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Washington University School of Medicine

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Rna Helicase Signaling Is Critical For Type I Interferon Production And Protection Against Rift Valley Fever Virus During Mucosal Challenge, Megan E. Ermler, Ekaterina Yerukhim, Jill Schriewer, Stefan Schattgen, Zachary Traylor, Adam R. Wespiser, Daniel R. Caffrey, Zhijian J. Chen, Charles H. King, Michael Gale Jr., Marco Colonna, Katherine A. Fitzgerald, R. Mark L. Buller, Amy G. Hise Jan 2013

Rna Helicase Signaling Is Critical For Type I Interferon Production And Protection Against Rift Valley Fever Virus During Mucosal Challenge, Megan E. Ermler, Ekaterina Yerukhim, Jill Schriewer, Stefan Schattgen, Zachary Traylor, Adam R. Wespiser, Daniel R. Caffrey, Zhijian J. Chen, Charles H. King, Michael Gale Jr., Marco Colonna, Katherine A. Fitzgerald, R. Mark L. Buller, Amy G. Hise

Open Access Publications

No abstract provided.


A Single-Amino-Acid Change In Murine Norovirus Ns1/2 Is Sufficient For Colonic Tropism And Persistence, Timothy J. Nice, David W. Strong, Broc T. Mccune, Calvin S. Pohl, Herbert W. Virgin Jan 2013

A Single-Amino-Acid Change In Murine Norovirus Ns1/2 Is Sufficient For Colonic Tropism And Persistence, Timothy J. Nice, David W. Strong, Broc T. Mccune, Calvin S. Pohl, Herbert W. Virgin

Open Access Publications

No abstract provided.


Advancing The Translation Of Optical Imaging Agents For Clinical Imaging, Eva M. Sevick-Muraca, Walter J. Akers, Bishnu P. Joshi, Gary D. Lurker, Cathy S. Cutler, Lawrence J. Marnett, Christopher H. Contag, Thomas D. Wang, Ali Azhdarinia Jan 2013

Advancing The Translation Of Optical Imaging Agents For Clinical Imaging, Eva M. Sevick-Muraca, Walter J. Akers, Bishnu P. Joshi, Gary D. Lurker, Cathy S. Cutler, Lawrence J. Marnett, Christopher H. Contag, Thomas D. Wang, Ali Azhdarinia

Open Access Publications

No abstract provided.


Immune Responses To West Nile Virus Infection In The Central Nervous System, Hyelim Cho, Michael S. Diamond Dec 2012

Immune Responses To West Nile Virus Infection In The Central Nervous System, Hyelim Cho, Michael S. Diamond

Open Access Publications

No abstract provided.


Neonatal Diethylstilbestrol Exposure Alters The Metabolic Profile Of Uterine Epithelial Cells, Yan Yin, Congxing Lin, G. Michael Veith, Hong Chen, Maulik Dhandha, Liang Ma Nov 2012

Neonatal Diethylstilbestrol Exposure Alters The Metabolic Profile Of Uterine Epithelial Cells, Yan Yin, Congxing Lin, G. Michael Veith, Hong Chen, Maulik Dhandha, Liang Ma

Open Access Publications

No abstract provided.


Zebrafish Neurofibromatosis Type 1 Genes Have Redundant Functions In Tumorigenesis And Embryonic Development, Jimann Shin, Arun Padmanabhan, Eric D. De Groh, Jeong-Soo Lee, Sam Haidar, Suzanne Dahlberg, Feng Guo, Shuning He, Marc A. Wolman, Michael Granato, Nathan D. Lawson, Scot A. Wolfe, Seok-Hyung Kim, Lilianna Solnica-Krezel, John P. Kanki, Keith L. Ligon, Jonathan A. Epstein, A. Thomas Look Nov 2012

Zebrafish Neurofibromatosis Type 1 Genes Have Redundant Functions In Tumorigenesis And Embryonic Development, Jimann Shin, Arun Padmanabhan, Eric D. De Groh, Jeong-Soo Lee, Sam Haidar, Suzanne Dahlberg, Feng Guo, Shuning He, Marc A. Wolman, Michael Granato, Nathan D. Lawson, Scot A. Wolfe, Seok-Hyung Kim, Lilianna Solnica-Krezel, John P. Kanki, Keith L. Ligon, Jonathan A. Epstein, A. Thomas Look

Open Access Publications

No abstract provided.


Mapping A Complete Neural Population In The Retina, Olivier Marre, Dario Amodei, Nikhil Deshmukh, Kolia Sadeghi, Frederick Soo, Timothy E. Holy, Michael J. Berry Oct 2012

Mapping A Complete Neural Population In The Retina, Olivier Marre, Dario Amodei, Nikhil Deshmukh, Kolia Sadeghi, Frederick Soo, Timothy E. Holy, Michael J. Berry

Open Access Publications

Recording simultaneously from essentially all of the relevant neurons in a local circuit is crucial to understand how they collectively represent information. Here we show that the combination of a large, dense multielectrode array and a novel, mostly automated spike-sorting algorithm allowed us to record simultaneously from a highly overlapping population of >200 ganglion cells in the salamander retina. By combining these methods with labeling and imaging, we showed that up to 95% of the ganglion cells over the area of the array were recorded. By measuring the coverage of visual space by the receptive fields of the recorded cells, …


Bjc Today Oct 2012

Bjc Today

BJC Today

No abstract provided.


Metabolic Effects Of Darunavir/Ritonavir Versus Atazanavir/Ritonavir In Treatment-Naive, Hiv Type 1-Infected Subjects Over 48 Weeks, Judith A. Aberg, Pablo Tebas, Edgar Turner Overton, Samir K. Gupta, Paul E. Sax, Alan Landay, Ron Falcon, Robert Ryan, Guy De La Rosa Sep 2012

Metabolic Effects Of Darunavir/Ritonavir Versus Atazanavir/Ritonavir In Treatment-Naive, Hiv Type 1-Infected Subjects Over 48 Weeks, Judith A. Aberg, Pablo Tebas, Edgar Turner Overton, Samir K. Gupta, Paul E. Sax, Alan Landay, Ron Falcon, Robert Ryan, Guy De La Rosa

Open Access Publications

No abstract provided.


Polygenic Threshold Model With Sex Dimorphism In Adolescent Idiopathic Scoliosis: The Carter Effect, Lisa M. Kruse, Jillian G. Buchan, Christina A. Gurnett, Matthew B. Dobbs Aug 2012

Polygenic Threshold Model With Sex Dimorphism In Adolescent Idiopathic Scoliosis: The Carter Effect, Lisa M. Kruse, Jillian G. Buchan, Christina A. Gurnett, Matthew B. Dobbs

Open Access Publications

No abstract provided.


Bjc Today Aug 2012

Bjc Today

BJC Today

No abstract provided.


Loss Of Atm Kinase Activity Leads To Embryonic Lethality In Mice, Jeremy A. Daniel, Manuela Pellegrini, Baeck-Seung Lee, Zhi Guo, Darius Filsuf, Natalya V. Belkina, Zhongsheng You, Tanya T. Paull, Barry P. Sleckman, Lionel Feigenbaum, André Nussenzweig Aug 2012

Loss Of Atm Kinase Activity Leads To Embryonic Lethality In Mice, Jeremy A. Daniel, Manuela Pellegrini, Baeck-Seung Lee, Zhi Guo, Darius Filsuf, Natalya V. Belkina, Zhongsheng You, Tanya T. Paull, Barry P. Sleckman, Lionel Feigenbaum, André Nussenzweig

Open Access Publications

No abstract provided.


I(A) Channels Encoded By Kv1.4 And Kv4.2 Regulate Neuronal Firing In The Suprachiasmatic Nucleus And Circadian Rhythms In Locomotor Activity, Daniel Granados-Fuentes, Aaron J. Norris, Yarimar Carrasquillo, Jeanne M. Nerbonne, Erik D. Herzog Jul 2012

I(A) Channels Encoded By Kv1.4 And Kv4.2 Regulate Neuronal Firing In The Suprachiasmatic Nucleus And Circadian Rhythms In Locomotor Activity, Daniel Granados-Fuentes, Aaron J. Norris, Yarimar Carrasquillo, Jeanne M. Nerbonne, Erik D. Herzog

Open Access Publications

Neurons in the suprachiasmatic nucleus (SCN) display coordinated circadian changes in electrical activity that are critical for daily rhythms in physiology, metabolism, and behavior. SCN neurons depolarize spontaneously and fire repetitively during the day and hyperpolarize, drastically reducing firing rates, at night. To explore the hypothesis that rapidly activating and inactivating A-type (I(A)) voltage-gated K(+) (Kv) channels, which are also active at subthreshold membrane potentials, are critical regulators of the excitability of SCN neurons, we examined locomotor activity and SCN firing in mice lacking Kv1.4 (Kv1.4(-/-)), Kv4.2 (Kv4.2(-/-)), or Kv4.3 (Kv4.3(-/-)), the pore-forming (α) subunits of I(A) channels. Mice lacking …


Person-Specific Changes In Motor Performance Accompany Upper Extremity Functional Gains After Stroke, Stacey L. Dejong, Rebecca L. Birkenmeier, Catherine E. Lang Jul 2012

Person-Specific Changes In Motor Performance Accompany Upper Extremity Functional Gains After Stroke, Stacey L. Dejong, Rebecca L. Birkenmeier, Catherine E. Lang

Physical Therapy Faculty Publications

No abstract provided.


Hunter-Gatherer Energetics And Human Obesity, Herman Pontzer, David A. Raichlen, Brian M. Wood, Audax Z. P. Mabulla, Susan B. Racette, Frank W. Marlowe Jul 2012

Hunter-Gatherer Energetics And Human Obesity, Herman Pontzer, David A. Raichlen, Brian M. Wood, Audax Z. P. Mabulla, Susan B. Racette, Frank W. Marlowe

Open Access Publications

No abstract provided.


Loss Of Intranetwork And Internetwork Resting State Functional Connections With Alzheimer's Disease Progression, Mathew R. Brier, Jewell B. Thomas, Abraham Z. Snyder, Tammie L. Benzinger, Dongyang Zhang, Marcus E. Raichle, David M. Holtzman, John C. Morris, Beau M. Ances Jun 2012

Loss Of Intranetwork And Internetwork Resting State Functional Connections With Alzheimer's Disease Progression, Mathew R. Brier, Jewell B. Thomas, Abraham Z. Snyder, Tammie L. Benzinger, Dongyang Zhang, Marcus E. Raichle, David M. Holtzman, John C. Morris, Beau M. Ances

Open Access Publications

Alzheimer's disease (AD) is the most common cause of dementia. Much is known concerning AD pathophysiology but our understanding of the disease at the systems level remains incomplete. Previous AD research has used resting-state functional connectivity magnetic resonance imaging (rs-fcMRI) to assess the integrity of functional networks within the brain. Most studies have focused on the default-mode network (DMN), a primary locus of AD pathology. However, other brain regions are inevitably affected with disease progression. We studied rs-fcMRI in five functionally defined brain networks within a large cohort of human participants of either gender (n = 510) that ranged in …


What's New In Spine Surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, Jeffrey C. Wang Jun 2012

What's New In Spine Surgery, Keith H. Bridwell, Paul A. Anderson, Scott D. Boden, Alexander R. Vaccaro, Jeffrey C. Wang

Open Access Publications

No abstract provided.


Alix Binds A Ypx3l Motif Of The Gpcr Par1 And Mediates Ubiquitin-Independent Escrt-Iii/Mvb Sorting, Michael R. Dores, Buxin Chen, Huilan Lin, May M. Paing, William A. Montagne, Timo Meerlo, Joann Trejo Apr 2012

Alix Binds A Ypx3l Motif Of The Gpcr Par1 And Mediates Ubiquitin-Independent Escrt-Iii/Mvb Sorting, Michael R. Dores, Buxin Chen, Huilan Lin, May M. Paing, William A. Montagne, Timo Meerlo, Joann Trejo

Open Access Publications

No abstract provided.


Bjc Today Apr 2012

Bjc Today

BJC Today

No abstract provided.


A Model Of Toxic Neuropathy In Drosophila Reveals A Role For Morn4 In Promoting Axonal Degeneration, Martha R.C. Bhattacharya, Josiah Gerdts, Sarah A. Naylor, Emily X. Royse, Sarah Y. Ebstein, Yo Sasaki, Jeffrey Milbrandt, Aaron Diantonio Apr 2012

A Model Of Toxic Neuropathy In Drosophila Reveals A Role For Morn4 In Promoting Axonal Degeneration, Martha R.C. Bhattacharya, Josiah Gerdts, Sarah A. Naylor, Emily X. Royse, Sarah Y. Ebstein, Yo Sasaki, Jeffrey Milbrandt, Aaron Diantonio

Open Access Publications

Axonal degeneration is a molecular self-destruction cascade initiated following traumatic, toxic, and metabolic insults. Its mechanism underlies a number of disorders including hereditary and diabetic neuropathies and the neurotoxic side effects of chemotherapy drugs. Molecules that promote axonal degeneration could represent potential targets for therapy. To identify such molecules, we designed a screening platform based on intoxication of Drosophila larvae with paclitaxel (taxol), a chemotherapeutic agent that causes neuropathy in cancer patients. In Drosophila, taxol treatment causes swelling, fragmentation, and loss of axons in larval peripheral nerves. This axonal loss is not due to apoptosis of neurons. Taxol-induced axonal degeneration …


Outcome Of Revision Anterior Cruciate Ligament Reconstruction: A Systematic Review, Rick W. Wright, Corey S. Gill, Ling Chen, Robert H. Brophy, Matthew J. Matava, Matthew V. Smith, Nathan A. Mall Mar 2012

Outcome Of Revision Anterior Cruciate Ligament Reconstruction: A Systematic Review, Rick W. Wright, Corey S. Gill, Ling Chen, Robert H. Brophy, Matthew J. Matava, Matthew V. Smith, Nathan A. Mall

Open Access Publications

No abstract provided.


Molecular Analysis Of Age And Sex-Related Gene Expression In Meniscal Tears With And Without A Concomitant Anterior Cruciate Ligament Tear, Robert H. Brophy, Muhammad Farooq Rai, Zhiqi Zhang, Adelina Torgomyan, Linda J. Sandell Mar 2012

Molecular Analysis Of Age And Sex-Related Gene Expression In Meniscal Tears With And Without A Concomitant Anterior Cruciate Ligament Tear, Robert H. Brophy, Muhammad Farooq Rai, Zhiqi Zhang, Adelina Torgomyan, Linda J. Sandell

Open Access Publications

No abstract provided.


Bjc Today Feb 2012

Bjc Today

BJC Today

No abstract provided.


Pacs Bulletin 2012-2013, Program In Audiology And Communication Sciences Jan 2012

Pacs Bulletin 2012-2013, Program In Audiology And Communication Sciences

PACS News

No abstract provided.


The Effect Of An External Auditory Stimulus On Postural Stability Of Participants With Cochlear Implants, Rachael Jeanette Mangiore Jan 2012

The Effect Of An External Auditory Stimulus On Postural Stability Of Participants With Cochlear Implants, Rachael Jeanette Mangiore

Independent Studies and Capstones

Postural control was evaluated in cochlear implant participants with and without amplification under several auditory paradigms. Speed of sway was recorded in each condition by means of Computerized Dynamic Posturography. Results indicate that an external sound source significantly improves balance in patients with cochlear implants.


Primerbank: A Pcr Primer Database For Quantitative Gene Expression Analysis, 2012 Update, Xiaowei Wang, Athanasia Spandidos, Huajun Wang, Brian Seed Jan 2012

Primerbank: A Pcr Primer Database For Quantitative Gene Expression Analysis, 2012 Update, Xiaowei Wang, Athanasia Spandidos, Huajun Wang, Brian Seed

Open Access Publications

No abstract provided.


Outlook Magazine, Winter 2012 Jan 2012

Outlook Magazine, Winter 2012

Outlook Magazine

No abstract provided.


Outlook Magazine, Spring 2012 Jan 2012

Outlook Magazine, Spring 2012

Outlook Magazine

No abstract provided.


Outlook Magazine, Autumn 2012 Jan 2012

Outlook Magazine, Autumn 2012

Outlook Magazine

No abstract provided.


Fibroblast Growth Factor 2 Affects Vascular Remodeling After Acute Myocardial Infarction, Stacey House, Thomas Belanger, Carla Weinheimer, David Ornitz Jan 2012

Fibroblast Growth Factor 2 Affects Vascular Remodeling After Acute Myocardial Infarction, Stacey House, Thomas Belanger, Carla Weinheimer, David Ornitz

Conference Abstracts and Posters

No abstract provided.