Digital Commons Network^™

The Global Alzheimer's Association Round Robin Study On Plasma Amyloid Β Methods, Josef Pannee, Kwasi G Mawuenyega, Vitaliy Ovod, James Bollinger, Randall J Bateman, Yan Li, Et Al

Open Access Publications

Introduction: Blood-based assays to measure brain amyloid beta (Aβ) deposition are an attractive alternative to the cerebrospinal fluid (CSF)-based assays currently used in clinical settings. In this study, we examined different blood-based assays to measure Aβ and how they compare among centers and assays.

Methods: Aliquots from 81 plasma samples were distributed to 10 participating centers. Seven immunological assays and four mass-spectrometric methods were used to measure plasma Aβ concentrations.

Results: Correlations were weak for Aβ42 while Aβ40 correlations were stronger. The ratio Aβ42/Aβ40 did not improve the correlations and showed weak correlations.

Discussion: The poor correlations for Aβ42 in …

Pleiotropic Effects Between Cardiovascular Disease Risk Factors And Measures Of Cognitive And Physical Function In Long‑Lived Adults, Julia J. Yudkovicz, Ryan L. Minster, Emma Barinas-Mitchell, Kaare Christensen, Mary Feitosa, Megan S. Barker, Anne B. Newman, Allison L. Kuipers

Open Access Publications

No abstract provided.

Racial Disparities In The Sofa Score Among Patients Hospitalized With Covid-19, Benjamin Tolchin, Carol Oladele, Deron Galusha, Nitu Kashyap, Mary Showstark, Jennifer Bonito, Michelle C. Salazar, Jennifer L. Herbst, Steve Martino, Nancy Kim, Katherine A. Nash, Max Jordan Nguemeni Tiako, Shireen Roy, Rebeca Vergara Greeno, Karen Jubanyik

Open Access Publications

BACKGROUND: Sequential Organ Failure Assessment (SOFA) score predicts probability of in-hospital mortality. Many crisis standards of care suggest the use of SOFA scores to allocate medical resources during the COVID-19 pandemic.

RESEARCH QUESTION: Are SOFA scores elevated among Non-Hispanic Black and Hispanic patients hospitalized with COVID-19, compared to Non-Hispanic White patients?

STUDY DESIGN AND METHODS: Retrospective cohort study conducted in Yale New Haven Health System, including 5 hospitals with total of 2681 beds. Study population drawn from consecutive patients aged ≥18 admitted with COVID-19 from March 29th to August 1st, 2020. Patients excluded from the analysis if not their first …

Nanoparticulate Matter Exposure Results In White Matter Damage And An Inflammatory Microglial Response In An Experimental Murine Model, Michelle Connor, Krista Lamorie-Foote, Qinghai Liu, Kristina Shkirkova, Hans Baertsch, Constantinos Sioutas, Todd E. Morgan, Caleb E. Finch, William J. Mack

Open Access Publications

Exposure to ambient air pollution has been associated with white matter damage and neurocognitive decline. However, the mechanisms of this injury are not well understood and remain largely uncharacterized in experimental models. Prior studies have shown that exposure to particulate matter (PM), a sub-fraction of air pollution, results in neuroinflammation, specifically the upregulation of inflammatory microglia. This study examines white matter and axonal injury, and characterizes microglial reactivity in the corpus callosum of mice exposed to 10 weeks (150 hours) of PM. Nanoscale particulate matter (nPM, aerodynamic diameter ≤200 nm) consisting primarily of traffic-related emissions was collected from an urban …

The Treatment Gap In Osteoporosis, Nazia Ayub, Malak Faraj, Sam Ghatan, Joannes A A Reijers, Nicola Napoli, Ling Oei

Open Access Publications

Worldwide, there are millions of people who have been diagnosed with osteoporosis, a bone disease that increases the risk of fracture due to low bone mineral density and deterioration of bone architecture. In the US alone, there are approximately ten million men and women diagnosed with osteoporosis and this number is still growing. Diagnosis is made by measuring bone mineral density. Medications used for the treatment of osteoporosis are bisphosphonates, denosumab, raloxifene, and teriparatide. Recently, romosozumab has been added as well. In recent years, a number of advances have been made in the field of diagnostic methods and the diverse …

Nonliteral Language Processing Across The Lifespan, Kathrin Rothermich, Cristal Giorio, Sharon Falkins, Lindsay Leonard, Angela Roberts

2020-Current year OA Pubs

Studies investigating the effects of aging on nonliteral language processing have mainly focused on one sensory modality, for example written vignettes. In the current study, we used a video-based task to examine the effect of healthy aging on social communication perception using a novel database called RISC (Relation Inference in Social Communication). By means of an online recruitment platform, we asked young, middle-aged, and older adults between the ages of 18 and 76 (N = 100) to evaluate videos of actors using different forms of literal and nonliteral language, such as sarcasm or teasing. The participants' task was to infer …

The Genomics Of Heart Failure: Design And Rationale Of The Hermes Consortium, R. Thomas Lumbers, Douglas Mann, Et Al.

2020-Current year OA Pubs

No abstract provided.

The Perceived Challenge Of Everyday Technologies In Sweden, The United States And England: Exploring Differential Item Functioning In The Everyday Technology Use Questionnaire, Sarah Wallcook, Camilla Malinowsky, Louise Nygård, Georgina Charlesworth, Jenica Lee, Ryan Walsh, Sophie Gaber, Anders Kottorp

Open Access Publications

No abstract provided.

Hypothalamic Orexin And Mechanistic Target Of Rapamycin Activation Mediate Sleep Dysfunction In A Mouse Model Of Tuberous Sclerosis Complex, Bo Zhang, Dongjun Guo, Lirong Han, Nicholas Rensing, Akiko Satoh, Michael Wong

2020-Current year OA Pubs

Tuberous sclerosis complex (TSC) is a genetic disease related to hyperactivation of the mechanistic target of rapamycin (mTOR) pathway and manifested by neurological symptoms, such as epilepsy and sleep disorders. The pathophysiology of sleep dysfunction is poorly understood and is likely multifactorial, but may involve intrinsic biological regulators in the brain. Here, we characterized a mouse model of sleep disorders in TSC and investigated mechanisms of sleep dysfunction in this conditional knockout model involving inactivation of the Tsc1 gene in neurons and astrocytes (Tsc1

The Current State Of Hiv And Aging: Findings Presented At The 10th International Workshop On Hiv And Aging, Stephanie Shiau, Jane A. O'Halloran, Et Al.

Open Access Publications

No abstract provided.

Revisiting The Spectrum Of Bladder Health: Relationships Between Lower Urinary Tract Symptoms And Multiple Measures Of Well-Being, Siobhan Sutcliffe, Charles Cain, Tamara Bavendam, C. Neill Epperson, Colleen M. Fitzgerald, Sheila Gahagan, Alayne D. Markland, David A. Shoham, Ariana L. Smith, Kyle Rudser, Prevention Of Lower Urinary Tract Symptoms Research Consortium

Open Access Publications

No abstract provided.

Using A Developmental Perspective To Examine The Moderating Effects Of Marriage On Heavy Episodic Drinking In A Young Adult Sample Enriched For Risk, Seung Bin Cho, Rebecca L Smith, Kathleen Bucholz, Grace Chan, Howard J Edenberg, Victor Hesselbrock, John Kramer, Vivia V Mccutcheon, John Nurnberger, Marc Schuckit, Yong Zang, Danielle M Dick, Jessica E Salvatore

Open Access Publications

Many studies demonstrate that marriage protects against risky alcohol use and moderates genetic influences on alcohol outcomes; however, previous work has not considered these effects from a developmental perspective or in high-risk individuals. These represent important gaps, as it cannot be assumed that marriage has uniform effects across development or in high-risk samples. We took a longitudinal developmental approach to examine whether marital status was associated with heavy episodic drinking (HED), and whether marital status moderated polygenic influences on HED. Our sample included 937 individuals (53.25% female) from the Collaborative Study on the Genetics of Alcoholism who reported their HED …

Toxic Effects Of Endoplasmic Reticulum Stress Transducer Bbf2h7-Derived Small Peptide Fragments On Neuronal Cells, Koji Matsuhisa, Longjie Cai, Atsushi Saito, Fumika Sakaue, Yasunao Kamikawa, Sachiko Fujiwara, Rie Asada, Yukitsuka Kudo, Kazunori Imaizumi

Open Access Publications

No abstract provided.

Gut Microbiota: From The Forgotten Organ To A Potential Key Player In The Pathology Of Alzheimer's Disease, Dong-Oh Seo, David M Holtzman

Open Access Publications

More than 300 years ago, Antony van Leewenhoeck first described observing single-celled microorganisms, which he termed "animalcules," examining his saliva under a microscope. Although the idea of the coexistence of microorganisms in our body is not new, we have only recently been able to investigate their ecological relationship to our body, with the development of high-throughput molecular techniques. The diverse microorganism communities residing in our guts are established and maintained by complex interactions among microorganisms and their host. Notably, their alteration has been implicated in influencing various diseases including neurological diseases. Alzheimer's disease (AD) is the most common cause of …

Multiancestry Genome-Wide Association Study Of Lipid Levels Incorporating Gene-Alcohol Interactions, Paul S. De Vries, Yun J. Sung, Karen Schwander, Aldi T. Kraja, Mary F. Feitosa, Lisa De Las Fuentes, Renee De Mutsert, C Charles Gu, Yize Li, Treva K. Rice, Lihua Wang, Christine Williams, Mary K. Wojczynski, Michael A. Province, Dabeeru C. Rao, Et Al

Open Access Publications

A person's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multiancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in stage 1 (genome-wide discovery) and 66 studies in stage 2 (focused follow-up), for a total of 394,584 individuals from 5 ancestry groups. Analyses covered the period July 2014-November 2017. Genetic main effects and interaction effects were jointly assessed by means of a 2-degrees-of-freedom (df) test, and a 1-df test …

The Spectrum Of Bladder Health: The Relationship Between Lower Urinary Tract Symptoms And Interference With Activities, Siobhan Sutcliffe, Tamara Bavendam, Charles Cain, Neill Epperson, Colleen M. Fitzgerald, Sheila Gahagan, Alayne D. Markland, David A. Shoham, Ariana L. Smith, Mary K. Townsend, Kyle Rudser, Prevention Of Lower Urinary Tract Symptoms Research Consortium

Open Access Publications

No abstract provided.

U.S. Adolescent And Adult Women's Experiences Accessing And Using Toilets In Schools, Workplaces, And Public Spaces: A Multi-Site Focus Group Study To Inform Future Research In Bladder Health, Deepa R Camenga, Sonya S Brady, Cecilia T Hardacker, Beverly R Williams, Jeni Hebert-Beirne, Aimee S James, Kathryn Burgio, Jesse Nodora, Jean F Wyman, Amanda Berry, Lisa K Low, Prevention Of Lower Urinary Tract Symptoms (Plus) Research Consortium

Open Access Publications

The World Health Organization recognizes access to clean and safe toilets as crucial for public health. This study explored U.S. adolescent and adult cisgender women's lived experiences accessing toilets in schools, workplaces, and public spaces. As part of the Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium, we conducted 44 focus groups with female participants (n = 360; ages 11-93). Focus groups were stratified by age (11-14, 15-17, 18-25, 26-44, 45-64, 65+) and conducted across 7 geographically diverse U.S. sites from July 2017-April 2018. Using a transdisciplinary approach, we conducted conventional qualitative coding informed by our PLUS conceptual framework …

Type-2-Diabetes Alters Csf But Not Plasma Metabolomic And Ad Risk Profiles In Vervet Monkeys, Kylie Kavanagh, Stephen M. Day, Morgan C. Pait, William R. Mortiz, Christopher B. Newgard, Olga Ilkayeva, Donald A. Mcclain, Shannon L. Macauley

Open Access Publications

No abstract provided.

The Relationship Between Cognitive Dysfunction And Symptom Dimensions Across Schizophrenia, Bipolar Disorder, And Major Depressive Disorder, Fay Y. Womer, Et Al

Open Access Publications

No abstract provided.

Influence Of Environmental Factors On Social Participation Post-Stroke, Erin L. Foley, Marjorie L. Nicholas, Carolyn M. Baum, Lisa Tabor Connor

Open Access Publications

No abstract provided.

Neurocognitive Superaging In Older Adults Living With Hiv: Demographic, Neuromedical And Everyday Functioning Correlates, David B. Clifford, Et Al

Open Access Publications

No abstract provided.

Hyperadrenocorticism Of Calorie Restriction Contributes To Its Anti‐Inflammatory Action In Mice, Brian D. Allen, Chen-Yu Liao, Jianhua Shu, Louis J. Muglia, Joseph A. Majzoub, Vivian Diaz, James F. Nelson

Open Access Publications

No abstract provided.

A Clinical Trial Using Methylation Age To Evaluate Current Antiaging Practices, Josh Mitteldorf

Open Access Publications

No abstract provided.

Neuroinflammation And Myelin Status In Alzheimer’S Disease, Parkinson’S Disease, And Normal Aging Brains: A Small Sample Study, Fei Han, Richard J. Perrin, Qing Wang, Yong Wang, Joel S. Perlmutter, John C. Morris, Tammie L. S. Benzinger, Jinbin Xu

Open Access Publications

No abstract provided.

Bjc Today

BJC Today

No abstract provided.

Discovery And Validation Of Autosomal Dominant Alzheimer's Disease Mutations, Simon Hsu, Brian A Gordon, Russ Hornbeck, Joanne B Norton, Denise Levitch, Adia Louden, Ellen Ziegemeier, Robert Laforce, Jasmeer Chhatwal, Gregory S Day, Eric Mcdade, John C Morris, Anne M Fagan, Tammie L S Benzinger, Alison M Goate, Carlos Cruchaga, Randall J Bateman, Dominantly Inherited Alzheimer Network (Dian), Celeste M Karch

Open Access Publications

BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disease that is clinically characterized by progressive cognitive decline. Mutations in amyloid-β precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (PSEN2) are the pathogenic cause of autosomal dominant AD (ADAD). However, polymorphisms also exist within these genes.

METHODS: In order to distinguish polymorphisms from pathogenic mutations, the DIAN Expanded Registry has implemented an algorithm for determining ADAD pathogenicity using available information from multiple domains, including genetic, bioinformatic, clinical, imaging, and biofluid measures and in vitro analyses.

RESULTS: We propose that PSEN1 M84V, PSEN1 A396T, PSEN2 R284G, and APP T719N are likely pathogenic …

Systemic Activation Of Activin A Signaling Causes Chronic Kidney Disease-Mineral Bone Disorder, Toshifumi Sugatani

Open Access Publications

No abstract provided.

Effects Of 2 Years Of Caloric Restriction On Oxidative Status Assessed By Urinary F2‐Isoprostanes: The Calerie 2 Randomized Clinical Trial, Dora Il'yasova, Luigi Fontana, Manjushri Bhapkar, Carl F. Pieper, Ivan Spasojevic, Leanne M. Redman, Sai Krupa Das, Kim M. Huffman, William E. Kraus, The Calerie Study Investigators

Open Access Publications

No abstract provided.

Planning For A Nondriving Future: Behaviors And Beliefs Among Middle-Aged And Older Drivers, Annie C. Harmon, Ganesh M. Babulal, Jonathon M. Vivoda, Brian J. Zikmund-Fisher, David B. Carr

Open Access Publications

No abstract provided.

The Effects Of Graded Caloric Restriction: Xii. Comparison Of Mouse To Human Impact On Cellular Senescence In The Colon, Luigi Fontana, Sharon E. Mitchell, Boshi Wang, Valeria Tosti, Thijmen Van Vliet, Nicola Veronese, Beatrice Bertozzi, Dayna S. Early, Parcival Maissan, John R. Speakman, Marco Demaria

Open Access Publications

No abstract provided.