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Washington University School of Medicine

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Variants Near Chrnb3-Chrna6 Are Associated With Dsm-5 Cocaine Use Disorder: Evidence For Pleiotropy, Brooke Sadler, Gabe Haller, Arpana Agrawal, Rob Culverhouse, Kathleen Bucholz, Andy Brooks, Jay Tischfield, Eric O. Johnson, Howard Edenberg, Marc Schuckit, Nancy Saccone, Laura Bierut, Alison Goate Jan 2014

Variants Near Chrnb3-Chrna6 Are Associated With Dsm-5 Cocaine Use Disorder: Evidence For Pleiotropy, Brooke Sadler, Gabe Haller, Arpana Agrawal, Rob Culverhouse, Kathleen Bucholz, Andy Brooks, Jay Tischfield, Eric O. Johnson, Howard Edenberg, Marc Schuckit, Nancy Saccone, Laura Bierut, Alison Goate

Open Access Publications

No abstract provided.


Effect Of Epigallocatechin-3-Gallate On Graft-Versus-Host Disease, Jaebok Choi, Matthew L. Cooper, Edward D. Ziga, Julie Ritchey, John F. Dipersio Jan 2014

Effect Of Epigallocatechin-3-Gallate On Graft-Versus-Host Disease, Jaebok Choi, Matthew L. Cooper, Edward D. Ziga, Julie Ritchey, John F. Dipersio

Open Access Publications

No abstract provided.


Noninvasive Imaging Of Focal Atherosclerotic Lesions Using Fluorescence Molecular Tomography, Dolonchampa Maji, Metasebya Solomon, Annie Nguyen, Richard A. Pierce, Pamela K. Woodard, Walter J. Akers, Samuel Achilefu, Joseph P. Culver, Dana R. Abendschein, Monica Shokeen Jan 2014

Noninvasive Imaging Of Focal Atherosclerotic Lesions Using Fluorescence Molecular Tomography, Dolonchampa Maji, Metasebya Solomon, Annie Nguyen, Richard A. Pierce, Pamela K. Woodard, Walter J. Akers, Samuel Achilefu, Joseph P. Culver, Dana R. Abendschein, Monica Shokeen

Open Access Publications

No abstract provided.


Neuronal Activity Regulates Extracellular Tau In Vivo, Kaoru Yamada, Jerrah K. Holth, Fan Liao, Floy R. Stewart, Thomas E. Mahan, Hong Jiang, John R. Cirrito, Tirth K. Patel, Katja Hochgräfe, Eva-Maria Mandelkow, David M. Holtzman Jan 2014

Neuronal Activity Regulates Extracellular Tau In Vivo, Kaoru Yamada, Jerrah K. Holth, Fan Liao, Floy R. Stewart, Thomas E. Mahan, Hong Jiang, John R. Cirrito, Tirth K. Patel, Katja Hochgräfe, Eva-Maria Mandelkow, David M. Holtzman

Open Access Publications

Tau is primarily a cytoplasmic protein that stabilizes microtubules. However, it is also found in the extracellular space of the brain at appreciable concentrations. Although its presence there may be relevant to the intercellular spread of tau pathology, the cellular mechanisms regulating tau release into the extracellular space are not well understood. To test this in the context of neuronal networks in vivo, we used in vivo microdialysis. Increasing neuronal activity rapidly increased the steady-state levels of extracellular tau in vivo. Importantly, presynaptic glutamate release is sufficient to drive tau release. Although tau release occurred within hours in response to …


Potential Role Of Orexin And Sleep Modulation In The Pathogenesis Of Alzheimer's Disease, Jee Hoon Roh, Hong Jiang, Mary Beth Finn, Floy R. Stewart, Thomas E. Mahan, John R. Cirrito, Ashish Heda, B. Joy Snider, Mingjie Li, Masashi Yanagisawa, Luis De Lecea, David M. Holtzman Jan 2014

Potential Role Of Orexin And Sleep Modulation In The Pathogenesis Of Alzheimer's Disease, Jee Hoon Roh, Hong Jiang, Mary Beth Finn, Floy R. Stewart, Thomas E. Mahan, John R. Cirrito, Ashish Heda, B. Joy Snider, Mingjie Li, Masashi Yanagisawa, Luis De Lecea, David M. Holtzman

Open Access Publications

Age-related aggregation of amyloid-β (Aβ) is an upstream pathological event in Alzheimer's disease (AD) pathogenesis, and it disrupts the sleep-wake cycle. The amount of sleep declines with aging and to a greater extent in AD. Poor sleep quality and insufficient amounts of sleep have been noted in humans with preclinical evidence of AD. However, how the amount and quality of sleep affects Aβ aggregation is not yet well understood. Orexins (hypocretins) initiate and maintain wakefulness, and loss of orexin-producing neurons causes narcolepsy. We tried to determine whether orexin release or secondary changes in sleep via orexin modulation affect Aβ pathology. …


High-Coverage Sequencing And Annotated Assemblies Of The Budgerigar Genome, Ganeshkumar Ganapathy, Wesley C. Warren, Et Al Jan 2014

High-Coverage Sequencing And Annotated Assemblies Of The Budgerigar Genome, Ganeshkumar Ganapathy, Wesley C. Warren, Et Al

Open Access Publications

No abstract provided.


Secondhand Smoke Exposure And Severity Of Attention-Deficit/Hyperactivity Disorder In Preschoolers: A Pilot Investigation, Mini Tandon, Christina N. Lessov-Schlaggar, Rebecca Tillman, Melbourne F. Hovell, Joan Luby Jan 2014

Secondhand Smoke Exposure And Severity Of Attention-Deficit/Hyperactivity Disorder In Preschoolers: A Pilot Investigation, Mini Tandon, Christina N. Lessov-Schlaggar, Rebecca Tillman, Melbourne F. Hovell, Joan Luby

Open Access Publications

No abstract provided.


Illustrated Techniques For Performing The Cox-Maze Iv Procedure Through A Right Mini-Thoracotomy, Jason O. Robertson, Lindsey L. Saint, Jeremy E. Leidenfrost, Ralph J. Damiano Jr. Jan 2014

Illustrated Techniques For Performing The Cox-Maze Iv Procedure Through A Right Mini-Thoracotomy, Jason O. Robertson, Lindsey L. Saint, Jeremy E. Leidenfrost, Ralph J. Damiano Jr.

Open Access Publications

No abstract provided.


Hippocampal Long-Term Potentiation Is Disrupted During Expression And Extinction But Is Restored After Reinstatement Of Morphine Place Preference, George S. Portugal, Ream Al-Hasani, Amanda K. Fakira, Jose L. Gonzalez-Romero, Zare Melyan, Jordan G. Mccall, Michael R. Bruchas, Jose A. Moron Jan 2014

Hippocampal Long-Term Potentiation Is Disrupted During Expression And Extinction But Is Restored After Reinstatement Of Morphine Place Preference, George S. Portugal, Ream Al-Hasani, Amanda K. Fakira, Jose L. Gonzalez-Romero, Zare Melyan, Jordan G. Mccall, Michael R. Bruchas, Jose A. Moron

Open Access Publications

No abstract provided.


Whole-Genome Sequencing Of Salmonella Enterica Subsp. Enterica Serovar Cubana Strains Isolated From Agricultural Sources, George Weinstock, Et Al Jan 2014

Whole-Genome Sequencing Of Salmonella Enterica Subsp. Enterica Serovar Cubana Strains Isolated From Agricultural Sources, George Weinstock, Et Al

Open Access Publications

No abstract provided.


Targeting The Programmed Cell Death 1: Programmed Cell Death Ligand 1 Pathway Reverses T Cell Exhaustion In Patients With Sepsis, Katherine Chang, Catherine Svabek, Cristina Vazquez-Guillamet, Bryan Sato, David Rasche, Strother Wilson, Paul Robbins, Nancy Ulbrandt, Joann Suzich, Jonathan Green, Andriani C. Patera, Wade Blair, Subramaniam Krishnan, Richard Hotchkiss Jan 2014

Targeting The Programmed Cell Death 1: Programmed Cell Death Ligand 1 Pathway Reverses T Cell Exhaustion In Patients With Sepsis, Katherine Chang, Catherine Svabek, Cristina Vazquez-Guillamet, Bryan Sato, David Rasche, Strother Wilson, Paul Robbins, Nancy Ulbrandt, Joann Suzich, Jonathan Green, Andriani C. Patera, Wade Blair, Subramaniam Krishnan, Richard Hotchkiss

Open Access Publications

No abstract provided.


Novel Treatment Option For Muc16-Positive Malignancies With The Targeted Trail-Based Fusion Protein Meso-Tr3, Gunjal Garg, Jesse Gibbs, Brian Belt, Matthew A. Powell, David G. Mutch, Peter Goedegebuure, Lynne Collins, David Piwnica-Worms, William G. Hawkins, Dirk Spitzer Jan 2014

Novel Treatment Option For Muc16-Positive Malignancies With The Targeted Trail-Based Fusion Protein Meso-Tr3, Gunjal Garg, Jesse Gibbs, Brian Belt, Matthew A. Powell, David G. Mutch, Peter Goedegebuure, Lynne Collins, David Piwnica-Worms, William G. Hawkins, Dirk Spitzer

Open Access Publications

No abstract provided.


Over-Expression Of Tresk K(+) Channels Reduces The Excitability Of Trigeminal Ganglion Nociceptors, Zhaohua Guo, Yu-Qing Cao Jan 2014

Over-Expression Of Tresk K(+) Channels Reduces The Excitability Of Trigeminal Ganglion Nociceptors, Zhaohua Guo, Yu-Qing Cao

Open Access Publications

No abstract provided.


High Pressure Freezing/Freeze Substitution Fixation Improves The Ultrastructural Assessment Of Wolbachia Endosymbiont – Filarial Nematode Host Interaction, Kerstin Fischer, Wandy L. Beatty, Gary J. Weil, Peter U. Fischer Jan 2014

High Pressure Freezing/Freeze Substitution Fixation Improves The Ultrastructural Assessment Of Wolbachia Endosymbiont – Filarial Nematode Host Interaction, Kerstin Fischer, Wandy L. Beatty, Gary J. Weil, Peter U. Fischer

Open Access Publications

No abstract provided.


Il-15 Deficient Tax Mice Reveal A Role For Il-1Α In Tumor Immunity, Daniel A. Rauch, John C. Harding, Lee Ratner Jan 2014

Il-15 Deficient Tax Mice Reveal A Role For Il-1Α In Tumor Immunity, Daniel A. Rauch, John C. Harding, Lee Ratner

Open Access Publications

No abstract provided.


Wise Regulates Bone Deposition Through Genetic Interactions With Lrp5, Debra L. Ellies, Androulla Economou, Beth Viviano, Jean-Philippe Rey, Stephanie Paine-Saunders, Robb Krumlauf, Scott Saunders Jan 2014

Wise Regulates Bone Deposition Through Genetic Interactions With Lrp5, Debra L. Ellies, Androulla Economou, Beth Viviano, Jean-Philippe Rey, Stephanie Paine-Saunders, Robb Krumlauf, Scott Saunders

Open Access Publications

No abstract provided.


Impact Of Host Age And Parity On Susceptibility To Severe Urinary Tract Infection In A Murine Model, Kimberly A. Kline, Drew J. Schwartz, Nicole M. Gilbert, Amanda L. Lewis Jan 2014

Impact Of Host Age And Parity On Susceptibility To Severe Urinary Tract Infection In A Murine Model, Kimberly A. Kline, Drew J. Schwartz, Nicole M. Gilbert, Amanda L. Lewis

Open Access Publications

No abstract provided.


Increased Iron Sequestration In Alveolar Macrophages In Chronic Obtructive Pulmonary Disease, Quentin Philippot, Gaetan Deslee, Tracy L. Adair-Kirk, Jason C. Woods, Derek Byers, Susan Conradi, Sandra Dury, Jeanne Marie Perotin, Francois Lebargy, Christelle Cassan, Richard Le Naour, Michael J. Holtzman, Richard A. Pierce Jan 2014

Increased Iron Sequestration In Alveolar Macrophages In Chronic Obtructive Pulmonary Disease, Quentin Philippot, Gaetan Deslee, Tracy L. Adair-Kirk, Jason C. Woods, Derek Byers, Susan Conradi, Sandra Dury, Jeanne Marie Perotin, Francois Lebargy, Christelle Cassan, Richard Le Naour, Michael J. Holtzman, Richard A. Pierce

Open Access Publications

No abstract provided.


Arabidopsis Thaliana Glyoxalase 2-1 Is Required During Abiotic Stress But Is Not Essential Under Normal Plant Growth, Sriram Devanathan, Alexander Erban, Rodolfo Perez-Torres, Joachim Kopka, Christopher A. Makaroff Jan 2014

Arabidopsis Thaliana Glyoxalase 2-1 Is Required During Abiotic Stress But Is Not Essential Under Normal Plant Growth, Sriram Devanathan, Alexander Erban, Rodolfo Perez-Torres, Joachim Kopka, Christopher A. Makaroff

Open Access Publications

No abstract provided.


The Role Of Neutrophil Myeloperoxidase In Models Of Lung Tumor Development, Amy Rymaszewski, Everett Tate, Joannes P. Yimbesalu, Andrew E. Gelman, Jason A. Jarzembowski, Hao Zhang, Kirkwood A. Pritchard Jr., Haris G. Vikis Jan 2014

The Role Of Neutrophil Myeloperoxidase In Models Of Lung Tumor Development, Amy Rymaszewski, Everett Tate, Joannes P. Yimbesalu, Andrew E. Gelman, Jason A. Jarzembowski, Hao Zhang, Kirkwood A. Pritchard Jr., Haris G. Vikis

Open Access Publications

No abstract provided.


Chemokines In The Balance: Maintenance Of Homeostasis And Protection At Cns Barriers, Jessica L. Williams, David W. Holman, Robyn S. Klein Jan 2014

Chemokines In The Balance: Maintenance Of Homeostasis And Protection At Cns Barriers, Jessica L. Williams, David W. Holman, Robyn S. Klein

Open Access Publications

No abstract provided.


Anti-Apoe Antibody Given After Plaque Onset Decreases Aβ Accumulation And Improves Brain Function In A Mouse Model Of Aβ Amyloidosis, Fan Liao, Adam Q. Bauer, Hong Jiang, Thomas E. Mahan, Katheryn B. Lefton, Tony J. Zhang, Joshua T. Dearborn, Joseph P. Culver, David F. Wozniak, David M. Holtzman, Et Al Jan 2014

Anti-Apoe Antibody Given After Plaque Onset Decreases Aβ Accumulation And Improves Brain Function In A Mouse Model Of Aβ Amyloidosis, Fan Liao, Adam Q. Bauer, Hong Jiang, Thomas E. Mahan, Katheryn B. Lefton, Tony J. Zhang, Joshua T. Dearborn, Joseph P. Culver, David F. Wozniak, David M. Holtzman, Et Al

Open Access Publications

No abstract provided.


Tumor-Induced Stat3 Activation In Monocytic Myeloid-Derived Suppressor Cells Enhances Stemness And Mesenchymal Properties In Human Pancreatic Cancer, Roheena Z. Panni, Dominic E. Sanford, Brian A. Belt, Jonathan B. Mitchem, Lori A. Worley, Brian D. Goetz, Pinku Mukherjee, Andrea Wang-Gillam, Daniel C. Link, David G. Denardo, S. Peter Goedegebuure, David C. Linehan Jan 2014

Tumor-Induced Stat3 Activation In Monocytic Myeloid-Derived Suppressor Cells Enhances Stemness And Mesenchymal Properties In Human Pancreatic Cancer, Roheena Z. Panni, Dominic E. Sanford, Brian A. Belt, Jonathan B. Mitchem, Lori A. Worley, Brian D. Goetz, Pinku Mukherjee, Andrea Wang-Gillam, Daniel C. Link, David G. Denardo, S. Peter Goedegebuure, David C. Linehan

Open Access Publications

No abstract provided.


Altered Microglial Response To Aβ Plaques In Appps1-21 Mice Heterozygous For Trem2, Jason D. Ulrich, Mary Beth Finn, Yaming Wang, Alice Shen, Thomas E. Mahan, Hong Jiang, Floy R. Stewart, Laura Piccio, Marco Colonna, David M. Holtman Jan 2014

Altered Microglial Response To Aβ Plaques In Appps1-21 Mice Heterozygous For Trem2, Jason D. Ulrich, Mary Beth Finn, Yaming Wang, Alice Shen, Thomas E. Mahan, Hong Jiang, Floy R. Stewart, Laura Piccio, Marco Colonna, David M. Holtman

Open Access Publications

No abstract provided.


Astrocytes Modulate The Polarization Of Cd4+ T Cells To Th1 Cells, Eleonore Beurel, Laurie E. Harrington, William Buchser, Vance Lemmon, Richard S. Jope Jan 2014

Astrocytes Modulate The Polarization Of Cd4+ T Cells To Th1 Cells, Eleonore Beurel, Laurie E. Harrington, William Buchser, Vance Lemmon, Richard S. Jope

Open Access Publications

No abstract provided.


Genetic Modulation Of Soluble Aβ Rescues Cognitive And Synaptic Impairment In A Mouse Model Of Alzheimer's Disease, Stephanie W. Fowler, Angie C A Chiang, Ricky R. Savjani, Mathew A. Sherman, Dorothy R. Schuler, Sylvain E. Lesne, Joanna L. Jankowsky, John R. Cirrito Jan 2014

Genetic Modulation Of Soluble Aβ Rescues Cognitive And Synaptic Impairment In A Mouse Model Of Alzheimer's Disease, Stephanie W. Fowler, Angie C A Chiang, Ricky R. Savjani, Mathew A. Sherman, Dorothy R. Schuler, Sylvain E. Lesne, Joanna L. Jankowsky, John R. Cirrito

Open Access Publications

No abstract provided.


Designing Vaccines To Neutralize Effective Toxin Delivery By Enterotoxigenic Escherichia Coli, James M. Fleckenstein, Alaullah Sheikh Jan 2014

Designing Vaccines To Neutralize Effective Toxin Delivery By Enterotoxigenic Escherichia Coli, James M. Fleckenstein, Alaullah Sheikh

Open Access Publications

No abstract provided.


Phosphorylation Of Ribosomal Protein S6 Confers Parp Inhibitor Resistance In Brca1-Deficient Cancers, Chong-Kui Sun, Fan Zhang, Tao Xiang, Qianming Chen, Tej K. Pandita, Yuping Huang, Mickey C T Hu, Qin Yang Jan 2014

Phosphorylation Of Ribosomal Protein S6 Confers Parp Inhibitor Resistance In Brca1-Deficient Cancers, Chong-Kui Sun, Fan Zhang, Tao Xiang, Qianming Chen, Tej K. Pandita, Yuping Huang, Mickey C T Hu, Qin Yang

Open Access Publications

No abstract provided.


Cns Amyloid-Β, Soluble App-Α And-Β Kinetics During Bace Inhibition, Justyna A. Dobrowolska, Bruce W. Patterson, Robert Chott, Vitality Ovod, Yuriy Pyatkivskyy, Kristin R. Wildsmith, Tom Kasten, Kevin E. Yarasheski, Randall J. Bateman, Et Al Jan 2014

Cns Amyloid-Β, Soluble App-Α And-Β Kinetics During Bace Inhibition, Justyna A. Dobrowolska, Bruce W. Patterson, Robert Chott, Vitality Ovod, Yuriy Pyatkivskyy, Kristin R. Wildsmith, Tom Kasten, Kevin E. Yarasheski, Randall J. Bateman, Et Al

Open Access Publications

No abstract provided.


Inputs Drive Cell Phenotype Variability, James Park, Anthony Brureau, Kate Kernan, Alexandria Starks, Sonali Gulati, Babatunde Ogunnaike, James Schwaber, Rajanikanth Vadigepalli Jan 2014

Inputs Drive Cell Phenotype Variability, James Park, Anthony Brureau, Kate Kernan, Alexandria Starks, Sonali Gulati, Babatunde Ogunnaike, James Schwaber, Rajanikanth Vadigepalli

Open Access Publications

No abstract provided.