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Cannabinoid Modulation Of Hiv-1 Tat-Stimulated Adhesion Of Macrophage-Like Cells To The Extracellular Matrix, Johnathan Drevik Jan 2013

Cannabinoid Modulation Of Hiv-1 Tat-Stimulated Adhesion Of Macrophage-Like Cells To The Extracellular Matrix, Johnathan Drevik

Theses and Dissertations

HIV-Associated Neurocognitive Disorders (HANDs) are becoming one of the largest problems in patients infected with HIV-1. The ability of infected cells such as monocytes and microglial cells to act as viral reservoirs causes extreme inflammation in the CNS and has led to several different types of neurocognitive problems. Specifically these HIV-1 infected monocytes are able to secrete inflammatory factors such as the regulatory protein Tat which acts as a chemoattractant for monocytes while also promoting the adhesion of leukocytes to the extracellular matrix (ECM). We have shown that one of the major features of the Tat protein is that it …

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Calcium/Calmodulin-Dependent Protein Kinase Ii Beta (Camkiiβ): A Regulator Of Oligodendrocyte Maturation And Myelination, Christopher Waggener Jan 2013

Calcium/Calmodulin-Dependent Protein Kinase Ii Beta (Camkiiβ): A Regulator Of Oligodendrocyte Maturation And Myelination, Christopher Waggener

Theses and Dissertations

Oligodendrocytes are cells located in the central nervous system (CNS) that are responsible for the production of the lipid rich membrane, myelin. Myelin and the process of making and wrapping myelin around an axon (also known as myelination) are critical for normal development since they ensure proper signal conduction in the vertebrate CNS. The loss or damage of this myelin, which is typically associated with the demyelinating disease multiple sclerosis (MS), is associated with improper axonal protection along with disrupted nerve signaling which can lead to a variety of different debilitating phenotypic responses. It has been shown that there are …

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The Metabolic Transitions Regulated By The Estrogen-Related Receptor (Err) In Drosophila Melanogaster, Yan Li Jan 2013

The Metabolic Transitions Regulated By The Estrogen-Related Receptor (Err) In Drosophila Melanogaster, Yan Li

Theses and Dissertations

In multicellular organism, bioenergetic metabolism is strictly regulated toward efficient generation of ATP. However, in certain situations, such as in limiting oxygen or in the rapidly proliferating system like growing juvenile or cancer cells, organisms apply the metabolic strategy that favors the production of biomass (e.g., nucleotides, amino acids, and lipids) over efficiency of ATP generation. The conserved estrogen-related receptors (ERRs) are master regulators in controlling metabolic homeostasis, and good candidates for mediating the metabolic transition induced by hypoxia and development. First, we investigate how dERR influences hypoxic adaptation in Drosophila melanogaster. We find that dERR is required for a …

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Association Of Family Structure And Glycemic Control In Adolescents With Type 1 Diabetes: Risk And Protective Factors, Laura Jean Caccavale Jan 2013

Association Of Family Structure And Glycemic Control In Adolescents With Type 1 Diabetes: Risk And Protective Factors, Laura Jean Caccavale

Theses and Dissertations

Youth with type 1 diabetes (T1D) from single-parent families are more likely to be in poorer glycemic control (HbA1c). Demographic trends indicate more households are composed of unmarried adults and fewer youths. Family density, or a youth: adult ratio, may be a more salient factor than single-parent status in the association with glycemic control. Data from 257 adolescents aged 11-14 years (M = 12.84) at two different sites were collected as part of a randomized control trial of a treatment intervention designed to increase parent involvement and prevent deterioration of adolescent diabetes disease care. Single-parent status was determined by parental …

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In Vitro Lung Epithelial Cell Transport And Anti-Inflammatory Activity For Liposomal Ciprofloxacin, Ruba Darweesh Jan 2013

In Vitro Lung Epithelial Cell Transport And Anti-Inflammatory Activity For Liposomal Ciprofloxacin, Ruba Darweesh

Theses and Dissertations

Liposomal ciprofloxacin (Lipo-CPFX) is being developed for inhalation, with a goal of sustaining the therapeutic activity, compared to unformulated ciprofloxacin (CPFX). However, the kinetics and mechanism of its sustained local lung retention and pharmacological activity are yet to be fully characterized. This project hypothesized that Lipo-CPFX enables slower and sustained lung epithelial transport and uptake, compared to CPFX, thereby producing prolonged local pharmacological actions. The human bronchial epithelial Calu-3 cells were used as monolayers to characterize the kinetics and mechanism of transport and/or uptake, and to assess the effects of such slow kinetics for Lipo-CPFX on its inhibition against lipopolysaccharide …

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Sphingosine-1-Phosphate And Fingolimod (Fty720) Regulate Icl,Swell In Hl-1 Cardiac Myocytes Via Intracellular Binding And Mitochondrial Ros Production, Pooja Desai Jan 2013

Sphingosine-1-Phosphate And Fingolimod (Fty720) Regulate Icl,Swell In Hl-1 Cardiac Myocytes Via Intracellular Binding And Mitochondrial Ros Production, Pooja Desai

Theses and Dissertations

Swelling-activated Cl− current (ICl,swell) is an outwardly-rectifying current that plays an important role in cardiac electrical activity, cellular volume regulation, apoptosis, and acts as a potential effector of mechanoelectrical feedback. Persistent activation of ICl,swell has been observed in models of cardiovascular disease. We previously suggested sphingosine-1-phosphate (S1P) activates volume-sensitive Cl- current (ICl,swell) by ROS-dependent signaling. S1P and its analog, FTY720 (fingolimod), primarily act via G-protein coupled receptors (S1PR; S1PR1-3 in heart), but several intracellular S1P ligands are known. We investigated how these agents regulate ICl,swell. ICl,swell was elicited by bath S1P (500 nM), FTY720 (S1PR1,3 agonist; 10 μM), and SEW2871 …

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The Atlantic Bluefin Tuna: A Public Policy Approach To Saving An Iconic Species, Timothy Patrick O'Brien Dec 2012

The Atlantic Bluefin Tuna: A Public Policy Approach To Saving An Iconic Species, Timothy Patrick O'Brien

Theses and Dissertations

The Atlantic Bluefin Tuna (Thunnus thynnus) is perhaps the most magnificent and most marvelous nomadic wild animal living in the world. It lives in the deep blue waters of the Atlantic Ocean and is one of the largest of the world’s fin fish and the largest of the 48 other species of tuna (Kuhn, 1996). It is a species that seems to have been designed and sculpted by an artist—sleek, smooth, and beautiful—instead of having been a product of an evolutionary process. Today, the existence and future of the Atlantic Bluefin Tuna is in question because of the constant overexploitation …

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Information Theoretic Approaches Towards Regulatory Network Inference, Vijender Chaitankar Dec 2012

Information Theoretic Approaches Towards Regulatory Network Inference, Vijender Chaitankar

Theses and Dissertations

In spite of many efforts in the past, inference or reverse engineering of regulatory networks from microarray data remains an unsolved problem in the area of systems biology. Such regulatory networks play a critical role in cellular function and organization and are of interest in the study of a variety of disease areas and ecotoxicology to name a few. This dissertation proposes information theoretic methods/algorithms for inferring regulatory networks from microarray data. Most of the algorithms proposed in this dissertation can be implemented both on time series and multifactorial microarray data sets. The work proposed here infers regulatory networks considering …

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Life History Analysis Of James River Atlantic Sturgeon (Acipenser Oxyrinchus Oxyrinchus) With Implications For Management And Recovery Of The Species, Matthew Balazik Dec 2012

Life History Analysis Of James River Atlantic Sturgeon (Acipenser Oxyrinchus Oxyrinchus) With Implications For Management And Recovery Of The Species, Matthew Balazik

Theses and Dissertations

Sturgeon species (family Acipenseridae) are threatened globally due to habitat destruction, pollution, and overfishing. The Atlantic sturgeon Acipenser oxyrinchus oxyrinchus was listed as a federally endangered species in 2012. Atlantic sturgeon have a complex life history that utilizes a wide range of habitats. Timing of life history varies in different areas requiring each population to be studied. Very little work has been published on Atlantic sturgeon reproduction in the James River, Virginia. To aid the recovery of James River Atlantic sturgeon, aspects of life history need to be addressed. To increase understanding of Atlantic sturgeon life history a length at …

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From Linkage To Gwas: A Multifaceted Exploration Of The Genetic Risk For Alcohol Dependence, Amy Adkins Dec 2012

From Linkage To Gwas: A Multifaceted Exploration Of The Genetic Risk For Alcohol Dependence, Amy Adkins

Theses and Dissertations

Family, twin and adoption studies consistently suggest that genetic factors strongly influence the risk for alcohol dependence (AD). Although the literature supports the role of genetics in AD, identification of specific genes contributing to the etiology of AD has proven difficult. These difficulties are due in part to the complex set of risk factors contributing to the development of AD. These risk factors include comorbidities with other clinical diagnoses and behavioral phenotypes (e.g., major depression), physiological differences that contribute to the differences between people in their level of response to ethanol (e.g., initial sensitivity) and finally the large number of …

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The Economic Burden Of Opioid Poisoning In The United States And Determinants Of Increased Costs In Opioid Poisoning, Timothy Inocencio Dec 2012

The Economic Burden Of Opioid Poisoning In The United States And Determinants Of Increased Costs In Opioid Poisoning, Timothy Inocencio

Theses and Dissertations

Introduction: Opioid poisoning has been rapidly increasing in the past decade, and has been driven in large part due to increases in opioid prescribing. This has been accompanied by intervention efforts aimed at preventing and reversing opioid poisoning through naloxone prescription programs. Current literature have not quantified the economic burden of opioid poisoning. Understanding this information can help inform these efforts and bring light to this growing problem. In addition understanding various determinants of increased costs can help to identify the types of populations more likely to have greater costs. Main Objectives: The objectives are 1) to quantify the economic …

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Characterization Of The Expression Of The Intercellular Adhesin Locus In Staphylococcus Aureus, Jamie Brooks Dec 2012

Characterization Of The Expression Of The Intercellular Adhesin Locus In Staphylococcus Aureus, Jamie Brooks

Theses and Dissertations

Poly-N-acetylglucosamine (PNAG) is an important Staphylococcus aureus virulence factor. It is a major component of the extracellular polymeric matrix in biofilms, and contributes to resistance to the innate immune response. The proteins encoded in the icaADBC (intercellular adhesin) operon are responsible for PNAG production. Here, we present evidence of a new mechanism of phase variation for switching off PNAG production that involves slipped strand mutagenesis, along with further insight into the regulation and expression of the icaADBC operon. S. aureus strain MN8m (mucoid) is a spontaneous mutant of strain MN8 (non-mucoid). It is characterized by constitutive overproduction of PNAG, resulting …

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Investigation Of Possible Novel Peptide Inhibitors To Bag-1 Based On Peptidyl-Biomimetics, Jonathan Brunn Dec 2012

Investigation Of Possible Novel Peptide Inhibitors To Bag-1 Based On Peptidyl-Biomimetics, Jonathan Brunn

Theses and Dissertations

In this Master’s Thesis Research the results can be summarized from two major tasks: (1) In our first task, we utilized our two protein system (BAG-1 and HSP 70) as part of beta testing of a computational software 1 that can take three dimensional x-ray crystallography information about protein complexes and predict the strength of atom –atom interactions between amino-acid residues Open Contact predicts binding hotspots that can be used to identify short amino acid chains or peptides that mimic that particular binding segment of the larger protein. These peptides are called pepidyl-biomimetics. The peptide can potentially act as an …

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Acid-Base Catalysis In Proton-Coupled Electron Transfer Reactions (Pcet): The Effects Of Brönsted Bases On The Oxidation Of Glutathione And Hydroquinone, Ramos Jonnathan Medina Dec 2012

Acid-Base Catalysis In Proton-Coupled Electron Transfer Reactions (Pcet): The Effects Of Brönsted Bases On The Oxidation Of Glutathione And Hydroquinone, Ramos Jonnathan Medina

Theses and Dissertations

This thesis presents the results and discussion of the investigation of the effects of Brönsted bases on the kinetics and thermodynamics of two proton-coupled electron transfer processes: the mediated oxidation of glutathione and the electrochemical oxidation of hydroquinone. Proton-coupled electron transfer (PCET) is the name given to reactions that involve the transfer of electron(s) accompanied by the exchange of proton(s). PCETs are found in many chemical and biological processes, some of current technological relevance such as the oxygen reduction reaction in fuel cells, which involves the transfer of four electrons and four protons (4e-, 4H+); or the splitting of water …

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There Is A Beginning, Catherine Stark Dec 2012

There Is A Beginning, Catherine Stark

Theses and Dissertations

Science and nature inspire me to create. I have always found a unique beauty in abstracted views of organic matter. I have built a visual vocabulary for my imagery through examinations of scientific images from topography and biology. In addition, my responses to the natural environment inform my abstract, expressionistic, mixed media paintings. Using oil paint in a nontraditional way, I rub, brush, and manipulate paper surfaces to create subtle texture and color. Then, I add a vast range of materials such as resin, varnish, and enamel to build depth and layers. My works suggest actual surfaces in nature and …

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Ige Enhances B Cell-Derived Exosomal Induced T Cell Proliferation, Brooks Keith Nov 2012

Ige Enhances B Cell-Derived Exosomal Induced T Cell Proliferation, Brooks Keith

Theses and Dissertations

For many years it has been known that the injection of antigen bound to an antibody leads to more than a 1000-fold increase in antigen specific antibody response. This observation holds true for IgE, which is dependent upon CD23 expression, as this enhancement is not present in mice deficient in CD23. It also has been shown that when mice are injected with IgE-antigen complexes also display an increase in antigen specific T cell proliferation. While there are published studies that demonstrate a role for B cell derived exosomes in the activation and proliferation of T cells, none have focused upon …

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The Effects Of River Sediment, Endosulfan, And Moderate Hypoxia On Blue Crabs (Callinectes Sapidus) From The Tidal, Freshwater James River, Laura Williams Nov 2012

The Effects Of River Sediment, Endosulfan, And Moderate Hypoxia On Blue Crabs (Callinectes Sapidus) From The Tidal, Freshwater James River, Laura Williams

Theses and Dissertations

Juvenile male blue crabs move into the tidal, freshwater James River during warmer months to feed and grow by undergoing molting. In crustaceans, growth and molting are hormonally controlled. The physiological effects of a multiple-stressor environment are determined by comparing the blue crab’s oxygen uptake after exposure to pure sand, James River sediment, or endosulfan-spiked sand. The effect of multiple stressors on molting is measured by the activity level of N-acetyl-ß-glucosaminidase (NAG), an enzyme in epidermal tissue important to molting. The oxygen uptake was decreased by exposure to James River sediment but not for exposure to endosulfan for seven days. …

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Perceived Stress And Surgical Wound Cytokine Patterns, Valentina Lucas Nov 2012

Perceived Stress And Surgical Wound Cytokine Patterns, Valentina Lucas

Theses and Dissertations

Normal wound healing is a complex process that occurs in overlapping phases and depends upon interactions of the patient, environment and a large number of cells, growth factors, cytokines, chemokines, and other biochemical mediators. Psychological stress has been shown to adversely affect the normal wound healing process through its impact on cellular immunity. Cellular immunity impacts wound healing through the production and regulation of many of the above biochemical mediators of wound healing. The purpose of this pilot study was to examine the relationships among pre- and post-operative psychological stress experienced by women who were undergoing either immediate or delayed …

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Role Of Tyrosyl-Dna Phosphodiesterase (Tdp 1) On Repair Of 3′-Phosphoglycolate (3′- Pg) Terminated Dna Double-Strand Breaks (Dsbs) And In Response To Oxidative Stress, Tong Zhou Nov 2012

Role Of Tyrosyl-Dna Phosphodiesterase (Tdp 1) On Repair Of 3′-Phosphoglycolate (3′- Pg) Terminated Dna Double-Strand Breaks (Dsbs) And In Response To Oxidative Stress, Tong Zhou

Theses and Dissertations

DNA DSBs are most toxic to cells because they can lead to genomic rearrangements and even cell death. Most DSBs induced by ionizing radiation or radiomimetic drugs such as calicheamicin and bleomycin, bear 3′-phosphate or 3′- PG moieties that must be removed to allow subsequent gap filling and ligation. DSBs can be repaired by two main pathways: the homologous recombination (HR) pathway and the non-homologous end-joining (NHEJ) pathway, NHEJ is the primary repair pathway in mammalian cells. While HR repairs single strand breaks (SSBs) or DSBs accurately by using an undamaged copy of the sequence mostly at late S phase …

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Costs And Use Of Oral Anti-Cancer Medications Among Senior Medicare Part D Beneficiaries, Nantana Kaisaeng Nov 2012

Costs And Use Of Oral Anti-Cancer Medications Among Senior Medicare Part D Beneficiaries, Nantana Kaisaeng

Theses and Dissertations

Oral cancer drugs are branded and expensive medications that generally do not have generics available. The restrictions of the Medicare Part D program, including the coverage gap and high cost-sharing, and the high cost of oral chemotherapy may lead to patients’ non-adherence to medication. Few studies have examined the cost and utilization of oral anti-cancer medications. This study will be the first to examine the costs associated with the use of oral anti-cancer medications and the impact of cost-sharing and type of prescription drug subsidy on medication discontinuation in the Medicare Part D elderly population. Objectives: To determine the usage …

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Investigating A Model For Fetal Alcohol Damage In Caenorhabditis Elegans, Lindsay Kondo Nov 2012

Investigating A Model For Fetal Alcohol Damage In Caenorhabditis Elegans, Lindsay Kondo

Theses and Dissertations

Alcohol use and abuse has many harmful effects, especially to children exposed prenatally, including fetal alcohol spectrum disorders (FASDs). The disabilities due to fetal alcohol exposure continue throughout life and cause major financial burdens to society. The molecular mechanisms underlying FASDs are not well understood. We have taken a genetic approach to characterize ethanol’s effect on changing a discrete cell fate decision during embryogenesis in the nematode, Caenorhabditis elegans (C. elegans). Our preliminary data suggest that ethanol can affect the development of AWC neurons, a pair of olfactory neurons in C. elegans. We suggest that lipids can protect AWC neurons …

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Nobody’S Perfect: A Qualitative Examination Of African American Caregivers And Their Adolescent Daughters’ Perceptions Of Adolescent Girls’ Body Image, Michell Pope Nov 2012

Nobody’S Perfect: A Qualitative Examination Of African American Caregivers And Their Adolescent Daughters’ Perceptions Of Adolescent Girls’ Body Image, Michell Pope

Theses and Dissertations

The increasingly high rates of body dissatisfaction among adolescent girls are alarming. Research suggests that cultural norms emphasizing thinness and unrealistic standards of beauty may be contributing to this growing problem. This is concerning given the link between negative body image and a host of unhealthy behaviors in girls. Although historically African American adolescent girls have exhibited higher levels of body satisfaction than their counterparts, there is growing evidence to suggest that this may be changing because of the body-related messages they receive from their parents, peers and the media. The present study examines these messages from both maternal caregivers’ …

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Changing The Game: Corporate Social Responsibility In Women's Professional Sport, Lorie Coker Nov 2012

Changing The Game: Corporate Social Responsibility In Women's Professional Sport, Lorie Coker

Theses and Dissertations

Research indicates that female athletes have long occupied marginal and sometimes invisible positions in sport settings and mainstream media. The focus of this study is on understanding and analyzing how race, class, gender, and other forms of oppression shape women’s professional sport using as the focal point, corporate social responsibility (CSR) and the type of mainstream media coverage it receives. The researcher believes that a better understanding of these varied experiences would add depth and knowledge to research on CSR in sport, women and sport research, as well as allow professional leagues and teams to move forward with a more …

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Successful Emergent Literacy Head Start Teachers Of Urban African American Boys Living In Poverty, John Michael Holland Nov 2012

Successful Emergent Literacy Head Start Teachers Of Urban African American Boys Living In Poverty, John Michael Holland

Theses and Dissertations

This integrated methods study used a sequential explanatory design to explore the culturally relevant teaching beliefs of successful emergent literacy Head Start teachers of urban African American boys living in poverty. The study utilized emergent literacy gain scores as a measure of success, a survey of culturally relevant teaching beliefs to describe variation in beliefs within the sample, and two rounds of interviews to explore the context of teacher agency with urban African American boys living in poverty. The four teachers interviewed expressed culturally relevant beliefs integral to their teaching practices. These beliefs were conveyed through descriptions of relationships with …

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A New Approach To Dried Blood Spot Analysis For Newborn Screening Using High Resolution Liquid Chromatography Tandem Mass Spectrometry, John H. Miller Iv Nov 2012

A New Approach To Dried Blood Spot Analysis For Newborn Screening Using High Resolution Liquid Chromatography Tandem Mass Spectrometry, John H. Miller Iv

Theses and Dissertations

The primary purpose of newborn screening is to quickly identify children that are at risk of having a specific disorder in order to start treatment, prevent early death and reduce the chances of permanent physical or mental damage. The current and widely accepted approach used for identification of metabolism disorders involves a flow injection analysis with mass spectrometry detection of acylcarnitines and amino acids. Although this approach is widely accepted and has shown to be sufficient for identification of multiple metabolism disorders the method is not fully quantitative and results often have to be confirmed by second-tier tests. The primary …

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Growth Gone Awry: Exploring The Role Of Embryonic Liver Development Genes In Hcv Induced Cirrhosis And Hepatocellular Carcinoma, Martha K. Behnke Nov 2012

Growth Gone Awry: Exploring The Role Of Embryonic Liver Development Genes In Hcv Induced Cirrhosis And Hepatocellular Carcinoma, Martha K. Behnke

Theses and Dissertations

Introduction and methods: Hepatocellular carcinoma (HCC) remains a difficult disease to study even after a decade of genomic analysis. Metabolic and cell-cycle perturbations are known, large changes in tumors that add little to our understanding of the development of tumors, but generate “noise” that obscures potentially important smaller scale expression changes in “driver genes”. Recently, some researchers have suggested that HCC shares pathways involving the master regulators of embryonic development. Here, we investigated the involvement and specificity of developmental genes in HCV-cirrhosis and HCV-HCC. We obtained microarray studies from 30 patients with HCV-cirrhosis and 49 patients with HCV-HCC and compared …

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Novel Strategies To Improve Metabolic Parameters And Precondition Diabetic Hearts Against Ischemia/Reperfusion Injury, Amit Varma Nov 2012

Novel Strategies To Improve Metabolic Parameters And Precondition Diabetic Hearts Against Ischemia/Reperfusion Injury, Amit Varma

Theses and Dissertations

Insulin resistance and chronic hyperglycemia promote vascular damage, increase circulating levels of inflammatory cytokines and lead to increased morbidity and mortality. MicroRNAs (miRs) -103/107 have been shown to negatively regulate insulin sensitivity and glucose homeostasis. Based on complimentary binding profiles, the downstream target gene of miR-103/107 is caveolin-1 (Cav-1). We hypothesized that daily administration of the phosphodiesterase-5 inhibitor tadalafil (TAD) ± the curcumin analogue (HO-3867) will attenuate inflammation, improve metabolic parameters and reduce infarct size after ischemia/reperfusion injury (IRI). Furthermore, we propose that TAD therapy will reduce myocardial expression of miR-103/107 and increase mRNA and protein levels of its target …

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The Role Of Magl Inhibition In Nicotine Withdrawal And Reward, Pretal Muldoon Nov 2012

The Role Of Magl Inhibition In Nicotine Withdrawal And Reward, Pretal Muldoon

Theses and Dissertations

ROLE OF MAGL INHIBITION IN NICOTINE WITHDRAWAL AND REWARD. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. by Pretal Ishvarlal Patel Muldoon Director: M. Imad Damaj, PhD Professor, Department of Pharmacology and Toxicology Tobacco use is one of the leading causes of preventable deaths worldwide. Nicotine, the main psychoactive component of tobacco, sustains and initiates tobacco addiction. Cessation of nicotine induces a dependence withdrawal syndrome. Recent in vivo studies indicate that the endocannabinoid (EC) system modulates both nicotine reward and withdrawal. The purpose of this proposal is to …

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Commonwealth Times 2012-11-15 Nov 2012

Commonwealth Times 2012-11-15

Commonwealth Times, 1969-

No abstract provided.

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Spanish, Nahua, And Maya Narratives On The 1585 Relación Geográfica Map Of Santiago Atitlán, Kaitlan Smith Nov 2012

Spanish, Nahua, And Maya Narratives On The 1585 Relación Geográfica Map Of Santiago Atitlán, Kaitlan Smith

Theses and Dissertations

The 1585 Relación Geográfica Map of Santiago Atitlán, Guatemala gives scholars a rare glimpse of sixteenth- century southern Guatemala. The map displays the use of Spanish, Nahua, and Maya perspectives. The coexistence of indigenous Nahua versus Spanish or European iconographies and narratives is a theme constantly explored in the studies of the Relaciones Geográficas maps. However, the opposition of two different indigenous narratives and iconographies, as well as Spanish, is not. This project examines the convergences and conflicts among these narratives and iconographies as evidenced on the map and in the accompanying text. The individual discussion of each narrative is …

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