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Navigating The Space Of My Body, Ferwa Ibrahim Jan 2011

Navigating The Space Of My Body, Ferwa Ibrahim

Theses and Dissertations

This paper explores my process of orienting myself within spaces and inhabiting them. It focuses on how I use my own body as an instrument for developing a relationship between the two. A ritual is a social conditioning of the body and Authentic Movement is discovering body’s own route. This paper reviews my process of situating myself within a space by using both of them as the language of my body. It also discusses the development of some of my recent work through understanding the language of my own body.

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Genetic Manipulation Of The Relapsing Fever Spirochete Borrelia Hermsii Permits Novel Investigation Into The Role Of Factor H Binding In Borrelial Virulence, Lindy Fine Jan 2011

Genetic Manipulation Of The Relapsing Fever Spirochete Borrelia Hermsii Permits Novel Investigation Into The Role Of Factor H Binding In Borrelial Virulence, Lindy Fine

Theses and Dissertations

Borrelia hermsii, an etiologic agent of tick-borne relapsing fever, binds negative complement regulator factor H (FH) via its FhbA protein. Direct demonstration of the role of FhbA in the disease process has been hindered by the lack of genetic manipulation systems for the relapsing fever Borrelia. Here, we demonstrate successful generation of a B. hermsii strain YOR fhbA deletion mutant (Bh YORΔfhbA) that constitutively produces green fluorescent protein (GFP). Genetic manipulation did not affect growth rate or plasmid composition. Bh YORΔfhbA lost factor H-binding and C3b-inactivation capabilities, but retained resistance to killing in human serum and infectivity in mice. Stable …

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Faith Based Environmental Stewardship: Practices And Attitudes Of Christian Churches On Virginia’S Northern Neck And Eastern Shore, Paoula Sehannie Dec 2010

Faith Based Environmental Stewardship: Practices And Attitudes Of Christian Churches On Virginia’S Northern Neck And Eastern Shore, Paoula Sehannie

Theses and Dissertations

In recent years there has been a growing interest in the relationship between religion and the environment. The purpose of this project is to explore the environmental practices and attitudes of Christian churches in two Virginia Communities. The two communities; the Northern Neck and Eastern Shore are located on the Chesapeake Bay and have a shared history of dependence on the Bay. The results of the dissertation demonstrate the prevalence of environmental programs in the population, the nature of these programs and the respondents’ attitudes towards a host of environmental issues. These results can be used by environmental professionals and …

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Systemic And Microcirculatory Effects Of Hboc-201: A Hemoglobin-Based Oxygen Carrier, Bjorn Song Dec 2010

Systemic And Microcirculatory Effects Of Hboc-201: A Hemoglobin-Based Oxygen Carrier, Bjorn Song

Theses and Dissertations

Top-loading This study compared the effects on oxygen (O2) transport of four fluids: 5.9% human serum albumin (HSA) a non-O2 carrying iso-oncotic solution (volume control);HBOC-201 (Hemopure, Biopure Corp., Cambridge, MA); MP50, HBOC-201 with a P50 of 18 mmHg; and lastly LP50, an HBOC-201 with P50 of 17 mmHg and higher viscosity (4 cP). It has been proposed that HBOC with a higher O2 affinity and a viscosity closer to that of whole blood will cause less vasoconstriction and thus a lower MAP than Hemopure (P50 = 40 mmHg and 2.2 cP). Intravital microscopic measurements were made on the spinotrapezius muscle …

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Development Of A Rigid Body Computational Model For Investigation Of Wrist Biomechanics, Benjamin Majors Dec 2010

Development Of A Rigid Body Computational Model For Investigation Of Wrist Biomechanics, Benjamin Majors

Theses and Dissertations

The wrist is one of the most complex joints in the human body. As such, the wrist joint is difficult to model due to the number of bones involved and its intricate soft tissue interactions. Many studies have attempted modeling the wrist previously; however, the majority of these studies simplify the joint into two-dimensions or idealized mechanical joints to reduce the complexity of the simulation. While these approaches still yield valuable information, the omission of a third-dimension or geometry defined movements limits the models’ usefulness in predicting joint function under non-idealized conditions. Therefore, the goal of this study was to …

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African American Women's Health: An Examination Of Resource Needs, Context, And Public Policy Over The Life Course, Cynthia Newbille Dec 2010

African American Women's Health: An Examination Of Resource Needs, Context, And Public Policy Over The Life Course, Cynthia Newbille

Theses and Dissertations

African American Women's Health: An Examination of Resource Needs, Context, and Public Policy over the Life Course

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Nurse Anesthetist's Perceptions Regarding Utilization Of Anesthesia Support Personnel, Mary Ford Dec 2010

Nurse Anesthetist's Perceptions Regarding Utilization Of Anesthesia Support Personnel, Mary Ford

Theses and Dissertations

Anesthesia support personnel (ASP) provide direct support to health care providers administering anesthesia (Certified Registered Nurse Anesthetists [CRNAs] and anesthesiologists). Because these anesthesia providers are caring for a patient whom they cannot legally or ethically leave unattended, ASP are employed to bring them extra supplies or equipment, prepare equipment for the case, maintain and clean equipment, and generally function as directed by the anesthesia provider. Given the limited literature and importance of ASP in maintaining equipment essential to safe practice, it is necessary to describe the population to understand who is functioning in this role to insure that these individuals …

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The Effects Of Age And Heterochromatin On Frequencies Of Acquired Chromosomal Aneuploidy In Uncultured Human Leukocytes, Noran Aboalela Dec 2010

The Effects Of Age And Heterochromatin On Frequencies Of Acquired Chromosomal Aneuploidy In Uncultured Human Leukocytes, Noran Aboalela

Theses and Dissertations

While age-related sex chromosomal aneuploidy is a well-characterized phenomenon, the relationship between autosomal loss and age remains unclear. The emergence of the specific and highly sensitive fluorescence in situ hybridization (FISH) technology has enabled investigators to study interphase cells, thereby overcoming problems inherent with the study of metaphase spreads for acquired aneuploidy assessment. Despite all the advantages of this technique, there are some limitations that could be misleading when scoring interphase autosomal aneuploidy. In this study we show that sex chromosomal hypoploidy is correlated with age. By using a twin study design, we evaluated Y chromosome hypoploidy frequencies and found …

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An Evaluation Of Cardiorespiratory Responses And Ventilatory Efficiency During Treadmill And Cycling Exercise In Overweight Adolescents, Amanda Scheps Dec 2010

An Evaluation Of Cardiorespiratory Responses And Ventilatory Efficiency During Treadmill And Cycling Exercise In Overweight Adolescents, Amanda Scheps

Theses and Dissertations

The assessment of ventilatory efficiency (VE/VCO2 slope) is increasingly being utilized to complement traditional cardiorespiratory fitness testing during graded exercise. The purpose of this study was to compare cardiorespiratory responses and ventilatory efficiency in obese children during a progressive exercise test to volitional fatigue performed on a treadmill and a cycle ergometer. Fifteen obese male (N=3) and female (N=12) adolescents aged 10 to 18 years were recruited in the study and completed both the treadmill and cycle ergometer trials. Mean age and BMI of the sample was 13.3 years and 38.0 kg/m2, respectively. Maximal oxygen consumption (VO2max) and ventilatory efficiency …

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Relations Of Depression, Social Support, And Socio-Demographic Factors On Health Behaviors Of Mothers With Premature Infants Hospitalized In A Neonatal Intensive Care Unit (Nicu), Surbhi Kanotra Dec 2010

Relations Of Depression, Social Support, And Socio-Demographic Factors On Health Behaviors Of Mothers With Premature Infants Hospitalized In A Neonatal Intensive Care Unit (Nicu), Surbhi Kanotra

Theses and Dissertations

The present study examined the relationships of depression, social support, and socio-demographic factors on health behaviors of mothers with preterm infants hospitalized in the neonatal intensive care unit (NICU). In addition, the study also assessed the moderation effect of social support on the relationship between depression and health behaviors. Eighty-nine mothers with hospitalized infants in the central Richmond area participated in the study. Analyses found that mother’s education level and her marital status to be significantly associated with her health behaviors. Mothers with a higher level of education and those who were married, were less likely to smoke and more …

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Factors Influencing Macroinvertebrate Diversity And Community Composition In Riverine Freshwater Rock Pools, Chtaura Jackson Dec 2010

Factors Influencing Macroinvertebrate Diversity And Community Composition In Riverine Freshwater Rock Pools, Chtaura Jackson

Theses and Dissertations

I examined a system of 378-riverine rock pools situated along the James River in Richmond, Virginia, to uncover the factors influencing their macroinvertebrate diversity and community composition. I characterized (total = 60) the physical characteristics, water quality, hydrology, and community assemblages in July 2009 for a subset of pools. I examined whether selected environmental factors (pH, nearest neighbor distance, depth, surface area and inundation height) were related to macroinvertebrate diversity and community composition. Species richness and total abundance of all taxa increased with pool pH and surface area. Ordination indicates that nearest neighbor distance (NND) and pH varied significantly among …

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Synthesis And Characterization Of Electrospun Gelatin/Dendrimer Scaffold Encapsulated With A Silver As A Potential Antimicrobial Wound Dressing, Alpana Dongargaonkar Dec 2010

Synthesis And Characterization Of Electrospun Gelatin/Dendrimer Scaffold Encapsulated With A Silver As A Potential Antimicrobial Wound Dressing, Alpana Dongargaonkar

Theses and Dissertations

A novel nanofiber scaffold was fabricated and characterized as a potential antimicrobial wound dressing. Half generation polyamidoamine (PAMAM) dendrimer G3.5 was covalently conjugated to gelatin. Gelatin alone or with gelatin-dendrimer conjugates was electrospun into nanofiber scaffolds. Gelatin is a derivative of natural collagen, and it is biocompatible, non-toxic and inexpensive, making it a desirable component in a wound dressing. Dendrimers are synthetic polymers comprising of a central core, internal branches and reactive surface groups. They provide a structurally controlled architecture for drug release. Silver was incorporated into the scaffold in situ due to its broad spectrum of antimicrobial properties. The …

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Distribution And Molecular Analysis Of Avian Malaria Vectors On Four Central Virginia Prothonotary Warbler (Protonotaria Citrea) Breeding Sites, Catherine Wallace Dec 2010

Distribution And Molecular Analysis Of Avian Malaria Vectors On Four Central Virginia Prothonotary Warbler (Protonotaria Citrea) Breeding Sites, Catherine Wallace

Theses and Dissertations

Avian malaria is a devastating disease that has decimated numerous bird species. This study sought to identify the vectors of avian malaria at four central Virginia Prothonotary warbler breeding sites. Twenty one thousand mosquitoes were collected and Culex salinarius, Cx. erraticus, and Cx. pipiens/restuans were found to be the dominant species at these sites. Geographic factors, such as crop land and forest type, were determined to be potential indicators for species abundance variation between sites. Of the mosquitoes collected, ninety one (0.4%) were identified as blood fed. The blood fed mosquitoes were found to have fed on avian, mammalian, amphibian, …

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Maternal Depressive Symptoms And Health Outcomes In Youths With Type 1 Diabetes: A Mediational Model, Struemph Kari Morgan Dec 2010

Maternal Depressive Symptoms And Health Outcomes In Youths With Type 1 Diabetes: A Mediational Model, Struemph Kari Morgan

Theses and Dissertations

Objectives: The rate and impact of depressive symptoms were examined with two models based on known effects of depression on variables related to diabetes management, parental involvement and diabetes conflict. The proposed models will measure potential effects high maternal depressive symptoms may have on parental monitoring and involvement and diabetes specific conflict and how these variables may in turn relate to poor regimen adherence. Methods: Participants included 225 mothers and young adolescents (aged 11-14) with T1D. Diabetes self-care behaviors were measured with the 24 Hour Recall Interview, parental involvement and monitoring were measured with the Parent Management of Diabetes Scale, …

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Mother-Infant Synchrony During Infant Feeding, Barbara Reyna Dec 2010

Mother-Infant Synchrony During Infant Feeding, Barbara Reyna

Theses and Dissertations

MOTHER-INFANT SYNCHRONY DURING INFANT FEEDING By Barbara A. Reyna, PhD A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2010. Major Director: Rita H. Pickler, PhD Endowed Nursing Alumni Professor Department of Family and Community Health Nursing, School of Nursing Synchrony between a mother and her infant is fundamental to their developing relationship. Feeding is an essential activity that provides an opportunity for interaction between a mother and her infant and may lead to synchronous interaction. The purpose this study was to develop and test a …

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A Novel Method To Detect Functional Subgraphs In Biomolecular Networks, Sterling Thomas Dec 2010

A Novel Method To Detect Functional Subgraphs In Biomolecular Networks, Sterling Thomas

Theses and Dissertations

Several biomolecular pathways governing the control of cellular processes have been discovered over the last several years. Additionally, advances resulting from combining these pathways into networks have produced new insights into the complex behaviors observed in cell function assays. Unfortunately, identification of important subnetworks, or “motifs”, in these networks has been slower in development. This study focused on identifying important network motifs and their rate of occurrence in two different biomolecular networks. The two networks evaluated for this study represented both ends of the spectrum of interaction knowledge by comparing a well defined network (apoptosis) with and poorly studied network …

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Isolationism, Internationalism And The “Other:” The Yellow Peril, Mad Brute And Red Menace In Early To Mid Twentieth Century Pulp Magazines And Comic Books, Nathan Vernon Madison Dec 2010

Isolationism, Internationalism And The “Other:” The Yellow Peril, Mad Brute And Red Menace In Early To Mid Twentieth Century Pulp Magazines And Comic Books, Nathan Vernon Madison

Theses and Dissertations

This thesis’ purpose is to demonstrate, via the examination of popular youth literature (primarily pulp magazines and comic books) from the 1920s through to the 1950s, that the stories found therein drew their definitions of heroism and villainy from an overarching, nativist fear of outsiders that had existed before the Great War, but intensified afterwards. These depictions were transferred to America’s “new” enemies following both the United States’ entry into the Second World War, as well as the early stages of the Cold War. This transference of nativist imagery left behind the ethnically-based origins of such depictions, showing that racism …

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Depth And Time Related Variations Of Microbial Communiites In An Emergent Freshwater Wetland, Amy Jenkins Dec 2010

Depth And Time Related Variations Of Microbial Communiites In An Emergent Freshwater Wetland, Amy Jenkins

Theses and Dissertations

Soils, and the microbial communities contained within them, are vital for most chemical, physical, and biological processes. This study investigated how microbial community structure responded to environmental changes, such as hydrology, across vertical space (depth) and time in an emergent fresh water wetland. Research was conducted in a non-tidal freshwater wetland along the James River (Charles City County, Virginia) by establishing plots in two areas that experienced different hydrologic regimes and plant communities. Soil cores (30 cm) were collected monthly from January 2008 to February 2009, and then every two to three months thereafter until October 2009, for a total …

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Utility Of The General Validity Scale Model: Development Of Validity Scales For The Co-Parenting Behavior Questionnaire, Kimberly Parker Dec 2010

Utility Of The General Validity Scale Model: Development Of Validity Scales For The Co-Parenting Behavior Questionnaire, Kimberly Parker

Theses and Dissertations

Validity scales for child-report measures are necessary tools in clinical and forensic settings in which major decisions affecting the child and family are in question. Currently there is no standard model for the development and testing of such validity scales. The present study focused on 1) creating the General Validity Scale (GVS) Model to serve as a guide in validity scale development and 2) applying this model in the development of validity scales for the Co-parenting Behavior Questionnaire (CBQ), a child-report measure of parenting and co-parenting behaviors for children whose parents are divorced. Study 1 used the newly developed GVS …

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Approaches To Identify Surface Proteins Of Anaplasma Phagocytophilum Dense-Cored Organisms As Adhesins To Human P-Selectin Glycoprotein Ligand-1, Matthew Troese Dec 2010

Approaches To Identify Surface Proteins Of Anaplasma Phagocytophilum Dense-Cored Organisms As Adhesins To Human P-Selectin Glycoprotein Ligand-1, Matthew Troese

Theses and Dissertations

Anaplasma phagocytophilum is an obligatory intracellular bacterium that infects neutrophils to cause human granulocytic anaplasmosis. Sialyl Lewis x (sLex)-modified P-selectin glycoprotein ligand-1 (PSGL-1) is the confirmed receptor utilized by A. phagocytophilum to bind and invade human neutrophils and myeloid cell lines. As an obligate intracellular pathogen, the binding of A. phagocytophilum to a host cell receptor is a prerequisite step for entry and replication, and thus its survival. However, the bacterial adhesins mediating this process have yet to be identified. In this study, we sought to identify surface proteins of A. phagocytophilum as putative adhesins. A. phagocytophilum undergoes a biphasic …

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Phytoremediation Of Copper Contaminated Waste Water Using Lemna Minor, Mark Apelt Nov 2010

Phytoremediation Of Copper Contaminated Waste Water Using Lemna Minor, Mark Apelt

Theses and Dissertations

The use of natural remediation methods to remove contaminants from waste water is becoming more popular. Plants have been used for several decades, yet their use for municipal waste water contaminated by heavy metals is limited to a few studies which focus on the Mercury and Chromium (Bennicelli, et.al, 2004). This study specifically attempted to determine the viability for using Lemna minor to remediate municipally generated wastewater contaminated with copper. The study used 100 ml samples of wastewater, artificially spiked with 8 mg/L of copper sulfate and seeded with approximately 100 Lemna minor fronds. Each treatment was repeated 15 times …

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Inferential Methods For High-Throughput Methylation Data, Maria Capparuccini Nov 2010

Inferential Methods For High-Throughput Methylation Data, Maria Capparuccini

Theses and Dissertations

The role of abnormal DNA methylation in the progression of disease is a growing area of research that relies upon the establishment of sound statistical methods. The common method for declaring there is differential methylation between two groups at a given CpG site, as summarized by the difference between proportions methylated db=b1-b2, has been through use of a Filtered Two Sample t-test, using the recommended filter of 0.17 (Bibikova et al., 2006b). In this dissertation, we performed a re-analysis of the data used in recommending the threshold by fitting a mixed-effects ANOVA model. It was determined that the 0.17 filter …

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Network Analysis And Comparative Phylogenomics Of Micrornas And Their Respective Messenger Rna Targets Using Twelve Drosophila Species, M Ryan Woodcock Nov 2010

Network Analysis And Comparative Phylogenomics Of Micrornas And Their Respective Messenger Rna Targets Using Twelve Drosophila Species, M Ryan Woodcock

Theses and Dissertations

MicroRNAs represent a special class of small (~21–25 nucleotides) non-coding RNA molecules which exert powerful post-transcriptional control over gene expression in eukaryotes. Indeed microRNAs likely represent the most abundant class of regulators in animal gene regulatory networks. This study describes the recovery and network analyses of a suite of homologous microRNA targets recovered through two different prediction methods for whole gene regions across twelve Drosophila species. Phylogenetic criteria under an accepted tree topology were used as a reference frame to 1) make inference into microRNA-target predictions, 2) study mathematical properties of microRNA-gene regulatory networks, 3) and conduct novel phylogenetic analyses …

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Commonwealth Times 2010-11-08 Nov 2010

Commonwealth Times 2010-11-08

Commonwealth Times, 1969-

No abstract provided.

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Genetic Evaluation Of American Shad Alosa Sapidissima Restoration Success In James River, Virginia, Aaron Aunins Nov 2010

Genetic Evaluation Of American Shad Alosa Sapidissima Restoration Success In James River, Virginia, Aaron Aunins

Theses and Dissertations

The American shad Alosa sapidissima has experienced severe declines throughout its native range due to habitat degradation, fragmentation, and over-fishing. Hatchery supplementation is often used for stock restoration, but the effects of supplementation on population structure and genetic diversity are rarely assessed. This study employed molecular markers to evaluate how supplementation of the James River American shad population with Pamunkey River origin larvae since 1994 has impacted genetic diversity and population structure. Population genetic parameters of other major Chesapeake Bay tributaries (Susquehanna, Rappahannock, Potomac, and Nanticoke) also were characterized. Prior to stocking, the James and Pamunkey populations exhibited subtle genetic …

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Determination Of Structure Of Hepatitis B Virus E Antigen, Asheel Patel Oct 2010

Determination Of Structure Of Hepatitis B Virus E Antigen, Asheel Patel

Theses and Dissertations

Hepatitis B virus is a member of the hepadnavirus family. The hepatitis B virus core gene codes for two proteins viz. core protein and pre-core protein. These proteins assemble to form particles viz. HBcAg and HBeAg respectively. The structure of the HBcAg has been widely studied but very little is known about the structure of HBeAg. Therefore, the aim of this study was to identify the disulfide bonding patterns in HBeAg. Recombinant HBeAg was isolated from E.coli and used for this study along with various mutants of HBeAg. There are four cysteines present in HBeAg each at position -7, 48, …

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Adenovirus-5 Infection Affects Lipid Metabolism In Hepatic And Adipose Tissues, Marianna Sukholutsky Oct 2010

Adenovirus-5 Infection Affects Lipid Metabolism In Hepatic And Adipose Tissues, Marianna Sukholutsky

Theses and Dissertations

Our recent studies have shown a link between Adenovirus-5 (Ad-5) and elevated lipids, which prompted the hypothesis that Ad-5 infection might augment hepatic and/or adipose tissue lipid metabolism. To test our hypothesis, mice were infected with Ad-5 and screened for changes in lipogenesis and plasma markers associated with the metabolic syndrome. We observed increased expression of sterol regulatory element binding protein 1 (SREBP-1) in infected liver tissues, but not in adipose tissues and this correlated with elevated plasma and hepatic triglyceride levels. Elevated expression of adiponectin was seen in Ad-5 infected adipose tissues and this correlated with phosphorylated AMPK in …

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Brachytherapy Seed And Applicator Localization Via Iterative Forward Projection Matching Algorithm Using Digital X-Ray Projections, Damodar Pokhrel Oct 2010

Brachytherapy Seed And Applicator Localization Via Iterative Forward Projection Matching Algorithm Using Digital X-Ray Projections, Damodar Pokhrel

Theses and Dissertations

Interstitial and intracavitary brachytherapy plays an essential role in management of several malignancies. However, the achievable accuracy of brachytherapy treatment for prostate and cervical cancer is limited due to the lack of intraoperative planning and adaptive replanning. A major problem in implementing TRUS-based intraoperative planning is an inability of TRUS to accurately localize individual seed poses (positions and orientations) relative to the prostate volume during or after the implantation. For the locally advanced cervical cancer patient, manual drawing of the source positions on orthogonal films can not localize the full 3D intracavitary brachytherapy (ICB) applicator geometry. A new iterative forward …

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Application Of An Inverse-Hysteresis Iterative Control Algorithm For Afm Fabrication, Seth Ashley Oct 2010

Application Of An Inverse-Hysteresis Iterative Control Algorithm For Afm Fabrication, Seth Ashley

Theses and Dissertations

An iterative control algorithm (ICA) which uses an approximate inverse-hysteresis model is implemented to compensate for hysteresis to precisely fabricate features on a soft polymer substrate using an atomic force microscope (AFM). The AFM is an important instrument in micro/nanotechnology because of its ability to interrogate, manipulate, and fabricate objects at the micro/nanoscale. The AFM uses a piezoelectric actuator to position an AFM-probe tip relative to the sample surface in three dimensions. In particular, precision lateral control of the AFM-probe tip relative to the sample surface is needed to ensure high-performance operation of the AFM. However, precision lateral positioning of …

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Electronic Structure Based Classification Of Neurotransmitters And Related Drugs, Amrita Jha Oct 2010

Electronic Structure Based Classification Of Neurotransmitters And Related Drugs, Amrita Jha

Theses and Dissertations

A fundamental understanding of the relationship between structure and activity of neurotransmitters in the human brain is of vital importance for the design targeted drugs. Using density functional theory and hybrid exchange correlation energy functionals we have studied the structure-activity-relationships of some important neurotransmitters and selected drugs by calculating their absolute hardness (η) and absolute electronegativity (χ). A plot of the η- χ diagram allowed us to assign them into three distinct groups, namely, (i) Acetylcholine analogs (positively charged structure), (ii) GABA analogs (zwitterionic structures) and (iii) monoamines. The results suggest that brain stem is chemically soft because of distribution …

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