Tumor From Breast Cancer, Afroz S. Mohammad, Chris E. Adkins, Neal Shah, Rawaa Aljammal, Jessica I. G. Griffith, Rachel M. Tallman, Katherine L. Jarrell, Paul R. Lockman

Faculty & Staff Scholarship

Abstract

Background: Brain tumor vasculature can be significantly compromised and leakier than that of normal brain blood vessels. Little is known if there are vascular permeability alterations in the brain adjacent to tumor (BAT). Changes in BAT permeability may also lead to increased drug permeation in the BAT, which may exert toxicity on cells of the central nervous system. Herein, we studied permeation changes in BAT using quantitative fluorescent microscopy and autoradiography, while the effect of chemotherapy within the BAT region was determined by staining for activated astrocytes.

Methods: Human metastatic breast cancer cells (MDA-MB-231Br) were injected into left ventricle …

Food Insecurity And Behavioral Characteristics For Academic Success In Young Adults Attending An Appalachian University, Rebecca L. Hagedorn, Melissa D. Olfert

Faculty & Staff Scholarship

In order to investigate the impact of food insecurity on college students in a highly health disparate region we (1) assessed the prevalence of food insecurity among young adults at a large, rural university in Appalachia, and (2) investigated the relationship between food insecurity and behavioral characteristics including academic performance, coping strategies, and money expenditure. A cross-sectional design was used to capture a representative sample of young adults attending a large, central Appalachian university in Fall 2016. The United States Department of Agriculture (USDA) Adult Food Security Survey was used to measure food insecurity. Independent variables include money expenditure (MES), …

Organic Versus Conventional Cropping Sustainability: A Comparative System Analysis, Tiffany L. Fess, Vagner Benedito

Faculty & Staff Scholarship

We are at a pivotal time in human history, as the agricultural sector undergoes consolidation coupled with increasing energy costs in the context of declining resource availability. Although organic systems are often thought of as more sustainable than conventional operations, the lack of concise and widely accepted means to measure sustainability makes coming to an agreement on this issue quite challenging. However, an accurate assessment of sustainability can be reached by dissecting the scientific underpinnings of opposing production practices and crop output between cropping systems. The purpose of this review is to provide an in-depth and comprehensive evaluation of modern …

County-Level Cie Supply Chain Analysis, Randall Jackson, Peter Jarosi

Appalachian Coal Industry Ecosystem

This report examines the impact of the decline in coal production on supply chain industries at the county level across Appalachia. It offers, and uses, a typology to classify counties based on their dependence on the CIE, recent employment changes due to reduced coal production, and their risk for further impacts due to any future declines in the coal industry.

Position On House Bill 2931, Megan Rinker

Honors Projects

No abstract provided.

Towards A Rule-Based Model Of Human Choice: On The Nature Of Homo Constitutionalus, Roger Congleton

Economics Faculty Working Papers Series

Anglo-American jurisprudence emphasizes the rule of reason; it grossly neglects the reason of rules. We play socioeconomic-legal-political games that can be described empirically only by their rules. But most of us play without an understanding or ap-preciation of the rules, how they came into being, how they are enforced, how they can be changed, and most important, how they can be normatively evaluated. (Bren-nan and Buchanan, 1985, preface).

The Spatial Distribution Of Urban Consumer Service Firms: Evidence From Yelp Reviews, Brad Humphreys, Josh Matti

Economics Faculty Working Papers Series

A growing literature employs distance-based measures of localization to assess the spatial distribution of firms with a focus on manufacturing across a country. We analyze the spatial concentration of a variety of consumer services firms in the Phoenix, AZ area using geo-referenced Yelp data from over 29,000 establishments. Results from a K-density approach indicate substantial localization and service differentiation among localized firms. Firm concentration varies across service cost and quality; higher quality/cost establishments tend to cluster. Our results further understanding of the modern urban landscape as cities are increasingly centers of consumption.

The Constitutional Conundrum: Commerce And The Tenth Amendment, Jennifer Marie Walker

Capstones and Honors Theses

Since the drafting of the United States Constitution, the power of both the federal government and the individual state governments has been a topic of controversy. The Constitution's strong focus on federal powers ultimately threatened to derail ratification. To secure the ratification of the Constitution, a Bill of Rights was added to the document. Comprised of ten amendments, the Bill of Rights generally elaborated on individual rights. The Tenth Amendment, however, dealt more specifically with the federal-state relationship. Several early federal court cases established the federal judiciary's power to answer important Constitutional questions. This power thus granted the federal judiciary …

The Importance Of Perspective In The Stranger And The Myth Of Sisyphus: The Absurdist's Need For Conscious Rebellion., Riley Keaton Imlay

Capstones and Honors Theses

No abstract provided.

Finding Myself Back Home In Botswana: Reflections On A Semester Abroad, Anne M. Odonnell

Capstones and Honors Theses

Anthropology aims to study people and their culture in order to understand the breadth of human experience. This paper examines the ways in which a semester of study abroad can supplement and aid in future work in anthropology. Primarily, it examines culture shock and how it can be managed and the connections between cultures that are separated across space. It also explores the ways in which the environment and wildlife of a new area can contribute to a person's experience of place.

The Punitive Effect Of Electric Shock In Rats In Relation To The Rate Of Food Reinforcement, Vincent A. Bello

Capstones and Honors Theses

The purpose of the present experiment was to examine effects of the rate of reinforcement on the punitive function of shock for 4 rats. In baseline conditions, rats’ lever presses were reinforced with food according to a VI schedule. During punishment conditions, a VR-5 schedule of shock punishment was superimposed on the VI schedule. Across pairs of baseline and punishment conditions, the rate of reinforcement ranged from 0.5 to 6 food deliveries per min. Response rates during the baseline and punishment conditions generally increased as the reinforcement rate was raised for two out of four rats. For three rats, suppression …

The Effect Of Downregulation Of A Cell-Wall Modigying Gene On Bud Set Timing In Populus Deltoides., Luke Jarrod Stover

Capstones and Honors Theses

In an attempt to enhance the efficiency of biofuel production, research has traditionally focused on wood chemistry in forest trees. Altered wood chemistry has the potential to reduce recalcitrance to carbohydrate extraction and conversion, but may have unintended effects on dormancy. In Populus deltoides (eastern cottonwood), changes in dormancy may inhibit annual growth rates or put the trees at risk for frost damage, compromising benefits of genetic engineering. Genome wide association analysis indicates that multiple polymorphisms in and around the Potri.013G001600.1 gene of unknown function have a strong association with bud set date. This experiment isolated the gene's transcription levels …

Gas County: A Case Study On How West Virginia's Recent Gas Boom Is Transforming A County, Egill Karlsson

Graduate Theses, Dissertations, and Problem Reports (ETD)

A case study on horizontal hydraulic fracturing through the eyes of Doddridge County, WV; how it's affected the residents and various stakeholders in different ways, from economy to health and environment.

Caregiver Selection Of Treatments For Their Child With Autism, Amy Kurowski-Burt

Graduate Theses, Dissertations, and Problem Reports (ETD)

This project was completed to understand what treatments caregivers are selecting for their child with autism and why treatments were selected and discontinued. Caregivers of children with autism participated in a mixed methods study. An online survey was completed (N=127) to identify treatments used for their child. Interviews were completed (n=14) to understand why treatments were selected and discontinued. Selection of medical, dietary, therapeutic, complimentary/ alternative medicine, community-based, behavioral, and educational treatments were mostly influenced by recommendations of others. Caregivers reported discontinuing because relationships and professionalism were lacking between provider and family. Providers must consider all the variables that influence …

The Microvascular And Systemic Effects Of Titanium Dioxide Nanoparticle Exposure: A Physiological Perspective, Alaeddin Bashir Abukabda

Graduate Theses, Dissertations, and Problem Reports (ETD)

Titanium dioxide nanoparticles (nano-TiO₂) are one of the most widely used engineered nanomaterials (ENM). Their ubiquitous inclusion warrants a more thorough understanding of their toxicity, particularly in sensitive populations such as pregnant women and the developing fetus.

The aim of the first study was to determine the most sensitive segments of the vasculature to pulmonary ENM exposure. Macrovascular function was investigated in the thoracic aorta, common femoral artery and 3^rd order mesenteric arterioles using wire myography. Microvascular function was assessed in 4^th and 5^th order mesenteric arterioles via pressure myography. Nano-TiO₂ exposure induced impairments …

Application Of Molecular Pathology Techniques To Understand Mechanisms Of Disease In Smallmouth Bass, Heather Leigh Walsh

Graduate Theses, Dissertations, and Problem Reports (ETD)

In the Chesapeake Bay drainage, smallmouth bass Micropterus dolomieu are used as an indicator species of estrogenic contaminant exposure and have been implicated in fish kills and disease since 2005. In the Potomac River drainage, adult smallmouth bass have experienced mortality and disease and males have a high prevalence of intersex (testicular oocytes). Conversely, in the Susquehanna River drainage mortalities and disease of young-of-the-year smallmouth bass (YOY SMB) have occurred and resulted in a population shift to older and larger fish. The exact cause of these events remains unknown; however, factors such as poor water quality, contaminants, pathogens and parasites, …

Effects Of Delay And Signals On Choice Between Delayed Food Alone And Immediate Food With Delayed Shock, Forrest James Toegel

Graduate Theses, Dissertations, and Problem Reports (ETD)

Much of the research in the area of self-control has examined choice between small immediate reinforcers and large delayed reinforcers, but many problems result from situations in which a single choice produces consequences of conflicting valence: Those in which the immediate outcome is reinforcing and the delayed outcome is aversive. Recent research has evaluated how preference for a large reinforcer which is followed by a delayed shock changes as a function of the delay to shock and how the intensity and duration of delayed shock affects the value of a large reinforcer. The present set of experiments investigated how the …

Impact Of A Fruit And Vegetable Diet Intervention In Young Adults With Metabolic Syndrome On Behavior And Gut Microbiome, Rashel L. Clark

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Metabolic Syndrome (MetS) is a clustering of factors that increases the risk of developing cardiovascular diseases and diabetes. The rates of MetS are on the rise, even among young adults. The primary objective of the Fruvedomics phase 2 study was to determine changes in behavior, cardiovascular, and gut microbiome health in a group of young adults with MetS following an 8-week, free-living, dietary intervention.;Methods: The dietary intervention followed the USDA Dietary Guidelines for Americans and focused on increasing fruit and vegetable intake to equal half their diet. University students (18--30 years old) with MetS were recruited on the West …

Estimating Bald Eagle Occupancy And Density In The Chesapeake Bay Watershed, Bethany Drahota

Graduate Theses, Dissertations, and Problem Reports (ETD)

Bald eagles (Haliaeetus leucocephalus) are a newly recovered species, and as such, little is known about their modern population dynamics and how these dynamics interact with their ecology. With the recent expansion of eagle populations, managers have begun to question assumptions about bald eagles, including their sensitivity to disturbances. Discerning how eagles react to both outside influences and internal factors is crucial for eagle conservation, especially in focal areas of importance, such as the Chesapeake Bay. I used seven years of monitoring data from the Virginia Department of Game and Inland Fisheries (VDGIF) to determine the occupancy (chapter 1) and …

Connecting Talent To Technique An Actor's Exploration Of Connecting Back To Their Roots, Madeline Hintz

Graduate Theses, Dissertations, and Problem Reports (ETD)

This paper is a reflection of my experience performing the role of Sara Jane Moore in the musical Assassins. To work through this role and honor the simplicity of the comedy, I needed to divulge my insecurities that stem from my past musical theatre and comedic experiences. Working through my past and my time here at WVU, the realization of how personal tensions affected my work made the role of Sara Jane Moore the most challenging experience of my graduate school education. The increased awareness of my resistance to new acting and voice techniques allowed me to grow and develop, …

The Role Of Kndy Neurons And Neuronal Nitric Oxide Synthase In The Control Of Reproduction In Female Sheep And Nonhuman Primates, Michelle Nichole Bedenbaugh

Graduate Theses, Dissertations, and Problem Reports (ETD)

Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus is an important regulator of ovarian function and reproductive cyclicity. During the reproductive cycle, the pattern of GnRH secretion from the hypothalamus, and subsequently luteinizing hormone (LH) secretion from the anterior pituitary, is modulated by ovarian hormones. However, the effects of estradiol (E2) and progesterone cannot be directly communicated to GnRH neurons because these neurons do not express progesterone receptors or estrogen receptor alpha (ERalpha), the estrogen receptor that influences estrogenic regulation of GnRH secretion. Thus, neuronal intermediates that do express these receptors must exist to communicate steroidal feedback to GnRH neurons. Kisspeptin, …

How Connectedness To Nature Relates To Well-Being Over Time, Amy Knepple Carney

Graduate Theses, Dissertations, and Problem Reports (ETD)

Correlational and experimental studies have found evidence that connectedness to nature (CN) leads to increases in well-being. Higher CN relates to higher positive affect, lower negative affect, and better health (Herzog & Strevey, 2008; Korpela & Ylen, 2007; Mayer, Frantz, Bruehlman-Senecal, & Dolliver, 2009). Little research, though, has examined the relation of CN and well-being over time. With the lack of longitudinal data, it is impossible to assess how CN might be associated with well-being and health over a person's lifetime. This study is among the first to evaluate CN and well-being with three-time points. Final analyses were conducted on …

Sphingomyelin And Gm1 Influence Huntingtin Binding To, Disruption Of, And Aggregation On Lipid Membranes, Maxmore Chaibva, Xiang Gao, Pranav Jain, Warren A. Campbell, Shelli L. Frey, Justin Legleiter

Faculty & Staff Scholarship

Huntington disease (HD) is an inherited neurodegenerative disease caused by the expansion beyond a critical threshold of a polyglutamine (polyQ) tract near the N- terminus of the huntingtin (htt) protein. Expanded polyQ promotes the formation of a variety of oligomeric and fibrillar aggregates of htt that accumulate into the hallmark proteina- ceous inclusion bodies associated with HD. htt is also highly associated with numerous cellular and subcellular membranes that contain a variety of lipids. As lipid homeostasis and metabolism abnormalities are observed in HD patients, we investigated how varying both the sphingomyelin (SM) and ganglioside (GM1) contents modifies the interactions …

Altered Spring Phenology Of North American Freshwater Turtles And The Importance Of Representative Populations, Fredric J. Janzen, Luke A. Hoekstra, Ronald J. Brooks, David M. Carroll, J Whitfield Gibbons, Judith L. Greene, John B. Iverson, Jacqueline D. Litzgus, Edwin D. Michael, Steven G. Parren, Willem M. Roosenburg, Gabriel F. Strain, John K. Tucker, Gordon R. Ultsch

Faculty & Staff Scholarship

Globally, populations of diverse taxa have altered phenology in response to climate change. However, most research has focused on a single population of a given taxon, which may be unrepresentative for comparative analyses, and few long-term studies of phenology in ectothermic amniotes have been published. We test for climate- altered phenology using long-term studies (10–36 years) of nesting behavior in 14 populations representing six genera of freshwater turtles (Chelydra, Chrysemys, Kinosternon, Malaclemys, Sternotherus, and Trachemys). Nesting season initiation oc- curs earlier in more recent years, with 11 of the populations advancing phenology. The onset of nesting for nearly all populations …

Characterization Of Worm-Eating Warbler (Helmitheros Vermivorum) Breeding Habitat At The Landscape Level And Nest Scale, Patrick J. Ruhl, Kenneth F. Kellner, Jameson M. Pierce, Jeffrey K. Riegel, Robert K. Swihart, Mike R. Saunders, John B. Dunning Jr

Faculty & Staff Scholarship

The Worm-eating Warbler (Helmitheros vermivorum) is typically described as a mature forest species requiring moderate to steep slopes and dense understory vegetation for breeding. However, nesting microhabitat characteristics vary regionally. Given the extensive variation in landscape topography, forest composition, and habitat structure across the breeding range, identification of important local landscape features and microhabitat characteristics is needed to formulate and implement improved conservation actions for the species. We characterized important habitat associations at two distinct scales (the landscape scale and the nest scale) to provide a detailed description of Worm-eating Warbler breeding habitat requirements in southern Indiana. Results from our …

Pseudomonas And Burkholderia Inhibit Growth And Asexual Development Of Phytophthora Capsici, Amena Khatun, Tarin Farhana, Abdullah As Sabir, Shah Mohammad Naimul Islam, Helen M. West, Mahfuzur Rahman, Tofazzal Islam

Faculty & Staff Scholarship

The objective of this study was to isolate and characterize antagonistic rhizobacteria from chili against a notorious phytopathogen Phytophthora capsici. Among the 48 bacteria isolated, BTLbbc-02, BTLbbc-03, and BTLbbc-05 were selected based on their inhibitory activity against P. capsici. They were tentatively identified as Burkholderia metallica BTLbbc-02, Burkholderia cepacia BTLbbc-03, and Pseudomonas aeruginosa BTLbbc-05, respectively, based on their 16S rRNA gene sequencing. All inhibited the growth of P. capsici at varying levels by inducing characteristic morphological alterations of P. capsici hyphae. The cell-free culture supernatant of all three isolates impaired motility (up to 100%) and caused lysis …

Dissensual Women: Modernist Women Writers, The Senses, And Technology, Allyson Demaagd

Graduate Theses, Dissertations, and Problem Reports (ETD)

My project, Dissensual Women: Modernist Women Writers, the Senses, and Technology, analyzes depictions of the senses and technology in modernist women's writing. I argue that modernist women writers challenge traditional sensory hierarchies that value the so-called masculine senses of sight and sound and denigrate the so-called feminine senses of smell, taste, and touch. H.D., Mina Loy, Virginia Woolf, and Elizabeth Bowen revalue the feminine senses, challenge sensory elitism, and advocate for an inclusive sensorium, one that features the perceptions and experiences of women, queer women, the lower classes, the nonhuman, and the differently abled. They wage their dissent through experimentation …

Examining The Association Amongst Expected Costs And Benefits, Peer Use, And Self-Reported Use Of Electronic Cigarettes In Adolescents, Kristine Durkin

Graduate Theses, Dissertations, and Problem Reports (ETD)

Understanding why e-cigarettes are becoming increasingly popular with adolescents, despite the potential negative health consequences of these products, is critical to informing prevention and intervention efforts. Prior research has identified peer use as a salient risk factor of adolescent e-cigarette use, but has not expanded on the mechanism of this association. For this study, 569 adolescents were recruited from an adolescent medicine clinic and public schools in rural and suburban areas of the mid-Atlantic United States. Participants completed a study-specific demographic questionnaire, the Youth Risk Behavior Survey (YRBS) to assess substance use, and the Smoking Expectancy Scale for Adolescents (SESA) …