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Washington University School of Medicine

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Mechanical Unloading Activates Foxo3 To Trigger Bnip3‐Dependent Cardiomyocyte Atrophy, Dian J. Cao, Nan Jiang, Andrew Blagg, Janet L. Johnstone, Raj Gondalia, Misook Oh, Xiang Luo, Kai-Chun Yang, John M. Shelton, Beverly A. Rothermel, Thomas G. Gillette, Gerald W. Dorn, Joseph A. Hill Jan 2013

Mechanical Unloading Activates Foxo3 To Trigger Bnip3‐Dependent Cardiomyocyte Atrophy, Dian J. Cao, Nan Jiang, Andrew Blagg, Janet L. Johnstone, Raj Gondalia, Misook Oh, Xiang Luo, Kai-Chun Yang, John M. Shelton, Beverly A. Rothermel, Thomas G. Gillette, Gerald W. Dorn, Joseph A. Hill

Open Access Publications

No abstract provided.


Cd14 Directs Adventitial Macrophage Precursor Recruitment: Role In Early Abdominal Aortic Aneurysm Formation, Robert W. Thompson, Et Al Jan 2013

Cd14 Directs Adventitial Macrophage Precursor Recruitment: Role In Early Abdominal Aortic Aneurysm Formation, Robert W. Thompson, Et Al

Open Access Publications

No abstract provided.


Identification Of Novel Viruses Using Virushunter -- An Automated Data Analysis Pipeline, Guoyan Zhao, Siddharth Krishnamurthy, Zhengqiu Cai, Vsevolod L. Popov, Amelia P. Travassos Da Rossa, Hilda Guzman, Song Cao, Herbert W. Virgin, Robert B. Tesh, David Wang Jan 2013

Identification Of Novel Viruses Using Virushunter -- An Automated Data Analysis Pipeline, Guoyan Zhao, Siddharth Krishnamurthy, Zhengqiu Cai, Vsevolod L. Popov, Amelia P. Travassos Da Rossa, Hilda Guzman, Song Cao, Herbert W. Virgin, Robert B. Tesh, David Wang

Open Access Publications

No abstract provided.


A Fully Implantable Pacemaker For The Mouse: From Battery To Wireless Power, Jacob I. Laughner, Scott B. Marrus, Erik R. Zellmer, Carla J. Weinheimer, Matthew R. Macewan, Sophia X. Cui, Jeanne M. Nerbonne, Igor R. Efimov Jan 2013

A Fully Implantable Pacemaker For The Mouse: From Battery To Wireless Power, Jacob I. Laughner, Scott B. Marrus, Erik R. Zellmer, Carla J. Weinheimer, Matthew R. Macewan, Sophia X. Cui, Jeanne M. Nerbonne, Igor R. Efimov

Open Access Publications

No abstract provided.


Imaging The L-Type Amino Acid Transporter-1 (Lat1) With Zr-89 Immunopet, Oluwatayo F. Ikotun, Bernadette V. Marquez, Chaofeng Huang, Kazue Masuko, Miyamoto Daiji, Takashi Masuko, Jonathan Mcconathy, Suzanne E. Lapi Jan 2013

Imaging The L-Type Amino Acid Transporter-1 (Lat1) With Zr-89 Immunopet, Oluwatayo F. Ikotun, Bernadette V. Marquez, Chaofeng Huang, Kazue Masuko, Miyamoto Daiji, Takashi Masuko, Jonathan Mcconathy, Suzanne E. Lapi

Open Access Publications

No abstract provided.


F11r Is A Novel Monocyte Prognostic Biomarker For Malignant Glioma, Winnie W. Pong, Jason Walker, Todd Wylie, Vincent Magrini, Jingqin Luo, Ryan J. Emnett, Jaebok Choi, Matthew L. Cooper, Malachi Griffith, Obi L. Griffith, Joshua B. Rubin, Gregory N. Fuller, David Piwnica-Worms, Xi Feng, Dolores Hambardzumyan, John F. Dipersio, Elaine R. Mardis, David H. Gutmann Jan 2013

F11r Is A Novel Monocyte Prognostic Biomarker For Malignant Glioma, Winnie W. Pong, Jason Walker, Todd Wylie, Vincent Magrini, Jingqin Luo, Ryan J. Emnett, Jaebok Choi, Matthew L. Cooper, Malachi Griffith, Obi L. Griffith, Joshua B. Rubin, Gregory N. Fuller, David Piwnica-Worms, Xi Feng, Dolores Hambardzumyan, John F. Dipersio, Elaine R. Mardis, David H. Gutmann

Open Access Publications

No abstract provided.


Diagnosis Of Clostridium Difficile Infection: An Ongoing Conundrum For Clinicians And For Clinical Laboratories, Carey-Ann D. Burnham, Karen C. Carroll Jan 2013

Diagnosis Of Clostridium Difficile Infection: An Ongoing Conundrum For Clinicians And For Clinical Laboratories, Carey-Ann D. Burnham, Karen C. Carroll

Open Access Publications

No abstract provided.


Inhibitory Humoral Responses To The Plasmodium Falciparum Vaccine Candidate Eba-175 Are Independent Of The Erythrocyte Invasion Pathway, Aida S. Badiane, Amy K. Bei, Ambroise D. Ahouidi, Saurabh D. Patel, Nichole Salinas, Daouda Ndiaye, Ousmane Sarr, Omar Ndir, Niraj H. Tolia, Souleymane Mboup, Manoj T. Duraisingh Jan 2013

Inhibitory Humoral Responses To The Plasmodium Falciparum Vaccine Candidate Eba-175 Are Independent Of The Erythrocyte Invasion Pathway, Aida S. Badiane, Amy K. Bei, Ambroise D. Ahouidi, Saurabh D. Patel, Nichole Salinas, Daouda Ndiaye, Ousmane Sarr, Omar Ndir, Niraj H. Tolia, Souleymane Mboup, Manoj T. Duraisingh

Open Access Publications

No abstract provided.


Transcription Factors Ovol1 And Ovol2 Induce The Mesenchymal To Epithelial Transition In Human Cancer, Hernan Roca, James Hernandez, Savannah Weidner, Richard C. Mceachin, David Fuller, Sudha Sud, Taibriana Schumann, John E. Wilkinson, Alexander Zaslavsky, Hangwen Li, Christopher A. Maher, Stephanie Daignault-Newton, Patrick N. Healy, Kenneth J. Pienta Jan 2013

Transcription Factors Ovol1 And Ovol2 Induce The Mesenchymal To Epithelial Transition In Human Cancer, Hernan Roca, James Hernandez, Savannah Weidner, Richard C. Mceachin, David Fuller, Sudha Sud, Taibriana Schumann, John E. Wilkinson, Alexander Zaslavsky, Hangwen Li, Christopher A. Maher, Stephanie Daignault-Newton, Patrick N. Healy, Kenneth J. Pienta

Open Access Publications

No abstract provided.


Synergistic Effects Of Concurrent Blockade Of Pi3k And Mek Pathways In Pancreatic Cancer Preclinical Models, Hua Zhong, Cesar Sanchez, Dirk Spitrzer, Stacy Plambeck-Suess, Jesse Gibbs, William G. Hawkins, David Denardo, Feng Gao, Robert A. Pufahl, Albert C. Lockhart, Mai Xu, David Linehan, Jason Weber, Andrea Wang-Gillam Jan 2013

Synergistic Effects Of Concurrent Blockade Of Pi3k And Mek Pathways In Pancreatic Cancer Preclinical Models, Hua Zhong, Cesar Sanchez, Dirk Spitrzer, Stacy Plambeck-Suess, Jesse Gibbs, William G. Hawkins, David Denardo, Feng Gao, Robert A. Pufahl, Albert C. Lockhart, Mai Xu, David Linehan, Jason Weber, Andrea Wang-Gillam

Open Access Publications

No abstract provided.


Klf15 Is A Molecular Link Between Endoplasmic Reticulum Stress And Insulin Resistance, Fumihiko Urano, Et Al Jan 2013

Klf15 Is A Molecular Link Between Endoplasmic Reticulum Stress And Insulin Resistance, Fumihiko Urano, Et Al

Open Access Publications

No abstract provided.


Leucoagaricus Gongylophorus Produces Diverse Enzymes For The Degradation Of Recalcitrant Plant Polymers In Leaf-Cutter Ant Fungus Gardens, George M. Weinstock, Et Al Jan 2013

Leucoagaricus Gongylophorus Produces Diverse Enzymes For The Degradation Of Recalcitrant Plant Polymers In Leaf-Cutter Ant Fungus Gardens, George M. Weinstock, Et Al

Open Access Publications

No abstract provided.


Inhibition Of Intestinal Epithelial Apoptosis Improves Survival In A Murine Model Of Radiation Combined Injury, Enjae Jung, Erin E. Perrone, Pavan Brahmamdan, Jacquelyn S. Mcdonough, Ann M. Leathersich, Jessica A. Dominguez, Andrew T. Clark, Amy C. Fox, W. Michael Dunne, Richard S. Hotchkiss, Craig M. Coopersmith Jan 2013

Inhibition Of Intestinal Epithelial Apoptosis Improves Survival In A Murine Model Of Radiation Combined Injury, Enjae Jung, Erin E. Perrone, Pavan Brahmamdan, Jacquelyn S. Mcdonough, Ann M. Leathersich, Jessica A. Dominguez, Andrew T. Clark, Amy C. Fox, W. Michael Dunne, Richard S. Hotchkiss, Craig M. Coopersmith

Open Access Publications

No abstract provided.


Pilin And Sortase Residues Critical For Endocarditis- And Biofilm-Associated Pilus Biogenesis In Enterococcus Faecalis, Hailyn V. Nielsen, Ana L. Flores-Mireles, Andrew L. Kau, Kimberly A. Kline, Jerome S. Pinkner, Fabrice Neiers, Staffan Normark, Birgitta Henriques-Normark, Michael G. Caparon Jan 2013

Pilin And Sortase Residues Critical For Endocarditis- And Biofilm-Associated Pilus Biogenesis In Enterococcus Faecalis, Hailyn V. Nielsen, Ana L. Flores-Mireles, Andrew L. Kau, Kimberly A. Kline, Jerome S. Pinkner, Fabrice Neiers, Staffan Normark, Birgitta Henriques-Normark, Michael G. Caparon

Open Access Publications

No abstract provided.


Impact Of Six Rounds Of Mass Drug Administration On Brugian Filariasis And Soil-Transmitted Helminth Infections In Eastern Indonesia, Taniawati Supali, Yenny Djuardi, Mark Bradley, Rahmah Noordin, Paul Ruckert, Peter U. Fischer Jan 2013

Impact Of Six Rounds Of Mass Drug Administration On Brugian Filariasis And Soil-Transmitted Helminth Infections In Eastern Indonesia, Taniawati Supali, Yenny Djuardi, Mark Bradley, Rahmah Noordin, Paul Ruckert, Peter U. Fischer

Open Access Publications

No abstract provided.


Improved Function And Proliferation Of Adult Human Beta Cells Engrafted In Diabetic Immunodeficient Nod-Scid Il2rγ(Null) Mice Treated With Alogliptin, Agata Jurczyk, Philip Diiorio, Dean Brostowin, Linda Leehy, Chaoxing Yang, Fumihiko Urano, David M. Harlan, Leonard D. Shultz, Dale L. Greiner, Rita Bortell Jan 2013

Improved Function And Proliferation Of Adult Human Beta Cells Engrafted In Diabetic Immunodeficient Nod-Scid Il2rγ(Null) Mice Treated With Alogliptin, Agata Jurczyk, Philip Diiorio, Dean Brostowin, Linda Leehy, Chaoxing Yang, Fumihiko Urano, David M. Harlan, Leonard D. Shultz, Dale L. Greiner, Rita Bortell

Open Access Publications

No abstract provided.


Hiv-Infected Adolescent, Young Adult And Pregnant Smokers: Important Targets For Effective Tobacco Control Programs, Gerome Escota, Nur Önen Jan 2013

Hiv-Infected Adolescent, Young Adult And Pregnant Smokers: Important Targets For Effective Tobacco Control Programs, Gerome Escota, Nur Önen

Open Access Publications

No abstract provided.


Child-Oriented Marketing Techniques In Snack Food Packages In Guatemala, Violeta Chacon, Paola Letona, Joaquin Barnoya Jan 2013

Child-Oriented Marketing Techniques In Snack Food Packages In Guatemala, Violeta Chacon, Paola Letona, Joaquin Barnoya

Open Access Publications

No abstract provided.


An Anti-Inflammatory Nod-Like Receptor Is Required For Microglia Development, Celia E. Shiau, Kelly R. Monk, William Joo, William S. Talbot Jan 2013

An Anti-Inflammatory Nod-Like Receptor Is Required For Microglia Development, Celia E. Shiau, Kelly R. Monk, William Joo, William S. Talbot

Open Access Publications

No abstract provided.


Cerebellar Cortex Granular Layer Interneurons In The Macaque Monkey Are Functionally Driven By Mossy Fiber Pathways Through Net Excitation Or Inhibition, Jean Laurens, Shane A. Heiney, Gyutae Kim, Pablo M. Blazquez Jan 2013

Cerebellar Cortex Granular Layer Interneurons In The Macaque Monkey Are Functionally Driven By Mossy Fiber Pathways Through Net Excitation Or Inhibition, Jean Laurens, Shane A. Heiney, Gyutae Kim, Pablo M. Blazquez

Open Access Publications

No abstract provided.


An Empirical Muscle Intracellular Action Potential Model With Multiple Erlang Probability Density Functions Based On A Modified Newton Method, Gyutae Kim, Mohammed M. Ferdjallah, Frederic D. Mckenzie Jan 2013

An Empirical Muscle Intracellular Action Potential Model With Multiple Erlang Probability Density Functions Based On A Modified Newton Method, Gyutae Kim, Mohammed M. Ferdjallah, Frederic D. Mckenzie

Open Access Publications

No abstract provided.


Fecal Microbiota Diversity In Survivors Of Adolescent/Young Adult Hodgkin Lymphoma: A Study Of Twins, Wendy Cozen, Guoqin Yu, Mitchell H. Gail, Vanessa K. Ridaura, Bharat N. Nathwani, Amie E. Hwang, Ann S. Hamilton, Thomas M. Mack, Jeffrey I. Gordon, James J. Goedert Jan 2013

Fecal Microbiota Diversity In Survivors Of Adolescent/Young Adult Hodgkin Lymphoma: A Study Of Twins, Wendy Cozen, Guoqin Yu, Mitchell H. Gail, Vanessa K. Ridaura, Bharat N. Nathwani, Amie E. Hwang, Ann S. Hamilton, Thomas M. Mack, Jeffrey I. Gordon, James J. Goedert

Open Access Publications

No abstract provided.


Fgf20 Governs Formation Of Primary And Secondary Dermal Condensations In Developing Hair Follicles, Sung-Ho Huh, Katja Narhi, Paivi H. Lindfors, Otso Haara, Lu Yang, David M. Ornitz, Maria L. Mikkola Jan 2013

Fgf20 Governs Formation Of Primary And Secondary Dermal Condensations In Developing Hair Follicles, Sung-Ho Huh, Katja Narhi, Paivi H. Lindfors, Otso Haara, Lu Yang, David M. Ornitz, Maria L. Mikkola

Open Access Publications

No abstract provided.


Hdl And Glut1 Inhibition Reverse A Hypermetabolic State In Mouse Models Of Myeloproliferative Disorders, Emmanuel L. Gautier, Marit Westerterp, Neha Bhagwat, Serge Cremers, Alan Shih, Omar Abdel-Wahab, Dieter Lütjohann, Gwendalyn J. Randolph, Ross L. Levine, Alan R. Tall, Laurent Yvan-Charvet Jan 2013

Hdl And Glut1 Inhibition Reverse A Hypermetabolic State In Mouse Models Of Myeloproliferative Disorders, Emmanuel L. Gautier, Marit Westerterp, Neha Bhagwat, Serge Cremers, Alan Shih, Omar Abdel-Wahab, Dieter Lütjohann, Gwendalyn J. Randolph, Ross L. Levine, Alan R. Tall, Laurent Yvan-Charvet

Open Access Publications

A high metabolic rate in myeloproliferative disorders is a common complication of neoplasms, but the underlying mechanisms are incompletely understood. Using three different mouse models of myeloproliferative disorders, including mice with defective cholesterol efflux pathways and two models based on expression of human leukemia disease alleles, we uncovered a mechanism by which proliferating and inflammatory myeloid cells take up and oxidize glucose during the feeding period, contributing to energy dissipation and subsequent loss of adipose mass. In vivo, lentiviral inhibition of Glut1 by shRNA prevented myeloproliferation and adipose tissue loss in mice with defective cholesterol efflux pathway in leukocytes. Thus, …


Lncipedia: A Database For Annotated Human Lncrna Transcript Sequences And Structures, Pieter-Jan Volders, Kenny Helsens, Xiaowei Wang, Bjorn Menten, Lennart Martens, Kris Gevaert, Jo Vandesompele, Pieter Mestdagh Jan 2013

Lncipedia: A Database For Annotated Human Lncrna Transcript Sequences And Structures, Pieter-Jan Volders, Kenny Helsens, Xiaowei Wang, Bjorn Menten, Lennart Martens, Kris Gevaert, Jo Vandesompele, Pieter Mestdagh

Open Access Publications

No abstract provided.


Molecular Insight Into The Association Between Cartilage Regeneration And Ear Wound Healing In Genetic Mouse Models: Targeting New Genes In Regeneration, Muhammad Farooq Rai, Eric J. Schmidt, Audrey Mcalinden, James M. Cheverud, Linda J. Sandell Jan 2013

Molecular Insight Into The Association Between Cartilage Regeneration And Ear Wound Healing In Genetic Mouse Models: Targeting New Genes In Regeneration, Muhammad Farooq Rai, Eric J. Schmidt, Audrey Mcalinden, James M. Cheverud, Linda J. Sandell

Open Access Publications

No abstract provided.


Cd2ap Links Cortactin And Capping Protein At The Cell Periphery To Facilitate Formation Of Lamellipodia, Jianping Zhao, Serawit Bruck, Saso Cemerski, Lei Zhang, Boyd Butler, Adish Dani, John A. Cooper, Andrey S. Shaw Jan 2013

Cd2ap Links Cortactin And Capping Protein At The Cell Periphery To Facilitate Formation Of Lamellipodia, Jianping Zhao, Serawit Bruck, Saso Cemerski, Lei Zhang, Boyd Butler, Adish Dani, John A. Cooper, Andrey S. Shaw

Open Access Publications

Understanding the physiology of complex relationships between components of signaling pathways and the actin cytoskeleton is an important challenge. CD2AP is a membrane scaffold protein implicated in a variety of physiological and disease processes. The physiological function of CD2AP is unclear, but its biochemical interactions suggest that it has a role in dynamic actin assembly. Here, we report that CD2AP functions to facilitate the recruitment of actin capping protein (CP) to the Src kinase substrate, cortactin, at the cell periphery, and that this is necessary for formation of the short branched filaments that characterize lamellipodium formation and are required for …


Investigation Of Neovascularization In Three-Dimensional Porous Scaffolds In Vivo By A Combination Of Multiscale Photoacoustic Microscopy And Optical Coherence Tomography, Xin Cai, Yu Zhang, Li Li, Sung-Wook Choi, Matthew R. Macewan, Junjie Yao, Chulhong Kim, Younan Xia, Lihong V. Wang Jan 2013

Investigation Of Neovascularization In Three-Dimensional Porous Scaffolds In Vivo By A Combination Of Multiscale Photoacoustic Microscopy And Optical Coherence Tomography, Xin Cai, Yu Zhang, Li Li, Sung-Wook Choi, Matthew R. Macewan, Junjie Yao, Chulhong Kim, Younan Xia, Lihong V. Wang

Open Access Publications

No abstract provided.


Gene-Alcohol Interactions Identify Several Novel Blood Pressure Loci Including A Promising Locus Near Slc16a9, Jeannette Simino, Yun Ju Sung, Rezart Kume, Karen Schwander, D. C. Rao Jan 2013

Gene-Alcohol Interactions Identify Several Novel Blood Pressure Loci Including A Promising Locus Near Slc16a9, Jeannette Simino, Yun Ju Sung, Rezart Kume, Karen Schwander, D. C. Rao

Open Access Publications

No abstract provided.


Oct4/Sox2 Binding Sites Contribute To Maintaining Hypomethylation Of The Maternal Igf2/H19 Imprinting Control Region, David L. Zimmerman, Craig S. Boddy, Christopher S. Schoenherr Jan 2013

Oct4/Sox2 Binding Sites Contribute To Maintaining Hypomethylation Of The Maternal Igf2/H19 Imprinting Control Region, David L. Zimmerman, Craig S. Boddy, Christopher S. Schoenherr

Open Access Publications

No abstract provided.