Digital Commons Network^™

Identifying Risk Of Depressive Symptoms In Adults With Physical Disabilities Receiving Rehabilitation Services: Propensity Score Approaches, Yejin Lee, Ickpyo Hong, Mi Jung Lee, Hae Yean Park

Open Access Publications

No abstract provided.

Mechanisms By Which Sialylated Milk Oligosaccharides Impact Bone Biology In A Gnotobiotic Mouse Model Of Infant Undernutrition, Carrie A. Cowardin, Philip P. Ahern, Vanderlene L. Kung, Matthew C. Hibberd, Jiye Cheng, Janaki L. Guruge, Vinaik Sundaresan, Richard D. Head, Daniela Barile, David A. Mills, Michael J. Barratt, Sayeeda Huq, Tahmeed Ahmed, Jeffrey I. Gordon

Open Access Publications

No abstract provided.

A Mutation In Site-1 Protease Is Associated With A Complex Phenotype That Includes Episodic Hyperckemia And Focal Myoedema, George G. Schweitzer, Connie Gan, Robert C. Bucelli, Daniel Wegner, Robert E. Schmidt, Marwan Shinawi, Brian N. Finck, Rita T. Brookheart

Open Access Publications

No abstract provided.

A Qualitative Study Identifying Barriers And Facilitators Of Physical Activity In Rural Communities, Amanda S. Gilbert, Dixie D. Duncan, Alan M. Beck, Amy A. Eyler, Ross C. Brownson

Open Access Publications

No abstract provided.

Neuroinflammation And Myelin Status In Alzheimer’S Disease, Parkinson’S Disease, And Normal Aging Brains: A Small Sample Study, Fei Han, Richard J. Perrin, Qing Wang, Yong Wang, Joel S. Perlmutter, John C. Morris, Tammie L. S. Benzinger, Jinbin Xu

Open Access Publications

No abstract provided.

Perioperative Serum Albumin And Its Influence On Clinical Outcomes In Neonates And Infants Undergoing Cardiac Surgery With Cardiopulmonary Bypass: A Multi-Centre Retrospective Study, Brandon M. Henry, Santiago Borasino, Laura Ortmann, Mayte Figueroa, A.K.M. F. Rahman, Kristal M. Hock, Mario Briceno-Medina, Jeffrey A. Alten

Open Access Publications

No abstract provided.

(P)Ppgpp And Cody Promote Enterococcus Faecalis Virulence In A Murine Model Of Catheter-Associated Urinary Tract Infection, C. Colomer-Winter, A. L. Flores-Mireles, S. Kundra, S. J. Hultgren, J. A. Lemos

Open Access Publications

No abstract provided.

Omics Driven Understanding Of The Intestines Of Parasitic Nematodes, Douglas P. Jasmer, Bruce A. Rosa, Rahul Tyagi, Makedonka Mitreva

Open Access Publications

No abstract provided.

Modelling Resilience In Adolescence And Adversity: A Novel Framework To Inform Research And Practice, Gin S. Malhi, Pritha Das, Erica Bell, Greg Mattingly, Zola Mannie

Open Access Publications

No abstract provided.

Mechanisms Underlying Bone Loss Associated With Gut Inflammation, Ke Ke, Manoj Arra, Yousef Abu-Amer

Open Access Publications

Patients with gastrointestinal diseases frequently suffer from skeletal abnormality, characterized by reduced bone mineral density, increased fracture risk, and/or joint inflammation. This pathological process is characterized by altered immune cell activity and elevated inflammatory cytokines in the bone marrow microenvironment due to disrupted gut immune response. Gastrointestinal disease is recognized as an immune malfunction driven by multiple factors, including cytokines and signaling molecules. However, the mechanism by which intestinal inflammation magnified by gut-residing actors stimulates bone loss remains to be elucidated. In this article, we discuss the main risk factors potentially contributing to intestinal disease-associated bone loss, and summarize current …

A Review Of The Immunomodulating Components Of Maternal Breast Milk And Protection Against Necrotizing Enterocolitis, Lila S Nolan, Olivia B Parks, Misty Good

Open Access Publications

Breast milk contains immunomodulating components that are beneficial to newborns during maturation of their immune system. Human breast milk composition is influenced by an infant's gestational and chronological age, lactation stage, and the mother and infant's health status. Major immunologic components in human milk, such as secretory immunoglobulin A (IgA) and growth factors, have a known role in regulating gut barrier integrity and microbial colonization, which therefore protect against the development of a life-threatening gastrointestinal illness affecting newborn infants called necrotizing enterocolitis (NEC). Breast milk is a known protective factor in the prevention of NEC when compared with feeding with …

Changes In Food Cravings And Eating Behavior After A Dietary Carbohydrate Restriction Intervention Trial, Katherene O-B Anguah, Majid M Syed-Abdul, Qiong Hu, Miriam Jacome-Sosa, Colette Heimowitz, Vicki Cox, Elizabeth J Parks

Open Access Publications

Compared to low-fat diets, low-carbohydrate (CHO) diets cause weight loss (WL) over a faster time frame; however, it is unknown how changes in food cravings and eating behavior contribute to this more rapid WL in the early phases of dieting. We hypothesized that reductions in food cravings and improved eating behaviors would be evident even after a relatively short (4-week) duration of CHO-restriction, and that these changes would be associated with WL. Adult participants (

Adaptation Of An Evidence-Based Cardiovascular Health Intervention For Rural African Americans In The Southeast, Kiana D. Bess, Leah Frerichs, Tiffany Young, Giselle Corbie-Smith, Gaurav Dave, Kia Davis, Shirley Mcfarlin, Sable Watson, Mysha Wynn, Crystal W. Cene

Open Access Publications

No abstract provided.

Edematous Severe Acute Malnutrition Is Characterized By Hypomethylation Of Dna, Katharina V. Schulze, Mark J. Manary, Indi Trehan, Et Al.

Open Access Publications

No abstract provided.

Local Health Department Accreditation Is Associated With Organizational Supports For Evidence-Based Decision Making, Peg Allen, Stephanie Mazzucca, Renee G Parks, Mackenzie Robinson, Rachel G Tabak, Ross Brownson

Open Access Publications

No abstract provided.

Small Bowel Obstruction Secondary To Wild Banana Seed Ingestion, Divya K Natarajan, Phonexay Homthavong, Indi Trehan

Open Access Publications

No abstract provided.

Veliparib With First-Line Chemotherapy And As Maintenance Therapy In Ovarian Cancer, Robert L. Coleman, Andrea R. Hagemann, Et Al.

Open Access Publications

No abstract provided.

Syndemic Effects Of Hiv Risk Behaviours: Results From The Nhanes Study, L Smith, C Cao, X Zong, D T Mcdermott, S Stefanac, S Haider, S E Jackson, N Veronese, G F López-Sánchez, A Koyanagi, L Yang, I Grabovac

Open Access Publications

The aim of the present study is to use the syndemic framework to investigate the risk of contracting HIV in the US population. Cross-sectional analyses are from The National Health and Nutrition Examination Survey. We extracted and aggregated data on HIV antibody test, socio-demographic characteristics, alcohol use, drug use, depression, sexual behaviours and sexually transmitted diseases from cycle 2009-2010 to 2015-2016. We carried out weighted regression among young adults (20-39 years) and adults (40-59 years) separately. In total, 5230 men and 5794 women aged 20-59 years were included in the present analyses. In total, 0.8% men and 0.2% women were …

Top 10 Research Priorities In Spatial Lifecourse Epidemiology, Peng Jia, Ross C. Brownson, Et Al.

Open Access Publications

No abstract provided.

A Strategy For Building And Using A Human Reference Pangenome, Bastien Llamas, Allison Regier, Et Al

Open Access Publications

In March 2019, 45 scientists and software engineers from around the world converged at the University of California, Santa Cruz for the first pangenomics codeathon. The purpose of the meeting was to propose technical specifications and standards for a usable human pangenome as well as to build relevant tools for genome graph infrastructures. During the meeting, the group held several intense and productive discussions covering a diverse set of topics, including advantages of graph genomes over a linear reference representation, design of new methods that can leverage graph-based data structures, and novel visualization and annotation approaches for pangenomes. Additionally, the …

Bjc Today

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Bjc Today

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Bjc Today

BJC Today

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A Web-Based Calculator For The Prediction Of Severe Neurodevelopmental Impairment In Preterm Infants Using Clinical And Imaging Characteristics, Zachary A Vesoulis, Nathalie M El Ters, Maja Herco, Halana V Whitehead, Amit M Mathur

Open Access Publications

Although the most common forms of brain injury in preterm infants have been associated with adverse neurodevelopmental outcomes, existing MRI scoring systems lack specificity, do not incorporate clinical factors, and are technically challenging to perform. The objective of this study was to develop a web-based, clinically-focused prediction system which differentiates severe neurodevelopmental outcomes from normal-moderate outcomes at two years. Infants were retrospectively identified as those who were born ≤30 weeks gestation and who had MRI imaging at term-equivalent age and neurodevelopmental testing at 18⁻24 months. Each MRI was scored on injury in three domains (intraventricular hemorrhage, white matter injury, and …

Changes In The Us Burden Of Chronic Kidney Disease From 2002 To 2016: An Analysis Of The Global Burden Of Disease Study, Benjamin Bowe, Yan Xie, Tingting Li, Ali H. Mokdad, Hong Xian, Yan Yan, Geetha Maddukuri, Ziyad Al-Aly

Open Access Publications

Introduction: Over the past 15 years, changes in demographic, social, and epidemiologic trends occurred in the United States. These changes likely contributed to changes in chronic kidney disease (CKD) epidemiology.

Objective: To describe the change in burden of CKD at the US state level from 2002 to 2016.

Design, Setting, and Participants: This systematic analysis used data and methodologies from the 2016 Global Burden of Disease study in the United States. Data on CKD from 2002 to 2016 were examined at the state level.

Main Outcomes and Measures: Disability-adjusted life years (DALYs) and death due to CKD.

Results: In this …

Dietary Protein Restriction Reduces Circulating Vldl Triglyceride Levels Via Crebh-Apoa5-Dependent And -Independent Mechanisms, J Humberto Treviño-Villarreal, Valeria Tosti, Nicola Veronese, Beatrice Bertozzi, Arnold D Bullock, Robert S Figenshau, Gerald L Andriole, Luigi Fontana, Et Al

Open Access Publications

Hypertriglyceridemia is an independent risk factor for cardiovascular disease. Dietary interventions based on protein restriction (PR) reduce circulating triglycerides (TGs), but underlying mechanisms and clinical relevance remain unclear. Here, we show that 1 week of a protein-free diet without enforced calorie restriction significantly lowered circulating TGs in both lean and diet-induced obese mice. Mechanistically, the TG-lowering effect of PR was due, in part, to changes in very low-density lipoprotein (VLDL) metabolism both in liver and peripheral tissues. In the periphery, PR stimulated VLDL-TG consumption by increasing VLDL-bound APOA5 expression and promoting VLDL-TG hydrolysis and clearance from circulation. The PR-mediated increase …

Teenage Exercise Is Associated With Earlier Symptom Onset In Dysferlinopathy: A Retrospective Cohort Study, Ursula R Moore, Matthew Harms, Alan Pestronk, Et Al

Open Access Publications

No abstract provided.

Bjc Today

BJC Today

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Timing And Mechanism Of Conceptus Demise In A Complement Regulatory Membrane Protein Deficient Mouse, Michael P Triebwasser, Xiaobo Wu, Paula Bertram, Dennis E Hourcade, Donald Michael Nelson, John P Atkinson

Open Access Publications

PROBLEM: Crry is a widely expressed type 1 transmembrane complement regulatory protein in rodents which protects self-tissue by downregulating C3 activation. Crry

METHOD OF STUDY: We investigated the basis of Crry

RESULTS: We narrowed the critical period of the complement effect from 6.5 to 8.5 days post-coitus (dpc), which is immediately after the conceptus is exposed to maternal blood. Deposition by 5.5 dpc of maternal C3b on the placental vasculature lacking Crry

CONCLUSION: Our data are most consistent with the deposition of C3b being responsible for the failure of the allantois to fuse to the chorion leading to subsequent conceptus …

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BJC Today

No abstract provided.