Digital Commons Network^™

Welcome To The Sitting Garden At The Busy Hands Museum, Stacie Sabady

Theses and Dissertations

I wanted to attend VCU to learn how to unravel my mind and find the words to describe it. While I did make progress in that area, my surprise discovery is that I need to unravel my body too. It has become unbalanced from years of neglect. When working, I find solace through escape. I find a positive outlet for my perfectionist tendencies. I find a way to visually illustrate my obsessive qualities. Throughout the years of these findings, I have ignored my body pleading with me to take it easy. I have always honored the materials and the tools, …

Rooted In Between, Manavi Singh

Theses and Dissertations

Rooted in Between is a personal project that explores the complexities of belonging and the emotions that come with navigating between spaces that we call home. This written thesis is in support of the carefully curated video based and photographic work presented at an exhibition of the same title. The project's primary objective is to delve into the physical and emotional baggage that we carry with us as we move from one place to another. The project highlights the coping mechanisms adopted by the different generations in my family while struggling to find a place where we truly belong.

Profiles Of Family Functioning In Pediatric Hematology-Oncology Patients: Longitudinal Associations With Child Well-Being, Sydney Sumrall

Theses and Dissertations

This study aims to assess 1) patterns of family functioning and 2) longitudinal associations between family functioning patterns and well-being in a vulnerable cohort of children with chronic illness. Caregivers of hematology (16.4%) and oncology (83.6%) patients ages 7-20 (N=55; M_age = 13.3 [SD = 2.7]; 52.7% female; 45.5% non-Latinx White, 38.2% Black or African American, 12.7% Latinx, 1.8% Asian, and 1.8% multi-racial,) reported on family functioning via the Family Assessment Device. Cluster analyses identified three mutually exclusive clusters: one high adaptive group, one moderate adaptive group, and one maladaptive group. Group membership was not significantly …

Frewayni's Garden: Preserving Tigrayan Culture During A Period Of Ethnocide, Gabrielle F. Tesfaye

Theses and Dissertations

The recent and ongoing genocidal war in Tigray, Ethiopia, has witnessed the destruction and looting of countless historical religious sites, ancient manuscripts, and artifacts, leaving Tigray’s remaining cultural heritage extremely vulnerable. Such cultural loss erases a shared understanding across generations, robbing them of their history and identity. My work contributes to the safeguarding of Tigray’s cultural heritage and collective memory, informed by literature on cultural preservation efforts in post-war societies, and a series of interviews with Tigrayans in the diaspora and in Ethiopia.

The outcome of this thesis is embodied in a series of distinct jebenas, traditional Tigrayan clay coffee …

Illusion: Immersive Experience, Tessa S. Trowbridge

Theses and Dissertations

Can society learn from art, and if so, what type of knowledge can be gained from art? It is currently understood that art and design can help humans explore, discover, and understand philosophical and imaginative topics. There is a general agreement that art can create insight and awareness in ways that logical and rational statements cannot, and from these unique interactions, humans can see the world with a new perspective (Worth, n.d.). This thesis will investigate the claim that art can inspire human imagination and allow viewers to gain insight into a surreal reality using designed, physically immersive spaces.

Immersive …

Nuff Love: From Me To You, Katherine S. Thompson

Theses and Dissertations

The thesis exhibition, Nuff Love: From Me to You, explores the profound impact of diasporic memory on identity within the family structure, particularly for those who were born after immigration. This unpacking of memories is achieved through photographs, collages, and installations that reveal the distant and absent attributes that reside within the home. As a second-generation American of Afro-Jamaican descent, this thesis navigates how the dual identity becomes too complex and is never allowed to exist in a binary state. The constant state of in-betweenness between both cultures led to further questioning of selfhood beyond the Caribbean identity maintained by …

Poly(Tfema) Surface Coating Applied On Perovskite Thin Films Using Supercritical Carbon Dioxide., Kasey Handy

Theses and Dissertations

Perovskite-based solar cells face challenges with stability due to external environment conditions; especially moisture. A new production to counteract this is reported. Poly(trifluoroethyl methacrylate) is applied as a thin film to improve hydrophobicity of the CH3NH3PbI3 films; this post deposition treatment is processed using supercritical carbon dioxide accompanied by ethanol. The quality of the Poly(TFEMA) deposition is analyzed using Raman Spectroscopy and Scanning Electron Microscopy.

The Lived Experience Of Postpartum Sleep For Black And White Women, Ashley R. Macpherson

Theses and Dissertations

This qualitative study utilized a phenomenological research approach (van Manen, 1990), and intersectional feminist lens (Collins, 2000; Crenshaw ,1989; hooks, 2000), to uncover the lived experience of sleep in the postpartum period. Participants were 10 mothers who were less than 12 months postpartum. Data collection consisted of in-depth interviews. Data analysis procedures followed recommendations by van Manen (1990, 1997). In order to increase the trustworthiness and rigor of the study, the researcher engaged in reflexive journaling, member checking, and peer debriefing. The results were organized into six themes; 1) the importance of the sleep environment, 2) anxiety and hypervigilance, …

Physical Activity In Adolescents With And Without Adhd: Longitudinal Associations With Sleep, Adhd, And Internalizing Symptoms, Caroline N. Cusick Lowman

Theses and Dissertations

Adolescents with Attention-Deficit/Hyperactivity Disorder (ADHD) are at risk for developing clinically significant sleep problems and comorbid internalizing symptoms. Physical activity (PA) has significant positive associations with a variety of health outcomes, including sleep and aspects of mental health. As such, the US Department of Health and Human Services recommends adolescents receive at least 60 minutes of moderate-to-vigorous PA (MVPA) per day. However, it is unknown whether adolescents with ADHD have different patterns of physical activity compared to their peers. Importantly, it may be that PA can serve as a buffer between ADHD symptoms and development of comorbid difficulties with sleep …

Sleep And Health Behaviors In A Safety-Net Primary Care Setting, Sahar Sabet

Theses and Dissertations

Nearly half of all premature deaths in the United States are attributable to preventable and modifiable health risk behaviors. For decades, the leading behavioral health contributors to morbidity and mortality are tobacco use, physical inactivity, and alcohol consumption. Medication adherence is a relatively less studied yet critical interrelated health behavior that is tied to health and treatment outcomes. Sleep, an important pillar of health, is a daily and modifiable behavior that shows promise as a health behavior facilitator. Better understanding the dynamics of these modifiable health behaviors is essential for the improvement of health promotion, particularly among underserved populations (e.g., …

Sustaining Breaths For Restorative Rest: A Preliminary Evaluation Of Sleep, Mental Health, And Cognitive Function Following Hypoglossal Nerve Stimulation For Obstructive Sleep Apnea, Elliottnell Perez

Theses and Dissertations

Introduction: Obstructive sleep apnea (OSA) is a sleep-related breathing disorder that produces repetitive obstruction or collapse of the upper airway. Positive airway pressure (PAP) therapy is the gold standard treatment for OSA. Hypoglossal nerve stimulation (HNS) is considered an alternative treatment for patients who are unable to tolerate PAP therapy. The purpose of the study was to examine sleep, mental health, and cognitive health outcomes before and after HNS to determine its viability as an alternative treatment.

Methods: The study utilized a single-group, pretest-posttest design. Objective and subjective sleep was measured using actigraphy, sleep diary, and questionnaires. Objective and subjective …

Building A Macrosystems Ecology Framework To Identify Links Between Environmental And Human Health, Felisha N. Walls

Theses and Dissertations

The structure and functions of natural systems continue to be degraded by human activities such as land-use change. One potential consequence that has received relatively little attention is a corresponding decline in human health. Altered ecosystems can present a host of risks to human health. Yet the consequences of environmental degradation are rarely considered in national-scale research on human well-being. The guiding objective of this work is to compare stream health and socioeconomic metrics with spatially congruent human health metrics throughout the conterminous United States, then to identify potential links between environmental health, socioeconomic factors and human health. Environmental health …

Characterizing The Effects Of Antiandrogens And Senolytics To Enhance The Therapeutic Response To Castration-Resistant Prostate Cancer, Justin M. Silverman

Theses and Dissertations

Prostate cancer is the most frequently diagnosed cancer in males and the second most common cause of cancer deaths. Androgen deprivation therapy, whether through surgical or chemical castration, is the mainstay for treatment of advanced prostate cancer; however, despite an initial response, most patients eventually develop a progressive PSA rise, and castration- sensitive prostate cancer gives rise to castration-resistant prostate cancer. The standard of care therapy includes the antiandrogens such as enzalutamide and abiraterone acetate as well as the microtubule poison, docetaxel, and various immunotherapies; however, while prostate cancer research is progressing, there continues to be a compelling need for …

Integrative Post-Gwas Analyses Of Psychiatric Disorders: Identifying Putative Risk Genes And Gene Sets Using Transcriptome, Proteome And Methylome Information, Huseyin Gedik

Theses and Dissertations

Genome-wide association studies (GWAS) of psychiatric disorders (PD) yield numerous loci with significant signals, but often they do not implicate specific protein coding genes. Because GWAS risk loci are enriched in expression/protein/methylation quantitative loci (e/p/mQTL, hereafter xQTL), transcriptome/proteome/methylome-wide association studies (T/P/MWAS, hereafter XWAS), which integrate information from GWAS and x-level (mRNA, protein or DNA methylation levels) coming from largest xQTL studies, can link GWAS signals to effects on specific genes. For gene level analyses, researchers use mendelian randomization (MR) methods to fine-map the association between x-levels and trait. However, none of the previous studies ever jointly analyzed XWAS of multiple …

Real-Time Motion Controller For Human-Robot Teams Utilizing Artificial Potential Fields, Gabriella Graziani

Theses and Dissertations

This thesis presents a real-time robotic motion control system for human-robot teams. The framework utilizes artificial potential fields (APFs) to guide robotic agents towards a “goal” agent while navigating around “obstacle” agents; these goals and obstacles are also dynamic agents with their own set of tasks. This system is also developed for a live-programming environment, where a controlling agent updates the tasks of all agents within the system at any time during the system’s runtime. This motion controller was created and tested for a human-robot choreographic team. After the controller was fully integrated on a Trossen Robotic LoCobot Wx200 robotic …

Association Of Interpersonal Trauma And Polygenic Risk Scores With Depressive Symptoms In College Students, Rowan K. O'Hara

Theses and Dissertations

Major depression is considered a complex trait influenced by both polygenic risk factors and environmental exposures, such as childhood trauma. This study applied statistical genetic methods to calculate aggregate genetic risk for major depression to predict depressive symptoms scores in a college student sample. Data were from the Spit for Science (S4S) study in which college students from a large urban university self-reported interpersonal trauma (IPT) exposure prior to college and depressive symptoms from the past month (N = 7502; ancestry group: 20% African [AFR], 12% Admixed Americas [AMR], 10% East Asian [EAS], 49% European [EUR], 8% South Asian [SAS]). …

Witnessing Community Violence And Its Consequences: Changes Across Middle School, Sarah Pittman

Theses and Dissertations

Community violence exposure is prevalent among youth residing in economically marginalized communities that have high rates of violence. Witnessing community violence has been concurrently associated with persistent adverse consequences. However, few studies have applied a developmental psychopathology framework and examined dynamic developmental processes between witnessing community violence and outcomes over time. Moreover, most prior studies have used analyses that assume that associations between witnessing violence and outcomes are the same for all adolescents, which is inconsistent with both developmental theories and theories specific to community violence exposure. The goal of this study was to apply a developmental psychopathological framework to …

Enhancing Neuromorphic Computing With Advanced Spiking Neural Network Architectures, Paolo Gabriel Alejandro Cachi Delgado

Theses and Dissertations

This dissertation proposes ways to address current limitations of neuromorphic computing to create energy-efficient and adaptable systems for AI applications. It does so by designing novel spiking neural networks architectures that improve their performance. Specifically, the two proposed architectures address the issues of training complexity, hyperparameter selection, computational flexibility, and scarcity of neuromorphic training data. The first architecture uses auxiliary learning to improve training performance and data usage, while the second architecture leverages neuromodulation capability of spiking neurons to improve multitasking classification performance. The proposed architectures are tested on Intel's Loihi2 neuromorphic chip using several neuromorphic datasets, such as NMIST, …

Quantifying Fibronectin Mechanical Properties Using Antibody-Mediated Optical Tweezing (Amot), Caleb Dalton

Theses and Dissertations

Despite decades of investigations into fibronectin (FN) fibrillogenesis, fibril mechanics remain unclear. One of the most important roles for FN fibrils is in the arena of cellular mechanotransduction. Numerous studies have demonstrated that cells sense and respond to the mechanical properties of their surroundings; since FN fibrils are a major constituent of the ECM that links cells to their surroundings, mechanotransduction cannot be fully understood without understanding the mechanical properties of FN fibrils. In this proposal, a novel biomechanical assay is developed to probe isolated FN fibrils and quantify their response to specific loading conditions. This will be accomplished by …

The Impact Of Hiv-1 Tat And Morphine On Spatial Distribution Of Drugs In The Brain., Austin M. Jones

Theses and Dissertations

Despite combination antiretroviral therapy effectively suppressing HIV within the periphery, the central nervous system (CNS) remains affected by the virus. Approximately half of people living with HIV will experience HIV-associated neurocognitive disorders (HAND) or neuroHIV. Concurrent opioid use exacerbates neuroHIV by promoting neuroinflammation, viral replication, and potentially altering the antiretroviral concentrations within the brain.

Using a transgenic mouse that expresses the HIV-1 Tat protein, we examined the effects of Tat and morphine on antiretroviral accumulation and distribution and the effects of Tat on morphine accumulation within the brain using infrared matrix-assisted laser desorption electrospray ionization with mass spectrometry imaging (IR-MALDESI-MSI). …

Virtual Plc Platform For Security And Forensics Of Industrial Control Systems, Syed Ali Qasim

Theses and Dissertations

Industrial Control Systems (ICS) are vital in managing critical infrastructures, including nuclear power plants and electric grids. With the advent of the Industrial Internet of Things (IIoT), these systems have been integrated into broader networks, enhancing efficiency but also becoming targets for cyberattacks. Central to ICS are Programmable Logic Controllers (PLCs), which bridge the physical and cyber worlds and are often exploited by attackers. There's a critical need for tools to analyze cyberattacks on PLCs, uncover vulnerabilities, and improve ICS security. Existing tools are hindered by the proprietary nature of PLC software, limiting scalability and efficiency.

To overcome these challenges, …

Developing Novel Femtosecond Time-Resolved Mass Spectrometry Techniques For Analysis Of Energetic Materials, Shane L. Mcpherson

Theses and Dissertations

Energetic materials and the unimolecular dissociation dynamics attributed to their initiation and subsequent bimolecular detonation have been a subject of interest for defense agencies such as the Department of Defense (DoD) for decades. The timescale in which these initial dynamics exist ranges from several picoseconds to dozens of femtoseconds, necessitating equally fast time-resolved experiments to capture and characterize these events. Our lab specializes in one such laser-based technique: femtosecond time-resolved mass spectrometry (FTRMS). FTRMS is an essentially nondiscriminatory pump-probe laser technique with nearly infinite modifications via pulse shaping, intensity, and wavelength modulation that can readily examine previously undefined dissociation pathways …

Recovery Sleepers: A Pilot Study Of A Sleep Health Intervention For College Students In Recovery From Substance Use Disorder, Morgan P. Reid

Theses and Dissertations

There is an increasing number of students in recovery from substance use disorder (SUD) on college campuses, and collegiate recovery programs have been designed to support students’ recovery and global health needs. However, little research has focused on interventions that can promote health outcomes within this population. Chronic substance misuse can have lingering, negative effects on sleep even after sustained remission; thus, the present paper describes a pilot study of Recovery Sleepers, a sleep health promotion intervention rooted in self-determination theory for college students in recovery from SUD. Study aims were to examine the feasibility, acceptability, and fidelity of the …

Reassessing Replication: Addressing The Replication Crisis From A Statistical Perspective, Alicia Richards Phd

Theses and Dissertations

In 2015, Open Science Framework directly replicated 100 psychology studies and found astonishingly low replication rates. Since, researchers have suggested factors that may have influenced the low rates, including the metrics used to assess replications. The definitions used to decide whether a replication study was successful all suffer from flaws. Therefore, we propose a new metric for assessing replication that can estimate the likelihood a study successfully replicated rather than forcing a binary choice and accounts for study design limitations.

Using equivalence study techniques, we first propose a new metric to assess replication, defining a successful replication as one where …

Thermal Performance And Fluid Flow Studies Of Twisted Tape Inserts Using Scaled Surrogate Fluids For Molten Salt Energy Applications, Arturo Cabral

Theses and Dissertations

Global energy consumption is expected to increase with population growth and innovative clean sources of energy are sought out that can help meet the needs of a continuously power-hungry world. Some of these innovative sources of energy use molten salts as their operating and cooling fluid, such as fission reactors, fusion reactors, and solar power with energy storage. Molten salts are considered due to their efficient heat transfer properties, thermal energy storage capabilities, and high operating temperatures. To expedite their deployment, a further understanding of the heat transfer systems is required to accurately design and develop the heat transfer components …

Integrating Historically Marginalized Students’ Funds Of Knowledge For Culturally Responsive Teaching And Learning, Martinique Ann Sealy

Theses and Dissertations

The United States historically has not always recognized the unique knowledge, or Funds of Knowledge (FoK; Moll et. al, 1992) that Black (and other historically marginalized) students’ have as assets to classroom learning and much of today’s mainstream curriculum represents White cultural norms as the basis (Sjursen, 2021). Because of this reality, marginalized students must navigate mainstream cultural norms alongside their own culture to be successful in the classroom. This three-paper dissertation includes 1. a systematic literature review of Black U.S. k-8 students language and identity in relation to achievement, 2. a qualitative case study centered on middle school urban …

Transcriptional Coregulation Among Diabetes-Associated Pathways By Genome Organization, Musaddiq K. Lodi

Theses and Dissertations

There are currently 96 million individuals affected by diabetes in the United States alone. Crucial information such as biomarkers, regulatory networks, and metabolic pathways in diabetes still remain an active area of research. The primary focus of this study is on a phenomena known as transcription factor co-regulation. Transcription factors (TFs) are DNA-binding proteins that can control the rate of transcription of genetic information from DNA to mRNA, hence misregulation of one of them can lead to misregulation of many of its target genes and associated pathways. In this study I propose a framework to quantify transcriptional coherence in co-regulated …

Face Anti-Spoofing And Deep Learning Based Unsupervised Image Recognition Systems, Enoch Solomon

Theses and Dissertations

One of the main problems of a supervised deep learning approach is that it requires large amounts of labeled training data, which are not always easily available. This PhD dissertation addresses the above-mentioned problem by using a novel unsupervised deep learning face verification system called UFace, that does not require labeled training data as it automatically, in an unsupervised way, generates training data from even a relatively small size of data. The method starts by selecting, in unsupervised way, k-most similar and k-most dissimilar images for a given face image. Moreover, this PhD dissertation proposes a new loss function to …

Improving The Performance, Energy Efficiency And Security Of Gpus, Xin Wang

Theses and Dissertations

The work in this dissertation achieves to enhance the performance, energy-efficiency, and security of the GPUs. We noticed that, as the demand of hardware resources keeps rising in GPUs, the energy consumption becomes unaffordable and places barriers for further performance boost. To resolve this issue, we have proposed several novel GPU micro-architectures that are able to assist the GPUs to execute in an energy-efficient manner. They also provide the potential for further performance enhancement in GPUs. Firstly, we proposed a GPU register packing scheme that stores multiple narrow-width operands to a single register to save register file resources. The unoccupied …

Age-Associated Collagen Crosslinking And Its Role In Skeletal Muscle Regeneration, Lucas C. Olson

Theses and Dissertations

Advanced glycation end-products (AGEs) non-enzymatically accumulate on skeletal muscle collagen in old age via the Maillard reaction, causing an increase in intramuscular collagen and a stiffening of the muscle’s microenvironment. AGEs abrogate muscle regeneration through stiffening the muscle stem cell (MuSC) microenvironment and by binding to the receptor for advanced glycation end products (RAGE). Stiffer substrates promote MuSC proliferation at the expense of differentiation, and soluble AGEs are known to abrogate myogenic differentiation. Previously our group has demonstrated that decellularized muscle matrix (DMM), a type of extracellular matrix (ECM) scaffold extracted from skeletal muscle, encourages regeneration in a challenging rat …