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Articles 3481 - 3510 of 8119
Full-Text Articles in Entire DC Network
Ilc2s Are The Predominant Source Of Intestinal Ilc-Derived Il-10, Jennifer K Bando, Susan Gilfillan, Blanda Di Luccia, José L Fachi, Cristiane Sécca, Marina Cella, Marco Colonna
Ilc2s Are The Predominant Source Of Intestinal Ilc-Derived Il-10, Jennifer K Bando, Susan Gilfillan, Blanda Di Luccia, José L Fachi, Cristiane Sécca, Marina Cella, Marco Colonna
Open Access Publications
Although innate lymphoid cells (ILCs) functionally analogous to T helper type 1 (Th1), Th2, and Th17 cells are well characterized, an ILC subset strictly equivalent to IL-10-secreting regulatory T cells has only recently been proposed. Here, we report the absence of an intestinal regulatory ILC population distinct from group 1 ILCs (ILC1s), ILC2s, and ILC3s in (1) mice bred in our animal facility; (2) mice from The Jackson Laboratory, Taconic Biosciences, and Charles River Laboratories; and (3) mice subjected to intestinal inflammation. Instead, a low percentage of intestinal ILC2s produced IL-10 at steady state. A screen for putative IL-10 elicitors …
Gene Therapy Targeting Sarm1 Blocks Pathological Axon Degeneration In Mice, Stefanie Geisler, Shay X. Huang, Amy Strickland, Ryan A. Doan, Daniel W. Summers, Xianrong Mao, Jiwoong Park, Aaron Diantonio, Jeffrey Milbrandt
Gene Therapy Targeting Sarm1 Blocks Pathological Axon Degeneration In Mice, Stefanie Geisler, Shay X. Huang, Amy Strickland, Ryan A. Doan, Daniel W. Summers, Xianrong Mao, Jiwoong Park, Aaron Diantonio, Jeffrey Milbrandt
Open Access Publications
Axonal degeneration (AxD) following nerve injury, chemotherapy, and in several neurological disorders is an active process driven by SARM1, an injury-activated NADase. Axons of SARM1-null mice exhibit greatly delayed AxD after transection and in models of neurological disease, suggesting that inhibiting SARM1 is a promising strategy to reduce pathological AxD. Unfortunately, no drugs exist to target SARM1. We, therefore, developed SARM1 dominant-negatives that potently block AxD in cellular models of axotomy and neuropathy. To assess efficacy in vivo, we used adeno-associated virus-mediated expression of the most potent SARM1 dominant-negative and nerve transection as a model of severe AxD. While axons …
Gen-1 Immunotherapy For The Treatment Of Ovarian Cancer, Premal H Thaker, Nicholas Borys, Jason Fewell, Khursheed Anwer
Gen-1 Immunotherapy For The Treatment Of Ovarian Cancer, Premal H Thaker, Nicholas Borys, Jason Fewell, Khursheed Anwer
2010-2019 OA Pubs
GEN-1 is a gene-based immunotherapy, comprising a human IL-12 gene expression plasmid and a synthetic plasmid delivery system, delivered intraperitoneally (ip.) to produce local and persistent levels of a pleiotropic immunocytokine, IL-12, at the tumor site in patients with advanced ovarian cancer. The goal of local and persistent IL-12 delivery is to remodel the highly immunosuppressive tumor microenvironment to favor immune stimulation while avoiding serious systemic toxicities, a major limitation of recombinant IL-12 therapy. Safe and sustained local production of IL-12 and related immunocytokines at the tumor site could produce potentially more favorable immunological changes in the tumor microenvironment and …
White Matter Damage, Neuroinflammation, And Neuronal Integrity In Hand, Aljoharah Alakkas, David B Clifford, Et Al.
White Matter Damage, Neuroinflammation, And Neuronal Integrity In Hand, Aljoharah Alakkas, David B Clifford, Et Al.
2010-2019 OA Pubs
HIV-associated neurocognitive disorders (HANDs) persist even with virologic suppression on combination antiretroviral therapy (cART), and the underlying pathophysiological mechanisms are not well understood. We performed structural magnetic resonance imaging and MR spectroscopy (MRS) in HIV+ individuals without major neurocognitive comorbidities. Study participants were classified as neurocognitively unimpaired (NU), asymptomatic (ANI), mild neurocognitive disorder (MND), or HIV-associated dementia (HAD). Using structural MRI, we measured volumes of cortical and subcortical gray matter and total and abnormal white matter (aWM). Using single-voxel MRS, we estimated metabolites in frontal gray matter (FGM) and frontal white matter (FWM) and basal ganglia (BG) regions. Adjusted odds …
Comprehensive Behavioral And Biochemical Outcomes Of Novel Murine Models Of Gm1-Gangliosidosis And Morquio Syndrome Type B, Michael J Przybilla, Li Ou, Alexandru-Flaviu Tăbăran, Xuntian Jiang, Rohini Sidhu, Pamela J Kell, Daniel S Ory, M Gerard O'Sullivan, Chester B Whitley
Comprehensive Behavioral And Biochemical Outcomes Of Novel Murine Models Of Gm1-Gangliosidosis And Morquio Syndrome Type B, Michael J Przybilla, Li Ou, Alexandru-Flaviu Tăbăran, Xuntian Jiang, Rohini Sidhu, Pamela J Kell, Daniel S Ory, M Gerard O'Sullivan, Chester B Whitley
Open Access Publications
Deficiencies in the lysosomal hydrolase β-galactosidase (β-gal) lead to two distinct diseases: the skeletal disease Morquio syndrome type B, and the neurodegenerative disease GM1-gangliosidosis. Utilizing CRISPR-Cas9 genome editing, the mouse β-gal encoding gene, Glb1, was targeted to generate both models of β-gal deficiency in a single experiment. For Morquio syndrome type B, the common human missense mutation W273L (position 274 in mice) was introduced into the Glb1 gene (Glb1
Mitochondrial Fusion Supports Increased Oxidative Phosphorylation During Cell Proliferation, Cong-Hui Yao, Rencheng Wang, Yahui Wang, Che-Pei Kung, Jason D. Weber, Gary J. Patti
Mitochondrial Fusion Supports Increased Oxidative Phosphorylation During Cell Proliferation, Cong-Hui Yao, Rencheng Wang, Yahui Wang, Che-Pei Kung, Jason D. Weber, Gary J. Patti
Open Access Publications
Proliferating cells often have increased glucose consumption and lactate excretion relative to the same cells in the quiescent state, a phenomenon known as the Warburg effect. Despite an increase in glycolysis, however, here we show that non-transformed mouse fibroblasts also increase oxidative phosphorylation (OXPHOS) by nearly two-fold and mitochondrial coupling efficiency by ~30% during proliferation. Both increases are supported by mitochondrial fusion. Impairing mitochondrial fusion by knocking down mitofusion-2 (Mfn2) was sufficient to attenuate proliferation, while overexpressing Mfn2 increased proliferation. Interestingly, impairing mitochondrial fusion decreased OXPHOS but did not deplete ATP levels. Instead, inhibition caused cells to transition from excreting …
B Cell-Mediated Antigen Presentation Through Mhc Class Ii Is Dispensable For Atherosclerosis Progression, Jesse W Williams, Andrew Elvington, Skyler Kessler, Mary Wohltmann, Gregory F Wu, Gwendalyn J Randolph
B Cell-Mediated Antigen Presentation Through Mhc Class Ii Is Dispensable For Atherosclerosis Progression, Jesse W Williams, Andrew Elvington, Skyler Kessler, Mary Wohltmann, Gregory F Wu, Gwendalyn J Randolph
2020-Current year OA Pubs
Depletion of B cells attenuates plaque development and modulates T cell responses in mouse models of atherosclerosis, suggesting that Ag presentation by B cells may promote disease progression. Thus, we set out to determine the role of B cell-mediated MHC class II (MHC II) Ag presentation during atherosclerotic plaque development. We developed murine conditional MHC II deletion and expression systems under control of the B cell-restricted CD19 promoter in an experimental model of atherosclerosis. Mice lacking MHC II expression only on B cells exhibited systemic shifts in germinal center and marginal zone B cell populations, leading to a reduced Ab …
Apo-Opsin Exists In Equilibrium Between A Predominant Inactive And A Rare Highly Active State, Shinya Sato, Beata Jastrzebska, Andreas Engel, Krzysztof Palczewski, Vladimir J. Kefalov
Apo-Opsin Exists In Equilibrium Between A Predominant Inactive And A Rare Highly Active State, Shinya Sato, Beata Jastrzebska, Andreas Engel, Krzysztof Palczewski, Vladimir J. Kefalov
Open Access Publications
Bleaching adaptation in rod photoreceptors is mediated by apo-opsin, which activates phototransduction with effective activity 10
Inducible Down-Regulation Of Mhc Class I Results In Natural Killer Cell Tolerance, Michael D. Bern, Bijal A. Parikh, Liping Yang, Diana L. Beckman, Jennifer Poursine-Laurent, Wayne M. Yokoyama
Inducible Down-Regulation Of Mhc Class I Results In Natural Killer Cell Tolerance, Michael D. Bern, Bijal A. Parikh, Liping Yang, Diana L. Beckman, Jennifer Poursine-Laurent, Wayne M. Yokoyama
Open Access Publications
Natural killer (NK) cells are innate lymphocytes that are thought to kill cells that down-regulate MHC class I (MHC-I) through "missing-self" recognition. NK cells from
The Transcriptional Regulator Snon Promotes The Proliferation Of Cerebellar Granule Neuron Precursors In The Postnatal Mouse Brain, Xiaoying Chen, Ayan Chanda, Yoshiho Ikeuchi, Xiaoqing Zhang, Jared V. Goodman, Naveen C. Reddy, Shahriyar P. Majidi, Dennis Y. Wu, Sarah E. Smith, Abigail Godec, Anna Oldenborg, Harrison W. Gabel, Guoyan Zhao, Shirin Bonni, Azad Bonni
The Transcriptional Regulator Snon Promotes The Proliferation Of Cerebellar Granule Neuron Precursors In The Postnatal Mouse Brain, Xiaoying Chen, Ayan Chanda, Yoshiho Ikeuchi, Xiaoqing Zhang, Jared V. Goodman, Naveen C. Reddy, Shahriyar P. Majidi, Dennis Y. Wu, Sarah E. Smith, Abigail Godec, Anna Oldenborg, Harrison W. Gabel, Guoyan Zhao, Shirin Bonni, Azad Bonni
Open Access Publications
Control of neuronal precursor cell proliferation is essential for normal brain development, and deregulation of this fundamental developmental event contributes to brain diseases. Typically, neuronal precursor cell proliferation extends over long periods of time during brain development. However, how neuronal precursor proliferation is regulated in a temporally specific manner remains to be elucidated. Here, we report that conditional KO of the transcriptional regulator SnoN in cerebellar granule neuron precursors robustly inhibits the proliferation of these cells and promotes their cell cycle exit at later stages of cerebellar development in the postnatal male and female mouse brain. In laser capture microdissection …
Voltage-Independent Sk-Channel Dysfunction Causes Neuronal Hyperexcitability In The Hippocampus Of Fmr1 Knock-Out Mice, Pan-Yue Deng, Dan Carlin, Young Mi Oh, Leila K. Myrick, Stephen T. Warren, Valeria Cavalli, Vitaly A. Klyachko
Voltage-Independent Sk-Channel Dysfunction Causes Neuronal Hyperexcitability In The Hippocampus Of Fmr1 Knock-Out Mice, Pan-Yue Deng, Dan Carlin, Young Mi Oh, Leila K. Myrick, Stephen T. Warren, Valeria Cavalli, Vitaly A. Klyachko
Open Access Publications
Neuronal hyperexcitability is one of the major characteristics of fragile X syndrome (FXS), yet the molecular mechanisms of this critical dysfunction remain poorly understood. Here we report a major role of voltage-independent potassium (K
A Hox-Tale Regulatory Circuit For Neural Crest Patterning Is Conserved Across Vertebrates, Hugo J. Parker, Bony De Kumar, Stephen A. Green, Karin D. Prummel, Christopher Hess, Charles K. Kaufman, Christian Mosimann, Leanne M. Wiedemann, Marianne E. Bronner, Robb Krumlauf
A Hox-Tale Regulatory Circuit For Neural Crest Patterning Is Conserved Across Vertebrates, Hugo J. Parker, Bony De Kumar, Stephen A. Green, Karin D. Prummel, Christopher Hess, Charles K. Kaufman, Christian Mosimann, Leanne M. Wiedemann, Marianne E. Bronner, Robb Krumlauf
Open Access Publications
No abstract provided.
Clinical Characterization Of Host Response To Simian Hemorrhagic Fever Virus Infection In Permissive And Refractory Hosts: A Model For Determining Mechanisms Of Vhf Pathogenesis, Adam L. Bailey, Et Al
Clinical Characterization Of Host Response To Simian Hemorrhagic Fever Virus Infection In Permissive And Refractory Hosts: A Model For Determining Mechanisms Of Vhf Pathogenesis, Adam L. Bailey, Et Al
Open Access Publications
No abstract provided.
Aav-Mediated Taz Gene Replacement Restores Mitochondrial And Cardioskeletal Function In Barth Syndrome, Silveli Suzuki-Hatano, Madhurima Saha, Skylar A. Rizzo, Rachael L. Witko, Bennett J. Gosiker, Manashwi Ramanathan, Meghan S. Soustek, Michael D. Jones, Peter B. Kang, Barry J. Byrne, W. Todd Cade, Christina A. Pacak
Aav-Mediated Taz Gene Replacement Restores Mitochondrial And Cardioskeletal Function In Barth Syndrome, Silveli Suzuki-Hatano, Madhurima Saha, Skylar A. Rizzo, Rachael L. Witko, Bennett J. Gosiker, Manashwi Ramanathan, Meghan S. Soustek, Michael D. Jones, Peter B. Kang, Barry J. Byrne, W. Todd Cade, Christina A. Pacak
Open Access Publications
No abstract provided.
Imaging Of Her2 With [89zr]Pertuzumab In Response To T-Dm1 Therapy, Adriana V.F. Massicano, Supum Lee, Bryant K. Crenshaw, Tolulope A. Aweda, Retta El Sayed, Ian Super, Ron Bose, Bernadette V. Marquez-Nostra, Suzanne E. Lapi
Imaging Of Her2 With [89zr]Pertuzumab In Response To T-Dm1 Therapy, Adriana V.F. Massicano, Supum Lee, Bryant K. Crenshaw, Tolulope A. Aweda, Retta El Sayed, Ian Super, Ron Bose, Bernadette V. Marquez-Nostra, Suzanne E. Lapi
Open Access Publications
No abstract provided.
Phosphatidylcholine Synthesis Through Cholinephosphate Cytidylyltransferase Is Dispensable In Leishmania Major, Samrat Moitra, Mattie C. Pawlowic, Fong-Fu Hsu, Kai Zhang
Phosphatidylcholine Synthesis Through Cholinephosphate Cytidylyltransferase Is Dispensable In Leishmania Major, Samrat Moitra, Mattie C. Pawlowic, Fong-Fu Hsu, Kai Zhang
Open Access Publications
No abstract provided.
Mild Chronic Perturbation Of Inhibition Severely Alters Hippocampal Function, Min-Yu Sun, Luke Ziolkowski, Peter Lambert, Hong-Jin Shu, Micah Keiser, Nicholas Rensing, Natasha Warikoo, Monika Martinek, Carson Platnick, Ann Benz, John Bracamontes, Gustav Akk, Joe Henry Steinbach, Charles F. Zorumski, Michael Wong, Steven Mennerick
Mild Chronic Perturbation Of Inhibition Severely Alters Hippocampal Function, Min-Yu Sun, Luke Ziolkowski, Peter Lambert, Hong-Jin Shu, Micah Keiser, Nicholas Rensing, Natasha Warikoo, Monika Martinek, Carson Platnick, Ann Benz, John Bracamontes, Gustav Akk, Joe Henry Steinbach, Charles F. Zorumski, Michael Wong, Steven Mennerick
Open Access Publications
No abstract provided.
A Short Translational Ramp Determines The Efficiency Of Protein Synthesis, Manasvi Verma, Junhong Choi, Kyle A. Cottrell, Zeno Lavagnino, Erica N. Thomas, Slavica Pavlovic-Djuranovic, Pawel Szczesny, David W. Piston, Hani S. Zaher, Joseph D. Puglisi, Sergej Djuranovic
A Short Translational Ramp Determines The Efficiency Of Protein Synthesis, Manasvi Verma, Junhong Choi, Kyle A. Cottrell, Zeno Lavagnino, Erica N. Thomas, Slavica Pavlovic-Djuranovic, Pawel Szczesny, David W. Piston, Hani S. Zaher, Joseph D. Puglisi, Sergej Djuranovic
Open Access Publications
No abstract provided.
Deficiency Of Dietary Fiber In Slc5a8-Null Mice Promotes Bacterial Dysbiosis And Alters Colonic Epithelial Transcriptome Towards Proinflammatory Milieu, Sathish Sivaprakasam, Pramodh K. Ganapathy, Mohd Omar Faruk Sikder, Moamen Elmassry, Sabarish Ramachandran, Kameswara Rao Kottapalli, Vadivel Ganapathy
Deficiency Of Dietary Fiber In Slc5a8-Null Mice Promotes Bacterial Dysbiosis And Alters Colonic Epithelial Transcriptome Towards Proinflammatory Milieu, Sathish Sivaprakasam, Pramodh K. Ganapathy, Mohd Omar Faruk Sikder, Moamen Elmassry, Sabarish Ramachandran, Kameswara Rao Kottapalli, Vadivel Ganapathy
Open Access Publications
No abstract provided.
Crocodylian Head Width Allometry And Phylogenetic Prediction Of Body Size In Extinct Crocodyliforms, Haley D O'Brien, Leigha M Lynch, Kent A Vliet, John Brueggen, Gregory M Erickson, Paul M Gignac
Crocodylian Head Width Allometry And Phylogenetic Prediction Of Body Size In Extinct Crocodyliforms, Haley D O'Brien, Leigha M Lynch, Kent A Vliet, John Brueggen, Gregory M Erickson, Paul M Gignac
2010-2019 OA Pubs
Body size and body-size shifts broadly impact life-history parameters of all animals, which has made accurate body-size estimates for extinct taxa an important component of understanding their paleobiology. Among extinct crocodylians and their precursors (e.g., suchians), several methods have been developed to predict body size from suites of hard-tissue proxies. Nevertheless, many have limited applications due to the disparity of some major suchian groups and biases in the fossil record. Here, we test the utility of head width (HW) as a broadly applicable body-size estimator in living and fossil suchians. We use a dataset of sexually mature male and female …
Reduction Of Leukocyte Microvascular Adherence And Preservation Of Blood-Brain Barrier Function By Superoxide-Lowering Therapies In A Piglet Model Of Neonatal Asphyxia, Jacob B. Ruden, Kevin L. Quick, Ernesto R. Gonzales, Aarti R. Shah, T. S. Park, Nan Kennedy, Laura L. Dugan, Jeffrey M. Gidday
Reduction Of Leukocyte Microvascular Adherence And Preservation Of Blood-Brain Barrier Function By Superoxide-Lowering Therapies In A Piglet Model Of Neonatal Asphyxia, Jacob B. Ruden, Kevin L. Quick, Ernesto R. Gonzales, Aarti R. Shah, T. S. Park, Nan Kennedy, Laura L. Dugan, Jeffrey M. Gidday
Open Access Publications
No abstract provided.
Crispr/Cas9 Mediated Generation Of An Ovine Model For Infantile Neuronal Ceroid Lipofuscinosis (Cln1 Disease), S. L. Eaton, C. Proudfoot, S. G. Lillico, P. Skehel, R. A. Kline, K. Hamer, N. M. Rzechorzek, E. Clutton, R. Gregson, T. King, C. A. O'Neill, J. D. Cooper, G. Thompson, C. B. Whitelaw, T. M. Wishart
Crispr/Cas9 Mediated Generation Of An Ovine Model For Infantile Neuronal Ceroid Lipofuscinosis (Cln1 Disease), S. L. Eaton, C. Proudfoot, S. G. Lillico, P. Skehel, R. A. Kline, K. Hamer, N. M. Rzechorzek, E. Clutton, R. Gregson, T. King, C. A. O'Neill, J. D. Cooper, G. Thompson, C. B. Whitelaw, T. M. Wishart
Open Access Publications
No abstract provided.
Promising Recent Strategies With Potential Clinical Translational Value To Combat Antibacterial Resistant Surge, Partha Karmakar, Vishwanath Gaitonde
Promising Recent Strategies With Potential Clinical Translational Value To Combat Antibacterial Resistant Surge, Partha Karmakar, Vishwanath Gaitonde
Open Access Publications
No abstract provided.
Ether-A-Go-Go Related Gene-1a Potassium Channel Abundance Varies Within Specific Skeletal Muscle Fiber Type, Luke B. Anderson, Chase D. Latour, Omar Khader, Bryce H. Massey, Brittan Cobb, Amber L. Pond
Ether-A-Go-Go Related Gene-1a Potassium Channel Abundance Varies Within Specific Skeletal Muscle Fiber Type, Luke B. Anderson, Chase D. Latour, Omar Khader, Bryce H. Massey, Brittan Cobb, Amber L. Pond
Open Access Publications
No abstract provided.
N-Acyl-O-Phosphocholineserines: Structures Of A Novel Class Of Lipids That Are Biomarkers For Niemann-Pick C1 Disease, Rohini Sidhu, Yawo Mondjinou, Mingxing Qian, Fong-Fu Hsu, Dennis J. Dietzen, Jean E. Schaffer, Daniel S. Ory, Xuntian Jiang, Et Al.
N-Acyl-O-Phosphocholineserines: Structures Of A Novel Class Of Lipids That Are Biomarkers For Niemann-Pick C1 Disease, Rohini Sidhu, Yawo Mondjinou, Mingxing Qian, Fong-Fu Hsu, Dennis J. Dietzen, Jean E. Schaffer, Daniel S. Ory, Xuntian Jiang, Et Al.
Open Access Publications
No abstract provided.
The Safety Of Double- And Triple-Drug Community Mass Drug Administration For Lymphatic Filariasis: A Multicenter, Open-Label, Cluster-Randomized Study, Gary J. Weil, Joshua Bogus, Peter U. Fischer, Charles W. Goss, K. O'Brian, Kenneth B. Schechtman, Dolf Ida Safety Study Group, Et Al.
The Safety Of Double- And Triple-Drug Community Mass Drug Administration For Lymphatic Filariasis: A Multicenter, Open-Label, Cluster-Randomized Study, Gary J. Weil, Joshua Bogus, Peter U. Fischer, Charles W. Goss, K. O'Brian, Kenneth B. Schechtman, Dolf Ida Safety Study Group, Et Al.
Open Access Publications
No abstract provided.
The Factor Structure Of The Boston Diagnostic Aphasia Examination, Third Edition, Mandy W.M Fong, Ryan Van Patten, Robert P. Fucetola
The Factor Structure Of The Boston Diagnostic Aphasia Examination, Third Edition, Mandy W.M Fong, Ryan Van Patten, Robert P. Fucetola
Open Access Publications
No abstract provided.
The Role Of Membrane Excitability In Pancreatic Β-Cell Glucotoxicity, Zeenat A. Shyr, Zhiyu Wang, Nathaniel W. York, Colin G. Nichols, Maria S. Remedi
The Role Of Membrane Excitability In Pancreatic Β-Cell Glucotoxicity, Zeenat A. Shyr, Zhiyu Wang, Nathaniel W. York, Colin G. Nichols, Maria S. Remedi
Open Access Publications
No abstract provided.