Digital Commons Network^™

Using Diffusion Tractography To Predict Cortical Connection Strength And Distance: A Quantitative Comparison With Tracers In The Monkey, Chad J. Donahue, Stamatios N. Sotiropoulos, Saad Jbabdi, Moises Hernandez-Fernandez, Timothy E. Behrens, Tim B. Dyrby, Timothy Coalson, Henry Kennedy, Kenneth Knoblauch, David C. Van Essen, Matthew F. Glasser

Open Access Publications

UNLABELLED: Tractography based on diffusion MRI offers the promise of characterizing many aspects of long-distance connectivity in the brain, but requires quantitative validation to assess its strengths and limitations. Here, we evaluate tractography's ability to estimate the presence and strength of connections between areas of macaque neocortex by comparing its results with published data from retrograde tracer injections. Probabilistic tractography was performed on high-quality postmortem diffusion imaging scans from two Old World monkey brains. Tractography connection weights were estimated using a fractional scaling method based on normalized streamline density. We found a correlation between log-transformed tractography and tracer connection weights …

Bjc Today

BJC Today

No abstract provided.

Tmem184b Promotes Axon Degeneration And Neuromuscular Junction Maintenance, Martha R.C. Bhattacharya, Stefanie Geisler, Sara K. Pittman, Ryan A. Doan, Conrad C. Weihl, Jeffrey Milbrandt, Aaron Diantonio

Open Access Publications

UNLABELLED: Complex nervous systems achieve proper connectivity during development and must maintain these connections throughout life. The processes of axon and synaptic maintenance and axon degeneration after injury are jointly controlled by a number of proteins within neurons, including ubiquitin ligases and mitogen activated protein kinases. However, our understanding of these molecular cascades is incomplete. Here we describe the phenotype resulting from mutation of TMEM184b, a protein identified in a screen for axon degeneration mediators. TMEM184b is highly expressed in the mouse nervous system and is found in recycling endosomes in neuronal cell bodies and axons. Disruption of TMEM184b expression …

Functional Significance Of The Discordance Between Transcriptional Profile And Left Ventricular Structure/Function During Reverse Remodeling, Veli K. Topkara, Kari T. Chambers, Kai-Chien Yang, Huei-Ping Tzeng, Sarah Evans, Carla Weinheimer, Attila Kovacs, Jeffrey Robbins, Philip Barger, Douglas L. Mann

Open Access Publications

To elucidate the mechanisms for reverse LV remodeling, we generated a conditional (doxycycline [dox] off) transgenic mouse tetracycline transactivating factor-TRAF2 (tTA-TRAF2) that develops a dilated heart failure (HF) phenotype upon expression of a proinflammatory transgene, TNF receptor-associated factor 2 (TRAF2), and complete normalization of LV structure and function when the transgene is suppressed. tTA-TRAF2 mice developed a significant increase in LV dimension with decreased contractile function, which was completely normalized in the tTA-TRAF2 mice fed dox for 4 weeks (tTA-TRAF2

Provisional Tic Disorder: What To Tell Parents When Their Child First Starts Ticcing, Kevin J. Black, Elizabeth Rose Black, Deanna J. Greene, Bradley L. Schlaggar

Open Access Publications

No abstract provided.

Maturation Of Nav And Kv Channel Topographies In The Auditory Nerve Spike Initiator Before And After Developmental Onset Of Hearing Function, Kyunghee X. Kim, Mark A. Rutherford

Open Access Publications

No abstract provided.

Oncomodulin, An Ef-Hand Ca2+ Buffer, Is Critical For Maintaining Cochlear Function In Mice, Benton Tong, Aubrey J. Hornak, Stéphane F. Maison, Kevin K. Ohlemiller, M Charles Liberman, Dwayne D. Simmons

Open Access Publications

UNLABELLED: Oncomodulin (Ocm), a member of the parvalbumin family of calcium binding proteins, is expressed predominantly by cochlear outer hair cells in subcellular regions associated with either mechanoelectric transduction or electromotility. Targeted deletion of Ocm caused progressive cochlear dysfunction. Although sound-evoked responses are normal at 1 month, by 4 months, mutants show only minimal distortion product otoacoustic emissions and 70-80 dB threshold shifts in auditory brainstem responses. Thus, Ocm is not critical for cochlear development but does play an essential role for cochlear function in the adult mouse.

SIGNIFICANCE STATEMENT: Numerous proteins act as buffers, sensors, or pumps to control …

Getting To More Effective Weight Management In Antipsychotic-Treated Youth: A Survey Of Barriers And Preferences, Ginger Nicol, Elizabeth Worsham, Debra Haire-Joshu, Alexis Duncan, Julia Schweiger, Michael Yingling, Eric Lenze

Open Access Publications

No abstract provided.

Pacs Bulletin 2016-2017, Program In Audiology And Communication Sciences

PACS News

No abstract provided.

Estimates Of Mental Health Problems In A Vulnerable Population Within A Primary Care Setting, Darrell L. Hudson, Kimberly A. Kaphingst, Merriah A. Croston, Melvin S. Blanchard, Melody S. Goodman

Health Disparities Faculty Publications

No abstract provided.

Modelling Proteins’ Hidden Conformations To Predict Antibiotic Resistance, Kathryn M. Hart, Chris M. W. Ho, Supratik Dutta, Michael L. Gross, Gregory R. Bowman

Open Access Publications

No abstract provided.

Chemical Chaperone Tudca Prevents Apoptosis And Improves Survival During Polymicrobial Sepsis In Mice, Marcel Doerflinger, Jason Glab, Christina Nedeva, Irvin Jose, Ann Lin, Lorraine O’Reilly, Cody Allison, Marc Pellegrini, Richard S. Hotchkiss, Hamsa Puthalakath

Open Access Publications

No abstract provided.

Spatially- And Temporally-Controlled Postnatal P53 Knockdown Cooperates With Embryonic Schwann Cell Precursor Nf1 Gene Loss To Promote Malignant Peripheral Nerve Sheath Tumor Formation, Angela C. Hirbe, Sonika Dahiya, Dinorah Friedmann-Morvinski, Inder M. Verma, D. Wade Clapp, David H. Gutmann

Open Access Publications

No abstract provided.

Coa Protects Against The Deleterious Effects Of Caloric Overload In Drosophila, Laura Palanker Musselman, Jill L. Fink, Thomas J. Baranski

Open Access Publications

No abstract provided.

Human Metabolome-Derived Cofactors Are Required For The Antibacterial Activity Of Siderocalin In Urine, Robin R. Shields-Cutler, Jan R. Crowley, Connelly D. Miller, Ann E. Stapleton, Weidong Cui, Jeffery P. Henderson

Open Access Publications

No abstract provided.

A Recurrent Mosaic Mutation In Smo, Encoding The Hedgehog Signal Transducer Smoothened, Is The Major Cause Of Curry-Jones Syndrome, Dorothy K. Grange, Et Al

Open Access Publications

No abstract provided.

Human Central Nervous System (Cns) Apoe Isoforms Are Increased By Age, Differentially Altered By Amyloidosis, And Relative Amounts Reversed In The Cns Compared With Plasma, Alaina T. Baker-Nigh, Kwasi G. Mawuenyega, James G. Bollinger, Vitaliy Ovod, Tom Kasten, Erin E. Franklin, Fan Liao, Hong Jiang, David Holtzman, Nigel J. Cairns, John C. Morris, Randall J. Bateman

Open Access Publications

No abstract provided.

Within-Subjects Changes In Lipreading And Visual Enhancement Among Older Adults, Adam Harrison Voss

Independent Studies and Capstones

After 10-14 years, 14 older adults were retested to assess changes in Vonly ability and VE. Results showed no significant declines, however, strong correlations were found between previous V-only performance and current Vonly performance, as well as between previous VE and current VE, although not as strong. Age and PTA were not predictors of changes in lipreading or VE. In addition, older adults perform less well on auditory-only tasks over time.

Effects Of Hearing Aid Programming Equipment And Assistive Listening Devices On Implantable Cardiac Devices, Farah Dubaybo

Independent Studies and Capstones

This study examines the potential for electromagnetic interference from the use of neck-worn hearing aid programming equipment and assistive listening devices to affect cardiac pacemakers and defibrillators.

Why A Diagnosis Of Neurofibromatosis Calls For The Attention Of A Deaf Educator, Lydia Marie López

Independent Studies and Capstones

This paper will seek to describe neurofibromatosis (NF), the scope of its impact, how NF relates to hearing loss, and why someone with a teacher of the deaf’s expertise may have information to offer the intervention team for a child diagnosed with NF.

Inflammation In Benign Prostate Tissue And Prostate Cancer In The Finasteride Arm Of The Prostate Cancer Prevention Trial, Teemu J. Murtola, Bora Gurel, Martin Umbehr, M. Scott Lucia, Ian M. Thompson Jr., Phyllis J. Goodman, Alan R. Kristal, Howard L. Parnes, Scott M. Lippman, Siobhan Sutcliffe, Sarah B. Peskoe, John R. Barber, Charles G. Drake, William G. Nelson, Angelo M. De Marzo, Elizabeth A. Platz

Cancer Prevention Faculty Publications

No abstract provided.

Inhibition Of Dna Methyltransferases Blocks Mutant Huntingtin-Induced Neurotoxicity, Yanchun Pan, Takuji Daito, Yo Sasaki, Yong Hee Chung, Xiaoyun Xing, Santhi Pondugula, S. Joshua Swamidass, Ting Wang, Albert H. Kim, Hiroko Yano

Open Access Publications

No abstract provided.

Predicting All-Cause Mortality From Basic Physiology In The Framingham Heart Study, William B. Zhang, Zachary Pincus

Open Access Publications

No abstract provided.

Changes In The Relative Abundance Of Two Saccharomyces Species From Oak Forests To Wine Fermentations, Sofia Dashko, Ping Liu, Helena Volk, Lorena Butinar, Jure Piškur, Justin C. Fay

Open Access Publications

No abstract provided.

Genseed-Hmm: A Tool For Progressive Assembly Using Profile Hmms As Seeds And Its Application In Alpavirinae Viral Discovery From Metagenomic Data, João M.P. Alves, Andre L. De Oliveira, Tatiana O.M. Sandberg, Jaime L. Moreno-Gallego, Marcelo A.F. De Toledo, Elisabeth M.M. De Moura, Liliane S. Oliveira, Alan M. Durham, Dolores U. Mehnert, Paolo M. De A. Zanotto, Alejandro Reyes, Arthur Gruber

Open Access Publications

No abstract provided.

Genome-Wide Association Study Of Lifetime Cannabis Use Based On A Large Meta-Analytic Sample Of 32,330 Subjects From The International Cannabis Consortium, A C. Heath, Et Al

Open Access Publications

No abstract provided.

Critical Evaluation Of The Expression Of Gastrin-Releasing Peptide In Dorsal Root Ganglia And Spinal Cord, Devin M. Barry, Hui Li, Xian-Yu Liu, Kai-Feng Shen, Xue-Ting Liu, Zhen-Yu Wu, Admire Munanairi, Xiao-Jun Chen, Jun Yin, Yan-Gang Sun, Yun-Qing Li, Zhou-Feng Chen

Open Access Publications

No abstract provided.

Geographic Variation In Maternal Smoking During Pregnancy In The Missouri Adolescent Female Twin Study (Moafts), Min Lian, Pamela A. Madden, Michael T. Lynskey, Graham A. Colditz, Christina N. Lessov-Schlaggar, Mario Schootman, Andrew C. Heath

Open Access Publications

No abstract provided.

Rna-Seq Of The Caribbean Reef-Building Coral Orbicella Faveolata (Scleractinia-Merulinidae) Under Bleaching And Disease Stress Expands Models Of Coral Innate Immunity, David A. Anderson, Marcus E. Walz, Ernesto Weil, Peter Tonellato, Matthew C. Smith

Open Access Publications

No abstract provided.

Hyperthermic Laser Ablation Of Recurrent Glioblastoma Leads To Temporary Disruption Of The Peritumoral Blood Brain Barrier, Eric C. Leuthardt, Chong Duan, Michael J. Kim, Jian L. Campian, Albert H. Kim, Michelle M. Miller-Thomas, Joshua S. Shimony, David D. Tran

Open Access Publications

No abstract provided.