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Washington University School of Medicine

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Exploiting Oxytricha Trifallax Nanochromosomes To Screen For Non-Coding Rna Genes, Seolkyoung Jung, Estienne C. Swart, Patrick J. Minx, Vincent Magrini, Elaine R. Mardis, Laura F. Landweber, Sean R. Eddy Jan 2011

Exploiting Oxytricha Trifallax Nanochromosomes To Screen For Non-Coding Rna Genes, Seolkyoung Jung, Estienne C. Swart, Patrick J. Minx, Vincent Magrini, Elaine R. Mardis, Laura F. Landweber, Sean R. Eddy

Open Access Publications

No abstract provided.


Autophagy In Antigen-Presenting Cells Results In Presentation Of Citrullinated Peptides To Cd4 T Cells, Jamie M. Ireland, Emil R. Unanue Jan 2011

Autophagy In Antigen-Presenting Cells Results In Presentation Of Citrullinated Peptides To Cd4 T Cells, Jamie M. Ireland, Emil R. Unanue

Open Access Publications

Antibody responses to citrullinated self-proteins are found in autoimmunities, particularly in rheumatoid arthritis, where they serve as a diagnostic indicator. We show here that processing of the protein hen egg-white lysozyme (HEL) resulted in citrullination of peptides presented on class II MHC molecules by antigen-presenting cells. The presentation of the citrullinated peptides but not of the unmodified peptides was associated with autophagy. Dendritic cells (DCs), macrophages, and thymic DCs presented citrullinated peptides constitutively. Their treatment with 3-methyladenine (3MA) blocked presentation of citrullinated HEL peptides, but presentation of unmodified peptides was not affected. Presentation of citrullinated peptides was not detected on …


Barth Syndrome Mutations That Cause Tafazzin Complex Lability, Steven M. Claypool, Kevin Whited, Santi Srijumnong, Xianlin Han, Carla M. Koehler Jan 2011

Barth Syndrome Mutations That Cause Tafazzin Complex Lability, Steven M. Claypool, Kevin Whited, Santi Srijumnong, Xianlin Han, Carla M. Koehler

Open Access Publications

Deficits in mitochondrial function result in many human diseases. The X-linked disease Barth syndrome (BTHS) is caused by mutations in the tafazzin gene TAZ1. Its product, Taz1p, participates in the metabolism of cardiolipin, the signature phospholipid of mitochondria. In this paper, a yeast BTHS mutant tafazzin panel is established, and 18 of the 21 tested BTHS missense mutations cannot functionally replace endogenous tafazzin. Four BTHS mutant tafazzins expressed at low levels are degraded by the intermembrane space AAA (i-AAA) protease, suggesting misfolding of the mutant polypeptides. Paradoxically, each of these mutant tafazzins assembles in normal protein complexes. Furthermore, in the …


Year In Review 2010: Critical Care- Neurocritical Care, Michael T. Scalfani, Michael N. Diringer Jan 2011

Year In Review 2010: Critical Care- Neurocritical Care, Michael T. Scalfani, Michael N. Diringer

Open Access Publications

No abstract provided.


Cd2ap In Mouse And Human Podocytes Controls A Proteolytic Program That Regulates Cytoskeletal Structure And Cellular Survival, Andrey S. Shaw, Suma Yaddanapudi, Mehmet M. Altintas, Andreas D. Kistler, Isabel Fernandez, Clemens C. Moller, Changli Wei, Vasil Peev, Jan B. Flesche, Anna-Lena Forst, Jing Li, Jaakko Patrakka, Zhijie Xiao, Florian Grahammer, Et Al. Jan 2011

Cd2ap In Mouse And Human Podocytes Controls A Proteolytic Program That Regulates Cytoskeletal Structure And Cellular Survival, Andrey S. Shaw, Suma Yaddanapudi, Mehmet M. Altintas, Andreas D. Kistler, Isabel Fernandez, Clemens C. Moller, Changli Wei, Vasil Peev, Jan B. Flesche, Anna-Lena Forst, Jing Li, Jaakko Patrakka, Zhijie Xiao, Florian Grahammer, Et Al.

Open Access Publications

No abstract provided.


Oscar Is A Collagen Receptor That Costimulates Osteoclastogenesis In Dap12-Deficient Humans And Mice, Alexander David Barrow, Marina Cella, Marco Colonna, Nicolas Raynal, Thomas Levin Anderson, David A. Slatter, Dominique Bihan, Nicholas Pugh, Taesoo Kim, Jaerang Rho, Takako Nedishi-Koga, Jean-Marie Delaisse, Hiroshi Takayanagi, Joseph Lorenzo, Et Al. Jan 2011

Oscar Is A Collagen Receptor That Costimulates Osteoclastogenesis In Dap12-Deficient Humans And Mice, Alexander David Barrow, Marina Cella, Marco Colonna, Nicolas Raynal, Thomas Levin Anderson, David A. Slatter, Dominique Bihan, Nicholas Pugh, Taesoo Kim, Jaerang Rho, Takako Nedishi-Koga, Jean-Marie Delaisse, Hiroshi Takayanagi, Joseph Lorenzo, Et Al.

Open Access Publications

No abstract provided.


Pml-Rara Can Increase Hematopoietic Self-Renewal Without Causing A Myeloproliferative Disease In Mice, John S. Welch, Wenlin Yuan, Timothy J. Ley Jan 2011

Pml-Rara Can Increase Hematopoietic Self-Renewal Without Causing A Myeloproliferative Disease In Mice, John S. Welch, Wenlin Yuan, Timothy J. Ley

Open Access Publications

No abstract provided.


Micrornas, An Active And Versatile Group In Cancers, Jeffrey Liu, Min Zheng, Ya-Ling Tang, Xin-Hua Liang, Qin Yang Jan 2011

Micrornas, An Active And Versatile Group In Cancers, Jeffrey Liu, Min Zheng, Ya-Ling Tang, Xin-Hua Liang, Qin Yang

Open Access Publications

No abstract provided.


Molecular Determinants Of Human T-Lymphotropic Virus Type 1 Transmission And Spread, Michael D. Lairmore, Rajaneesh Anupam, Nadine Bowden, Robyn Haines, Rashade A. H. Hayness Ii, Lee Ratner, Patrick L. Green Jan 2011

Molecular Determinants Of Human T-Lymphotropic Virus Type 1 Transmission And Spread, Michael D. Lairmore, Rajaneesh Anupam, Nadine Bowden, Robyn Haines, Rashade A. H. Hayness Ii, Lee Ratner, Patrick L. Green

Open Access Publications

No abstract provided.


Genetic Basis For In Vivo Daptomycin Resistance In Enterococci, Elizabeth Lobos, Erica Sodergren, George M. Weinstock, Et Al Jan 2011

Genetic Basis For In Vivo Daptomycin Resistance In Enterococci, Elizabeth Lobos, Erica Sodergren, George M. Weinstock, Et Al

Open Access Publications

No abstract provided.


Fine Mapping Of Genetic Variants In Bin1, Clu, Cr1 And Picalm For Association With Cerebrospinal Fluid Biomarkers For Alzheimer’S Disease, John S. K. Kauwe, Carlos Cruchaga, Celeste M. Karch, Brooke Sadler, Mo Lee, Kevin Mayo, Wayne Latu, Manti Su'a, Anne M. Fagan, David M. Holtzman, John C. Morris, Alzheimer's Disease Neuroimaging Initative, Alison M. Goate Jan 2011

Fine Mapping Of Genetic Variants In Bin1, Clu, Cr1 And Picalm For Association With Cerebrospinal Fluid Biomarkers For Alzheimer’S Disease, John S. K. Kauwe, Carlos Cruchaga, Celeste M. Karch, Brooke Sadler, Mo Lee, Kevin Mayo, Wayne Latu, Manti Su'a, Anne M. Fagan, David M. Holtzman, John C. Morris, Alzheimer's Disease Neuroimaging Initative, Alison M. Goate

Open Access Publications

No abstract provided.


Complete Genome Sequence Of Treponema Paraluiscuniculi, Strain Cuniculi A: The Loss Of Infectivity To Humans Is Associated With Genome Decay, David Smajs, Marie Zobanikova, Michal Strouhal, Darina Cejkova, Shannon Dugan-Rocha, Petra Pospisilova, Steven J. Norris, Tom Albert, Xiang Qin, Kym Hallsworth-Pepin, Christian Buhay, Donna M. Muzny, Lei Chen, Richard A. Gibbs, George M. Weinstock Jan 2011

Complete Genome Sequence Of Treponema Paraluiscuniculi, Strain Cuniculi A: The Loss Of Infectivity To Humans Is Associated With Genome Decay, David Smajs, Marie Zobanikova, Michal Strouhal, Darina Cejkova, Shannon Dugan-Rocha, Petra Pospisilova, Steven J. Norris, Tom Albert, Xiang Qin, Kym Hallsworth-Pepin, Christian Buhay, Donna M. Muzny, Lei Chen, Richard A. Gibbs, George M. Weinstock

Open Access Publications

No abstract provided.


Host Type I Ifn Signals Are Required For Antitumor Cd8+ T Cell Responses Through Cd8Α+ Dendritic Cells, Mercedes B. Fuertes, Aalok K. Kacha, Justin Kline, Seng-Ryong Woo, David M. Kranz, Kenneth M. Murphy, Thomas F. Gajewski Jan 2011

Host Type I Ifn Signals Are Required For Antitumor Cd8+ T Cell Responses Through Cd8Α+ Dendritic Cells, Mercedes B. Fuertes, Aalok K. Kacha, Justin Kline, Seng-Ryong Woo, David M. Kranz, Kenneth M. Murphy, Thomas F. Gajewski

Open Access Publications

No abstract provided.


A Nine Amino Acid Domain Is Essential For Mutant Prion Protein Toxicity, Laura Westergard, Jessie A. Turnbaugh, David A. Harris Jan 2011

A Nine Amino Acid Domain Is Essential For Mutant Prion Protein Toxicity, Laura Westergard, Jessie A. Turnbaugh, David A. Harris

Open Access Publications

No abstract provided.


Short-Term Plasticity Optimizes Synaptic Information Transmission, Ziv Rotman, Pan-Yue Deng, Vitaly A. Klyachko Jan 2011

Short-Term Plasticity Optimizes Synaptic Information Transmission, Ziv Rotman, Pan-Yue Deng, Vitaly A. Klyachko

Open Access Publications

No abstract provided.


Stathmin Is Required For Stability Of The Drosophila Neuromuscular Junction, Ethan R. Graf, Heather M. Heerssen, Christina M. Wright, Graeme W. Davis, Aaron Diantonio Jan 2011

Stathmin Is Required For Stability Of The Drosophila Neuromuscular Junction, Ethan R. Graf, Heather M. Heerssen, Christina M. Wright, Graeme W. Davis, Aaron Diantonio

Open Access Publications

No abstract provided.


The Role Of Attenuated Astrocyte Activation In Infantile Neuronal Ceroid Lipofuscinosis, Shannon L. Macauley, Milos Pekny, Mark S. Sands Jan 2011

The Role Of Attenuated Astrocyte Activation In Infantile Neuronal Ceroid Lipofuscinosis, Shannon L. Macauley, Milos Pekny, Mark S. Sands

Open Access Publications

No abstract provided.


Positive Affect Versus Reward: Emotional And Motivational Influences On Cognitive Control, Kimberly S. Chiew, Todd S. Braver Jan 2011

Positive Affect Versus Reward: Emotional And Motivational Influences On Cognitive Control, Kimberly S. Chiew, Todd S. Braver

Open Access Publications

No abstract provided.


Oxytocin Receptor (Oxtr) Polymorphisms And Attachment In Human Infants, Frances S. Chen, Maria E. Barth, Stephen L. Johnson, Ian H. Gotlib, Susan C. Johnson Jan 2011

Oxytocin Receptor (Oxtr) Polymorphisms And Attachment In Human Infants, Frances S. Chen, Maria E. Barth, Stephen L. Johnson, Ian H. Gotlib, Susan C. Johnson

Open Access Publications

No abstract provided.


Organogenesis Of The Kidney Glomerulus: Focus On The Glomerular Basement Membrane, Jeffrey H. Miner Jan 2011

Organogenesis Of The Kidney Glomerulus: Focus On The Glomerular Basement Membrane, Jeffrey H. Miner

Open Access Publications

No abstract provided.


The [Rnq+] Prion: A Model Of Both Functional And Pathological Amyloid, Kevin C. Stein, Heather L. True Jan 2011

The [Rnq+] Prion: A Model Of Both Functional And Pathological Amyloid, Kevin C. Stein, Heather L. True

Open Access Publications

No abstract provided.


Institute Of Clinical And Translational Sciences News, Vol. 4, Issue 2 Jan 2011

Institute Of Clinical And Translational Sciences News, Vol. 4, Issue 2

ICTS Newsletters

No abstract provided.


Evaluation Of Anti-Vibration Interventions For The Hand During Sheet Metal Assembly Work, Ann Marie Dale, A E. Rohn, A Burwell, W Shannon, J Standeven, A Patton, Bradley A. Evanoff Jan 2011

Evaluation Of Anti-Vibration Interventions For The Hand During Sheet Metal Assembly Work, Ann Marie Dale, A E. Rohn, A Burwell, W Shannon, J Standeven, A Patton, Bradley A. Evanoff

Occupational and Health Faculty Publications

No abstract provided.


The Development And Characterization Of A 60k Snp Chip For Chicken, Martin Am Groenen, Hendrik-Jan Megens, Yalda Zare, Wesley C. Warren, Ladeana W. Hillier, Richard Pma Crooijmans, Addie Vereijken, Ron Okimoto, Williams M. Muir, Hans H. Cheng Jan 2011

The Development And Characterization Of A 60k Snp Chip For Chicken, Martin Am Groenen, Hendrik-Jan Megens, Yalda Zare, Wesley C. Warren, Ladeana W. Hillier, Richard Pma Crooijmans, Addie Vereijken, Ron Okimoto, Williams M. Muir, Hans H. Cheng

Open Access Publications

No abstract provided.


Fluorescence Manipulation By Gold Nanoparticles: From Complete Quenching To Extensive Enhancement, Kyung A. Kang, Jianting Wang, Jacek B. Jasinski, Samuel Achilefu Jan 2011

Fluorescence Manipulation By Gold Nanoparticles: From Complete Quenching To Extensive Enhancement, Kyung A. Kang, Jianting Wang, Jacek B. Jasinski, Samuel Achilefu

Open Access Publications

No abstract provided.


Genome-Wide Identification Of Allele-Specific Expression (Ase) In Response To Marek’S Disease Virus Infection Using Next Generation Sequencing, Sean Maceachern, William M. Muir, Seth Crosby, Hans H. Cheng Jan 2011

Genome-Wide Identification Of Allele-Specific Expression (Ase) In Response To Marek’S Disease Virus Infection Using Next Generation Sequencing, Sean Maceachern, William M. Muir, Seth Crosby, Hans H. Cheng

Open Access Publications

No abstract provided.


Sox10 Directly Modulates Erbb3 Transcription Via An Intronic Neural Crest Enhancer, Megana K. Prasad, Xylena Reed, David U. Gorkin, Julia C. Cronin, Anthony R. Mcadow, Kristopher Chain, Chani J. Hodonsky, Erin A. Jones, John Svaren, Anthony Antonellis, Stephen L. Johnson, Stacie K. Loftus, William J. Pavan, Andrew S. Mccallion Jan 2011

Sox10 Directly Modulates Erbb3 Transcription Via An Intronic Neural Crest Enhancer, Megana K. Prasad, Xylena Reed, David U. Gorkin, Julia C. Cronin, Anthony R. Mcadow, Kristopher Chain, Chani J. Hodonsky, Erin A. Jones, John Svaren, Anthony Antonellis, Stephen L. Johnson, Stacie K. Loftus, William J. Pavan, Andrew S. Mccallion

Open Access Publications

No abstract provided.


Pcr-Based Genotyping Of Helicobacter Pylori Of Gambian Children And Adults Directly From Biopsy Specimens And Bacterial Cultures, Ousman Secka, Martin Antonio, Mary Tapgun, Douglas E. Berg, Christian Bottomley, Vivat Thomas, Robert Walton, Tumani Corrah, Richard A. Adegbola, Julian E. Thomas Jan 2011

Pcr-Based Genotyping Of Helicobacter Pylori Of Gambian Children And Adults Directly From Biopsy Specimens And Bacterial Cultures, Ousman Secka, Martin Antonio, Mary Tapgun, Douglas E. Berg, Christian Bottomley, Vivat Thomas, Robert Walton, Tumani Corrah, Richard A. Adegbola, Julian E. Thomas

Open Access Publications

No abstract provided.


Flyfactorsurvey: A Database Of Drosophila Transcription Factor Binding Specificities Determined Using The Bacterial One-Hybrid System, Lihua J. Zhu, Ryan G. Christensen, Majid Kazemian, Christopher J. Hull, Metewo S. Enuameh, Matthew D. Basciotta, Jessie A. Brasefield, Cong Zhu, Yuna Asriyan, David S. Lapointe, Saurabh Sinha, Scot A. Wolfe, Michael H. Brodsky Jan 2011

Flyfactorsurvey: A Database Of Drosophila Transcription Factor Binding Specificities Determined Using The Bacterial One-Hybrid System, Lihua J. Zhu, Ryan G. Christensen, Majid Kazemian, Christopher J. Hull, Metewo S. Enuameh, Matthew D. Basciotta, Jessie A. Brasefield, Cong Zhu, Yuna Asriyan, David S. Lapointe, Saurabh Sinha, Scot A. Wolfe, Michael H. Brodsky

Open Access Publications

No abstract provided.


Improving Salmonella Vector With Rec Mutation To Stabilize The Dna Cargoes, Xiangmin Zhang, Soo-Young Wanda, Karen Brenneman, Wei Kong, Xin Zhang, Kenneth Roland, Roy Curtiss Iii Jan 2011

Improving Salmonella Vector With Rec Mutation To Stabilize The Dna Cargoes, Xiangmin Zhang, Soo-Young Wanda, Karen Brenneman, Wei Kong, Xin Zhang, Kenneth Roland, Roy Curtiss Iii

Open Access Publications

No abstract provided.