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Bjc Today

BJC Today

No abstract provided.

Reward Improves Response Inhibition By Enhancing Attentional Capture, Yanqing Wang, Todd S Braver, Shouhang Yin, Xueping Hu, Xiangpeng Wang, Antao Chen

2010-2019 OA Pubs

Reward plays a crucial role in enhancing response inhibition. While it is generally assumed that the process of response inhibition involves attentional capture and the stopping of action, it is unclear whether this reflects a direct impact of reward on response inhibition or rather an indirect mediation via attentional capture. Here, we employed a revised stop-signal task (SST) that separated these two cognitive elements, by including a continue signal that required the same motor response as in go trials, but also attention to a cue, as in stop trials. We first confirmed the engagement of the right inferior frontal gyrus …

The Transcriptional Regulator Snon Promotes The Proliferation Of Cerebellar Granule Neuron Precursors In The Postnatal Mouse Brain, Xiaoying Chen, Ayan Chanda, Yoshiho Ikeuchi, Xiaoqing Zhang, Jared V. Goodman, Naveen C. Reddy, Shahriyar P. Majidi, Dennis Y. Wu, Sarah E. Smith, Abigail Godec, Anna Oldenborg, Harrison W. Gabel, Guoyan Zhao, Shirin Bonni, Azad Bonni

Open Access Publications

Control of neuronal precursor cell proliferation is essential for normal brain development, and deregulation of this fundamental developmental event contributes to brain diseases. Typically, neuronal precursor cell proliferation extends over long periods of time during brain development. However, how neuronal precursor proliferation is regulated in a temporally specific manner remains to be elucidated. Here, we report that conditional KO of the transcriptional regulator SnoN in cerebellar granule neuron precursors robustly inhibits the proliferation of these cells and promotes their cell cycle exit at later stages of cerebellar development in the postnatal male and female mouse brain. In laser capture microdissection …

Voltage-Independent Sk-Channel Dysfunction Causes Neuronal Hyperexcitability In The Hippocampus Of Fmr1 Knock-Out Mice, Pan-Yue Deng, Dan Carlin, Young Mi Oh, Leila K. Myrick, Stephen T. Warren, Valeria Cavalli, Vitaly A. Klyachko

Open Access Publications

Neuronal hyperexcitability is one of the major characteristics of fragile X syndrome (FXS), yet the molecular mechanisms of this critical dysfunction remain poorly understood. Here we report a major role of voltage-independent potassium (K

Pacs Viewbook 2019-2020, Program In Audiology And Communication Sciences

PACS News

No abstract provided.

A Hox-Tale Regulatory Circuit For Neural Crest Patterning Is Conserved Across Vertebrates, Hugo J. Parker, Bony De Kumar, Stephen A. Green, Karin D. Prummel, Christopher Hess, Charles K. Kaufman, Christian Mosimann, Leanne M. Wiedemann, Marianne E. Bronner, Robb Krumlauf

Open Access Publications

No abstract provided.

Clinical Characterization Of Host Response To Simian Hemorrhagic Fever Virus Infection In Permissive And Refractory Hosts: A Model For Determining Mechanisms Of Vhf Pathogenesis, Adam L. Bailey, Et Al

Open Access Publications

No abstract provided.

Aav-Mediated Taz Gene Replacement Restores Mitochondrial And Cardioskeletal Function In Barth Syndrome, Silveli Suzuki-Hatano, Madhurima Saha, Skylar A. Rizzo, Rachael L. Witko, Bennett J. Gosiker, Manashwi Ramanathan, Meghan S. Soustek, Michael D. Jones, Peter B. Kang, Barry J. Byrne, W. Todd Cade, Christina A. Pacak

Open Access Publications

No abstract provided.

Clinical Trials In Multiple Sclerosis: Potential Future Trial Designs, Navid Manouchehri, Yinan Zhang, Amber Salter, Rehana Z Hussain, Hans-Peter Hartung, Bernhard Hemmer, Ralf Linker, Benjamin M Segal, Gary Cutter, Olaf Stüve

Open Access Publications

Clinical trials of new treatments in multiple sclerosis (MS) currently require large sample sizes and long durations in order to yield reliable results. The differential responses of an already heterogeneous population of MS patients to individual disease-modifying therapies (DMTs) will further complicate future trials. MS trials with smaller samples and faster outcomes are conceivable through the substitution of current clinical and MRI outcomes with objectively measureable genomic and proteomic biomarkers. Currently, biomarkers that could be utilized for diagnosis and monitoring of MS disease activity are in the early validation phase. The power of single biomarkers or multiple correlated biomarkers to …

Glopid-R Report On Chikungunya, O'Nyong-Nyong And Mayaro Virus, Part I: Biological Diagnostics, Michael S. Diamond, Et Al

Open Access Publications

No abstract provided.

Phosphatidylcholine Synthesis Through Cholinephosphate Cytidylyltransferase Is Dispensable In Leishmania Major, Samrat Moitra, Mattie C. Pawlowic, Fong-Fu Hsu, Kai Zhang

Open Access Publications

No abstract provided.

Association Of High Birth Weight With Incident Heart Failure In The Aric Study, Abdirahim Rashid, Anandita Agarwala, Eric Novak, David L. Brown

Open Access Publications

No abstract provided.

Estimates Of The 2016 Global Burden Of Kidney Disease Attributable To Ambient Fine Particulate Matter Air Pollution, Benjamin Bowe, Yan Xie, Tingting Li, Yan Yan, Hong Xian, Ziyad Al-Aly

Open Access Publications

No abstract provided.

Mild Chronic Perturbation Of Inhibition Severely Alters Hippocampal Function, Min-Yu Sun, Luke Ziolkowski, Peter Lambert, Hong-Jin Shu, Micah Keiser, Nicholas Rensing, Natasha Warikoo, Monika Martinek, Carson Platnick, Ann Benz, John Bracamontes, Gustav Akk, Joe Henry Steinbach, Charles F. Zorumski, Michael Wong, Steven Mennerick

Open Access Publications

No abstract provided.

A Short Translational Ramp Determines The Efficiency Of Protein Synthesis, Manasvi Verma, Junhong Choi, Kyle A. Cottrell, Zeno Lavagnino, Erica N. Thomas, Slavica Pavlovic-Djuranovic, Pawel Szczesny, David W. Piston, Hani S. Zaher, Joseph D. Puglisi, Sergej Djuranovic

Open Access Publications

No abstract provided.

The Single-Cell Transcriptomic Landscape Of Early Human Diabetic Nephropathy, Parker C. Wilson, Haojia Wu, Yuhei Kirita, Kohei Uchimura, Nicolas Ledru, Helmut G. Rennke, Paul A. Welling, Sushrut S. Waikar, Benjamin D. Humphreys

Open Access Publications

No abstract provided.

Deficiency Of Dietary Fiber In Slc5a8-Null Mice Promotes Bacterial Dysbiosis And Alters Colonic Epithelial Transcriptome Towards Proinflammatory Milieu, Sathish Sivaprakasam, Pramodh K. Ganapathy, Mohd Omar Faruk Sikder, Moamen Elmassry, Sabarish Ramachandran, Kameswara Rao Kottapalli, Vadivel Ganapathy

Open Access Publications

No abstract provided.

Crocodylian Head Width Allometry And Phylogenetic Prediction Of Body Size In Extinct Crocodyliforms, Haley D O'Brien, Leigha M Lynch, Kent A Vliet, John Brueggen, Gregory M Erickson, Paul M Gignac

2010-2019 OA Pubs

Body size and body-size shifts broadly impact life-history parameters of all animals, which has made accurate body-size estimates for extinct taxa an important component of understanding their paleobiology. Among extinct crocodylians and their precursors (e.g., suchians), several methods have been developed to predict body size from suites of hard-tissue proxies. Nevertheless, many have limited applications due to the disparity of some major suchian groups and biases in the fossil record. Here, we test the utility of head width (HW) as a broadly applicable body-size estimator in living and fossil suchians. We use a dataset of sexually mature male and female …

Reduction Of Leukocyte Microvascular Adherence And Preservation Of Blood-Brain Barrier Function By Superoxide-Lowering Therapies In A Piglet Model Of Neonatal Asphyxia, Jacob B. Ruden, Kevin L. Quick, Ernesto R. Gonzales, Aarti R. Shah, T. S. Park, Nan Kennedy, Laura L. Dugan, Jeffrey M. Gidday

Open Access Publications

No abstract provided.

Tau Phosphorylation Rates Measured By Mass Spectrometry Differ In The Intracellular Brain Vs. Extracellular Cerebrospinal Fluid Compartments And Are Differentially Affected By Alzheimer’S Disease, Nicolas R. Barthelemy, Nipun Mallipeddi, Paul Moiseyev, Chihiro Sato, Randall J. Bateman

Open Access Publications

No abstract provided.

Cellular And Molecular Characterization Of Multiplex Autism In Human Induced Pluripotent Stem Cell-Derived Neurons, Emily M A Lewis, Kesavan Meganathan, Dustin Baldridge, Paul Gontarz, Bo Zhang, Azad Bonni, John N Constantino, Kristen L Kroll

Open Access Publications

Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with pronounced heritability in the general population. This is largely attributable to the effects of polygenic susceptibility, with inherited liability exhibiting distinct sex differences in phenotypic expression. Attempts to model ASD in human cellular systems have principally involved rare de novo mutations associated with ASD phenocopies. However, by definition, these models are not representative of polygenic liability, which accounts for the vast share of population-attributable risk.

Methods: Here, we performed what is, to our knowledge, the first attempt to model multiplex autism using patient-derived induced pluripotent stem cells (iPSCs) in a …

Crispr/Cas9 Mediated Generation Of An Ovine Model For Infantile Neuronal Ceroid Lipofuscinosis (Cln1 Disease), S. L. Eaton, C. Proudfoot, S. G. Lillico, P. Skehel, R. A. Kline, K. Hamer, N. M. Rzechorzek, E. Clutton, R. Gregson, T. King, C. A. O'Neill, J. D. Cooper, G. Thompson, C. B. Whitelaw, T. M. Wishart

Open Access Publications

No abstract provided.

Increased Mtdna Abundance And Improved Function In Human Barth Syndrome Patient Fibroblasts Following Aav-Taz Gene Delivery, Silveli Suzuki-Hatano, Mughil Sriramvenugopal, Manash Ramanathan, Meghan Soustek, Barry J. Byrne, W. T. Cade, Peter B. Kang, Christina A. Pacak

Open Access Publications

No abstract provided.

Washington University Magazine, Spring 2019

Washington University Magazine

No abstract provided.

Comorbid Conditions Explain The Association Between Posttraumatic Stress Disorder And Incident Cardiovascular Disease, Jeffrey F. Scherrer, Joanne Salas, Beth E. Cohen, Paula P. Schnurr, F. David Schneider, Kathleen M. Chard, Peter Tuerk, Matthew J. Friedman, Sonya B. Norman, Carissa Van Den Berk-Clark, Patrick J. Lustman

Open Access Publications

No abstract provided.

First International Descriptive And Interventional Survey For Cholesterol And Non-Cholesterol Sterol Determination By Gas- And Liquid-Chromatography-Urgent Need For Harmonisation Of Analytical Methods, Dieter Lütjohann, Richard E. Ostlund, Et Al

Open Access Publications

No abstract provided.

Toward A Comprehensive View Of Cancer Immune Responsiveness: A Synopsis From The Sitc Workshop, Davide Bedognetti, David G. Denardo, Et Al

Open Access Publications

No abstract provided.

Multiplatform Urinary Metabolomics Profiling To Discriminate Cachectic From Non-Cachectic Colorectal Cancer Patients: Pilot Results From The Colocare Study, Jennifer Ose, Adetunji T Toriola, Et Al

Open Access Publications

Cachexia is a multifactorial syndrome that is characterized by loss of skeletal muscle mass in cancer patients. The biological pathways involved remain poorly characterized. Here, we compare urinary metabolic profiles in newly diagnosed colorectal cancer patients (stage I-IV) from the ColoCare Study in Heidelberg, Germany. Patients were classified as cachectic (

Regulation Of Rep Helicase Unwinding By An Auto-Inhibitory Subdomain, Monika A. Makuratha, Kevin D. Whitley, Binh Nguyen, Timothy M. Lohman, Yann R. Chemla

Open Access Publications

No abstract provided.

Sedentary Behaviors, Tv Viewing Time, And Risk Of Young-Onset Colorectal Cancer, Long H. Nguyen, Po-Hong Liu, Xiaobin Zheng, Nana Keum, Xiaoyu Zong, Xiao Li, Kana Wu, Charles S. Fuchs, Shuji Ogino, Kimmie Ng, Walter C. Willett, Andrew T. Chan, Edward L. Giovannucci, Yin Cao

Open Access Publications

No abstract provided.