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Washington University School of Medicine

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Mice Lacking Mannose 6-Phosphate Uncovering Enzyme Activity Have A Milder Phenotype Than Mice Deficient For N-Acetylglucosamine-1-Phosphotransferase Activity, Marielle Boonen, Peter Vogel, Kenneth A. Platt, Nancy Dahms, Stuart Kornfeld Jan 2009

Mice Lacking Mannose 6-Phosphate Uncovering Enzyme Activity Have A Milder Phenotype Than Mice Deficient For N-Acetylglucosamine-1-Phosphotransferase Activity, Marielle Boonen, Peter Vogel, Kenneth A. Platt, Nancy Dahms, Stuart Kornfeld

Open Access Publications

No abstract provided.


Detection And Characterization Of The Fimbrial Sfp Cluster In Enterohemorrhagic Escherichia Coli O165:H25/Nm Isolates From Humans And Cattle, Martina Bielaszewska, Rita Prager, Liz Vandivinit, Anne Musken, Alexander Mellmann, Nicholas J. Holt, Phillip I. Tarr, Helge Karch, Wenlan Zhang Jan 2009

Detection And Characterization Of The Fimbrial Sfp Cluster In Enterohemorrhagic Escherichia Coli O165:H25/Nm Isolates From Humans And Cattle, Martina Bielaszewska, Rita Prager, Liz Vandivinit, Anne Musken, Alexander Mellmann, Nicholas J. Holt, Phillip I. Tarr, Helge Karch, Wenlan Zhang

Open Access Publications

No abstract provided.


Potentially Pathogenic Bacteria In Shower Water And Air Of A Stem Cell Transplant Unit, Sarah D. Perkins, Jennie Mayfield, Victoria Fraser, Largus T. Angenent Jan 2009

Potentially Pathogenic Bacteria In Shower Water And Air Of A Stem Cell Transplant Unit, Sarah D. Perkins, Jennie Mayfield, Victoria Fraser, Largus T. Angenent

Open Access Publications

No abstract provided.


Chemosensitizing And Cytotoxic Effects Of 2-Deoxy-D-Glucose On Breast Cancer Cells, Fanjie Zhang, Rebecca L. Aft Jan 2009

Chemosensitizing And Cytotoxic Effects Of 2-Deoxy-D-Glucose On Breast Cancer Cells, Fanjie Zhang, Rebecca L. Aft

Open Access Publications

No abstract provided.


G Protein Subunit Dissociation And Translocation Regulate Cellular Response To Receptor Stimulation, Mariangela Chisari, Deepak Kumar Saini, Joon-Ho Cho, Vani Kalyanaraman, N. Gautam Jan 2009

G Protein Subunit Dissociation And Translocation Regulate Cellular Response To Receptor Stimulation, Mariangela Chisari, Deepak Kumar Saini, Joon-Ho Cho, Vani Kalyanaraman, N. Gautam

Open Access Publications

No abstract provided.


Selection At A Single Locus Leads To Widespread Expansion Of Toxoplasma Gondii Lineages That Are Virulent In Mice, Asis Khan, Sonya Taylor, James W. Ajioka, Benjamin M. Rosenthal, L. David Sibley Jan 2009

Selection At A Single Locus Leads To Widespread Expansion Of Toxoplasma Gondii Lineages That Are Virulent In Mice, Asis Khan, Sonya Taylor, James W. Ajioka, Benjamin M. Rosenthal, L. David Sibley

Open Access Publications

No abstract provided.


Vav Links The T Cell Antigen Receptor To The Actin Cytoskeleton And T Cell Activation Independently Of Intrinsic Guanine Nucleotide Exchange Activity, Ana V. Miletic, Daniel B. Graham, Kumiko Sakata-Sogawa, Michio Hiroshima, Michael J. Hamann, Saso Cemerski, Tracie Kloeppel, Daniel D. Billadeau, Osami Kanagawa, Makio Tokunaga, Wojciech Swat Jan 2009

Vav Links The T Cell Antigen Receptor To The Actin Cytoskeleton And T Cell Activation Independently Of Intrinsic Guanine Nucleotide Exchange Activity, Ana V. Miletic, Daniel B. Graham, Kumiko Sakata-Sogawa, Michio Hiroshima, Michael J. Hamann, Saso Cemerski, Tracie Kloeppel, Daniel D. Billadeau, Osami Kanagawa, Makio Tokunaga, Wojciech Swat

Open Access Publications

No abstract provided.


Phase Ii Study Of Continuous Daily Sunitinib Dosing In Patients With Previously Treated Advanced Non-Small Cell Lung Cancer, Silvia Novello, Giorgio V. Scagliotti, Rafael C. Rosell, Mark A. Socinski, Julie R. Brahmer, James N. Atkins, Cinta Palleres, Russell E. Burgess, Lesley Tye, Paulina Selaru, Erjian Wang, Richard Chao, Ramaswamy Govindan Jan 2009

Phase Ii Study Of Continuous Daily Sunitinib Dosing In Patients With Previously Treated Advanced Non-Small Cell Lung Cancer, Silvia Novello, Giorgio V. Scagliotti, Rafael C. Rosell, Mark A. Socinski, Julie R. Brahmer, James N. Atkins, Cinta Palleres, Russell E. Burgess, Lesley Tye, Paulina Selaru, Erjian Wang, Richard Chao, Ramaswamy Govindan

Open Access Publications

No abstract provided.


A Phase 2 Study Of Vorinostat In Acute Myeloid Leukemia, Eric W. Schaefer, Arturo Loaiza-Bonilla, Mark Juckett, John F. Dipersio, Vivek Roy, James Slack, Wenting Wu, Kristina Laumann, Igor Espinoza-Delgado, Steven D. Gore Jan 2009

A Phase 2 Study Of Vorinostat In Acute Myeloid Leukemia, Eric W. Schaefer, Arturo Loaiza-Bonilla, Mark Juckett, John F. Dipersio, Vivek Roy, James Slack, Wenting Wu, Kristina Laumann, Igor Espinoza-Delgado, Steven D. Gore

Open Access Publications

No abstract provided.


Key Role Of T Cell Defects In Age-Related Vulnerability To West Nile Virus, James D. Brien, Jennifer L. Uhrlaub, Alec Hirsch, Clayton A. Wiley, Janko Nikolich-Zugich Jan 2009

Key Role Of T Cell Defects In Age-Related Vulnerability To West Nile Virus, James D. Brien, Jennifer L. Uhrlaub, Alec Hirsch, Clayton A. Wiley, Janko Nikolich-Zugich

Open Access Publications

West Nile virus (WNV) infection causes a life-threatening meningoencephalitis that becomes increasingly more prevalent over the age of 50 and is 40-50x more prevalent in people over the age of 70, compared with adults under the age of 40. In a mouse model of age-related vulnerability to WNV, we demonstrate that death correlates with increased viral titers in the brain and that this loss of virus control with age was the result of defects in the CD4 and CD8 T cell response against WNV. Specific age-related defects in T cell responses against dominant WNV epitopes were detected at the level …


Unusual Composition Of A Yeast Chromosome Arm Is Associated With Its Delayed Replication, Célia Payen, Gilles Fischer, Christian Marck, Caroline Proux, David James Sherman, Jean-Yves Coppée, Mark Johnston, Bernard Dujon, Cécile Neuvéglise Jan 2009

Unusual Composition Of A Yeast Chromosome Arm Is Associated With Its Delayed Replication, Célia Payen, Gilles Fischer, Christian Marck, Caroline Proux, David James Sherman, Jean-Yves Coppée, Mark Johnston, Bernard Dujon, Cécile Neuvéglise

Open Access Publications

No abstract provided.


Identification Of Deleterious Mutations Within Three Human Genomes, Sung Chun, Justin C. Fay Jan 2009

Identification Of Deleterious Mutations Within Three Human Genomes, Sung Chun, Justin C. Fay

Open Access Publications

No abstract provided.


Drosophila Risc Component Vig And Its Homolog Vig2 Impact Heterochromatin Formation, Elena Gracheva, Monica Dus, Sarah C. R. Elgin Jan 2009

Drosophila Risc Component Vig And Its Homolog Vig2 Impact Heterochromatin Formation, Elena Gracheva, Monica Dus, Sarah C. R. Elgin

Open Access Publications

No abstract provided.


Measuring Impulsive Behavior In Inner-City Substance Abusers Using Translational Procedures Based On Preclinical Research, M. Mattila-Evenden, J. Shack, C. Heeney-Buggey, J. Evenden Jan 2009

Measuring Impulsive Behavior In Inner-City Substance Abusers Using Translational Procedures Based On Preclinical Research, M. Mattila-Evenden, J. Shack, C. Heeney-Buggey, J. Evenden

Posters

No abstract provided.


Marc Project 4: Australian Children Of Alcoholic Female Twins, Mary Waldron, Theodore Jacob, Wendy S. Slutske, Anne Glowinski, Nicholas Martin, Andrew Heath Jan 2009

Marc Project 4: Australian Children Of Alcoholic Female Twins, Mary Waldron, Theodore Jacob, Wendy S. Slutske, Anne Glowinski, Nicholas Martin, Andrew Heath

Posters

No abstract provided.


Focal Spot, Winter 2008/2009 Jan 2009

Focal Spot, Winter 2008/2009

Focal Spot All Issues

No abstract provided.


Intra-Tumor Heterogeneity Of Mlh1 Promoter Methylation Revealed By Deep Single Molecule Bisulfite Sequencing, Katherine E. Varley, David G. Mutch, Tina B. Edmonston, Paul J. Goodfellow, Robi D. Mitra Jan 2009

Intra-Tumor Heterogeneity Of Mlh1 Promoter Methylation Revealed By Deep Single Molecule Bisulfite Sequencing, Katherine E. Varley, David G. Mutch, Tina B. Edmonston, Paul J. Goodfellow, Robi D. Mitra

Open Access Publications

No abstract provided.


Chromatin Remodeling Finds Its Place In The Dna Double-Strand Break Response, Tej K. Pandita, Christine Richardson Jan 2009

Chromatin Remodeling Finds Its Place In The Dna Double-Strand Break Response, Tej K. Pandita, Christine Richardson

Open Access Publications

No abstract provided.


Low-Fidelity Dna Synthesis By The L979f Mutator Derivative Of Saccharomyces Cerevisiae Dna Polymerase Zeta, Jana E. Stone, Grace E. Kissling, Scott A. Lujan, Igor B. Rogozin, Carrie M. Stith, Peter M.J. Burgers, Thomas A. Kunkel Jan 2009

Low-Fidelity Dna Synthesis By The L979f Mutator Derivative Of Saccharomyces Cerevisiae Dna Polymerase Zeta, Jana E. Stone, Grace E. Kissling, Scott A. Lujan, Igor B. Rogozin, Carrie M. Stith, Peter M.J. Burgers, Thomas A. Kunkel

Open Access Publications

No abstract provided.


Polymorphisms In The Vegfa And Vegfr-2 Genes And Neovascular Age-Related Macular Degeneration, Amy M. Fang, Aaron Y. Lee, Mukti Kulkarni, Melissa P. Osborn, Milam A. Brantley Jr. Jan 2009

Polymorphisms In The Vegfa And Vegfr-2 Genes And Neovascular Age-Related Macular Degeneration, Amy M. Fang, Aaron Y. Lee, Mukti Kulkarni, Melissa P. Osborn, Milam A. Brantley Jr.

Open Access Publications

No abstract provided.


The Membrane Proteome Of The Mouse Lens Fiber Cell, Steven Bassnett, Phillip A. Wilmarth, Larry L. David Jan 2009

The Membrane Proteome Of The Mouse Lens Fiber Cell, Steven Bassnett, Phillip A. Wilmarth, Larry L. David

Open Access Publications

No abstract provided.


Between Community And Hospital: Healthcare-Associated Gram-Negative Bacteremia Among Hospitalized Patients, Jonas Marschall, Victoria J. Fraser, Joshua Doherty, David K. Warren Jan 2009

Between Community And Hospital: Healthcare-Associated Gram-Negative Bacteremia Among Hospitalized Patients, Jonas Marschall, Victoria J. Fraser, Joshua Doherty, David K. Warren

Open Access Publications

No abstract provided.


Zero: What Is It, And How Do We Get There?, Victoria J. Fraser Jan 2009

Zero: What Is It, And How Do We Get There?, Victoria J. Fraser

Open Access Publications

No abstract provided.


Evolution Of A Bacterial Regulon Controlling Virulence And Mg(2+) Homeostasis, J. Christian Perez, Dongwoo Shin, Igor Zwir, Tammy Latifi, Tricia J. Hadley, Eduardo A. Groisman Jan 2009

Evolution Of A Bacterial Regulon Controlling Virulence And Mg(2+) Homeostasis, J. Christian Perez, Dongwoo Shin, Igor Zwir, Tammy Latifi, Tricia J. Hadley, Eduardo A. Groisman

Open Access Publications

No abstract provided.


Quantitative Metabolomics Reveals An Epigenetic Blueprint For Iron Acquisition In Uropathogenic Escherichia Coli, Jeffrey P. Henderson, Jan R. Crowley, Jerome S. Pinker, Jennifer N. Walker, Pablo Tsukayama, Walter E. Stamm, Thomas M. Hooton, Scott J. Hultgren Jan 2009

Quantitative Metabolomics Reveals An Epigenetic Blueprint For Iron Acquisition In Uropathogenic Escherichia Coli, Jeffrey P. Henderson, Jan R. Crowley, Jerome S. Pinker, Jennifer N. Walker, Pablo Tsukayama, Walter E. Stamm, Thomas M. Hooton, Scott J. Hultgren

Open Access Publications

No abstract provided.


High Harvest Yield, High Expansion, And Phenotype Stability Of Cd146 Mesenchymal Stromal Cells From Whole Primitive Human Umbilical Cord Tissue, Rebecca C. Schugar, Steven M. Chirieleison, Kristin E. Wescoe, Benjamin T. Schmidt, Yuko Askew, Jordan J. Nance, Joshua M. Evron, Bruno Peault, Bridget M. Deasy Jan 2009

High Harvest Yield, High Expansion, And Phenotype Stability Of Cd146 Mesenchymal Stromal Cells From Whole Primitive Human Umbilical Cord Tissue, Rebecca C. Schugar, Steven M. Chirieleison, Kristin E. Wescoe, Benjamin T. Schmidt, Yuko Askew, Jordan J. Nance, Joshua M. Evron, Bruno Peault, Bridget M. Deasy

Open Access Publications

No abstract provided.


The Physical And Genetic Framework Of The Maize B73 Genome, Fusheng Wei, Jianwei Zhang, Shiguo Zhou, Ruifeng He, Mary Schaeffer, Kristi Collura, David Kudrna, Ben P. Faga, Marina Wissotski, Wolfgang Gloser, Susan M. Rock, Tina A. Graves, Robert S. Fulton, Ed Coe, Patrick S. Schnable, David C. Schwartz, Doreen Ware, Sandra W. Clifton, Richard K. Wilson, Rod A. Wing Jan 2009

The Physical And Genetic Framework Of The Maize B73 Genome, Fusheng Wei, Jianwei Zhang, Shiguo Zhou, Ruifeng He, Mary Schaeffer, Kristi Collura, David Kudrna, Ben P. Faga, Marina Wissotski, Wolfgang Gloser, Susan M. Rock, Tina A. Graves, Robert S. Fulton, Ed Coe, Patrick S. Schnable, David C. Schwartz, Doreen Ware, Sandra W. Clifton, Richard K. Wilson, Rod A. Wing

Open Access Publications

No abstract provided.


Should Burden Of Disease Estimates Include Cannabis Use As A Risk Factor For Psychosis?, Louisa Degenhardt, Wayne D. Hall, Michael Lynskey, John Mcgrath, Jennifer Mclaren, Bianca Calabria, Harvey Whiteford, Theo Vos Jan 2009

Should Burden Of Disease Estimates Include Cannabis Use As A Risk Factor For Psychosis?, Louisa Degenhardt, Wayne D. Hall, Michael Lynskey, John Mcgrath, Jennifer Mclaren, Bianca Calabria, Harvey Whiteford, Theo Vos

Open Access Publications

No abstract provided.


Cancer Stem Cells - From Initiation To Elimination, How Far Have We Reached?, Kamal Akhtar, Wendy Bussen, Shaun P. Scott Jan 2009

Cancer Stem Cells - From Initiation To Elimination, How Far Have We Reached?, Kamal Akhtar, Wendy Bussen, Shaun P. Scott

Open Access Publications

No abstract provided.


Altered States Of Telomere Deprotection And The Two-Stage Mechanism Of Replicative Aging, Ying Zhou, Sandeep Misri, Jerry W. Shay, Tej K. Pandita, Woodring E. Wright Jan 2009

Altered States Of Telomere Deprotection And The Two-Stage Mechanism Of Replicative Aging, Ying Zhou, Sandeep Misri, Jerry W. Shay, Tej K. Pandita, Woodring E. Wright

Open Access Publications

No abstract provided.