Digital Commons Network^™

Cannabis Use Among Cancer Survivors And The Impact On Cancer-Related Pain, Tiffanie A. Vargas

Theses and Dissertations

With a growing population of older adult cancer survivors—many of whom experience cancer-related pain—interest in medical cannabis as a pain management strategy has increased. This secondary analysis used data from the 2022 U.S. Behavioral Risk Factor Surveillance System (BRFSS) to examine cannabis use behaviors among cancer survivors and assess associations with cancer-related pain. The study had three aims: (1) to describe 30-day cannabis use (prevalence, intensity, and administration routes) by chronic health condition and cancer diagnosis, focusing on non-melanoma skin cancer, melanoma, and other cancers; (2) to compare demographics, health characteristics, and tobacco use by cannabis use status among cancer …

Existing In The Context: A Conjunctural Analysis Of Kamala Harris Memes, Amaya Mcneal

Theses and Dissertations

Political memes have become a common way for people to express their political views online, helping politics reach young adults who weren’t previously interested. Consequently, politicians have begun sharing and creating memes themselves. The memeification of American politics has diminished debate about ideas, ideals, issues, and people’s vital interests, debasing voters by treating them not as citizens but as passive “consumers” and “spectators” of mediated politics. This paper helps make sense of this crisis, focusing on the example of former Vice President Kamala Harris. Vice President Kamala Harris' memeified presidential campaign during the 2024 U.S. election targeted voters through a …

You Go, I Will Wait, Rasim Bayramov

Theses and Dissertations

On the other side of the coast, a hand is waiting. On the other side of the shore, someone is waiting for you to come. This space between you and them is an asymptote. The more you wait, the colder the pan is to the hand. But the salt of the sea will cover and warm your hand. There’s much to play with while you wait. The destination is only a promise, a figure disillusioned. Waiting spaces are enchantingly altering

in their premise. A bureaucratic fantasy with no avail and no ending. Systematically accumulated levels of power and control lies …

Civic Conservation Workshop: A User Manual For Creating A Makerspace Dedicated To Historic Preservation, Building Repair, And Civic Engagement, Madeleine Bean

Theses and Dissertations

Research Abstract:

Democracy depends on citizens’ participation at all levels, from local to national; moreover, engagement in one’s community is directly correlated with greater reported feelings of happiness and trust (Cox et al., 2021). This research examines how makerspaces can act as civic hubs that promote inclusive community interaction, facilitate the exchange of cultural and skills-based knowledge, encourage civic discourse, and serve as sites for political engagement through the provision of tools and resources that focus on historic home repair/preservation and craft-based trades. Specifically, this study proposes the development and design of a preservation-focused makerspace in Jackson Ward, a historically …

The Bacteriostatic, Regenerative, And Immunomodulatory Properties Of Extracellular Matrix Particles For Lung Injury, Keera P. Rhoads

Theses and Dissertations

Acute respiratory distress syndrome (ARDS) is a prevalent, life-threatening lung condition, affecting nearly 200,000 Americans annually, with a 40% international mortality rate. There is no cure for ARDS, and current pharmacological treatments have limited effectiveness. Symptoms can be mitigated with mechanical ventilation, though this often leads to ventilator-induced lung injuries (VILI) and puts critically ill patients at risk of infections, including ventilator-associated pneumonia (VAP). A promising therapeutic is the extracellular matrix (ECM), a complex network of structural proteins and bioactive molecules that has been shown to have anti-inflammatory properties and prevent fibrosis. We aim to utilize the regenerative and immunomodulatory …

Watchpeopledie . Tv, Noah Lebien

Theses and Dissertations

The thesis piece is a performance called watchpeopledie.tv performed four times at the Anderson Gallery in the Hidden Galleries. There are two rooms in the gallery. The first room is where the audience enters. There is a line on the floor marking that the audience is not to move further into the first room or into the second room. The audio consists of verbatim comments sourced from videos of violence against trans people from the website watchpeopledie.tv, a website in which users post real videos of shootings, suicides, car accidents, etc. The main text, which is my thesis writing below, …

Hafnium Oxide-Based Nanoheterostructures For Catalytic Radiosensitization And Enhanced X-Ray Radiotherapy, Marlen Dariela Calix Quezada

Theses and Dissertations

Orthovoltage X-ray beams are attractive for surface and intra-operative radiotherapy. Yet, their clinical utility is constrained by rapid attenuation and the limited dose that can be delivered without harming healthy tissue. High-Z hafnium oxide (HfO₂) nanoparticles can boost local energy deposition through the photoelectric effect, while catalytic surface defects accelerate water radiolysis. Harnessing both mechanisms in a single nano-heterostructure could enable potent radiosensitization at diagnostic-range energies.

This thesis develops and evaluates HfO₂-based nanoheterostructures, both bare and Au-decorated, as catalytic radiosensitizers.

Two types of HfO₂ were evaluated, one was synthesized following a specific route and the …

Reply Stop To Stop, Molly A. M. Garrett

Theses and Dissertations

Over the course of 8 years working in progressive political strategy, 2015–2023, I became increasingly critical of the systems, formulas and tools we were using to communicate with voters. Reply STOP to Stop is documentation of my time at graduate school, of wrestling with ideas of political design, language, communication and distribution. I analyzed my past work — all the texts, emails, social media posts, print ads, web banners, videos and other miscellaneous scripted content — and wondered if we would all be better off without it. Would elections be fairer, would there be less fake news, more community building? …

Mementos, Zixuan Guo

Theses and Dissertations

Relevance:

Personal Relevance: This project merges my passion for film photography and modern technology, aiming to create a design that bridges traditional and modern practices.

Local Relevance: Richmond’s rich historical context provides an ideal setting to illystrate that traditional arts like analog photography can be preserved while integrating modern digital technology.

Global Relevance: Globally, there is an increasing trend toward combining traditional and modern design approaches, particularly in architecture and interior design. Synthesizing analog and digital means is used to meet the balance between materiality and modern technology (Rose, 2014; Pelizzari & Scrivano, 2011). Designers balance tactile materials like wood …

An Exploration Of The Relationship Between School Counselor Access And Latine Students’ College-Going Behaviors, Kristen Tuxbury

Theses and Dissertations

This study examined the relationships between school counselor access and Latine students’ college-going behaviors using data from the High School Longitudinal Study of 2009 (HSLS:09). The study was guided by critical race theory and Yosso’s community cultural wealth model (2005). Binary logistic regression models, Chi-square tests of independence, and descriptive statistics were used to explore the associations between school counselor access, Latine student college-going behaviors, and caregiver expectations. The findings show stronger associations between caregiver expectations and Latine student college-going behaviors than school counselor access. Additionally, findings provide evidence that experiences of oppression are likely barriers to Bachelor’s degree programs …

Dynamic Expression Of Transposable Elements Contributes To Molecular And Behavioral Adaptations To Cocaine, Gabriella M. Silva

Theses and Dissertations

The comorbidity of substance use disorder (SUDs) — specifically cocaine use disorder (CUD)— with anxiety and social deficit disorders complicates effective long-term treatment. More research is needed to understand the brain-region and cell type-specific mechanisms underlying these disorders to better address treatment gaps. This dissertation investigates the role of the transcription factor of interest ZFP189, a Krüppel-associated box (KRAB) zinc finger protein (ZFP), in governing pro-social behavior and the development of CUD across interconnected brain regions. We show that ZFP189 directly regulates transposable elements (TEs), repetitive DNA sequences capable of mobilizing and reinserting into the genome, which leads to subsequent …

Leveraging Distributed Semantics From Deep Learning Architectures For Literature-Based Discovery, Clint A. Cuffy

Theses and Dissertations

Literature-based discovery (LBD) is a scientific process that introduces methods to automatically identify novel insights between non-interacting sets of literature. To date, numerous statistical and machine learning-based methods have been applied in the biomedical domain to find treatments for diseases such as Raynaud's disease, Parkinson's disease, and Multiple Sclerosis. However, the lack of standardized practices and creation of bespoke methodologies produces a scenario where the adoption of LBD remains challenging in real-world systems. Our work addresses these concerns through the improvement of five critical areas: 1) error propagation within LBD's a priori dependent tasks, 2) exploring the integration of modern …

Trauma-Informed Beliefs And Our Child Welfare System, Gabriela Ana Aisenberg

Theses and Dissertations

The integration of trauma-informed care (TIC) into behavioral health and child welfare systems has garnered increasing attention, reflecting a growing acknowledgment of the pervasive and multifaceted impacts of trauma on individuals, families, and service delivery structures (Barnett et al., 2019; Bartlett et al., 2018; Bassuk et al., 2017; Substance Abuse and Mental Health Services Administration [SAMHSA], 2014). Legislation such as the Family First Prevention Services Act (FFPSA) has led to increased adoption of trauma-informed practices through increased funding for training and services (Bowen & Murshid, 2016; Brown et al., 2023). Research shows that providers’ understanding and implementation of TIC is …

Rehabilitation In Stroke-Related Flexor Synergy, Shawn J. Dirocco

Theses and Dissertations

Upper extremity abnormal flexor synergy caused by stroke can impair individuals by coupling upper extremity muscles with deltoid activation. Previous studies have shown that reduction in deltoid loading can decrease flexor synergy. Robotic rehabilitation has the ability to allow for reduced deltoid loading while assisting or constraining joints along the arm to increase rehabilitation outcomes. The effects of higher degree of freedom low impedance robotics needs to be tested to learn how various parameters affect flexor synergy in comparison to end point robotics. During the first experiment, we tested 16 chronic stroke patients with flexor synergy problems in 3 tasks. …

Using A Dimension Reduction Approach To Parse Heterogeneity In Dietary Restriction, Amanda Makara

Theses and Dissertations

Dietary restriction, the problematic reduction of caloric or macronutrient intake, is a critical eating behavior occurring transdiagnostically across eating disorders and subclinical disordered eating. The definition of dietary restriction is highly heterogeneous, and restriction is often conflated with other distinct constructs, such as dietary restraint. The current practices related to the definition and measurement of dietary restriction have notable flaws, negatively impacting the ability to identify and establish risk, diagnosis, and treatment of eating disorders. There is also limited evidence that commonly-used dietary restriction measures can validly predict food choice and objective intake. These issues raise questions about whether dietary …

Beliefs Related To Diagnosing Bpd And Complex Ptsd, Bailey Pascuzzi

Theses and Dissertations

There has been speculation that Borderline personality disorder (BPD) and Complex post-traumatic stress disorder (Complex PTSD) are the same disorder or represent separate disorders on a broader trauma spectrum (Frost et al., 2020; Lewis & Grenyer, 2009). BPD and Complex PTSD share several symptoms but differ in their presentation (Ford & Courtis, 2021). Because the two disorders present so similarly, it could be that clinicians have difficulty differentiating them, leading to misdiagnosis (Miller, 2014). This study examined clinicians’ diagnostic decision-making and stigma toward BPD and Complex PTSD. Participants (N = 426) completed an online survey where they diagnosed a written …

“Some Vague Utopia”: Searching For Urania, Moira L. Neve

Theses and Dissertations

Despite the global pendulum swing of gender trouble marked by the United States’ President’s declaration that there are only two sexes, activists have been rejecting assimilation (ie. defining equality as gay marriage or queer people in the military) within queer studies long before 2025. In the first half of the 20th century, a journal by the name of Urania (1916-1940), privately published and circulated to their home base in the United Kingdom and beyond, five editors (Esther Roper, Eva Gore-Booth, Jessey Wade, Dorothy Cornish, and Irene Clyde/Thomas Baty), challenged the gender binary and the resulting assumptions of heterosexual marriage. This …

News Mediated Reporting And Governmental Narratives About The Enforcement Of Elite Criminality: Exploring The Social Construction Of Financial Frauds And Discrepancies In Punishment, Dominic J. Zicari

Theses and Dissertations

This study examines how financial crime enforcement decisions are socially constructed through a qualitative content analysis of news articles and government communications pertaining to two specific cases: the Enron scandal of 2001 and the subprime mortgage crisis of 2008. The study was guided by a theoretical framework that utilizes Barak’s (2017) theory of state-routinized crime control. The rigorous analysis of 394 news articles and government communication documents revealed that the media and the state rarely framed the subprime mortgage crisis as a criminal issue. Although the Enron scandal was frequently described as financial crime, journalists and government communicators were often …

“You’Re Only As Good As Your Resources”: Exploring Virginia Police Chiefs’ And Sheriffs’ Decisions As Public Administrators To Engage In Community Collaborations With Domestic And Sexual Violence Agencies, Christine E. Wengloski

Theses and Dissertations

The collaborations between domestic and sexual violence victim-serving agencies (DSVAs) and law enforcement agencies help connect victims of crime to needed services. To maximize the benefits of these victim-serving initiatives in Virginia, it is imperative that victim-serving agencies understand the perceptions and factors that influence the decision-making of law enforcement administrators. In this study, I first present a theoretical framework of Herbert Simon’s Decision-Making Theory as a guide to understanding police chiefs and sheriffs as public administrators. A review of the literature demonstrates gaps in existing scholarship around chiefs’ and sheriffs’ decision-making about domestic and sexual violence victim-serving initiatives. Next, …

Social Support, Tobacco Attitudes/Perceptions Of Harm, And Asthma Status As Moderators In The Association Between Tobacco Exposure And Cotinine Levels, Rachel L. Pitts

Theses and Dissertations

Tobacco use and exposure are linked to adverse health outcomes (e.g., respiratory conditions) and increased healthcare utilization (e.g., emergency room visits). This study examined the moderating role of social support, tobacco attitudes/perceptions of harm, and asthma status on associations between tobacco use (e.g., combustible product use) and exposure (e.g., secondhand smoke) and cotinine levels among individuals in Richmond, Virginia. We also explored differences in tobacco-related variables by asthma status and associations among tobacco use, secondhand smoke exposure, cotinine levels, and asthma control. Youth (n = 201) and adults (n = 209) (95.7% Black/African American; 60.6% female; 65.8% non-tobacco users; 21% …

Improving Telehealth Education And Training: A Needs Assessment Of Healthcare Providers And Trainees, Conor Duffy

Theses and Dissertations

Telehealth utilization has increased dramatically since the start of the COVID-19 pandemic. There are many positive impacts of this shift to telehealth, including increasing access to care and reducing patient burden. However, healthcare providers report several consistent challenges that limit their ability to deliver telehealth, such as effective communication, technological difficulties, and difficulty performing physical examinations. To address these concerns, it is necessary to integrate telehealth education and training into healthcare professional training programs and healthcare systems. While many institutions have implemented telehealth education and training since the start of the pandemic, there is little consistency in the content, duration, …

Associations Between Community Violence Exposure And Internalizing Outcomes: The Moderating Role Of Racial Identity, Kimberly S. Lazarus

Theses and Dissertations

Community violence continues to be an ongoing public health crisis, driven by structural inequities and systemic disinvestment. Due to historical discriminatory policies and ongoing systemic barriers, Black adolescents are disproportionately affected, placing them at heightened risk for adverse mental health outcomes, particularly post-traumatic stress symptoms (PTSS) and depressive symptoms. While existing literature highlights racial identity as a promotive factor linked to a lower likelihood of negative health outcomes, less is known about its protective role in buffering the mental health effects of adversity. There is an increasing call for public health researchers to consider racial-ethnic factors as potential moderators in …

Development Of Novel Signatures For Determination Of Cell Types In Blood And Saliva Mixtures, Caitlin Lydon

Master of Science in Forensic Science Directed Research Projects

Determination of tissue source and the time at which a biological material is transferred from its source to another surface, known as the time-since-deposition (TSD), would assist forensic analysts by providing crucial context for DNA profiles generated from biological evidence. Many methods for cell identification have been explored using biomolecule markers such as mRNA, miRNA, and differential DNA methylation. Forensic laboratories have also developed methods for TSD estimation that focus on degradation of biomolecules. Biomolecules such as mRNA or miRNA degrade at different rates due to some being more stable than others. The ratio of stable degrading biomolecules, therefore, can …

Impact Of Substrates And Deposition Time On Bacteria Associated With Saliva Samples And Its Implication On A Bacterial Signature-Based Body Fluid Identification Method, Olisdey Galano Cruz

Master of Science in Forensic Science Directed Research Projects

Traditional serological methods for body fluid detection are limited by poor specificity and sensitivity, lacking confirmatory capability and thereby increasing the risk of false positives that may compromise the integrity of forensic investigations. While molecular methods such as mRNA, miRNA, and DNA methylation offer improved specificity, they are often hindered by marker instability and operational complexity in routine forensic workflows. Bacterial signature profiling has emerged as a promising alternative, offering enhanced stability, abundance, and compatibility with existing DNA workflows. However, its forensic implementation requires further validation. This study evaluated the effects of substrate type and storage time on the salivary …

From Trans Health To Vaccines: A Theoretically Driven Model Exploring Factors Related To Susceptibility To Medical Misinformation, Catherine Wall

Theses and Dissertations

Medical misinformation represents a significant threat to both individual and public health. While some consequences of this form of misinformation are relatively benign, there can be serious consequences ranging from a decreased trust in healthcare systems to an increased likelihood of epidemic outbreak and death. One such consequence can be seen in the recent legislative actions taken regarding access to transgender healthcare in the United States. Gender affirming care has been shown to benefit the mental well-being of transgender youth and adults; however, the demonstrably false information that underlies these legislative efforts can and has yielded significant harm. But what …

(Art) Education In The Afterlife Of Massive Resistance: Constructing, Capturing, And Commodifying Racialized Disability In Virginia’S Student Assignment Practices, 1956-1966 And Present Day, Jenna E. Gabriel

Theses and Dissertations

This dissertation explores discursive functions of disability in pupil placement decisions in Massive Resistance Virginia, the relationship between disability and race that was constructed through these moves, and how these relationships surface in the reflections, perceptions, and pedagogy of a practicing art teacher, Nathan, who works at Arts High School (AHS), a Virginia specialty center high school. Under the umbrella of the Discourse Historical Approach, which relies on multiple, interdisciplinary data sources to explore how discourses evolve, I connect a robust archival analysis of historical data collected in the records of Virginia’s Pupil Placement Board (746 boxes, 1956-1966) with present-day …

Establishing A Conventional Linac-Based Electron Flash Beam, Justin Defrancisco

Theses and Dissertations

Problems: A rediscovered radiotherapy technique, FLASH, involves increasing the dose rate to >40 Gy/s. For a given dose, FLASH is shown to decrease the normal tissue complication probability without affecting the tumor control probability. More preclinical studies are necessary to confirm and enable these desirable properties on humans. Current preclinical investigations have diverse constraints, requiring FLASH apparatuses with flexible parameters and accurate control. However, there are limited FLASH platforms available, the existing ones are costly. Our institution is not in possession of any such infrastructure. Even if available, dosimetry and beam control in FLASH are extremely lacking. There is …

Psychometric Evaluation: Extending The Reliability And Validity Of The Teacher Attribution Measure For Early Elementary (Tam-Ee), Kerensa R. Nagle

Theses and Dissertations

Teacher attributions of student challenging behavior have the potential to influence teacher-student relationships. However, the literature on teachers’ attributions of challenging behavior is sparse and lacks measurement standardization. This limits the replicability and generalizability of research findings. To determine if teacher attributions of student challenging behaviors influence teacher-student relationships, a measure demonstrating a specific score reliability and validity profile is needed. The present study evaluated the item- and scale-level score reliability and validity of a measure of teacher attribution of student challenging behavior, the Teacher Attribution Measure for Early Elementary (TAM-EE; Nemer, 2019), within a sample of teachers (N …

Show Them, Teach Them, Let Them: Empowering Undergraduate Voices Through Student-Centered Theatre, Abigail G. Norris

Theses and Dissertations

This thesis explores the urgent need for theatrical works that resonate with undergraduate students, arguing that student-centered playwriting and production can foster deeper engagement with theatre, reflect contemporary issues, and empower the next generation of theatre-makers. Grounded in a hybrid methodology of creative practice and qualitative research, the study proposes a comprehensive, student-driven model for university theatre programs. Drawing from the author's experiences at both the University of North Carolina at Wilmington and Virginia Commonwealth University, the thesis examines institutional season selection processes, inclusive pedagogical strategies in playwriting, and the development of new works through student festivals. Central to the …

Sex-Specific Regulation Of Mash And Hepatocellular Carcinoma: A Role Of Sphk2 In Females, Bria Pierre

Theses and Dissertations

Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) is characterized by excessive fat accumulation in the liver, with metabolic dysfunction-associated steatohepatitis (MASH) representing a more severe form that can progress to cirrhosis or hepatocellular carcinoma (HCC). The sphingosine kinases and the S1P signaling pathway are key regulators of MASH and HCC progression. While much is known about the mechanisms contributing to MASH-HCC in males, less is known for females. Nevertheless, we previously identified sphingosine Kinase 2 (SphK2) to protect females from MASH-driven HCC. This study first performed differential gene expression analysis on human liver cohorts to examine sex-specific differences in gene expression …