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Articles 6391 - 6420 of 8115
Full-Text Articles in Entire DC Network
Induction Of Ifn-Beta And The Innate Antiviral Response In Myeloid Cells Occurs Through An Ips-1-Dependent Signal That Does Not Require Irf-3 And Irf-7, Stephane Daffis, Mehul S. Suthar, Kristy J. Szretter, Michael Gale Jr., Michael S. Diamond
Induction Of Ifn-Beta And The Innate Antiviral Response In Myeloid Cells Occurs Through An Ips-1-Dependent Signal That Does Not Require Irf-3 And Irf-7, Stephane Daffis, Mehul S. Suthar, Kristy J. Szretter, Michael Gale Jr., Michael S. Diamond
Open Access Publications
No abstract provided.
Chronic Cyclodextrin Treatment Of Murine Niemann-Pick C Disease Ameliorates Neuronal Cholesterol And Glycosphingolipid Storage And Disease Progression, Cristin D. Davidson, Nafeeza F. Ali, Mathew C. Micsenyi, Gloria Stephney, Sophie Renault, Kostantin Dobrenis, Daniel S. Ory, Marie T. Vanier, Steven U. Walkley
Chronic Cyclodextrin Treatment Of Murine Niemann-Pick C Disease Ameliorates Neuronal Cholesterol And Glycosphingolipid Storage And Disease Progression, Cristin D. Davidson, Nafeeza F. Ali, Mathew C. Micsenyi, Gloria Stephney, Sophie Renault, Kostantin Dobrenis, Daniel S. Ory, Marie T. Vanier, Steven U. Walkley
Open Access Publications
No abstract provided.
The Effects Of Tail Biopsy For Genotyping On Behavioral Responses To Nociceptive Stimuli, Maria Elena P. Morales, Robert W. Gereau Iv
The Effects Of Tail Biopsy For Genotyping On Behavioral Responses To Nociceptive Stimuli, Maria Elena P. Morales, Robert W. Gereau Iv
Open Access Publications
No abstract provided.
Dosage Effects Of Cohesin Regulatory Factor Pds5 On Mammalian Development: Implications For Cohesinopathies, Bin Zhang, Jufang Chang, Ming Fu, Jie Huang, Rakesh Kashyap, Ezequiel Salavaggione, Sanjay Jain, Kulkarni Shashikant, Matthew A. Deardorff, Maria L. Giovannucci Uzielli, Dale Dorsett, David C. Beebe, Patrick Y. Jay, Robert O. Heuckeroth, Ian Krantz, Jeffrey Milbrandt
Dosage Effects Of Cohesin Regulatory Factor Pds5 On Mammalian Development: Implications For Cohesinopathies, Bin Zhang, Jufang Chang, Ming Fu, Jie Huang, Rakesh Kashyap, Ezequiel Salavaggione, Sanjay Jain, Kulkarni Shashikant, Matthew A. Deardorff, Maria L. Giovannucci Uzielli, Dale Dorsett, David C. Beebe, Patrick Y. Jay, Robert O. Heuckeroth, Ian Krantz, Jeffrey Milbrandt
Open Access Publications
No abstract provided.
Functional Brain Networks Develop From A ‘‘Local To Distributed’’ Organization, Damian A. Fair, Alexander L. Cohen, Jonathan D. Power, Nico U. F. Dosenbach, Jessica A. Church, Fancis M. Miezin, Bradley L. Schlaggar, Steven E. Petersen
Functional Brain Networks Develop From A ‘‘Local To Distributed’’ Organization, Damian A. Fair, Alexander L. Cohen, Jonathan D. Power, Nico U. F. Dosenbach, Jessica A. Church, Fancis M. Miezin, Bradley L. Schlaggar, Steven E. Petersen
Open Access Publications
No abstract provided.
Helminth Genomics: The Implications For Human Health, Paul J. Brindley, Makedonka Mitreva, Elodie Ghedin, Sara Lustigman
Helminth Genomics: The Implications For Human Health, Paul J. Brindley, Makedonka Mitreva, Elodie Ghedin, Sara Lustigman
Open Access Publications
No abstract provided.
Degradation Of Host Sphingomyelin Is Essential For Leishmania Virulence, Ou Zhang, Mattie C. Wilson, Wei Xu, Fong-Fu Hsu, John Turk, F. Matthew Kuhlmann, Yingwei Wang, Lynn Soong, Phillip Key, Stephen M. Beverley, Kai Zhang
Degradation Of Host Sphingomyelin Is Essential For Leishmania Virulence, Ou Zhang, Mattie C. Wilson, Wei Xu, Fong-Fu Hsu, John Turk, F. Matthew Kuhlmann, Yingwei Wang, Lynn Soong, Phillip Key, Stephen M. Beverley, Kai Zhang
Open Access Publications
No abstract provided.
Selection At A Single Locus Leads To Widespread Expansion Of Toxoplasma Gondii Lineages That Are Virulent In Mice, Asis Khan, Sonya Taylor, James W. Ajioka, Benjamin M. Rosenthal, L. David Sibley
Selection At A Single Locus Leads To Widespread Expansion Of Toxoplasma Gondii Lineages That Are Virulent In Mice, Asis Khan, Sonya Taylor, James W. Ajioka, Benjamin M. Rosenthal, L. David Sibley
Open Access Publications
No abstract provided.
A Role Of Scn9a In Human Epilepsies, As A Cause Of Febrile Seizures And As A Potential Modifier Of Dravet Syndrome, Nanda A. Singh, Chris Pappas, E. Jill Dahle, Lieve R. F. Claes, Timothy H. Pruess, Peter De Jonghe, Joel Thompson, Missy Dixon, Christina Gurnett, Andy Peiffer, H. Steve White, Francis Filloux, Mark F. Leppert
A Role Of Scn9a In Human Epilepsies, As A Cause Of Febrile Seizures And As A Potential Modifier Of Dravet Syndrome, Nanda A. Singh, Chris Pappas, E. Jill Dahle, Lieve R. F. Claes, Timothy H. Pruess, Peter De Jonghe, Joel Thompson, Missy Dixon, Christina Gurnett, Andy Peiffer, H. Steve White, Francis Filloux, Mark F. Leppert
Open Access Publications
No abstract provided.
In Vitro Growth Environment Produces Lipidomic And Electron Transport Chain Abnormalities In Mitochondria From Nontumorigenic Astrocytes And Brain Tumours, Michael A. Kiebish, Xianlin Han, Hua Cheng, Thomas N. Seyfried
In Vitro Growth Environment Produces Lipidomic And Electron Transport Chain Abnormalities In Mitochondria From Nontumorigenic Astrocytes And Brain Tumours, Michael A. Kiebish, Xianlin Han, Hua Cheng, Thomas N. Seyfried
Open Access Publications
No abstract provided.
Bringing Kash Under The Sun: The Many Faces Of Nucleo-Cytoskeletal Connections, David Razafsky, Didier Hodzic
Bringing Kash Under The Sun: The Many Faces Of Nucleo-Cytoskeletal Connections, David Razafsky, Didier Hodzic
Open Access Publications
No abstract provided.
Evidence For High Bi-Allelic Expression Of Activating Ly49 Receptors, Arefeh Rouhi, C. B. Lai, Tammy P. Cheng, Fumio Takei, Wayne M. Yokoyama, Dixie L. Mager
Evidence For High Bi-Allelic Expression Of Activating Ly49 Receptors, Arefeh Rouhi, C. B. Lai, Tammy P. Cheng, Fumio Takei, Wayne M. Yokoyama, Dixie L. Mager
Open Access Publications
No abstract provided.
Nematode.Net Update 2008: Improvements Enabling More Efficient Data Mining And Comparative Nematode Genomics, John Martin, Sahar Abubucker, Todd Wylie, Yong Yin, Zhengyuan Wang, Makedonka Mitreva
Nematode.Net Update 2008: Improvements Enabling More Efficient Data Mining And Comparative Nematode Genomics, John Martin, Sahar Abubucker, Todd Wylie, Yong Yin, Zhengyuan Wang, Makedonka Mitreva
Open Access Publications
No abstract provided.
Key Role Of T Cell Defects In Age-Related Vulnerability To West Nile Virus, James D. Brien, Jennifer L. Uhrlaub, Alec Hirsch, Clayton A. Wiley, Janko Nikolich-Zugich
Key Role Of T Cell Defects In Age-Related Vulnerability To West Nile Virus, James D. Brien, Jennifer L. Uhrlaub, Alec Hirsch, Clayton A. Wiley, Janko Nikolich-Zugich
Open Access Publications
West Nile virus (WNV) infection causes a life-threatening meningoencephalitis that becomes increasingly more prevalent over the age of 50 and is 40-50x more prevalent in people over the age of 70, compared with adults under the age of 40. In a mouse model of age-related vulnerability to WNV, we demonstrate that death correlates with increased viral titers in the brain and that this loss of virus control with age was the result of defects in the CD4 and CD8 T cell response against WNV. Specific age-related defects in T cell responses against dominant WNV epitopes were detected at the level …
Trem-2 (Triggering Receptor Expressed On Myeloid Cells 2) Is A Phagocytic Receptor For Bacteria, Elsa-Noah N'Diaye, Catherine S. Branda, Steven S. Branda, Lisette Nevarez, Marco Colonna, Clifford Lowell, Jessica A. Hamerman, William E. Seaman
Trem-2 (Triggering Receptor Expressed On Myeloid Cells 2) Is A Phagocytic Receptor For Bacteria, Elsa-Noah N'Diaye, Catherine S. Branda, Steven S. Branda, Lisette Nevarez, Marco Colonna, Clifford Lowell, Jessica A. Hamerman, William E. Seaman
Open Access Publications
Phagocytosis, which is essential for the immune response to pathogens, is initiated by specific interactions between pathogens and cell surface receptors expressed by phagocytes. This study identifies triggering receptor expressed on myeloid cells 2 (TREM-2) and its signaling counterpart DAP12 as a molecular complex that promotes phagocytosis of bacteria. Expression of TREM-2-DAP12 enables nonphagocytic Chinese hamster ovary cells to internalize bacteria. This function depends on actin cytoskeleton dynamics and the activity of the small guanosine triphosphatases Rac and Cdc42. Internalization also requires src kinase activity and tyrosine phosphorylation. In bone marrow-derived macrophages, phagocytosis is decreased in the absence of DAP12 …
Cdc42 Antagonizes Rho1 Activity At Adherens Junctions To Limit Epithelial Cell Apical Tension, Stephen J. Warner, Gregory D. Longmore
Cdc42 Antagonizes Rho1 Activity At Adherens Junctions To Limit Epithelial Cell Apical Tension, Stephen J. Warner, Gregory D. Longmore
Open Access Publications
In epithelia, cells are arranged in an orderly pattern with a defined orientation and shape. Cadherin containing apical adherens junctions (AJs) and the associated actomyosin cytoskeleton likely contribute to epithelial cell shape by providing apical tension. The Rho guanosine triphosphatases are well known regulators of cell junction formation, maintenance, and function. Specifically, Rho promotes actomyosin activity and cell contractility; however, what controls and localizes this Rho activity as epithelia remodel is unresolved. Using mosaic clonal analysis in the Drosophila melanogaster pupal eye, we find that Cdc42 is critical for limiting apical cell tension by antagonizing Rho activity at AJs. Cdc42 …
Impact Speed Does Not Determine Severity Of Spinal Cord Injury In Mice With Fixed Impact Displacement, Joong Hee Kim, Tsang-Wei Tu, Philip V. Bayly, Sheng-Kwei Song
Impact Speed Does Not Determine Severity Of Spinal Cord Injury In Mice With Fixed Impact Displacement, Joong Hee Kim, Tsang-Wei Tu, Philip V. Bayly, Sheng-Kwei Song
Open Access Publications
No abstract provided.
A Proposal For A Coordinated Effort For The Determination Of Brainwide Neuroanatomical Connectivity In Model Organisms At A Mesoscopic Scale, Joseph L. Price, David C. Van Essen, Et Al.
A Proposal For A Coordinated Effort For The Determination Of Brainwide Neuroanatomical Connectivity In Model Organisms At A Mesoscopic Scale, Joseph L. Price, David C. Van Essen, Et Al.
Open Access Publications
No abstract provided.
Identification Of Atg5-Dependent Transcriptional Changes And Increases In Mitochondrial Mass In Atg5-Deficient T Lymphocytes, Linda M. Stephenson, Brian C. Miller, Aylwin Ng, Jason Eisenberg, Zijiang Zhao, Ken Cadwell, Daniel B. Graham, Noboru N. Mizushima, Ramnik Xavier, Herbert W. Virgin, Wojciech Swat
Identification Of Atg5-Dependent Transcriptional Changes And Increases In Mitochondrial Mass In Atg5-Deficient T Lymphocytes, Linda M. Stephenson, Brian C. Miller, Aylwin Ng, Jason Eisenberg, Zijiang Zhao, Ken Cadwell, Daniel B. Graham, Noboru N. Mizushima, Ramnik Xavier, Herbert W. Virgin, Wojciech Swat
Open Access Publications
No abstract provided.
Skin-Derived Tslp Triggers Progression From Epidermal- Barrier Defects To Asthma, Shadmehr Demehri, Mitsuru Morimoto, Michael J. Holtzman, Raphael Kopan
Skin-Derived Tslp Triggers Progression From Epidermal- Barrier Defects To Asthma, Shadmehr Demehri, Mitsuru Morimoto, Michael J. Holtzman, Raphael Kopan
Open Access Publications
No abstract provided.
The Mitogen-Activated Protein Kinase Scaffold Ksr1 Is Required For Recruitment Of Extracellular Signal-Regulated Kinase To The Immunological Synapse, Emanuele Giurisato, Joseph Lin, Angus Harding, Elisa Cerutti, Marina Cella, Robert E. Lewis, Marco Colonna, Andrey S. Shaw
The Mitogen-Activated Protein Kinase Scaffold Ksr1 Is Required For Recruitment Of Extracellular Signal-Regulated Kinase To The Immunological Synapse, Emanuele Giurisato, Joseph Lin, Angus Harding, Elisa Cerutti, Marina Cella, Robert E. Lewis, Marco Colonna, Andrey S. Shaw
Open Access Publications
No abstract provided.
In Vitro And Murine Efficacy And Toxicity Studies Of Nebulized Scc1, A Methylated Caffeine-Silver(I) Complex, For Treatment Of Pulmonary Infections, Carolyn L. Cannon, Lisa A. Hogue, Ravy K. Vajravelu, George H. Capps, Aida Ibricevic, Khadijah M. Hindi, Aysegul Kascatan-Nebioglu, Michael J. Walter, Steven L. Brody, Wiley J. Youngs
In Vitro And Murine Efficacy And Toxicity Studies Of Nebulized Scc1, A Methylated Caffeine-Silver(I) Complex, For Treatment Of Pulmonary Infections, Carolyn L. Cannon, Lisa A. Hogue, Ravy K. Vajravelu, George H. Capps, Aida Ibricevic, Khadijah M. Hindi, Aysegul Kascatan-Nebioglu, Michael J. Walter, Steven L. Brody, Wiley J. Youngs
Open Access Publications
No abstract provided.
The Metal Homeostasis Protein, Lsp, Of Streptococcus Pyogenes Is Necessary For Acquisition Of Zinc And Virulence, Benjamin F. Westin, Audrey Brenot, Michael G. Caparon
The Metal Homeostasis Protein, Lsp, Of Streptococcus Pyogenes Is Necessary For Acquisition Of Zinc And Virulence, Benjamin F. Westin, Audrey Brenot, Michael G. Caparon
Open Access Publications
No abstract provided.
Mechanism For Sortase Localization And The Role Of Sortase Localization In Efficient Pilus Assembly In Enterococcus Faecalis, Kimberly Kline, Andrew L. Kau, Swaine L. Chen, Adeline Lim, Jerome S. Pinkner, Jason Rosch, Sreedhar R. Nallapareddy, Barbara E. Murray, Birgitta Henriques-Normark, Wandy Beatty, Michael G. Caparon, Scott J. Hultgren
Mechanism For Sortase Localization And The Role Of Sortase Localization In Efficient Pilus Assembly In Enterococcus Faecalis, Kimberly Kline, Andrew L. Kau, Swaine L. Chen, Adeline Lim, Jerome S. Pinkner, Jason Rosch, Sreedhar R. Nallapareddy, Barbara E. Murray, Birgitta Henriques-Normark, Wandy Beatty, Michael G. Caparon, Scott J. Hultgren
Open Access Publications
No abstract provided.
Depth Sensitivity And Image Reconstruction Analysis Of Dense Imaging Arrays For Mapping Brain Function With Diffuse Optical Tomography, Hamid Dehghani, Brian R. White, Benjamin W. Zeff, Andrew Tizzard, Joseph P. Culver
Depth Sensitivity And Image Reconstruction Analysis Of Dense Imaging Arrays For Mapping Brain Function With Diffuse Optical Tomography, Hamid Dehghani, Brian R. White, Benjamin W. Zeff, Andrew Tizzard, Joseph P. Culver
Open Access Publications
No abstract provided.
Washington University Record, December 11, 2008
Washington University Record, December 11, 2008
Washington University Record
No abstract provided.
Washington University Record, December 4, 2008
Washington University Record, December 4, 2008
Washington University Record
No abstract provided.
Washington University Record, November 20, 2008
Washington University Record, November 20, 2008
Washington University Record
No abstract provided.
Washington University Record, November 13, 2008
Washington University Record, November 13, 2008
Washington University Record
No abstract provided.
Washington University Record, November 6, 2008
Washington University Record, November 6, 2008
Washington University Record
No abstract provided.