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Articles 4711 - 4740 of 8116
Full-Text Articles in Entire DC Network
Finely Tuned Temporal And Spatial Delivery Of Gdnf Promotes Enhanced Nerve Regeneration In A Long Nerve Defect Model, Laura M. Marquardt, Xueping Ee, Nisha Iyer, Daniel Hunter, Susan E. Mackinnon, Matthew D. Wood, Shelly E. Sakiyama-Elbert
Finely Tuned Temporal And Spatial Delivery Of Gdnf Promotes Enhanced Nerve Regeneration In A Long Nerve Defect Model, Laura M. Marquardt, Xueping Ee, Nisha Iyer, Daniel Hunter, Susan E. Mackinnon, Matthew D. Wood, Shelly E. Sakiyama-Elbert
Open Access Publications
No abstract provided.
Progressive Hearing Loss In Mice Carrying A Mutation In Usp53, Marcin Kazmierczak, Suzan L. Harris, Piotr Kazmierczak, Prahar Shah, Valentin Starovoytov, Kevin K. Ohlemiller, Martin Schwander
Progressive Hearing Loss In Mice Carrying A Mutation In Usp53, Marcin Kazmierczak, Suzan L. Harris, Piotr Kazmierczak, Prahar Shah, Valentin Starovoytov, Kevin K. Ohlemiller, Martin Schwander
Open Access Publications
UNLABELLED: Disordered protein ubiquitination has been linked to neurodegenerative disease, yet its role in inner ear homeostasis and hearing loss is essentially unknown. Here we show that progressive hearing loss in the ethylnitrosourea-generated mambo mouse line is caused by a mutation in Usp53, a member of the deubiquitinating enzyme family. USP53 contains a catalytically inactive ubiquitin-specific protease domain and is expressed in cochlear hair cells and a subset of supporting cells. Although hair cell differentiation is unaffected in mambo mice, outer hair cells degenerate rapidly after the first postnatal week. USP53 colocalizes and interacts with the tight junction scaffolding proteins …
The Licensing Function Of Galenic Anatomical Procedures, Text And Practice, Luis Alejandro Salas
The Licensing Function Of Galenic Anatomical Procedures, Text And Practice, Luis Alejandro Salas
Presentations
No abstract provided.
In Vivo Evaluation Of Adipose-Derived Stromal Cells Delivered With A Nanofiber Scaffold For Tendon-To-Bone Repair, Justin Lipner, Hua Shen, Leonardo Cavinatto, Wenying Liu, Necat Havlioglu, Younan Xia, Leesa M. Galatz, Stavros Thomopoulos
In Vivo Evaluation Of Adipose-Derived Stromal Cells Delivered With A Nanofiber Scaffold For Tendon-To-Bone Repair, Justin Lipner, Hua Shen, Leonardo Cavinatto, Wenying Liu, Necat Havlioglu, Younan Xia, Leesa M. Galatz, Stavros Thomopoulos
Open Access Publications
No abstract provided.
Propagated Infra-Slow Intrinsic Brain Activity Reorganizes Across Wake And Slow Wave Sleep, Anish Mitra, Abraham Z. Snyder, Enzo Tagliazucchi, Helmut Laufs, Marcus E. Raichle
Propagated Infra-Slow Intrinsic Brain Activity Reorganizes Across Wake And Slow Wave Sleep, Anish Mitra, Abraham Z. Snyder, Enzo Tagliazucchi, Helmut Laufs, Marcus E. Raichle
Open Access Publications
Propagation of slow intrinsic brain activity has been widely observed in electrophysiogical studies of slow wave sleep (SWS). However, in human resting state fMRI (rs-fMRI), intrinsic activity has been understood predominantly in terms of zero-lag temporal synchrony (functional connectivity) within systems known as resting state networks (RSNs). Prior rs-fMRI studies have found that RSNs are generally preserved across wake and sleep. Here, we use a recently developed analysis technique to study propagation of infra-slow intrinsic blood oxygen level dependent (BOLD) signals in normal adults during wake and SWS. This analysis reveals marked changes in propagation patterns in SWS vs. wake. …
Optics Of Cone Photoreceptors In The Chicken (Gallus Gallus Domesticus), David Wilby, Matthew B Toomey, Peter Olsson, Rikard Frederiksen, M Carter Cornwall, Ruth Oulton, Almut Kelber, Joseph C Corbo, Nicholas W Roberts
Optics Of Cone Photoreceptors In The Chicken (Gallus Gallus Domesticus), David Wilby, Matthew B Toomey, Peter Olsson, Rikard Frederiksen, M Carter Cornwall, Ruth Oulton, Almut Kelber, Joseph C Corbo, Nicholas W Roberts
2010-2019 OA Pubs
Vision is the primary sensory modality of birds, and its importance is evident in the sophistication of their visual systems. Coloured oil droplets in the cone photoreceptors represent an adaptation in the avian retina, acting as long-pass colour filters. However, we currently lack understanding of how the optical properties and morphology of component structures (e.g. oil droplet, mitochondrial ellipsoid and outer segment) of the cone photoreceptor influence the transmission of light into the outer segment and the ultimate effect they have on receptor sensitivity. In this study, we use data from microspectrophotometry, digital holographic microscopy and electron microscopy to inform …
Human And Murine Ifit1 Proteins Do Not Restrict Infection Of Negative-Sense Rna Viruses Of The Orthomyxoviridae, Bunyaviridae, And Filoviridae Families, Amelia K. Pinto, Graham D. Williams, Kristy J. Szretter, James P. White, José Luiz Proença-Módena, Gai Liu, Judith Olejnik, James D. Brien, Hideki Ebihara, Elke Mühlberger, Gaya Amarasinghe, Michael S. Diamond, Adrianus C.M. Boon
Human And Murine Ifit1 Proteins Do Not Restrict Infection Of Negative-Sense Rna Viruses Of The Orthomyxoviridae, Bunyaviridae, And Filoviridae Families, Amelia K. Pinto, Graham D. Williams, Kristy J. Szretter, James P. White, José Luiz Proença-Módena, Gai Liu, Judith Olejnik, James D. Brien, Hideki Ebihara, Elke Mühlberger, Gaya Amarasinghe, Michael S. Diamond, Adrianus C.M. Boon
Open Access Publications
UNLABELLED: Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) is a host protein with reported cell-intrinsic antiviral activity against several RNA viruses. The proposed basis for the activity against negative-sense RNA viruses is the binding to exposed 5'-triphosphates (5'-ppp) on the genome of viral RNA. However, recent studies reported relatively low binding affinities of IFIT1 for 5'-ppp RNA, suggesting that IFIT1 may not interact efficiently with this moiety under physiological conditions. To evaluate the ability of IFIT1 to have an impact on negative-sense RNA viruses, we infected Ifit1(-/-) and wild-type control mice and primary cells with four negative-sense RNA viruses (influenza …
Hepatocyte Growth Factor And Met Support Mouse Enteric Nervous System Development, The Peristaltic Response, And Intestinal Epithelial Proliferation In Response To Injury, Marina Avetisyan, Hongtao Wang, Ellen Merrick Schill, Saya Bery, John R. Grider, John A. Hassell, Thaddeus Stappenbeck, Robert O. Heuckeroth
Hepatocyte Growth Factor And Met Support Mouse Enteric Nervous System Development, The Peristaltic Response, And Intestinal Epithelial Proliferation In Response To Injury, Marina Avetisyan, Hongtao Wang, Ellen Merrick Schill, Saya Bery, John R. Grider, John A. Hassell, Thaddeus Stappenbeck, Robert O. Heuckeroth
Open Access Publications
UNLABELLED: Factors providing trophic support to diverse enteric neuron subtypes remain poorly understood. We tested the hypothesis that hepatocyte growth factor (HGF) and the HGF receptor MET might support some types of enteric neurons. HGF and MET are expressed in fetal and adult enteric nervous system. In vitro, HGF increased enteric neuron differentiation and neurite length, but only if vanishingly small amounts (1 pg/ml) of glial cell line-derived neurotrophic factor were included in culture media. HGF effects were blocked by phosphatidylinositol-3 kinase inhibitor and by MET-blocking antibody. Both of these inhibitors and MEK inhibition reduced neurite length. In adult mice, …
Temperatures Achieved In Human And Canine Neocortex During Intraoperative Passive Or Active Focal Cooling, Matthew D. Smyth, Rowland H. Han, Chester K. Yarbrough, Edward E. Patterson, Xiao-Feng Yang, John W. Miller, Steven M. Rothman, Raimondo D'Ambrosio
Temperatures Achieved In Human And Canine Neocortex During Intraoperative Passive Or Active Focal Cooling, Matthew D. Smyth, Rowland H. Han, Chester K. Yarbrough, Edward E. Patterson, Xiao-Feng Yang, John W. Miller, Steven M. Rothman, Raimondo D'Ambrosio
Open Access Publications
No abstract provided.
Selective Deletion Of Cochlear Hair Cells Causes Rapid Age-Dependent Changes In Spiral Ganglion And Cochlear Nucleus Neurons, Ling Tong, Melissa K. Strong, Tejbeer Kaur, Jose M. Juiz, Elizabeth C. Oesterle, Clifford Hume, Mark E. Warchol, Richard D. Palmiter, Edwin W. Rubel
Selective Deletion Of Cochlear Hair Cells Causes Rapid Age-Dependent Changes In Spiral Ganglion And Cochlear Nucleus Neurons, Ling Tong, Melissa K. Strong, Tejbeer Kaur, Jose M. Juiz, Elizabeth C. Oesterle, Clifford Hume, Mark E. Warchol, Richard D. Palmiter, Edwin W. Rubel
Open Access Publications
During nervous system development, critical periods are usually defined as early periods during which manipulations dramatically change neuronal structure or function, whereas the same manipulations in mature animals have little or no effect on the same property. Neurons in the ventral cochlear nucleus (CN) are dependent on excitatory afferent input for survival during a critical period of development. Cochlear removal in young mammals and birds results in rapid death of target neurons in the CN. Cochlear removal in older animals results in little or no neuron death. However, the extent to which hair-cell-specific afferent activity prevents neuronal death in the …
Mechanism-Based Combination Treatment Dramatically Increases Therapeutic Efficacy In Murine Globoid Cell Leukodystrophy, Jacqueline A. Hawkins-Salsbury, Lauren Shea, Xuntian Jiang, Daniel A. Hunter, A Miguel Guzman, Adarsh S. Reddy, Elizabeth Y. Qin, Yedda Li, Steven J. Gray, Daniel S. Ory, Mark S. Sands
Mechanism-Based Combination Treatment Dramatically Increases Therapeutic Efficacy In Murine Globoid Cell Leukodystrophy, Jacqueline A. Hawkins-Salsbury, Lauren Shea, Xuntian Jiang, Daniel A. Hunter, A Miguel Guzman, Adarsh S. Reddy, Elizabeth Y. Qin, Yedda Li, Steven J. Gray, Daniel S. Ory, Mark S. Sands
Open Access Publications
Globoid cell leukodystrophy (GLD, Krabbe disease) is a lysosomal storage disease (LSD) caused by a deficiency in galactocerebrosidase (GALC) activity. In the absence of GALC activity, the cytotoxic lipid, galactosylsphingosine (psychosine), accumulates in the CNS and peripheral nervous system. Oligodendrocytes and Schwann cells are particularly sensitive to psychosine, thus leading to a demyelinating phenotype. Although hematopoietic stem-cell transplantation provides modest benefit in both presymptomatic children and the murine model (Twitcher), there is no cure for GLD. In addition, GLD has been relatively refractory to virtually every experimental therapy attempted. Here, Twitcher mice were simultaneously treated with CNS-directed gene therapy, substrate …
Adamtsl2 Deletion Results In Bronchial Fibrillin Microfibril Accumulation And Bronchial Epithelial Dysplasia: A Novel Mouse Model Providing Insights On Geleophysic Dysplasia, Dirk Hubmacher, Lauren W. Wang, Robert P. Mecham, Dieter P. Reinhardt, Suneel S. Apte
Adamtsl2 Deletion Results In Bronchial Fibrillin Microfibril Accumulation And Bronchial Epithelial Dysplasia: A Novel Mouse Model Providing Insights On Geleophysic Dysplasia, Dirk Hubmacher, Lauren W. Wang, Robert P. Mecham, Dieter P. Reinhardt, Suneel S. Apte
Open Access Publications
No abstract provided.
Uni-Directional Ciliary Membrane Protein Trafficking By A Cytoplasmic Retrograde Ift Motor And Ciliary Ectosome Shedding, Muqing Cao, Jue Ning, Carmen I. Hernandez-Lara, Olivier Belzile, Qian Wang, Susan K. Dutcher, Yanjie Liu, William J. Snell
Uni-Directional Ciliary Membrane Protein Trafficking By A Cytoplasmic Retrograde Ift Motor And Ciliary Ectosome Shedding, Muqing Cao, Jue Ning, Carmen I. Hernandez-Lara, Olivier Belzile, Qian Wang, Susan K. Dutcher, Yanjie Liu, William J. Snell
Open Access Publications
The role of the primary cilium in key signaling pathways depends on dynamic regulation of ciliary membrane protein composition, yet we know little about the motors or membrane events that regulate ciliary membrane protein trafficking in existing organelles. Recently, we showed that cilium-generated signaling in Chlamydomonas induced rapid, anterograde IFT-independent, cytoplasmic microtubule-dependent redistribution of the membrane polypeptide, SAG1-C65, from the plasma membrane to the periciliary region and the ciliary membrane. Here, we report that the retrograde IFT motor, cytoplasmic dynein 1b, is required in the cytoplasm for this rapid redistribution. Furthermore, signaling-induced trafficking of SAG1-C65 into cilia is unidirectional and …
Together: Every Woman's Guide To Preventing Breast Cancer, Graham A. Colditz, Katherine N. Weilbaecher, Hank Dart
Together: Every Woman's Guide To Preventing Breast Cancer, Graham A. Colditz, Katherine N. Weilbaecher, Hank Dart
Cancer Prevention Faculty Publications
No abstract provided.
The Role Of Emotional Perception Abilities In Developing Friendships Between Young Children With Hearing Loss And Their Peers With Typical Hearing, April Lyn Wade
Independent Studies and Capstones
This paper will discuss the importance of emotional perception skills among children with hearing loss and those with typical hearing. It will also investigate the role that emotional perception plays in the formation of friendships.
Changes Of Cochlear Function During Cochlear Fluids Manipulations, Kathryn Marie Donovan
Changes Of Cochlear Function During Cochlear Fluids Manipulations, Kathryn Marie Donovan
Independent Studies and Capstones
Spatial origins of compound action potential responses to varying stimulation rates, frequencies, and levels were investigated. A technique to measure the regions in the cochlea generating each response in which a neurotoxic drug (kainic acid) is slowly injected into the cochlear apex was used. This induces a progressive ablation of responses from apex (low frequency) to base (high frequency), allowing the spatial origins of cochlear responses to be quantified.
Using Click-Evoked Auditory Brainstem Response Waveforms To Measure Hearing Loss In The Bottlenose Dolphin (Tursiops Truncatus), Krysta L. Gasser Rutledge
Using Click-Evoked Auditory Brainstem Response Waveforms To Measure Hearing Loss In The Bottlenose Dolphin (Tursiops Truncatus), Krysta L. Gasser Rutledge
Independent Studies and Capstones
Developing an improved methodology for efficient and informative hearing assessment in marine mammals would prove insightful in expanding current knowledge regarding marine mammal hearing sensitivity, particularly in studying the effects of anthropogenic noise. This study examines the click-evoked auditory brainstem response in relation to upper frequency limit of hearing in the bottlenose dolphin (Tursiops truncatus) as a proxy for hearing capacity.
Neuroimaging In Tourette Syndrome: Research Highlights From 2014 To 2015, Deanna J. Greene, Bradley L. Schlaggar, Kevin J. Black
Neuroimaging In Tourette Syndrome: Research Highlights From 2014 To 2015, Deanna J. Greene, Bradley L. Schlaggar, Kevin J. Black
Psychiatry Faculty Publications
No abstract provided.
Strial Capillary Permeability Studied With Fluorescent Tracers In Inbred Mice, Kaela Christine Fahrenthold
Strial Capillary Permeability Studied With Fluorescent Tracers In Inbred Mice, Kaela Christine Fahrenthold
Independent Studies and Capstones
The stria vascularis generates the endocochlear potential (EP), which relies on the maintenance of ionic boundaries. Strial and spiral ligament capillary permeability to FITC-conjugated dextrans and other tracers was assessed in mice of different strains, with and without prior systemic application of mannitol. Mannitol appeared to increase strial capillary permeability to 4 kDa FITC-dextran and effects of mannitol were clearest for post-injection times of less than 2 hours. Present results agree with previous work in suggesting that cochlear capillaries are very ‘leaky’ under normal conditions.
Highly Sensitive Image-Derived Indices Of Water-Stressed Plants Using Hyperspectral Imaging In Swir And Histogram Analysis, David M. Kim, Hairong Zhang, Haiying Zhou, Tommy Du, Qian Wu, Todd C. Mockler, Mikhail Y. Berezin
Highly Sensitive Image-Derived Indices Of Water-Stressed Plants Using Hyperspectral Imaging In Swir And Histogram Analysis, David M. Kim, Hairong Zhang, Haiying Zhou, Tommy Du, Qian Wu, Todd C. Mockler, Mikhail Y. Berezin
Open Access Publications
No abstract provided.
Cortical Alpha Activity Predicts The Confidence In An Impending Action, Jan Kubanek, N. Jeremy Hill, Lawrence H. Snyder, Gerwin Schalk
Cortical Alpha Activity Predicts The Confidence In An Impending Action, Jan Kubanek, N. Jeremy Hill, Lawrence H. Snyder, Gerwin Schalk
Open Access Publications
No abstract provided.