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Washington University School of Medicine

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The Toxoplasma Gondii Active Serine Hydrolase 4 Regulates Parasite Division And Intravacuolar Parasite Architecture, Ian T. Foe, Ouma Onguka, Katherine Amberg-Johnson, Rikki M. Garner, Neri Amara, Wandy Beatty, Ellen Yeh, Matthew Bogyo Jan 2018

The Toxoplasma Gondii Active Serine Hydrolase 4 Regulates Parasite Division And Intravacuolar Parasite Architecture, Ian T. Foe, Ouma Onguka, Katherine Amberg-Johnson, Rikki M. Garner, Neri Amara, Wandy Beatty, Ellen Yeh, Matthew Bogyo

Open Access Publications

No abstract provided.


Washington University Magazine, Fall/Winter 2018-2019 Jan 2018

Washington University Magazine, Fall/Winter 2018-2019

Washington University Magazine

No abstract provided.


Washington University Magazine, Spring 2018 Jan 2018

Washington University Magazine, Spring 2018

Washington University Magazine

No abstract provided.


The Immediate Early Gene Egr3 Is Required For Hippocampal Induction Of Bdnf By Electroconvulsive Stimulation, Kimberly T. Meyers, Ketan K. Marballi, Samuel J. Brunwasser, Briana Renda, Milad Charbel, Diano F. Marrone, Amelia L. Gallitano Jan 2018

The Immediate Early Gene Egr3 Is Required For Hippocampal Induction Of Bdnf By Electroconvulsive Stimulation, Kimberly T. Meyers, Ketan K. Marballi, Samuel J. Brunwasser, Briana Renda, Milad Charbel, Diano F. Marrone, Amelia L. Gallitano

Open Access Publications

No abstract provided.


Burosumab Therapy In Children With X-Linked Hypophosphatemia, Thomas O. Carpenter, Michael P. Whyte, Erik A. Imel, Annemieke M. Boot, Wolfgang Hogler, Agnes Linglart, Raja Padidela, William Van't Hoff, Meng Mao, Chao-Yin Chen, Alison Skrinar, Emil Kakkis, Javier San Martin, Anthony A. Portale Jan 2018

Burosumab Therapy In Children With X-Linked Hypophosphatemia, Thomas O. Carpenter, Michael P. Whyte, Erik A. Imel, Annemieke M. Boot, Wolfgang Hogler, Agnes Linglart, Raja Padidela, William Van't Hoff, Meng Mao, Chao-Yin Chen, Alison Skrinar, Emil Kakkis, Javier San Martin, Anthony A. Portale

Open Access Publications

No abstract provided.


Diltiazem Improves Contractile Properties Of Skeletal Muscle In Dysferlin‐Deficient Blaj Mice, But Does Not Reduce Contraction‐Induced Muscle Damage, Morium Begam, Alyssa F. Collier, Amber L. Mueller, Renuka Roche, Sujay S. Galen, Joseph A. Roche Jan 2018

Diltiazem Improves Contractile Properties Of Skeletal Muscle In Dysferlin‐Deficient Blaj Mice, But Does Not Reduce Contraction‐Induced Muscle Damage, Morium Begam, Alyssa F. Collier, Amber L. Mueller, Renuka Roche, Sujay S. Galen, Joseph A. Roche

Open Access Publications

No abstract provided.


Characterization Of Small Molecules Inhibiting The Pro-Angiogenic Activity Of The Zinc Finger Transcription Factor Vezf1, Ming He, Qianyi Yang, Allison B. Norvil, David Sherris, Humaira Gowher Jan 2018

Characterization Of Small Molecules Inhibiting The Pro-Angiogenic Activity Of The Zinc Finger Transcription Factor Vezf1, Ming He, Qianyi Yang, Allison B. Norvil, David Sherris, Humaira Gowher

Open Access Publications

No abstract provided.


Geogenomic Segregation And Temporal Trends Of Human Pathogenic Escherichia Coli O157:H7, Washington, Usa, 2005-2014, Gillian A. M. Tarr, Smriti Shringi, Amanda I. Phipps, Thomas E. Besser, Jonathan Mayer, Hanna N. Oltean, Jon Wakefield, Phillip I. Tarr, Peter Rabinowitz Jan 2018

Geogenomic Segregation And Temporal Trends Of Human Pathogenic Escherichia Coli O157:H7, Washington, Usa, 2005-2014, Gillian A. M. Tarr, Smriti Shringi, Amanda I. Phipps, Thomas E. Besser, Jonathan Mayer, Hanna N. Oltean, Jon Wakefield, Phillip I. Tarr, Peter Rabinowitz

Open Access Publications

No abstract provided.


Valuation Of Knowledge And Ignorance In Mesolimbic Reward Circuitry, Caroline J. Charpentier, Ethan S. Bromberg-Martin, Tali Sharot Jan 2018

Valuation Of Knowledge And Ignorance In Mesolimbic Reward Circuitry, Caroline J. Charpentier, Ethan S. Bromberg-Martin, Tali Sharot

Open Access Publications

No abstract provided.


New Insights Into The Role Of Trem2 In Alzheimer’S Disease, Maud Gratuze, Cheryl E.G. Leyns, David M. Holtzman Jan 2018

New Insights Into The Role Of Trem2 In Alzheimer’S Disease, Maud Gratuze, Cheryl E.G. Leyns, David M. Holtzman

Open Access Publications

No abstract provided.


Scn Vip Neurons Are Essential For Normal Light-Mediated Resetting Of The Circadian System, Jeff R. Jones, Tatiana Simon, Lorenzo Lones, Erik D. Herzog Jan 2018

Scn Vip Neurons Are Essential For Normal Light-Mediated Resetting Of The Circadian System, Jeff R. Jones, Tatiana Simon, Lorenzo Lones, Erik D. Herzog

Open Access Publications

No abstract provided.


Genetically Enhancing The Expression Of Chemokine Domain Of Cx3cl1 Fails To Prevent Tau Pathology In Mouse Models Of Tauopathy, Shane M. Bemiller, Nicole M. Maphis, Shane V. Formica, Gina N. Wilson, Crystal M. Miller, Guixiang Xu, Olga N. Kokiko-Cochran, Ki-Wook Kim, Steffen Jung, Judy L. Cannon, Samuel D. Crish, Astrid E. Cardona, Bruce T. Lamb, Kiran Bhaskar Jan 2018

Genetically Enhancing The Expression Of Chemokine Domain Of Cx3cl1 Fails To Prevent Tau Pathology In Mouse Models Of Tauopathy, Shane M. Bemiller, Nicole M. Maphis, Shane V. Formica, Gina N. Wilson, Crystal M. Miller, Guixiang Xu, Olga N. Kokiko-Cochran, Ki-Wook Kim, Steffen Jung, Judy L. Cannon, Samuel D. Crish, Astrid E. Cardona, Bruce T. Lamb, Kiran Bhaskar

Open Access Publications

No abstract provided.


Age-Specific Global Epidemiology Of Hydrocephalus: Systematic Review, Metanalysis And Global Birth Surveillance, Albert M. Isaacs, Jay Riva-Cambrin, Daniel Yavin, Aaron Hockley, Tamara M. Pringsheim, Nathalie Jette, Brendan Cord Lethebe, Mark Lowerison, Jarred Dronyk, Mark G. Hamilton Jan 2018

Age-Specific Global Epidemiology Of Hydrocephalus: Systematic Review, Metanalysis And Global Birth Surveillance, Albert M. Isaacs, Jay Riva-Cambrin, Daniel Yavin, Aaron Hockley, Tamara M. Pringsheim, Nathalie Jette, Brendan Cord Lethebe, Mark Lowerison, Jarred Dronyk, Mark G. Hamilton

Open Access Publications

No abstract provided.


Methylation-Based Enrichment Facilitates Low-Cost, Noninvasive Genomic Scale Sequencing Of Populations From Feces, Kenneth L. Chiou, Christina M. Bergey Jan 2018

Methylation-Based Enrichment Facilitates Low-Cost, Noninvasive Genomic Scale Sequencing Of Populations From Feces, Kenneth L. Chiou, Christina M. Bergey

Open Access Publications

No abstract provided.


Bioreducible Polymer Micelles Based On Acid-Degradable Poly(Ethylene Glycol)-Poly(Amino Ketal) Enhance The Stromal Cell-Derived Factor-1Α Gene Transfection Efficacy And Therapeutic Angiogenesis Of Human Adipose-Derived Stem Cells, Tae-Jin Lee, Min Suk Shim, Taekyung Yu, Kyunghee Choi, Dong-Ik Kim, Soo-Hong Lee, Suk Ho Bhang Jan 2018

Bioreducible Polymer Micelles Based On Acid-Degradable Poly(Ethylene Glycol)-Poly(Amino Ketal) Enhance The Stromal Cell-Derived Factor-1Α Gene Transfection Efficacy And Therapeutic Angiogenesis Of Human Adipose-Derived Stem Cells, Tae-Jin Lee, Min Suk Shim, Taekyung Yu, Kyunghee Choi, Dong-Ik Kim, Soo-Hong Lee, Suk Ho Bhang

Open Access Publications

No abstract provided.


A Knock-In Tristetraprolin (Ttp) Zinc Finger Point Mutation In Mice: Comparison With Complete Ttp Deficiency, Wi S. Lai, Deborah J. Stumpo, Lianqun Qiu, Roberta Faccio, Perry J. Blackshear Jan 2018

A Knock-In Tristetraprolin (Ttp) Zinc Finger Point Mutation In Mice: Comparison With Complete Ttp Deficiency, Wi S. Lai, Deborah J. Stumpo, Lianqun Qiu, Roberta Faccio, Perry J. Blackshear

Open Access Publications

No abstract provided.


Cell Circuits Between B Cell Progenitors And Il-7+ Mesenchymal Progenitor Cells Control B Cell Development, Chris Fistonich, Sandra Zehentmeier, Jeffrey J. Bednarski, Runfeng Miao, Hilde Schjerven, Barry P Sleckman, João P Pereira Jan 2018

Cell Circuits Between B Cell Progenitors And Il-7+ Mesenchymal Progenitor Cells Control B Cell Development, Chris Fistonich, Sandra Zehentmeier, Jeffrey J. Bednarski, Runfeng Miao, Hilde Schjerven, Barry P Sleckman, João P Pereira

Open Access Publications

B cell progenitors require paracrine signals such as interleukin-7 (IL-7) provided by bone marrow stromal cells for proliferation and survival. Yet, how B cells regulate access to these signals in vivo remains unclear. Here we show that proB and IL-7


The Role Of Bpifa1 In Upper Airway Microbial Infections And Correlated Diseases, Yung-An Tsou, Min-Che Tung, Katherine A. Alexander, Wen-Dien Chang, Ming-Hsui Tsai, Hsiao-Ling Chen, Chuan-Mu Chen Jan 2018

The Role Of Bpifa1 In Upper Airway Microbial Infections And Correlated Diseases, Yung-An Tsou, Min-Che Tung, Katherine A. Alexander, Wen-Dien Chang, Ming-Hsui Tsai, Hsiao-Ling Chen, Chuan-Mu Chen

Open Access Publications

No abstract provided.


Genome-Wide Mega-Analysis Identifies 16 Loci And Highlights Diverse Biological Mechanisms In The Common Epilepsies, Liu Lin Thio, Judith Weisenberg Jan 2018

Genome-Wide Mega-Analysis Identifies 16 Loci And Highlights Diverse Biological Mechanisms In The Common Epilepsies, Liu Lin Thio, Judith Weisenberg

Open Access Publications

No abstract provided.


Lj-1888, A Selective Antagonist For The A3 Adenosine Receptor, Ameliorates The Development Of Atherosclerosis And Hypercholesterolemia In Apolipoprotein E Knock-Out Mice, Jong-Gil Park, Se-Jin Jeong, Jinha Yu, Gyudong Kim, Lak Shin Jeong, Goo Taeg Oh Jan 2018

Lj-1888, A Selective Antagonist For The A3 Adenosine Receptor, Ameliorates The Development Of Atherosclerosis And Hypercholesterolemia In Apolipoprotein E Knock-Out Mice, Jong-Gil Park, Se-Jin Jeong, Jinha Yu, Gyudong Kim, Lak Shin Jeong, Goo Taeg Oh

Open Access Publications

No abstract provided.


A Method For Identifying Mouse Pancreatic Ducts, Chiemi Nakajima, Kenji Kamimoto, Katsuhiro Miyajima, Masahito Matsumoto, Yasushi Okazaki, Kazuo Kobayashi-Hattori, Makoto Shimizu, Takumi Yamane, Yuichi Oishi, Ken Iwatsuki Jan 2018

A Method For Identifying Mouse Pancreatic Ducts, Chiemi Nakajima, Kenji Kamimoto, Katsuhiro Miyajima, Masahito Matsumoto, Yasushi Okazaki, Kazuo Kobayashi-Hattori, Makoto Shimizu, Takumi Yamane, Yuichi Oishi, Ken Iwatsuki

Open Access Publications

No abstract provided.


Effects Of Hypercapnia In Sepsis: Protocol For A Systematic Review Of Clinical And Preclinical Data, Thomas P. Clyde, Michael Coletta, Christopher Jones, Hope Kilgannon, Brian M. Fuller, Stephen Trzeciak, Brian W. Roberts Jan 2018

Effects Of Hypercapnia In Sepsis: Protocol For A Systematic Review Of Clinical And Preclinical Data, Thomas P. Clyde, Michael Coletta, Christopher Jones, Hope Kilgannon, Brian M. Fuller, Stephen Trzeciak, Brian W. Roberts

Open Access Publications

No abstract provided.


Leishmania Guyanensis Parasites Block The Activation Of The Inflammasome By Inhibiting Maturation Of Il-1Β, Mary-Anne Hartley, Remzi O. Eren, Matteo Rossi, Florence Prevel, Patrik Castiglioni, Nathalie Isorce, Chantal Desponds, Lon-Fye Lye, Stephen M. Beverley, Stefan K. Drexler, Nicolas Fasel Jan 2018

Leishmania Guyanensis Parasites Block The Activation Of The Inflammasome By Inhibiting Maturation Of Il-1Β, Mary-Anne Hartley, Remzi O. Eren, Matteo Rossi, Florence Prevel, Patrik Castiglioni, Nathalie Isorce, Chantal Desponds, Lon-Fye Lye, Stephen M. Beverley, Stefan K. Drexler, Nicolas Fasel

Open Access Publications

No abstract provided.


Postoperative Opioids, Endocrine Changes, And Immunosuppression, Simon Haroutounian Jan 2018

Postoperative Opioids, Endocrine Changes, And Immunosuppression, Simon Haroutounian

Open Access Publications

No abstract provided.


Body Mass Index Throughout Adulthood, Physical Activity, And Risk Of Multiple Myeloma: A Prospective Analysis In Three Large Cohorts, Catherine R. Marinac, Brenda M. Birmann, I-Min Lee, Bernard A. Rosner, Mary K. Townsend, Edward Giovannucci, Timothy R. Rebbeck, Julie E. Buring, Graham A. Colditz Jan 2018

Body Mass Index Throughout Adulthood, Physical Activity, And Risk Of Multiple Myeloma: A Prospective Analysis In Three Large Cohorts, Catherine R. Marinac, Brenda M. Birmann, I-Min Lee, Bernard A. Rosner, Mary K. Townsend, Edward Giovannucci, Timothy R. Rebbeck, Julie E. Buring, Graham A. Colditz

Open Access Publications

No abstract provided.


Blood-Brain Barrier Disruption And Perivascular Beta-Amyloid Accumulation In The Brain Of Aged Rats With Spontaneous Hypertension: Evaluation With Dynamic Contrast-Enhanced Magnetic Resonance Imaging, Yu Wang, Ruzhi Zhang, Chuanyuan Tao, Ziqian Xu, Wei Chen, Chunhua Wang, Li Song, Jie Zheng, Fabao Gao Jan 2018

Blood-Brain Barrier Disruption And Perivascular Beta-Amyloid Accumulation In The Brain Of Aged Rats With Spontaneous Hypertension: Evaluation With Dynamic Contrast-Enhanced Magnetic Resonance Imaging, Yu Wang, Ruzhi Zhang, Chuanyuan Tao, Ziqian Xu, Wei Chen, Chunhua Wang, Li Song, Jie Zheng, Fabao Gao

Open Access Publications

No abstract provided.


The Beta 3-Integrin Endothelial Adhesome Regulates Microtubule-Dependent Cell Migration, Katherine N. Weilbaecher, Et Al Jan 2018

The Beta 3-Integrin Endothelial Adhesome Regulates Microtubule-Dependent Cell Migration, Katherine N. Weilbaecher, Et Al

Open Access Publications

No abstract provided.


Lightweight Scmos-Based High-Density Diffuse Optical Tomography, Karla M. Bergonzi, Tracy M. Burns-Yocum, Jonathan R. Bumstead, Elise M. Buckley, Patrick C. Mannion, Christopher H. Tracey, Eli Mennerick, Silvina L. Ferradal, Hamid Dehghani, Adam T. Eggebrecht, Jospeh P. Culver Jan 2018

Lightweight Scmos-Based High-Density Diffuse Optical Tomography, Karla M. Bergonzi, Tracy M. Burns-Yocum, Jonathan R. Bumstead, Elise M. Buckley, Patrick C. Mannion, Christopher H. Tracey, Eli Mennerick, Silvina L. Ferradal, Hamid Dehghani, Adam T. Eggebrecht, Jospeh P. Culver

Open Access Publications

No abstract provided.


Effective Connectivity Measured Using Optogenetically Evoked Hemodynamic Signals Exhibits Topography Distinct From Resting State Functional Connectivity In The Mouse, Adam Q Bauer, Andrew W Kraft, Grant A Baxter, Patrick W Wright, Matthew D Reisman, Annie R Bice, Jasmine J Park, Michael R Bruchas, Abraham Z Snyder, Jin-Moo Lee, Joseph P Culver Jan 2018

Effective Connectivity Measured Using Optogenetically Evoked Hemodynamic Signals Exhibits Topography Distinct From Resting State Functional Connectivity In The Mouse, Adam Q Bauer, Andrew W Kraft, Grant A Baxter, Patrick W Wright, Matthew D Reisman, Annie R Bice, Jasmine J Park, Michael R Bruchas, Abraham Z Snyder, Jin-Moo Lee, Joseph P Culver

2010-2019 OA Pubs

Brain connectomics has expanded from histological assessment of axonal projection connectivity (APC) to encompass resting state functional connectivity (RS-FC). RS-FC analyses are efficient for whole-brain mapping, but attempts to explain aspects of RS-FC (e.g., interhemispheric RS-FC) based on APC have been only partially successful. Neuroimaging with hemoglobin alone lacks specificity for determining how activity in a population of cells contributes to RS-FC. Wide-field mapping of optogenetically defined connectivity could provide insights into the brain's structure-function relationship. We combined optogenetics with optical intrinsic signal imaging to create an efficient, optogenetic effective connectivity (Opto-EC) mapping assay. We examined EC patterns of excitatory …


Epidemiology, Clinical Characteristics, And Antimicrobial Susceptibility Profiles Of Human Clinical Isolates Of Staphylococcus Intermedius Group, Melanie L. Yarbrough, William Lainhart, Carey-Ann D. Burnham Jan 2018

Epidemiology, Clinical Characteristics, And Antimicrobial Susceptibility Profiles Of Human Clinical Isolates Of Staphylococcus Intermedius Group, Melanie L. Yarbrough, William Lainhart, Carey-Ann D. Burnham

Open Access Publications

No abstract provided.