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Washington University School of Medicine

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Renal Tumor Models: Evaluation Of Ease Of Implementation, Quality Of Composition, And Imaging Characteristics, Brian M. Benway, Jose M. Cabello, Alana C. Desai, Robert S. Figenshaw, Sam B. Bhayani Feb 2011

Renal Tumor Models: Evaluation Of Ease Of Implementation, Quality Of Composition, And Imaging Characteristics, Brian M. Benway, Jose M. Cabello, Alana C. Desai, Robert S. Figenshaw, Sam B. Bhayani

Open Access Publications

No abstract provided.


Effect Of Short-Duration Low-Magnitude Cyclic Loading Versus Immobilization On Tendon-Bone Healing After Acl Reconstruction In A Rat Model, Robert H. Brophy, David Kovacevic, Carl W. Imhauser, Mark Stasiak, Asheesh Bedi, Alice J.S. Fox, Xiang-Hua Deng, Scott A. Rodeo Feb 2011

Effect Of Short-Duration Low-Magnitude Cyclic Loading Versus Immobilization On Tendon-Bone Healing After Acl Reconstruction In A Rat Model, Robert H. Brophy, David Kovacevic, Carl W. Imhauser, Mark Stasiak, Asheesh Bedi, Alice J.S. Fox, Xiang-Hua Deng, Scott A. Rodeo

Open Access Publications

No abstract provided.


Bjc Today Feb 2011

Bjc Today

BJC Today

No abstract provided.


Calcium-Independent Inhibitory G-Protein Signaling Induces Persistent Presynaptic Muting Of Hippocampal Synapses, Devon C. Crawford, Chun Yun Chang, Krzysztof L. Hyrc, Steven Mennerick Jan 2011

Calcium-Independent Inhibitory G-Protein Signaling Induces Persistent Presynaptic Muting Of Hippocampal Synapses, Devon C. Crawford, Chun Yun Chang, Krzysztof L. Hyrc, Steven Mennerick

Open Access Publications

Adaptive forms of synaptic plasticity that reduce excitatory synaptic transmission in response to prolonged increases in neuronal activity may prevent runaway positive feedback in neuronal circuits. In hippocampal neurons, for example, glutamatergic presynaptic terminals are selectively silenced, creating "mute" synapses, after periods of increased neuronal activity or sustained depolarization. Previous work suggests that cAMP-dependent and proteasome-dependent mechanisms participate in silencing induction by depolarization, but upstream activators are unknown. We, therefore, tested the role of calcium and G-protein signaling in silencing induction in cultured hippocampal neurons. We found that silencing induction by depolarization was not dependent on rises in intracellular calcium, …


In Vitro And In Vivo Evaluation Of 64cu-Radiolabeled Kccysl Peptides For Targeting Epidermal Growth Factor Receptor-2 In Breast Carcinomas, Senthil R. Kumar, Fabio A. Gallazzi, Riccardo Ferdani, Carolyn J. Anderson, Thomas P. Quinn, Susan L. Deutscher Jan 2011

In Vitro And In Vivo Evaluation Of 64cu-Radiolabeled Kccysl Peptides For Targeting Epidermal Growth Factor Receptor-2 In Breast Carcinomas, Senthil R. Kumar, Fabio A. Gallazzi, Riccardo Ferdani, Carolyn J. Anderson, Thomas P. Quinn, Susan L. Deutscher

Open Access Publications

No abstract provided.


Pacs Bulletin 2011-2012, Program In Audiology And Communication Sciences Jan 2011

Pacs Bulletin 2011-2012, Program In Audiology And Communication Sciences

PACS News

No abstract provided.


Institute Of Clinical And Translational Sciences News, Vol. 4, Issue 2 Jan 2011

Institute Of Clinical And Translational Sciences News, Vol. 4, Issue 2

ICTS Newsletters

No abstract provided.


Institute Of Clinical And Translational Sciences News, Vol. 4, Issue 3 Jan 2011

Institute Of Clinical And Translational Sciences News, Vol. 4, Issue 3

ICTS Newsletters

No abstract provided.


Cochlear Protein Expression In Kanamycin Treated Mice, Erin A. Rellinger Jan 2011

Cochlear Protein Expression In Kanamycin Treated Mice, Erin A. Rellinger

Independent Studies and Capstones

Experiments evaluated cochlear expression of key stress proteins in kanamycin and saline treated C57BL/6J and CBA/J mice using immunocytochemistry. A qualitative approach was used to assess immunoreactivity for HSP70, HSF-1, HO-1, and TNF-α as a function of strain and treatment.


Efficacy Of A Combined Drug Therapy For Ameliorating Noise-Induced Hearing Loss, Randi Lynn Luxmore Jan 2011

Efficacy Of A Combined Drug Therapy For Ameliorating Noise-Induced Hearing Loss, Randi Lynn Luxmore

Independent Studies and Capstones

Experiments investigated the median effective dose of antiepileptic drugs and synthetic glucocorticoids for the prevention and treatment of noise-induced hearing loss for C57BL/6J mice. We also tested the possible synergistic effects of combining drugs from the two drug families.


Evaluation Of Noise Levels Experienced By Medically Fragile Neonates During Emergency Helicopter Transport, Jennifer Lynn Johnson Jan 2011

Evaluation Of Noise Levels Experienced By Medically Fragile Neonates During Emergency Helicopter Transport, Jennifer Lynn Johnson

Independent Studies and Capstones

There was a concern medically fragile infants may be exposed to high noise levels during emergency helicopter transport. This study had been initiated in 2007. Data was collected using a Larson Davis noise dosimeter. The purpose of this study was to collect additional data to evaluate the noise exposure experienced by medically fragile neonates during emergency transport via helicopter inbound/outbound of St. Louis Children’s Hospital, St. Louis, MO. The results suggested neonates may be exposed to noise levels ranging 85 to 95 dBA during transport. These high noise exposures may pose a risk to hearing.


Interactions Of Alpha And Beta Synuclein Proteins In Auditory Functioning, Sarah Jane Carls Jan 2011

Interactions Of Alpha And Beta Synuclein Proteins In Auditory Functioning, Sarah Jane Carls

Independent Studies and Capstones

Alpha-synuclein is found in synaptic terminals at the base of both inner and outer hair cells, while the beta isoform is prominently localized to spiral ganglion neuron cell bodies. The present study assessed the role of beta-synuclein in auditory function, and potential interactions between isoforms.


Lower Physical Activity Is Associated With Higher Intermuscular Adipose Tissue In People With Type 2 Diabetes And Peripheral Neuropathy, Lori J. Tuttle, David R. Sinacore, W Todd Cade, Michael J. Mueller Jan 2011

Lower Physical Activity Is Associated With Higher Intermuscular Adipose Tissue In People With Type 2 Diabetes And Peripheral Neuropathy, Lori J. Tuttle, David R. Sinacore, W Todd Cade, Michael J. Mueller

Physical Therapy Faculty Publications

No abstract provided.


Outlook Magazine, Winter 2011 Jan 2011

Outlook Magazine, Winter 2011

Outlook Magazine

No abstract provided.


Outlook Magazine, Autumn 2011 Jan 2011

Outlook Magazine, Autumn 2011

Outlook Magazine

No abstract provided.


Genetic Influences On Early Cochlear Vulnerability To Noise And Protection From Noise By Low-Dose Kanamycin In Hybrid Mice, Emily Kathleen Barden Jan 2011

Genetic Influences On Early Cochlear Vulnerability To Noise And Protection From Noise By Low-Dose Kanamycin In Hybrid Mice, Emily Kathleen Barden

Independent Studies and Capstones

Experiments evaluated both noise vulnerability and the extent of protection from noise by sub-chronic low-dose kanamycin in young F1 hybrids resulting from a cross between C57BL/6J and CBA/J inbred mice.


Cellular Signals Of Cisplatin Ototoxicity, Lindsey M. Yarnell Jan 2011

Cellular Signals Of Cisplatin Ototoxicity, Lindsey M. Yarnell

Independent Studies and Capstones

Three separate theories of inhibiting cisplatin-induced apoptosis were investigated utilizing different cellular mechanisms. Specifically, the copper transport cycle, TRPV1, and the JNK pathway were inhibited and immunohistochemistry was performed to determine levels of apoptosis. All three resulted in statistically significant effects; increasing CuSO4 levels resulted in increased apoptosis, and inhibiting TRPV1


Improving Salmonella Vector With Rec Mutation To Stabilize The Dna Cargoes, Xiangmin Zhang, Soo-Young Wanda, Karen Brenneman, Wei Kong, Xin Zhang, Kenneth Roland, Roy Curtiss Iii Jan 2011

Improving Salmonella Vector With Rec Mutation To Stabilize The Dna Cargoes, Xiangmin Zhang, Soo-Young Wanda, Karen Brenneman, Wei Kong, Xin Zhang, Kenneth Roland, Roy Curtiss Iii

Open Access Publications

No abstract provided.


Pcr-Based Genotyping Of Helicobacter Pylori Of Gambian Children And Adults Directly From Biopsy Specimens And Bacterial Cultures, Ousman Secka, Martin Antonio, Mary Tapgun, Douglas E. Berg, Christian Bottomley, Vivat Thomas, Robert Walton, Tumani Corrah, Richard A. Adegbola, Julian E. Thomas Jan 2011

Pcr-Based Genotyping Of Helicobacter Pylori Of Gambian Children And Adults Directly From Biopsy Specimens And Bacterial Cultures, Ousman Secka, Martin Antonio, Mary Tapgun, Douglas E. Berg, Christian Bottomley, Vivat Thomas, Robert Walton, Tumani Corrah, Richard A. Adegbola, Julian E. Thomas

Open Access Publications

No abstract provided.


Vacuolization Of Mucolipidosis Type Ii Mouse Exocrine Gland Cells Represents Accumulation Of Autolysosomes, Marielle Boonen, Eline Van Meel, Viola Oorschot, Judith Klumperman, Stuart Kornfeld Jan 2011

Vacuolization Of Mucolipidosis Type Ii Mouse Exocrine Gland Cells Represents Accumulation Of Autolysosomes, Marielle Boonen, Eline Van Meel, Viola Oorschot, Judith Klumperman, Stuart Kornfeld

Open Access Publications

No abstract provided.


Differential Regional And Subtype-Specific Vulnerability Of Enteric Neurons To Mitochondrial Dysfunction, Andreu Viader, Elizabeth C. Wright-Jin, Bhupinder P.S Vohra, Robert O. Heuckeroth, Jeffrey Milbrandt Jan 2011

Differential Regional And Subtype-Specific Vulnerability Of Enteric Neurons To Mitochondrial Dysfunction, Andreu Viader, Elizabeth C. Wright-Jin, Bhupinder P.S Vohra, Robert O. Heuckeroth, Jeffrey Milbrandt

Open Access Publications

No abstract provided.


Fatty-Acid Binding Proteins Modulate Sleep And Enhance Long-Term Memory Consolidation In Drosophila, Jason R. Gerstner, William M. Vanderheyden, Paul J. Shaw, Charles F. Landry, Jerry C. P. Yin Jan 2011

Fatty-Acid Binding Proteins Modulate Sleep And Enhance Long-Term Memory Consolidation In Drosophila, Jason R. Gerstner, William M. Vanderheyden, Paul J. Shaw, Charles F. Landry, Jerry C. P. Yin

Open Access Publications

No abstract provided.


Transcriptome Analysis Of Female And Male Xiphophorus Maculatus Jp 163 A, Ziping Zhang, Yilei Wang, Shuhong Wang, Jingtao Liu, Wesley Warren, Makedonka Mitreva, Ronald B. Walter Jan 2011

Transcriptome Analysis Of Female And Male Xiphophorus Maculatus Jp 163 A, Ziping Zhang, Yilei Wang, Shuhong Wang, Jingtao Liu, Wesley Warren, Makedonka Mitreva, Ronald B. Walter

Open Access Publications

No abstract provided.


Lineage Relationship Of Direct-Developing Melanocytes And Melanocyte Stem Cells In The Zebrafish, Robert C. Tryon, Charles W. Higdon, Stephen L. Johnson Jan 2011

Lineage Relationship Of Direct-Developing Melanocytes And Melanocyte Stem Cells In The Zebrafish, Robert C. Tryon, Charles W. Higdon, Stephen L. Johnson

Open Access Publications

No abstract provided.


Bioluminescent Imaging Reveals Divergent Viral Pathogenesis In Two Strains Of Stat1-Deficient Mice, And In Αßγ Interferon Receptor-Deficient Mice, Tracy Jo Pasieka, Lynne Collins, Megan A. O'Connor, Yufei Chen, Zachary M. Parker, Brent L. Berwin, David R. Piwnica-Worms, David A. Leib Jan 2011

Bioluminescent Imaging Reveals Divergent Viral Pathogenesis In Two Strains Of Stat1-Deficient Mice, And In Αßγ Interferon Receptor-Deficient Mice, Tracy Jo Pasieka, Lynne Collins, Megan A. O'Connor, Yufei Chen, Zachary M. Parker, Brent L. Berwin, David R. Piwnica-Worms, David A. Leib

Open Access Publications

No abstract provided.


Diffusion Of Mmps On The Surface Of Collagen Fibrils: The Mobile Cell Surface - Collagen Substratum Interface, Ivan E. Collier, Wesley Legant, Barry Marmer, Olga Lubman, Saveez Saffarian, Tetsuro Wakatsuki, Elliot Elson, Gregory I. Goldberg Jan 2011

Diffusion Of Mmps On The Surface Of Collagen Fibrils: The Mobile Cell Surface - Collagen Substratum Interface, Ivan E. Collier, Wesley Legant, Barry Marmer, Olga Lubman, Saveez Saffarian, Tetsuro Wakatsuki, Elliot Elson, Gregory I. Goldberg

Open Access Publications

No abstract provided.


Representation Of Vestibular And Visual Cues To Self-Motion In Ventral Intraparietal Cortex, Aihua Chen, Gregory C. Deangelis, Dora E. Angelaki Jan 2011

Representation Of Vestibular And Visual Cues To Self-Motion In Ventral Intraparietal Cortex, Aihua Chen, Gregory C. Deangelis, Dora E. Angelaki

Open Access Publications

No abstract provided.


Institute Of Clinical And Translational Sciences News, Vol. 4, Issue 1 Jan 2011

Institute Of Clinical And Translational Sciences News, Vol. 4, Issue 1

ICTS Newsletters

No abstract provided.


Memory B Cells, But Not Long-Lived Plasma Cells, Possess Antigen Specificities For Viral Escape Mutants, Whitney E. Purtha, Thomas F. Tedder, Syd Johnson, Deepta Bhattacharya, Michael S. Diamond Jan 2011

Memory B Cells, But Not Long-Lived Plasma Cells, Possess Antigen Specificities For Viral Escape Mutants, Whitney E. Purtha, Thomas F. Tedder, Syd Johnson, Deepta Bhattacharya, Michael S. Diamond

Open Access Publications

No abstract provided.


Device Advice, Lynn Henley Jan 2011

Device Advice, Lynn Henley

2011 Device Advice from the FDA

No abstract provided.