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Washington University School of Medicine

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A Host Type I Interferon Response Is Induced By Cytosolic Sensing Of The Bacterial Second Messenger Cyclic-Di-Gmp, Sarah M. Mcwhirter, Roman Barbalat, Kathryn M. Monroe, Mary F. Fontana, Mamoru Hyodo, Nathalie T. Joncker, Ken J. Ishii, Shizuo Akira, Marco Colonna, Zhijian J. Chen, Katherine A. Fitzgerald, Yoshihiro Hayakawa, Russell E. Vance Jan 2009

A Host Type I Interferon Response Is Induced By Cytosolic Sensing Of The Bacterial Second Messenger Cyclic-Di-Gmp, Sarah M. Mcwhirter, Roman Barbalat, Kathryn M. Monroe, Mary F. Fontana, Mamoru Hyodo, Nathalie T. Joncker, Ken J. Ishii, Shizuo Akira, Marco Colonna, Zhijian J. Chen, Katherine A. Fitzgerald, Yoshihiro Hayakawa, Russell E. Vance

Open Access Publications

No abstract provided.


Lull1 Retargets Torsina To The Nuclear Envelope Revealing An Activity That Is Impaired By The Dyt1 Dystonia Mutation, Abigail B. Vander Heyden, Teresa V. Naismith, Erik L. Snapp, Didier Hodzic, Phyllis I. Hanson Jan 2009

Lull1 Retargets Torsina To The Nuclear Envelope Revealing An Activity That Is Impaired By The Dyt1 Dystonia Mutation, Abigail B. Vander Heyden, Teresa V. Naismith, Erik L. Snapp, Didier Hodzic, Phyllis I. Hanson

Open Access Publications

No abstract provided.


Topics In Biomedical Optics: Introduction To The Feature Issue, Joseph P. Culver, Wolfgang Drexler, Rebekah A. Drezek, Irene Georgakoudi, Elizabeth M C Hillman, Rebecca Richards-Kortum Jan 2009

Topics In Biomedical Optics: Introduction To The Feature Issue, Joseph P. Culver, Wolfgang Drexler, Rebekah A. Drezek, Irene Georgakoudi, Elizabeth M C Hillman, Rebecca Richards-Kortum

Open Access Publications

No abstract provided.


A Pcr-Based Platform For Microrna Expression Profiling Studies, Xiaowei Wang Jan 2009

A Pcr-Based Platform For Microrna Expression Profiling Studies, Xiaowei Wang

Open Access Publications

No abstract provided.


Oncogenic Hpv Infection Interrupts The Expression Of Tumor-Suppressive Mir-34a Through Viral Oncoprotein E6, Xiaohong Wang, Hsukun Wang, John P. Mccoy, Nilam Sanjib Banerjee, Janet S. Rader, Thomas R. Broker, Craig A. Meyers, Louise Chow, Zhiming Zheng Jan 2009

Oncogenic Hpv Infection Interrupts The Expression Of Tumor-Suppressive Mir-34a Through Viral Oncoprotein E6, Xiaohong Wang, Hsukun Wang, John P. Mccoy, Nilam Sanjib Banerjee, Janet S. Rader, Thomas R. Broker, Craig A. Meyers, Louise Chow, Zhiming Zheng

Open Access Publications

No abstract provided.


Extending The Duration Of Response In Chronic Myelogenous Leukemia: Targeted Therapy With Sequential Tyrosine Kinase Inhibitors, Michael G. Martin, John F. Dipersio, Geoffrey L. Uy Jan 2009

Extending The Duration Of Response In Chronic Myelogenous Leukemia: Targeted Therapy With Sequential Tyrosine Kinase Inhibitors, Michael G. Martin, John F. Dipersio, Geoffrey L. Uy

Open Access Publications

No abstract provided.


Trem-2 (Triggering Receptor Expressed On Myeloid Cells 2) Is A Phagocytic Receptor For Bacteria, Elsa-Noah N'Diaye, Catherine S. Branda, Steven S. Branda, Lisette Nevarez, Marco Colonna, Clifford Lowell, Jessica A. Hamerman, William E. Seaman Jan 2009

Trem-2 (Triggering Receptor Expressed On Myeloid Cells 2) Is A Phagocytic Receptor For Bacteria, Elsa-Noah N'Diaye, Catherine S. Branda, Steven S. Branda, Lisette Nevarez, Marco Colonna, Clifford Lowell, Jessica A. Hamerman, William E. Seaman

Open Access Publications

Phagocytosis, which is essential for the immune response to pathogens, is initiated by specific interactions between pathogens and cell surface receptors expressed by phagocytes. This study identifies triggering receptor expressed on myeloid cells 2 (TREM-2) and its signaling counterpart DAP12 as a molecular complex that promotes phagocytosis of bacteria. Expression of TREM-2-DAP12 enables nonphagocytic Chinese hamster ovary cells to internalize bacteria. This function depends on actin cytoskeleton dynamics and the activity of the small guanosine triphosphatases Rac and Cdc42. Internalization also requires src kinase activity and tyrosine phosphorylation. In bone marrow-derived macrophages, phagocytosis is decreased in the absence of DAP12 …


Cdc42 Antagonizes Rho1 Activity At Adherens Junctions To Limit Epithelial Cell Apical Tension, Stephen J. Warner, Gregory D. Longmore Jan 2009

Cdc42 Antagonizes Rho1 Activity At Adherens Junctions To Limit Epithelial Cell Apical Tension, Stephen J. Warner, Gregory D. Longmore

Open Access Publications

In epithelia, cells are arranged in an orderly pattern with a defined orientation and shape. Cadherin containing apical adherens junctions (AJs) and the associated actomyosin cytoskeleton likely contribute to epithelial cell shape by providing apical tension. The Rho guanosine triphosphatases are well known regulators of cell junction formation, maintenance, and function. Specifically, Rho promotes actomyosin activity and cell contractility; however, what controls and localizes this Rho activity as epithelia remodel is unresolved. Using mosaic clonal analysis in the Drosophila melanogaster pupal eye, we find that Cdc42 is critical for limiting apical cell tension by antagonizing Rho activity at AJs. Cdc42 …


Klassevirus 1, A Previously Undescribed Member Of The Family Picornaviridae, Is Globally Widespread, Lori R. Holtz, Stacy R. Finkbeiner, Guoyan Zhao, Carl D. Kirkwood, Rosina Girones, James M. Pipas, David Wang Jan 2009

Klassevirus 1, A Previously Undescribed Member Of The Family Picornaviridae, Is Globally Widespread, Lori R. Holtz, Stacy R. Finkbeiner, Guoyan Zhao, Carl D. Kirkwood, Rosina Girones, James M. Pipas, David Wang

ICTS Faculty Publications

No abstract provided.


Flexible Mx Specification Of Various Extended Twin Kinship Designs, Hermine H. Maes, Michael C. Neale, Sarah E. Medland, Matthew C. Keller, Nicholas G. Martin, Andrew C. Heath, Lindon J. Eaves Jan 2009

Flexible Mx Specification Of Various Extended Twin Kinship Designs, Hermine H. Maes, Michael C. Neale, Sarah E. Medland, Matthew C. Keller, Nicholas G. Martin, Andrew C. Heath, Lindon J. Eaves

Open Access Publications

No abstract provided.


Lack Of X-Linked Inhibitor Of Apoptosis Protein Leads To Increased Apoptosis And Tissue Loss Following Neonatal Brain Injury, Tim West, Madeliene Stump, Gregory Lodygensky, Jeff J. Neil, Mohanish Deshmukh, David M. Holtzman Jan 2009

Lack Of X-Linked Inhibitor Of Apoptosis Protein Leads To Increased Apoptosis And Tissue Loss Following Neonatal Brain Injury, Tim West, Madeliene Stump, Gregory Lodygensky, Jeff J. Neil, Mohanish Deshmukh, David M. Holtzman

Open Access Publications

No abstract provided.


Blast-Related Brain Injury: Imaging For Clinical And Research Applications: Report Of The 2008 St. Louis Workshop, Tammie L.S Benzinger, David Brody, Mark A. Mintun, R. Gilbert Jost, Karen Kharasch, Philip V. Bayly, Maurizio Corbetta, Joseph P. Culver, Evan D. Kharasch, Christine Mac Donald, Daniel Marcus, Steve Petersen, Kathy J. Pierce, Jose Pineda, Joshua S. Shimony, Victor Sheng-Kwei Song, Gregory Zipfel, Et Al Jan 2009

Blast-Related Brain Injury: Imaging For Clinical And Research Applications: Report Of The 2008 St. Louis Workshop, Tammie L.S Benzinger, David Brody, Mark A. Mintun, R. Gilbert Jost, Karen Kharasch, Philip V. Bayly, Maurizio Corbetta, Joseph P. Culver, Evan D. Kharasch, Christine Mac Donald, Daniel Marcus, Steve Petersen, Kathy J. Pierce, Jose Pineda, Joshua S. Shimony, Victor Sheng-Kwei Song, Gregory Zipfel, Et Al

Open Access Publications

No abstract provided.


Closed-Channel Block Of Bk Potassium Channels By Bbtba Requires Partial Activation, Qiong-Yao Tang, Xu-Hui Zeng, Christopher J. Lingle Jan 2009

Closed-Channel Block Of Bk Potassium Channels By Bbtba Requires Partial Activation, Qiong-Yao Tang, Xu-Hui Zeng, Christopher J. Lingle

Open Access Publications

No abstract provided.


The 9-Methyl Group Of Retinal Is Essential For Rapid Meta Ii Decay And Phototransduction Quenching In Red Cones, Maureen E. Estevez, Alexander V. Kolesnikov, Petri Ala-Laurila, Rosalie K. Crouch, Victor I. Govardovskii, M. Carter Cornwall Jan 2009

The 9-Methyl Group Of Retinal Is Essential For Rapid Meta Ii Decay And Phototransduction Quenching In Red Cones, Maureen E. Estevez, Alexander V. Kolesnikov, Petri Ala-Laurila, Rosalie K. Crouch, Victor I. Govardovskii, M. Carter Cornwall

Open Access Publications

No abstract provided.


Chronic Cyclodextrin Treatment Of Murine Niemann-Pick C Disease Ameliorates Neuronal Cholesterol And Glycosphingolipid Storage And Disease Progression, Cristin D. Davidson, Nafeeza F. Ali, Mathew C. Micsenyi, Gloria Stephney, Sophie Renault, Kostantin Dobrenis, Daniel S. Ory, Marie T. Vanier, Steven U. Walkley Jan 2009

Chronic Cyclodextrin Treatment Of Murine Niemann-Pick C Disease Ameliorates Neuronal Cholesterol And Glycosphingolipid Storage And Disease Progression, Cristin D. Davidson, Nafeeza F. Ali, Mathew C. Micsenyi, Gloria Stephney, Sophie Renault, Kostantin Dobrenis, Daniel S. Ory, Marie T. Vanier, Steven U. Walkley

Open Access Publications

No abstract provided.


Defects In Erbb-Dependent Establishment Of Adult Melanocyte Stem Cells Reveal Independent Origins For Embryonic And Regeneration Melanocytes, Keith A. Hultman, Erine H. Budi, Daniel C. Teasley, Andrew Y. Gottlieb, David M. Parichy, Stephen L. Johnson Jan 2009

Defects In Erbb-Dependent Establishment Of Adult Melanocyte Stem Cells Reveal Independent Origins For Embryonic And Regeneration Melanocytes, Keith A. Hultman, Erine H. Budi, Daniel C. Teasley, Andrew Y. Gottlieb, David M. Parichy, Stephen L. Johnson

Open Access Publications

No abstract provided.


Regulation Of The Drosophila Enhancer Of Split And Invected-Engrailed Gene Complexes By Sister Chromatid Cohesion Proteins, Cheri A. Schaaf, Ziva Misulovin, Gurmukh Sahota, Akbar M. Siddiqui, Yuri B. Schwartz, Tatyana G. Kahn, Vincenzo Pirrotta, Maria Gause, Dale Dorsett Jan 2009

Regulation Of The Drosophila Enhancer Of Split And Invected-Engrailed Gene Complexes By Sister Chromatid Cohesion Proteins, Cheri A. Schaaf, Ziva Misulovin, Gurmukh Sahota, Akbar M. Siddiqui, Yuri B. Schwartz, Tatyana G. Kahn, Vincenzo Pirrotta, Maria Gause, Dale Dorsett

Open Access Publications

No abstract provided.


Rna-Interference Knockdown Of Drosophila Pigment Dispersing Factor In Neuronal Subsets: The Anatomical Basis Of A Neuropeptide’S Circadian Functions, Orie T. Shafer, Paul H. Taghert Jan 2009

Rna-Interference Knockdown Of Drosophila Pigment Dispersing Factor In Neuronal Subsets: The Anatomical Basis Of A Neuropeptide’S Circadian Functions, Orie T. Shafer, Paul H. Taghert

Open Access Publications

No abstract provided.


Dosage Effects Of Cohesin Regulatory Factor Pds5 On Mammalian Development: Implications For Cohesinopathies, Bin Zhang, Jufang Chang, Ming Fu, Jie Huang, Rakesh Kashyap, Ezequiel Salavaggione, Sanjay Jain, Kulkarni Shashikant, Matthew A. Deardorff, Maria L. Giovannucci Uzielli, Dale Dorsett, David C. Beebe, Patrick Y. Jay, Robert O. Heuckeroth, Ian Krantz, Jeffrey Milbrandt Jan 2009

Dosage Effects Of Cohesin Regulatory Factor Pds5 On Mammalian Development: Implications For Cohesinopathies, Bin Zhang, Jufang Chang, Ming Fu, Jie Huang, Rakesh Kashyap, Ezequiel Salavaggione, Sanjay Jain, Kulkarni Shashikant, Matthew A. Deardorff, Maria L. Giovannucci Uzielli, Dale Dorsett, David C. Beebe, Patrick Y. Jay, Robert O. Heuckeroth, Ian Krantz, Jeffrey Milbrandt

Open Access Publications

No abstract provided.


Inferring Binding Energies From Selected Binding Sites, Yue Zhao, David Granas, Gary D. Stormo Jan 2009

Inferring Binding Energies From Selected Binding Sites, Yue Zhao, David Granas, Gary D. Stormo

Open Access Publications

No abstract provided.


Washington University Record, December 11, 2008 Dec 2008

Washington University Record, December 11, 2008

Washington University Record

No abstract provided.


Washington University Record, December 4, 2008 Dec 2008

Washington University Record, December 4, 2008

Washington University Record

No abstract provided.


Diagnosing Cervical Fusion: A Comprehensive Literature Review, Nanin Sethi, James Devney, Holly L. Steiner, K. Daniel Riew Dec 2008

Diagnosing Cervical Fusion: A Comprehensive Literature Review, Nanin Sethi, James Devney, Holly L. Steiner, K. Daniel Riew

Open Access Publications

STUDY DESIGN: Comprehensive literature review.

PURPOSE: To document the criteria for fusion utilized in these studies to determine if a consensus on the definition of a solid fusion exists.

OVERVIEW OF LITERATURE: Numerous studies have reported on fusion rates following anterior cervical arthrodesis. There is a wide discrepancy in the fusion rates in these studies. While factors such as graft type, Instrumentation, and technique play a factor in fusion rate, another reason for the difference may be a result of differences in the definition of fusion following anterior cervical spine surgery.

METHODS: A comprehensive English Medline literature review from 1966 …


Washington University Record, November 20, 2008 Nov 2008

Washington University Record, November 20, 2008

Washington University Record

No abstract provided.


Washington University Record, November 13, 2008 Nov 2008

Washington University Record, November 13, 2008

Washington University Record

No abstract provided.


Bjc Today Nov 2008

Bjc Today

BJC Today

No abstract provided.


Washington University Record, November 6, 2008 Nov 2008

Washington University Record, November 6, 2008

Washington University Record

No abstract provided.


Washington University Record, October 30, 2008 Oct 2008

Washington University Record, October 30, 2008

Washington University Record

No abstract provided.


Washington University Record, October 23, 2008 Oct 2008

Washington University Record, October 23, 2008

Washington University Record

No abstract provided.


Washington University Record, October 16, 2008 Oct 2008

Washington University Record, October 16, 2008

Washington University Record

No abstract provided.