Digital Commons Network^™

Adam17 Substrate Release In Proximal Tubule Drives Kidney Fibrosis, Eirini Kefaloyianni, Muthu Lakshmi Muthu, Jakob Kaeppler, Xiaoming Sun, Venkata Sabbisetti, Athena Chalaris, Stefan Rose-John, Eitan Wong, Irit Sagi, Sushrut S. Waikar, Helmut Rennke, Benjamin D. Humphreys, Joseph V. Bonventre, Andreas Herrlich

Open Access Publications

Kidney fibrosis following kidney injury is an unresolved health problem and causes significant morbidity and mortality worldwide. In a study into its molecular mechanism, we identified essential causative features. Acute or chronic kidney injury causes sustained elevation of a disintegrin and metalloprotease 17 (ADAM17); of its cleavage-activated proligand substrates, in particular of pro-TNFα and the EGFR ligand amphiregulin (pro-AREG); and of the substrates' receptors. As a consequence, EGFR is persistently activated and triggers the synthesis and release of proinflammatory and profibrotic factors, resulting in macrophage/neutrophil ingress and fibrosis. ADAM17 hypomorphic mice, specific ADAM17 inhibitor-treated WT mice, or mice with inducible …

Multiple Mechanisms For Processing Reward Uncertainty In The Primate Basal Forebrain, Noah M. Ledbetter, Charles D. Chen, Ilya E. Monosov

Open Access Publications

UNLABELLED: The ability to use information about the uncertainty of future outcomes is critical for adaptive behavior in an uncertain world. We show that the basal forebrain (BF) contains at least two distinct neural-coding strategies to support this capacity. The dorsal-lateral BF, including the ventral pallidum (VP), contains reward-sensitive neurons, some of which are selectively suppressed by uncertain-reward predictions (U(-)). In contrast, the medial BF (mBF) contains reward-sensitive neurons, some of which are selectively enhanced (U(+)) by uncertain-reward predictions. In a two-alternative choice-task, U(-) neurons were selectively suppressed while monkeys chose uncertain options over certain options. During the same choice-epoch, …

Using Diffusion Tractography To Predict Cortical Connection Strength And Distance: A Quantitative Comparison With Tracers In The Monkey, Chad J. Donahue, Stamatios N. Sotiropoulos, Saad Jbabdi, Moises Hernandez-Fernandez, Timothy E. Behrens, Tim B. Dyrby, Timothy Coalson, Henry Kennedy, Kenneth Knoblauch, David C. Van Essen, Matthew F. Glasser

Open Access Publications

UNLABELLED: Tractography based on diffusion MRI offers the promise of characterizing many aspects of long-distance connectivity in the brain, but requires quantitative validation to assess its strengths and limitations. Here, we evaluate tractography's ability to estimate the presence and strength of connections between areas of macaque neocortex by comparing its results with published data from retrograde tracer injections. Probabilistic tractography was performed on high-quality postmortem diffusion imaging scans from two Old World monkey brains. Tractography connection weights were estimated using a fractional scaling method based on normalized streamline density. We found a correlation between log-transformed tractography and tracer connection weights …

Bjc Today

BJC Today

No abstract provided.

Asfotase Alfa Therapy For Children With Hypophosphatasia, Michael P. Whyte, Katherine L. Madson, Dawn Phillips, Amy L. Reeves, William H. Mcalister, Amy Yakimoski, Karen E. Mack, Kim Hamilton, Kori Kagan, Kenji P. Fujita, David D. Thompson, Scott Moseley, Tatjana Odrljin, Cheryl Rockman-Greenberg

Open Access Publications

No abstract provided.

Tmem184b Promotes Axon Degeneration And Neuromuscular Junction Maintenance, Martha R.C. Bhattacharya, Stefanie Geisler, Sara K. Pittman, Ryan A. Doan, Conrad C. Weihl, Jeffrey Milbrandt, Aaron Diantonio

Open Access Publications

UNLABELLED: Complex nervous systems achieve proper connectivity during development and must maintain these connections throughout life. The processes of axon and synaptic maintenance and axon degeneration after injury are jointly controlled by a number of proteins within neurons, including ubiquitin ligases and mitogen activated protein kinases. However, our understanding of these molecular cascades is incomplete. Here we describe the phenotype resulting from mutation of TMEM184b, a protein identified in a screen for axon degeneration mediators. TMEM184b is highly expressed in the mouse nervous system and is found in recycling endosomes in neuronal cell bodies and axons. Disruption of TMEM184b expression …

Functional Significance Of The Discordance Between Transcriptional Profile And Left Ventricular Structure/Function During Reverse Remodeling, Veli K. Topkara, Kari T. Chambers, Kai-Chien Yang, Huei-Ping Tzeng, Sarah Evans, Carla Weinheimer, Attila Kovacs, Jeffrey Robbins, Philip Barger, Douglas L. Mann

Open Access Publications

To elucidate the mechanisms for reverse LV remodeling, we generated a conditional (doxycycline [dox] off) transgenic mouse tetracycline transactivating factor-TRAF2 (tTA-TRAF2) that develops a dilated heart failure (HF) phenotype upon expression of a proinflammatory transgene, TNF receptor-associated factor 2 (TRAF2), and complete normalization of LV structure and function when the transgene is suppressed. tTA-TRAF2 mice developed a significant increase in LV dimension with decreased contractile function, which was completely normalized in the tTA-TRAF2 mice fed dox for 4 weeks (tTA-TRAF2

Maturation Of Nav And Kv Channel Topographies In The Auditory Nerve Spike Initiator Before And After Developmental Onset Of Hearing Function, Kyunghee X. Kim, Mark A. Rutherford

Open Access Publications

No abstract provided.

Oncomodulin, An Ef-Hand Ca2+ Buffer, Is Critical For Maintaining Cochlear Function In Mice, Benton Tong, Aubrey J. Hornak, Stéphane F. Maison, Kevin K. Ohlemiller, M Charles Liberman, Dwayne D. Simmons

Open Access Publications

UNLABELLED: Oncomodulin (Ocm), a member of the parvalbumin family of calcium binding proteins, is expressed predominantly by cochlear outer hair cells in subcellular regions associated with either mechanoelectric transduction or electromotility. Targeted deletion of Ocm caused progressive cochlear dysfunction. Although sound-evoked responses are normal at 1 month, by 4 months, mutants show only minimal distortion product otoacoustic emissions and 70-80 dB threshold shifts in auditory brainstem responses. Thus, Ocm is not critical for cochlear development but does play an essential role for cochlear function in the adult mouse.

SIGNIFICANCE STATEMENT: Numerous proteins act as buffers, sensors, or pumps to control …

Decision Aids Can Support Cancer Clinical Trials Decisions: Results Of A Randomized Trial, Mary C. Politi, Marie D. Kuzemchak, Kimberly A. Kaphingst, Hannah Perkins, Jingxia Liu, Margaret M. Byrne

Public Health Faculty Publications

No abstract provided.

Electronic Books: Are They Effective Educational Tools For Students Who Are Deaf Or Hard Of Hearing?, Ainsley Vaughan

Independent Studies and Capstones

This literature review will examine the effectiveness of electronic book features on students’ reading development in the general education population and investigate whether or not these digital tools could be a useful tool and/or supplement in literacy for students who are deaf and hard of hearing.

Selective Targeting Of Il-2 To Nkg2d Bearing Cells For Improved Immunotherapy, Reza Ghasemi, Eric Lazear, Xiaoli Wang, Saeed Arefanian, Alexander Zheleznyak, Beatriz M. Carreno, Ryuji Higashikubo, Andrew E. Gelman, Daniel Kreisel, Daved H. Fremont, Alexander Sasha Krupnick

Open Access Publications

No abstract provided.

Chemical Chaperone Tudca Prevents Apoptosis And Improves Survival During Polymicrobial Sepsis In Mice, Marcel Doerflinger, Jason Glab, Christina Nedeva, Irvin Jose, Ann Lin, Lorraine O’Reilly, Cody Allison, Marc Pellegrini, Richard S. Hotchkiss, Hamsa Puthalakath

Open Access Publications

No abstract provided.

Spatially- And Temporally-Controlled Postnatal P53 Knockdown Cooperates With Embryonic Schwann Cell Precursor Nf1 Gene Loss To Promote Malignant Peripheral Nerve Sheath Tumor Formation, Angela C. Hirbe, Sonika Dahiya, Dinorah Friedmann-Morvinski, Inder M. Verma, D. Wade Clapp, David H. Gutmann

Open Access Publications

No abstract provided.

Antibody-Drug Conjugate Targeting Cd46 Eliminates Multiple Myeloma Cells, Daniel W. Sherbenou, Blake T. Aftab, Yang Su, Christopher R. Behrens, Arun Wiita, Aaron C. Logan, Diego Acosta-Alvear, Byron C. Hann, Peter Walter, Marc A. Shuman, Xiaobo Wu, John P. Atkinson, Jeffrey L. Wolf, Thomas G. Martin, Bin Liu

Open Access Publications

No abstract provided.

Coa Protects Against The Deleterious Effects Of Caloric Overload In Drosophila, Laura Palanker Musselman, Jill L. Fink, Thomas J. Baranski

Open Access Publications

No abstract provided.

Tourette Syndrome Research Highlights 2015 [Version 1; Referees: 3 Approved], Cheryl A. Richards, Kevin J. Black

Open Access Publications

No abstract provided.

Inflammation In Benign Prostate Tissue And Prostate Cancer In The Finasteride Arm Of The Prostate Cancer Prevention Trial, Teemu J. Murtola, Bora Gurel, Martin Umbehr, M. Scott Lucia, Ian M. Thompson Jr., Phyllis J. Goodman, Alan R. Kristal, Howard L. Parnes, Scott M. Lippman, Siobhan Sutcliffe, Sarah B. Peskoe, John R. Barber, Charles G. Drake, William G. Nelson, Angelo M. De Marzo, Elizabeth A. Platz

Cancer Prevention Faculty Publications

No abstract provided.

Inhibition Of Dna Methyltransferases Blocks Mutant Huntingtin-Induced Neurotoxicity, Yanchun Pan, Takuji Daito, Yo Sasaki, Yong Hee Chung, Xiaoyun Xing, Santhi Pondugula, S. Joshua Swamidass, Ting Wang, Albert H. Kim, Hiroko Yano

Open Access Publications

No abstract provided.

Enhanced Itch Elicited By Capsaicin In A Chronic Itch Model, Guang Yu, Fengxian Li, Changxiong J. Guo, Qin Liu, Et Al

Open Access Publications

No abstract provided.

Genseed-Hmm: A Tool For Progressive Assembly Using Profile Hmms As Seeds And Its Application In Alpavirinae Viral Discovery From Metagenomic Data, João M.P. Alves, Andre L. De Oliveira, Tatiana O.M. Sandberg, Jaime L. Moreno-Gallego, Marcelo A.F. De Toledo, Elisabeth M.M. De Moura, Liliane S. Oliveira, Alan M. Durham, Dolores U. Mehnert, Paolo M. De A. Zanotto, Alejandro Reyes, Arthur Gruber

Open Access Publications

No abstract provided.

Critical Evaluation Of The Expression Of Gastrin-Releasing Peptide In Dorsal Root Ganglia And Spinal Cord, Devin M. Barry, Hui Li, Xian-Yu Liu, Kai-Feng Shen, Xue-Ting Liu, Zhen-Yu Wu, Admire Munanairi, Xiao-Jun Chen, Jun Yin, Yan-Gang Sun, Yun-Qing Li, Zhou-Feng Chen

Open Access Publications

No abstract provided.

Case Report: Severe Cutaneous Leishmaniasis In A Human Immunodeficiency Virus Patient Coinfected With Leishmania Braziliensis And Its Endosymbiotic Virus, Laurent Parmentier, Alexia Cusini, Norbert Müller, Haroun Zangger, Mary-Anne Hartley, Chantal Desponds, Patrik Castiglioni, Patrick Dubach, Catherine Ronet, Stephen M. Beverley, Nicolas Fasel

Open Access Publications

No abstract provided.

Local Generation Of Kynurenines Mediates Inhibition Of Neutrophil Chemotaxis By Uropathogenic Escherichia Coli, Jennifer A. Loughman, Melanie L. Yarbrough, Kristin M. Tiemann, David A. Hunstad

Open Access Publications

No abstract provided.

Rna-Seq Of The Caribbean Reef-Building Coral Orbicella Faveolata (Scleractinia-Merulinidae) Under Bleaching And Disease Stress Expands Models Of Coral Innate Immunity, David A. Anderson, Marcus E. Walz, Ernesto Weil, Peter Tonellato, Matthew C. Smith

Open Access Publications

No abstract provided.

Hyperthermic Laser Ablation Of Recurrent Glioblastoma Leads To Temporary Disruption Of The Peritumoral Blood Brain Barrier, Eric C. Leuthardt, Chong Duan, Michael J. Kim, Jian L. Campian, Albert H. Kim, Michelle M. Miller-Thomas, Joshua S. Shimony, David D. Tran

Open Access Publications

No abstract provided.

The Yersiniabactin-Associated Atp Binding Cassette Proteins Ybtp And Ybtq Enhance Escherichia Coli Fitness During High-Titer Cystitis, Eun-Ik Koh, Chia S. Hung, Jeffrey P. Henderson

Open Access Publications

No abstract provided.

Small Molecule Dual-Inhibitors Of Trpv4 And Trpa1 For Attenuation Of Inflammation And Pain, Patrick Kanju, Yong Chen, Whasil Lee, Michele Yeo, Suk Hee Lee, Joelle Romac, Rafiq Shahid, Ping Fan, David M. Gooden, Sidney A. Simon, Ivan Spasojevic, Robert A. Mook, Rodger A. Liddle, Farshid Guilack, Wolfgang B. Liedtke

Open Access Publications

No abstract provided.

Evolutionary Inactivation Of A Sialidase In Group B Streptococcus, Masaya Yamaguchi, Yujiro Hirose, Masanobu Nakata, Satoshi Uchiyama, Yuka Yamaguchi, Kana Goto, Tomoko Sumitomo, Amanda L. Lewis, Shigetada Kawabata, Victor Nizet

Open Access Publications

No abstract provided.

Endothelial To Mesenchymal Transition Is Common In Atherosclerotic Lesions And Is Associated With Plaque Instability, Gwendalyn J. Randolph, Et Al

Open Access Publications

No abstract provided.