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Articles 4651 - 4680 of 11062
Full-Text Articles in Entire DC Network
Monitoring Behaviorally Induced Biochemical Changes Using Fluorescence Lifetime Photometry, Suk Joon Lee, Yao Chen, Bart Lodder, Bernardo L. Sabatini
Monitoring Behaviorally Induced Biochemical Changes Using Fluorescence Lifetime Photometry, Suk Joon Lee, Yao Chen, Bart Lodder, Bernardo L. Sabatini
Open Access Publications
No abstract provided.
Comparison Of The Pharmacokinetic Properties Of Triamcinolone And Dexamethasone For Local Therapy Of The Inner Ear, Alec Nicholas Salt, Jared James Hartsock, Jennifer Hou, Fabrice Piu
Comparison Of The Pharmacokinetic Properties Of Triamcinolone And Dexamethasone For Local Therapy Of The Inner Ear, Alec Nicholas Salt, Jared James Hartsock, Jennifer Hou, Fabrice Piu
Open Access Publications
No abstract provided.
Chronic Ly49h Receptor Engagement In Vivo Decreases Nk Cell Response To Stimulation Through Itam-Dependent And Independent Pathways Both In Vitro And In Vivo, Phillip N. Key, Joe Germino, Liping Yang, Sytse J. Piersma, Sandeep K. Tripathy
Chronic Ly49h Receptor Engagement In Vivo Decreases Nk Cell Response To Stimulation Through Itam-Dependent And Independent Pathways Both In Vitro And In Vivo, Phillip N. Key, Joe Germino, Liping Yang, Sytse J. Piersma, Sandeep K. Tripathy
Open Access Publications
No abstract provided.
Treatment, Complications, And Outcomes Of Metastatic Disease Of The Spine: From Patchell To Promis, Alexander T. Yahanda, Jacob M. Buchowski, Adam M. Wegner
Treatment, Complications, And Outcomes Of Metastatic Disease Of The Spine: From Patchell To Promis, Alexander T. Yahanda, Jacob M. Buchowski, Adam M. Wegner
Open Access Publications
No abstract provided.
Diffusion Tensor Model Links To Neurite Orientation Dispersion And Density Imaging At High B-Value In Cerebral Cortical Gray Matter, Hikaru Fukutomi, Matthew F. Glasser, Katsutoshi Murata, Thai Akasaka, Koji Fujimoto, Takayuki Yamamoto, Joonas A. Autio, Tomohisa Okada, Kaori Togashi, Hui Zhang, David C. Van Essen, Takuya Hayashi
Diffusion Tensor Model Links To Neurite Orientation Dispersion And Density Imaging At High B-Value In Cerebral Cortical Gray Matter, Hikaru Fukutomi, Matthew F. Glasser, Katsutoshi Murata, Thai Akasaka, Koji Fujimoto, Takayuki Yamamoto, Joonas A. Autio, Tomohisa Okada, Kaori Togashi, Hui Zhang, David C. Van Essen, Takuya Hayashi
Open Access Publications
No abstract provided.
Genetic Variation Across Rna Metabolism And Cell Death Gene Networks Is Implicated In The Semantic Variant Of Primary Progressive Aphasia, Celeste M. Karch, Natalie L. Wen, Et Al.
Genetic Variation Across Rna Metabolism And Cell Death Gene Networks Is Implicated In The Semantic Variant Of Primary Progressive Aphasia, Celeste M. Karch, Natalie L. Wen, Et Al.
Open Access Publications
No abstract provided.
A Meta-Analysis Of Genome-Wide Association Studies Identifies Multiple Longevity Genes, Mary K. Wojczynski, Michael A. Province, Et Al.
A Meta-Analysis Of Genome-Wide Association Studies Identifies Multiple Longevity Genes, Mary K. Wojczynski, Michael A. Province, Et Al.
Open Access Publications
No abstract provided.
Patients With Endometrial Cancer Continue To Lack Understanding Of Their Risks For Cancer, Subhjit Sekhon, L. Stewart Massad, Andrea R. Hagemann, Rebecca Dick, Andrea Leon, Abigail S. Zamorano, Premal H. Thaker, Carolyn K. Mccourt, David G. Mutch, Matthew A. Powell, Lindsay M. Kuroki
Patients With Endometrial Cancer Continue To Lack Understanding Of Their Risks For Cancer, Subhjit Sekhon, L. Stewart Massad, Andrea R. Hagemann, Rebecca Dick, Andrea Leon, Abigail S. Zamorano, Premal H. Thaker, Carolyn K. Mccourt, David G. Mutch, Matthew A. Powell, Lindsay M. Kuroki
Open Access Publications
No abstract provided.
Desmin Forms Toxic, Seeding-Competent Amyloid Aggregates That Persist In Muscle Fibers, Niraja Kedia, Khalid Arhzaouy, Sara K. Pittman, Yuanzi Sun, Mark Batchelor, Conrad C. Weihl, Jan Bieschke
Desmin Forms Toxic, Seeding-Competent Amyloid Aggregates That Persist In Muscle Fibers, Niraja Kedia, Khalid Arhzaouy, Sara K. Pittman, Yuanzi Sun, Mark Batchelor, Conrad C. Weihl, Jan Bieschke
Open Access Publications
No abstract provided.
Bogotá River Anthropogenic Contamination Alters Microbial Communities And Promotes Spread Of Antibiotic Resistance Genes, Carlos Eduardo Posada-Perlaza, Adán Ramírez-Rojas, Paola Porras, Boahemaa Adu-Oppong, Ana-María Botero-Coy, Félix Hernández, Juan M. Anzola, Lorena Díaz, Gautam Dantas, Alejandro Reyes, María Mercedes Zambrano
Bogotá River Anthropogenic Contamination Alters Microbial Communities And Promotes Spread Of Antibiotic Resistance Genes, Carlos Eduardo Posada-Perlaza, Adán Ramírez-Rojas, Paola Porras, Boahemaa Adu-Oppong, Ana-María Botero-Coy, Félix Hernández, Juan M. Anzola, Lorena Díaz, Gautam Dantas, Alejandro Reyes, María Mercedes Zambrano
Open Access Publications
No abstract provided.
A Regulatory Variant Of Chrm3 Is Associated With Cannabis-Induced Hallucinations In European Americans, Zhongshan Cheng, Chureerat Phokaew, Yi-Ling Chou, Dongbing Lai, Jacquelyn L. Meyers, Arpana Agrawal, Lindsay A. Farrer, Henry R. Kranzler, Joel Gelernter
A Regulatory Variant Of Chrm3 Is Associated With Cannabis-Induced Hallucinations In European Americans, Zhongshan Cheng, Chureerat Phokaew, Yi-Ling Chou, Dongbing Lai, Jacquelyn L. Meyers, Arpana Agrawal, Lindsay A. Farrer, Henry R. Kranzler, Joel Gelernter
Open Access Publications
No abstract provided.
Modelling Resilience In Adolescence And Adversity: A Novel Framework To Inform Research And Practice, Gin S. Malhi, Pritha Das, Erica Bell, Greg Mattingly, Zola Mannie
Modelling Resilience In Adolescence And Adversity: A Novel Framework To Inform Research And Practice, Gin S. Malhi, Pritha Das, Erica Bell, Greg Mattingly, Zola Mannie
Open Access Publications
No abstract provided.
Whole-Cortex Mapping Of Common Genetic Influences On Depression And A Social Deficits Dimension, Alexander S. Hatoum, Andrew E. Reineberg, Harry R. Smolker, John K. Hewitt, Naomi P. Friedman
Whole-Cortex Mapping Of Common Genetic Influences On Depression And A Social Deficits Dimension, Alexander S. Hatoum, Andrew E. Reineberg, Harry R. Smolker, John K. Hewitt, Naomi P. Friedman
Open Access Publications
No abstract provided.
Cisplatin Exposure Causes C-Myc-Dependent Resistance To Cdk4/6 Inhibition In Hpv-Negative Head And Neck Squamous Cell Carcinoma, Anthony M. Robinson, Richa Rathore, Nathan J. Redlich, Douglas R. Adkins, Todd Vanarsdale, Brian A. Van Tine, Loren S. Michel
Cisplatin Exposure Causes C-Myc-Dependent Resistance To Cdk4/6 Inhibition In Hpv-Negative Head And Neck Squamous Cell Carcinoma, Anthony M. Robinson, Richa Rathore, Nathan J. Redlich, Douglas R. Adkins, Todd Vanarsdale, Brian A. Van Tine, Loren S. Michel
Open Access Publications
No abstract provided.
Multi-Ancestry Sleep-By-Snp Interaction Analysis In 126,926 Individuals Reveals Lipid Loci Stratified By Sleep Duration, Raymond Noordam, Yun Ju Sung, Karen Schwander, Lisa De Las Fuentes, Treva K. Rice, Dabeeru C. Rao, Mary Feitosa, Aldi Kraja, Mike Province, Et Al.
Multi-Ancestry Sleep-By-Snp Interaction Analysis In 126,926 Individuals Reveals Lipid Loci Stratified By Sleep Duration, Raymond Noordam, Yun Ju Sung, Karen Schwander, Lisa De Las Fuentes, Treva K. Rice, Dabeeru C. Rao, Mary Feitosa, Aldi Kraja, Mike Province, Et Al.
Open Access Publications
No abstract provided.
Vertical Transmission In Caenorhabditis Nematodes Of Rna Molecules Encoding A Viral Rna-Dependent Rna Polymerase, Aurélien Richaud, Lise Frézal, Stephen Tahan, Hongbing Jiang, Joshua A. Blatter, Guoyan Zhao, Taniya Kaur, David Wang, Marie-Anne Félix
Vertical Transmission In Caenorhabditis Nematodes Of Rna Molecules Encoding A Viral Rna-Dependent Rna Polymerase, Aurélien Richaud, Lise Frézal, Stephen Tahan, Hongbing Jiang, Joshua A. Blatter, Guoyan Zhao, Taniya Kaur, David Wang, Marie-Anne Félix
Open Access Publications
No abstract provided.
End Points For Sickle Cell Disease Clinical Trials: Renal And Cardiopulmonary, Cure, And Low-Resource Settings, Ann T. Farrell, Shalini Shenoy, Et Al.
End Points For Sickle Cell Disease Clinical Trials: Renal And Cardiopulmonary, Cure, And Low-Resource Settings, Ann T. Farrell, Shalini Shenoy, Et Al.
Open Access Publications
No abstract provided.
End Points For Sickle Cell Disease Clinical Trials: Patient-Reported Outcomes, Pain, And The Brain, Ann T. Farrell, Allison A. King, Et Al.
End Points For Sickle Cell Disease Clinical Trials: Patient-Reported Outcomes, Pain, And The Brain, Ann T. Farrell, Allison A. King, Et Al.
Open Access Publications
No abstract provided.
Phase 1 Dose Escalation Study Of The Allosteric Akt Inhibitor Bay 1125976 In Advanced Solid Cancer-Lack Of Association Between Activating Akt Mutation And Akt Inhibition-Derived Efficacy, Andreas Schneeweiss, Dagmar Hess, Markus Joerger, Andrea Varga, Stacy Moulder, Apostolia M Tsimberidou, Cynthia Ma, Sara A Hurvitz, Christine Rentzsch, Marion Rudolph, Silke Thiele, Oliver Boix, Gary Wilkinson, Eleni Lagkadinou, Matthias Ocker
Phase 1 Dose Escalation Study Of The Allosteric Akt Inhibitor Bay 1125976 In Advanced Solid Cancer-Lack Of Association Between Activating Akt Mutation And Akt Inhibition-Derived Efficacy, Andreas Schneeweiss, Dagmar Hess, Markus Joerger, Andrea Varga, Stacy Moulder, Apostolia M Tsimberidou, Cynthia Ma, Sara A Hurvitz, Christine Rentzsch, Marion Rudolph, Silke Thiele, Oliver Boix, Gary Wilkinson, Eleni Lagkadinou, Matthias Ocker
Open Access Publications
This open-label, phase I first-in-human study (NCT01915576) of BAY 1125976, a highly specific and potent allosteric inhibitor of AKT1/2, aimed to evaluate the safety, pharmacokinetics, and maximum tolerated dose of BAY 1125976 in patients with advanced solid tumors. Oral dose escalation was investigated with a continuous once daily (QD) treatment (21 days/cycle) and a twice daily (BID) schedule. A dose expansion in 28 patients with hormone receptor-positive metastatic breast cancer, including nine patients harboring the
Mechanisms Underlying Bone Loss Associated With Gut Inflammation, Ke Ke, Manoj Arra, Yousef Abu-Amer
Mechanisms Underlying Bone Loss Associated With Gut Inflammation, Ke Ke, Manoj Arra, Yousef Abu-Amer
Open Access Publications
Patients with gastrointestinal diseases frequently suffer from skeletal abnormality, characterized by reduced bone mineral density, increased fracture risk, and/or joint inflammation. This pathological process is characterized by altered immune cell activity and elevated inflammatory cytokines in the bone marrow microenvironment due to disrupted gut immune response. Gastrointestinal disease is recognized as an immune malfunction driven by multiple factors, including cytokines and signaling molecules. However, the mechanism by which intestinal inflammation magnified by gut-residing actors stimulates bone loss remains to be elucidated. In this article, we discuss the main risk factors potentially contributing to intestinal disease-associated bone loss, and summarize current …
A Review Of The Immunomodulating Components Of Maternal Breast Milk And Protection Against Necrotizing Enterocolitis, Lila S Nolan, Olivia B Parks, Misty Good
A Review Of The Immunomodulating Components Of Maternal Breast Milk And Protection Against Necrotizing Enterocolitis, Lila S Nolan, Olivia B Parks, Misty Good
Open Access Publications
Breast milk contains immunomodulating components that are beneficial to newborns during maturation of their immune system. Human breast milk composition is influenced by an infant's gestational and chronological age, lactation stage, and the mother and infant's health status. Major immunologic components in human milk, such as secretory immunoglobulin A (IgA) and growth factors, have a known role in regulating gut barrier integrity and microbial colonization, which therefore protect against the development of a life-threatening gastrointestinal illness affecting newborn infants called necrotizing enterocolitis (NEC). Breast milk is a known protective factor in the prevention of NEC when compared with feeding with …
Changes In Food Cravings And Eating Behavior After A Dietary Carbohydrate Restriction Intervention Trial, Katherene O-B Anguah, Majid M Syed-Abdul, Qiong Hu, Miriam Jacome-Sosa, Colette Heimowitz, Vicki Cox, Elizabeth J Parks
Changes In Food Cravings And Eating Behavior After A Dietary Carbohydrate Restriction Intervention Trial, Katherene O-B Anguah, Majid M Syed-Abdul, Qiong Hu, Miriam Jacome-Sosa, Colette Heimowitz, Vicki Cox, Elizabeth J Parks
Open Access Publications
Compared to low-fat diets, low-carbohydrate (CHO) diets cause weight loss (WL) over a faster time frame; however, it is unknown how changes in food cravings and eating behavior contribute to this more rapid WL in the early phases of dieting. We hypothesized that reductions in food cravings and improved eating behaviors would be evident even after a relatively short (4-week) duration of CHO-restriction, and that these changes would be associated with WL. Adult participants (
Selective Small Molecule Parg Inhibitor Causes Replication Fork Stalling And Cancer Cell Death, Jerry H. Houl, Roderick A. Stegeman, Tom Ellenberger, In-Kwon Kim, Et Al.
Selective Small Molecule Parg Inhibitor Causes Replication Fork Stalling And Cancer Cell Death, Jerry H. Houl, Roderick A. Stegeman, Tom Ellenberger, In-Kwon Kim, Et Al.
Open Access Publications
No abstract provided.
New Statistical Method Identifes Cytokines That Distinguish Stool Microbiomes, Dake Yang, Jethro Johnson, Xin Zhou, Elena Deych, Berkley Shands, Blake Hanson, Erica Sodergren, George Weinstock, William D. Shannon
New Statistical Method Identifes Cytokines That Distinguish Stool Microbiomes, Dake Yang, Jethro Johnson, Xin Zhou, Elena Deych, Berkley Shands, Blake Hanson, Erica Sodergren, George Weinstock, William D. Shannon
Open Access Publications
No abstract provided.
De Novo Assembly Of The Brugia Malayi Genome Using Long Reads From A Single Minion Flowcell, Joseph R. Fauver, John Martin, Gary J. Weil, Makedonka Mitreva, Peter U. Fischer
De Novo Assembly Of The Brugia Malayi Genome Using Long Reads From A Single Minion Flowcell, Joseph R. Fauver, John Martin, Gary J. Weil, Makedonka Mitreva, Peter U. Fischer
Open Access Publications
No abstract provided.
The Epigenomic Landscape Of Transposable Elements Across Normal Human Development And Anatomy, Erica C. Pehrsson, Mayank N.K. Choudhary, Vasavi Sundaram, Ting Wang
The Epigenomic Landscape Of Transposable Elements Across Normal Human Development And Anatomy, Erica C. Pehrsson, Mayank N.K. Choudhary, Vasavi Sundaram, Ting Wang
Open Access Publications
No abstract provided.
Report From A Multidisciplinary Meeting On Anxiety As A Non-Motor Manifestation Of Parkinson’S Disease, Gregory M. Pontone, Eric J. Lenze, Et Al.
Report From A Multidisciplinary Meeting On Anxiety As A Non-Motor Manifestation Of Parkinson’S Disease, Gregory M. Pontone, Eric J. Lenze, Et Al.
Open Access Publications
No abstract provided.
Infammatory Bowel Disease-Associated Ubiquitin Ligase Rnf183 Promotes Lysosomal Degradation Of Dr5 And Trail-Induced Caspase Activation, Yan Wu, Yuka Kimura, Takumi Okamoto, Koji Matsuhisa, Rie Asada, Atsushi Saito, Fumika Sakaue, Kazunori Imaizumi, Masayuki Kaneko
Infammatory Bowel Disease-Associated Ubiquitin Ligase Rnf183 Promotes Lysosomal Degradation Of Dr5 And Trail-Induced Caspase Activation, Yan Wu, Yuka Kimura, Takumi Okamoto, Koji Matsuhisa, Rie Asada, Atsushi Saito, Fumika Sakaue, Kazunori Imaizumi, Masayuki Kaneko
Open Access Publications
No abstract provided.
Vaccine-Induced Skewing Of T Cell Responses Protects Against Chikungunya Virus Disease, Rebecca M Broeckel, Nicole Haese, Takeshi Ando, Igor Dmitriev, Craig N Kreklywich, John Powers, Michael Denton, Patricia Smith, Thomas E Morrison, Mark Heise, Victor Defilippis, Ilhem Messaoudi, David T Curiel, Daniel N Streblow
Vaccine-Induced Skewing Of T Cell Responses Protects Against Chikungunya Virus Disease, Rebecca M Broeckel, Nicole Haese, Takeshi Ando, Igor Dmitriev, Craig N Kreklywich, John Powers, Michael Denton, Patricia Smith, Thomas E Morrison, Mark Heise, Victor Defilippis, Ilhem Messaoudi, David T Curiel, Daniel N Streblow
Open Access Publications
Chikungunya virus (CHIKV) infections can cause severe and debilitating joint and muscular pain that can be long lasting. Current CHIKV vaccines under development rely on the generation of neutralizing antibodies for protection; however, the role of T cells in controlling CHIKV infection and disease is still unclear. Using an overlapping peptide library, we identified the CHIKV-specific T cell receptor epitopes recognized in C57BL/6 infected mice at 7 and 14 days post-infection. A fusion protein containing peptides 451, 416, a small region of nsP4, peptide 47, and an HA tag (CHKVf5) was expressed using adenovirus and cytomegalovirus-vectored vaccines. Mice vaccinated with …
Attribution Of Ghrelin To Cancer; Attempts To Unravel An Apparent Controversy, Saeed Soleyman-Jahi, Fatemeh Sadeghi, Amin Pastaki Khoshbin, Leila Khani, Venus Roosta, Kazem Zendehdel
Attribution Of Ghrelin To Cancer; Attempts To Unravel An Apparent Controversy, Saeed Soleyman-Jahi, Fatemeh Sadeghi, Amin Pastaki Khoshbin, Leila Khani, Venus Roosta, Kazem Zendehdel
Open Access Publications
Ghrelin is an endogenous peptide hormone mainly produced in the stomach. It has been known to regulate energy homeostasis, stimulate secretion of growth hormone, and mediate many other physiologic effects. Various effects attributed to ghrelin contribute to many aspects of cancer development and progression. Accordingly, a large body of evidence has emerged about the association of ghrelin with several types of cancer in scales of cell-line, animal, and human studies. However, existing data are controversial. This controversy occurs in two main domains: one is the controversial results in local effects of ghrelin on different types of human cancer cell-lines; the …