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Articles 4021 - 4050 of 8118
Full-Text Articles in Entire DC Network
Bioelectric-Calcineurin Signaling Module Regulates Allometric Growth And Size Of The Zebrafish Fin, Jacob M. Daane, Jennifer Lanni, Ina Rothenberg, Guiscard Seebohm, Charles W. Higdon, Stephen L. Johnson, Matthew P. Harris
Bioelectric-Calcineurin Signaling Module Regulates Allometric Growth And Size Of The Zebrafish Fin, Jacob M. Daane, Jennifer Lanni, Ina Rothenberg, Guiscard Seebohm, Charles W. Higdon, Stephen L. Johnson, Matthew P. Harris
Open Access Publications
No abstract provided.
Apoε4 Disrupts Neurovascular Regulation And Undermines White Matter Integrity And Cognitive Function, Kenzo Koizumi, Yorito Hattori, Sung Ji Ahn, Izaskun Buendia, Antonio Ciacciarelli, Ken Uekawa, Gang Wang, Abigail Hiller, Lingzhi Zhao, Henning U. Voss, Steven M. Paul, Chris Schaffer, Laibaik Park, Constantino Iadecola
Apoε4 Disrupts Neurovascular Regulation And Undermines White Matter Integrity And Cognitive Function, Kenzo Koizumi, Yorito Hattori, Sung Ji Ahn, Izaskun Buendia, Antonio Ciacciarelli, Ken Uekawa, Gang Wang, Abigail Hiller, Lingzhi Zhao, Henning U. Voss, Steven M. Paul, Chris Schaffer, Laibaik Park, Constantino Iadecola
Open Access Publications
No abstract provided.
High-Throughput Scaffold-Free Microtissues Through 3d Printing, Christen J. Boyer, David H. Ballard, Mansoureh Barzegar, J. Winny Yun, Jennifer E. Woerner, Ghali E. Ghali, Moheb Boktor, Yuping Wang, J. Steven Alexander
High-Throughput Scaffold-Free Microtissues Through 3d Printing, Christen J. Boyer, David H. Ballard, Mansoureh Barzegar, J. Winny Yun, Jennifer E. Woerner, Ghali E. Ghali, Moheb Boktor, Yuping Wang, J. Steven Alexander
Open Access Publications
No abstract provided.
3d Printing Of Surgical Hernia Meshes Impregnated With Contrast Agents: In Vitro Proof Of Concept With Imaging Characteristics On Computed Tomography, David H. Ballard, Udayabhanu Jammalamadaka, Karthik Tappa, Jeffery A. Weisman, Christen J. Boyer, Jonathan Steven Alexander, Pamela K. Woodard
3d Printing Of Surgical Hernia Meshes Impregnated With Contrast Agents: In Vitro Proof Of Concept With Imaging Characteristics On Computed Tomography, David H. Ballard, Udayabhanu Jammalamadaka, Karthik Tappa, Jeffery A. Weisman, Christen J. Boyer, Jonathan Steven Alexander, Pamela K. Woodard
Open Access Publications
No abstract provided.
Efficacy Of A T Cell-Biased Adenovirus Vector As A Zika Virus Vaccine, Brianna L. Bullard, Brigette N. Corder, Matthew J. Gorman, Michael S. Diamond, Eric A. Weaver
Efficacy Of A T Cell-Biased Adenovirus Vector As A Zika Virus Vaccine, Brianna L. Bullard, Brigette N. Corder, Matthew J. Gorman, Michael S. Diamond, Eric A. Weaver
Open Access Publications
No abstract provided.
Myopathy Associated Bag3 Mutations Lead To Protein Aggregation By Stalling Hsp70 Networks, Rocio Bengoechea, Conrad C. Weihl
Myopathy Associated Bag3 Mutations Lead To Protein Aggregation By Stalling Hsp70 Networks, Rocio Bengoechea, Conrad C. Weihl
Open Access Publications
No abstract provided.
Randomized, Double-Blind, Phase Ii Study Of Temozolomide In Combination With Either Veliparib Or Placebo In Patients With Relapsed-Sensitive Or Refractory Small-Cell Lung Cancer, M. Catherine Pietanza, Saiama N. Waqar, Et Al
Randomized, Double-Blind, Phase Ii Study Of Temozolomide In Combination With Either Veliparib Or Placebo In Patients With Relapsed-Sensitive Or Refractory Small-Cell Lung Cancer, M. Catherine Pietanza, Saiama N. Waqar, Et Al
Open Access Publications
No abstract provided.
Disrupted Cholesterol Metabolism Promotes Age-Related Photoreceptor Neurodegeneration, Norimitsu Ban, Tae Jun Lee, Abdoulaye Sene, Zhenyu Dong, Andrea Santeford, Jonathan B. Lin, Daniel S. Ory, Rajendra S. Apte
Disrupted Cholesterol Metabolism Promotes Age-Related Photoreceptor Neurodegeneration, Norimitsu Ban, Tae Jun Lee, Abdoulaye Sene, Zhenyu Dong, Andrea Santeford, Jonathan B. Lin, Daniel S. Ory, Rajendra S. Apte
Open Access Publications
No abstract provided.
Cftr/Enac-Dependent Regulation Of Membrane Potential During Human Sperm Capacitation Is Initiated By Bicarbonate Uptake Through Nbc, Lis C. Puga Molina, Nicolás A. Pinto, Nicolás I. Torres, Ana L. González-Cota, Guillermina M. Luque, Paula A. Balestrini, Ana Romarowski, Dario Krapf, Celia M. Santi, Claudia L. Treviño, Alberto Darszon, Mariano G. Buffone
Cftr/Enac-Dependent Regulation Of Membrane Potential During Human Sperm Capacitation Is Initiated By Bicarbonate Uptake Through Nbc, Lis C. Puga Molina, Nicolás A. Pinto, Nicolás I. Torres, Ana L. González-Cota, Guillermina M. Luque, Paula A. Balestrini, Ana Romarowski, Dario Krapf, Celia M. Santi, Claudia L. Treviño, Alberto Darszon, Mariano G. Buffone
Open Access Publications
No abstract provided.
Lysmd3 Is A Type Ii Membrane Protein Without An In Vivo Role In The Response To A Range Of Pathogens, Christine C. Yokoyama, Megan T. Baldridge, Daisy W. Leung, Guoyan Zhao, Chandni Desai, Ta-Chiang Liu, Jeremy P. Huynh, Jacqueline M. Kimmey, Camaron R. Hole, Rachel A. Idol, Sunmin Park, Caihong Wang, Ashley Viehmann Milam, Scott A. Handley, Indira U. Mysorekar, Paul M. Allen, Mary C. Dinauer, Tamara L. Doering, Christina L. Stallings, Gaya K. Amarasinghe, Craig A. Micchelli, Herbert W. Virgin, Et Al.
Lysmd3 Is A Type Ii Membrane Protein Without An In Vivo Role In The Response To A Range Of Pathogens, Christine C. Yokoyama, Megan T. Baldridge, Daisy W. Leung, Guoyan Zhao, Chandni Desai, Ta-Chiang Liu, Jeremy P. Huynh, Jacqueline M. Kimmey, Camaron R. Hole, Rachel A. Idol, Sunmin Park, Caihong Wang, Ashley Viehmann Milam, Scott A. Handley, Indira U. Mysorekar, Paul M. Allen, Mary C. Dinauer, Tamara L. Doering, Christina L. Stallings, Gaya K. Amarasinghe, Craig A. Micchelli, Herbert W. Virgin, Et Al.
Open Access Publications
No abstract provided.
Catsper Channels Are Regulated By Protein Kinase A, Gerardo Orta, José Luis De La Vega-Beltran, David Martin-Hidalgo, Celia M. Santi, Pablo E. Visconti, Alberto Darszon
Catsper Channels Are Regulated By Protein Kinase A, Gerardo Orta, José Luis De La Vega-Beltran, David Martin-Hidalgo, Celia M. Santi, Pablo E. Visconti, Alberto Darszon
Open Access Publications
No abstract provided.
Guanylate Cyclase–Activating Protein 2 Contributes To Phototransduction And Light Adaptation In Mouse Cone Photoreceptors, Frans Vinberg, Igor V. Peshenko, Jeannie Chen, Alexander M. Dizhoor, Vladimir J. Kefalov
Guanylate Cyclase–Activating Protein 2 Contributes To Phototransduction And Light Adaptation In Mouse Cone Photoreceptors, Frans Vinberg, Igor V. Peshenko, Jeannie Chen, Alexander M. Dizhoor, Vladimir J. Kefalov
Open Access Publications
No abstract provided.
Polyamines And Potassium Channels: A 25-Year Romance, Colin G. Nichols, Sun-Joo Lee
Polyamines And Potassium Channels: A 25-Year Romance, Colin G. Nichols, Sun-Joo Lee
Open Access Publications
No abstract provided.
Long-Range Function Of Secreted Small Nucleolar Rnas That Direct 2'-O-Methylation, Jamie M. Rimer, Jiyeon Lee, Christopher L. Holley, Robert J. Crowder, Delphine L. Chen, Phyllis I. Hanson, Daniel S. Ory, Jean E. Schaffer
Long-Range Function Of Secreted Small Nucleolar Rnas That Direct 2'-O-Methylation, Jamie M. Rimer, Jiyeon Lee, Christopher L. Holley, Robert J. Crowder, Delphine L. Chen, Phyllis I. Hanson, Daniel S. Ory, Jean E. Schaffer
Open Access Publications
No abstract provided.
Normalized Neutral Lipid Quantitation By Flow Cytometry, Nathan E. Wolins, Katerina N. Dehaan, Vincenza Cifarelli, Angela K. Stoeckman
Normalized Neutral Lipid Quantitation By Flow Cytometry, Nathan E. Wolins, Katerina N. Dehaan, Vincenza Cifarelli, Angela K. Stoeckman
Open Access Publications
No abstract provided.
Concentration Of 2c-Methyladenosine Triphosphate By Leishmania Guyanensis Enables Specific Inhibition Of Leishmania Rna Virus 1 Via Its Rna Polymerase, John I. Robinson, Stephen M. Beverley
Concentration Of 2c-Methyladenosine Triphosphate By Leishmania Guyanensis Enables Specific Inhibition Of Leishmania Rna Virus 1 Via Its Rna Polymerase, John I. Robinson, Stephen M. Beverley
Open Access Publications
No abstract provided.
Trisomy Of Human Chromosome 21 Enhances Amyloid-Β Deposition Independently Of An Extra Copy Of App, Frances K. Wiseman, Fan Liao, Floy Stewart, David M. Holtzman, Et Al
Trisomy Of Human Chromosome 21 Enhances Amyloid-Β Deposition Independently Of An Extra Copy Of App, Frances K. Wiseman, Fan Liao, Floy Stewart, David M. Holtzman, Et Al
Open Access Publications
No abstract provided.
Structural And Functional Differences Between Porcine Brain And Budding Yeast Microtubules, Stuart C. Howes, Elisabeth A. Geyer, Benjamin Lafrance, Rui Zhang, Elizabeth H. Kellogg, Stefan Westermann, Luke M. Rice, Eva Nogales
Structural And Functional Differences Between Porcine Brain And Budding Yeast Microtubules, Stuart C. Howes, Elisabeth A. Geyer, Benjamin Lafrance, Rui Zhang, Elizabeth H. Kellogg, Stefan Westermann, Luke M. Rice, Eva Nogales
Open Access Publications
No abstract provided.
Molecular Mechanisms Of Cell Death: Recommendations Of The Nomenclature Committee On Cell Death 2018, Lorenzo Galluzzi, Herbert W. Virgin, Et Al.
Molecular Mechanisms Of Cell Death: Recommendations Of The Nomenclature Committee On Cell Death 2018, Lorenzo Galluzzi, Herbert W. Virgin, Et Al.
Open Access Publications
No abstract provided.
Targeting Of Nonlipidated, Aggregated Apoe With Antibodies Inhibits Amyloid Accumulation, Fan Liao, Aimin Li, Monica Xiong, Hong Jiang, Mary Beth Finn, Rosa Hoyle, Jennifer Keyser, Katheryn B Lefton, Grace O Robinson, Javier Remolina Serrano, Cheryl Eg Leyns, Gilbert Gallardo, Jason D Ulrich, David M Holtzman, Et Al
Targeting Of Nonlipidated, Aggregated Apoe With Antibodies Inhibits Amyloid Accumulation, Fan Liao, Aimin Li, Monica Xiong, Hong Jiang, Mary Beth Finn, Rosa Hoyle, Jennifer Keyser, Katheryn B Lefton, Grace O Robinson, Javier Remolina Serrano, Cheryl Eg Leyns, Gilbert Gallardo, Jason D Ulrich, David M Holtzman, Et Al
Open Access Publications
The apolipoprotein E E4 allele of the APOE gene is the strongest genetic factor for late-onset Alzheimer disease (LOAD). There is compelling evidence that apoE influences Alzheimer disease (AD) in large part by affecting amyloid β (Aβ) aggregation and clearance; however, the molecular mechanism underlying these findings remains largely unknown. Herein, we tested whether anti-human apoE antibodies can decrease Aβ pathology in mice producing both human Aβ and apoE4, and investigated the mechanism underlying these effects. We utilized APPPS1-21 mice crossed to apoE4-knockin mice expressing human apoE4 (APPPS1-21/APOE4). We discovered an anti-human apoE antibody, anti-human apoE 4 (HAE-4), that specifically …
Walking, Gross Motor Development, And Brain Functional Connectivity In Infants And Toddlers, Natasha Marrus, Adam T. Eggebrecht, Alexandre Todorov, Lyndsey Cole, Cheryl L. Klohr, Chloe M. Adams, Kelly N. Botteron, Robert C. Mckinstry, John N. Constantino, The Ibis Network, Bradley L. Schlaggar, John R. Pruett Jr, Et Al
Walking, Gross Motor Development, And Brain Functional Connectivity In Infants And Toddlers, Natasha Marrus, Adam T. Eggebrecht, Alexandre Todorov, Lyndsey Cole, Cheryl L. Klohr, Chloe M. Adams, Kelly N. Botteron, Robert C. Mckinstry, John N. Constantino, The Ibis Network, Bradley L. Schlaggar, John R. Pruett Jr, Et Al
Open Access Publications
No abstract provided.
Regulation Of Amyloid-Β Dynamics And Pathology By The Circadian Clock, Geraldine J. Kress, Fan Liao, Julie Dimitry, Michelle R. Cedeno, Garret A Fitzgerald, David M. Holtzman, Erik S. Musiek
Regulation Of Amyloid-Β Dynamics And Pathology By The Circadian Clock, Geraldine J. Kress, Fan Liao, Julie Dimitry, Michelle R. Cedeno, Garret A Fitzgerald, David M. Holtzman, Erik S. Musiek
Open Access Publications
Nighttime restlessness and daytime drowsiness are common and early symptoms of Alzheimer's Disease (AD). This symptomology implicates dysfunctional biological timing, yet the role of the circadian system in AD pathogenesis is unknown. To evaluate the role of the circadian clock in amyloid-β (Aβ) dynamics and pathology, we used a mouse model of β-amyloidosis and disrupted circadian clock function either globally or locally in the brain via targeted deletion of the core clock gene
Selective Inhibition Of The P38Α Mapk-Mk2 Axis Inhibits Inflammatory Cues Including Inflammasome Priming Signals, Chun Wang, Yael Alippe, Yousef Abu-Amer, Gabriel Mbalaviele, Et Al
Selective Inhibition Of The P38Α Mapk-Mk2 Axis Inhibits Inflammatory Cues Including Inflammasome Priming Signals, Chun Wang, Yael Alippe, Yousef Abu-Amer, Gabriel Mbalaviele, Et Al
Open Access Publications
p38α activation of multiple effectors may underlie the failure of global p38α inhibitors in clinical trials. A unique inhibitor (CDD-450) was developed that selectively blocked p38α activation of the proinflammatory kinase MK2 while sparing p38α activation of PRAK and ATF2. Next, the hypothesis that the p38α-MK2 complex mediates inflammasome priming cues was tested. CDD-450 had no effect on NLRP3 expression, but it decreased IL-1β expression by promoting IL-1β mRNA degradation. Thus, IL-1β is regulated not only transcriptionally by NF-κB and posttranslationally by the inflammasomes but also posttranscriptionally by p38α-MK2. CDD-450 also accelerated TNF-α and IL-6 mRNA decay, inhibited inflammation in …
Combination Anti-Aβ Treatment Maximizes Cognitive Recovery And Rebalances Mtor Signaling In App Mice, Angie C.A. Chiang, Stephanie W. Fowler, Ricky R. Savjani, Susan G. Hilsenbeck, Clare E. Wallace, John R. Cirrito, Pritam Das, Joanna L. Jankowsky
Combination Anti-Aβ Treatment Maximizes Cognitive Recovery And Rebalances Mtor Signaling In App Mice, Angie C.A. Chiang, Stephanie W. Fowler, Ricky R. Savjani, Susan G. Hilsenbeck, Clare E. Wallace, John R. Cirrito, Pritam Das, Joanna L. Jankowsky
Open Access Publications
Drug development for Alzheimer's disease has endeavored to lower amyloid β (Aβ) by either blocking production or promoting clearance. The benefit of combining these approaches has been examined in mouse models and shown to improve pathological measures of disease over single treatment; however, the impact on cellular and cognitive functions affected by Aβ has not been tested. We used a controllable APP transgenic mouse model to test whether combining genetic suppression of Aβ production with passive anti-Aβ immunization improved functional outcomes over either treatment alone. Compared with behavior before treatment, arresting further Aβ production (but not passive immunization) was sufficient …
Altered Compensatory Cytokine Signaling Underlies The Discrepancy Between Flt3–/– And Flt3l–/– Mice, Vivek Durai, Prachi Bagadia, Carlos G. Briseño, Derek J. Theisen, Arifumi Iwata, Jesse T. Davidson, Marco Gargaro, Daved H. Fremont, Theresa L. Murphy, Kenneth M. Murphy
Altered Compensatory Cytokine Signaling Underlies The Discrepancy Between Flt3–/– And Flt3l–/– Mice, Vivek Durai, Prachi Bagadia, Carlos G. Briseño, Derek J. Theisen, Arifumi Iwata, Jesse T. Davidson, Marco Gargaro, Daved H. Fremont, Theresa L. Murphy, Kenneth M. Murphy
Open Access Publications
The receptor Flt3 and its ligand Flt3L are both critical for dendritic cell (DC) development, but DC deficiency is more severe in
Hypothalamic Sirt1 Protects Terminal Schwann Cells And Neuromuscular Junctions From Age‐Related Morphological Changes, Alison K. Snyder-Warwick, Akiko Satoh, Katherine B. Santosa, Shin-Ichiro Imai, Albina Jablonka-Shariff
Hypothalamic Sirt1 Protects Terminal Schwann Cells And Neuromuscular Junctions From Age‐Related Morphological Changes, Alison K. Snyder-Warwick, Akiko Satoh, Katherine B. Santosa, Shin-Ichiro Imai, Albina Jablonka-Shariff
Open Access Publications
No abstract provided.
Heart Failure And Sudden Cardiac Death In Heritable Thoracic Aortic Disease Caused By Pathogenic Variants In The Smad3 Gene, Julie De Backer, Alan C. Braverman
Heart Failure And Sudden Cardiac Death In Heritable Thoracic Aortic Disease Caused By Pathogenic Variants In The Smad3 Gene, Julie De Backer, Alan C. Braverman
Open Access Publications
No abstract provided.
Lifelong Reduction In Complex Iv Induces Tissue‐Specific Metabolic Effects But Does Not Reduce Lifespan Or Healthspan In Mice, Sathyaseelan S. Deepa, Gavin Pharaoh, Michael Kinter, Vivian Diaz, Wilson C. Fok, Kaitlyn Riddle, Daniel Pulliam, Shauna Hill, Kathleen E. Fischer, Vanessa Soto, Constantin Georgescu, Jonathan D. Wren, Carlo Viscomi, Arlan Richardson, Holly Van Remmen
Lifelong Reduction In Complex Iv Induces Tissue‐Specific Metabolic Effects But Does Not Reduce Lifespan Or Healthspan In Mice, Sathyaseelan S. Deepa, Gavin Pharaoh, Michael Kinter, Vivian Diaz, Wilson C. Fok, Kaitlyn Riddle, Daniel Pulliam, Shauna Hill, Kathleen E. Fischer, Vanessa Soto, Constantin Georgescu, Jonathan D. Wren, Carlo Viscomi, Arlan Richardson, Holly Van Remmen
Open Access Publications
No abstract provided.
Examining The Reversibility Of Long-Term Behavioral Disruptions In Progeny Of Maternal Ssri Exposure, Susan E. Maloney, Shyam Akula, Michael A. Rieger, Katherine B. Mccullough, Krystal Chandler, Adrian M. Corbett, Audrey E. Mcgowin, Joseph D. Dougherty
Examining The Reversibility Of Long-Term Behavioral Disruptions In Progeny Of Maternal Ssri Exposure, Susan E. Maloney, Shyam Akula, Michael A. Rieger, Katherine B. Mccullough, Krystal Chandler, Adrian M. Corbett, Audrey E. Mcgowin, Joseph D. Dougherty
Open Access Publications
No abstract provided.
Inhibition Of Nitric Oxide Production In Activated Macrophages Caused By Toxoplasma Gondii Infection Occurs By Distinct Mechanisms In Different Mouse Macrophage Cell Lines, Gabriel R. De Abreu Cabral, Zi T. Wang, L. D. Sibley, Renato A. Damatta
Inhibition Of Nitric Oxide Production In Activated Macrophages Caused By Toxoplasma Gondii Infection Occurs By Distinct Mechanisms In Different Mouse Macrophage Cell Lines, Gabriel R. De Abreu Cabral, Zi T. Wang, L. D. Sibley, Renato A. Damatta
Open Access Publications
No abstract provided.