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Cellular Effects Of Platinum Chemotherapeutics: Alterations By Antidepressants And Heparan Sulfate Proteoglycans, Brigitte Engelmann
Cellular Effects Of Platinum Chemotherapeutics: Alterations By Antidepressants And Heparan Sulfate Proteoglycans, Brigitte Engelmann
Theses and Dissertations
The work discussed here is divided into two projects. The first project involves the interactions between antidepressants and the platinum based chemotherapeutics while the second project begins to investigate possible implications of a recently discovered uptake mechanism for positively charged platinum drugs. Gaining understanding of the interactions between antidepressants and platinum-based chemotherapeutics is important due to the frequency with which they are prescribed together. Although using a combination regimen of antineoplastics is beneficial to the patient, not all drug interactions are. For instance, many of the serotonin reuptake inhibitors have been shown to decrease the efficacy of tamoxifen. Desipramine, a …
Practices Of Professionals Providing Services To Children With Autism Spectrum Disorders: Testing The Theory Of Planned Behavior In Predicting Use Of Evidence-Based Interventions And Family-Centered Care, Lillian Christon
Theses and Dissertations
Autism spectrum disorders (ASDs) are chronic and pervasive developmental disorders; children with ASDs require more multidisciplinary services than children with other developmental, behavioral, and emotional disorders (Kogan et al., 2008). Little research has been done on the practices and perspectives of the professionals providing services to children with ASDs. Evidence-based practice (combining use of evidence-based interventions [EBIs], family-centered care [FCC] respecting patient/family values, and clinical expertise) leads to the best outcomes for children with ASDs (APA Presidential Task Force on Evidence-Based Practice, 2006). The aim of this study was to assess the extent to which psychological constructs (attitudes, subjective norms, …
Health And Religious Commitment Among College Students: The Effects Of Health Behavior, Mental Health, And Social Support, Monica Yvette Jones
Health And Religious Commitment Among College Students: The Effects Of Health Behavior, Mental Health, And Social Support, Monica Yvette Jones
Theses and Dissertations
Empirical findings supporting the connection between religion and spirituality and health have been consistently found in the literature, whereas the factors explaining this relationship have lacked clarity. The present study sought to explore this relationship and establish health behavior, mental health, and social support as mediating factors to the proposed association between religious commitment and physical health. Physical health was measured by a number of indicators: body mass index, self-reported medical conditions, prescription drug use, over-the-counter medication usage, and problem use of drugs and alcohol. A sample of 150 college students from a university in Central Virginia participated in this …
A Study Towards Development Of An Automated Haptic User Interface (Ahui) For Individuals Who Are Blind Or Visually Impaired, Ravi Rastogi
A Study Towards Development Of An Automated Haptic User Interface (Ahui) For Individuals Who Are Blind Or Visually Impaired, Ravi Rastogi
Theses and Dissertations
An increasing amount of information content used in schools, work and everyday living is being presented in graphical form, creating accessibility challenges for individuals who are blind or visually impaired, especially in dynamic environments, such as over the internet. Refreshable haptic displays that can interact with computers can be used to access such information tactually. Main focus of this study was the development of specialized computer applications allowing users to actively compensate for the inherent issues of haptics when exploring visual diagrams as compared to vision, which we hypothesized, would improve the usability of such devices. An intuitive zooming algorithm …
The Effect Of Study Abroad On The Development Of Intercultural Sensitivity Among Mainland Chinese High School Students, Chenfang Hao
The Effect Of Study Abroad On The Development Of Intercultural Sensitivity Among Mainland Chinese High School Students, Chenfang Hao
Theses and Dissertations
This dissertation examined the effect of year-long study abroad program on the development of intercultural sensitivity among the Mainland Chinese high school students. The sample consisted of 50 study abroad participants and 50 students on home campus. The instrument Intercultural Development Inventory (IDI) was employed to assess the intercultural sensitivity level of Mainland Chinese students before and after study abroad experience. The paired samples t-test results reveal that study abroad students did not make statistically significant gains in the overall intercultural sensitivity through participation in the year-long study abroad program. Although there were statistically significant differences in the posttest ethnorelative …
The Severity Of Stages Estimation During Hemorrhage Using Error Correcting Output Codes Method, Yurong Luo
The Severity Of Stages Estimation During Hemorrhage Using Error Correcting Output Codes Method, Yurong Luo
Theses and Dissertations
As a beneficial component with critical impact, computer-aided decision making systems have infiltrated many fields, such as economics, medicine, architecture and agriculture. The latent capabilities for facilitating human work propel high-speed development of such systems. Effective decisions provided by such systems greatly reduce the expense of labor, energy, budget, etc. The computer-aided decision making system for traumatic injuries is one type of such systems that supplies suggestive opinions when dealing with the injuries resulted from accidents, battle, or illness. The functions may involve judging the type of illness, allocating the wounded according to battle injuries, deciding the severity of symptoms …
A Physiological Signal Processing System For Optimal Engagement And Attention Detection., Ashwin Belle
A Physiological Signal Processing System For Optimal Engagement And Attention Detection., Ashwin Belle
Theses and Dissertations
In today’s high paced, hi-tech and high stress environment, with extended work hours, long to-do lists and neglected personal health, sleep deprivation has become common in modern culture. Coupled with these factors is the inherent repetitious and tedious nature of certain occupations and daily routines, which all add up to an undesirable fluctuation in individuals’ cognitive attention and capacity. Given certain critical professions, a momentary or prolonged lapse in attention level can be catastrophic and sometimes deadly. This research proposes to develop a real-time monitoring system which uses fundamental physiological signals such as the Electrocardiograph (ECG), to analyze and predict …
Establishing The Discriminative Stimulus Properties Of The Atypical Antipsychotic Amisulpride In C57bl/6 Mice, Timothy J. Donahue
Establishing The Discriminative Stimulus Properties Of The Atypical Antipsychotic Amisulpride In C57bl/6 Mice, Timothy J. Donahue
Theses and Dissertations
Abstract ESTABLISHING THE DISCRIMINATIVE STIMULUS PROPERTIES OF THE ATYPICAL ANTIPSYCHOTIC AMISULPRIDE IN C57BL/6 MICE Antipsychotic medications are used to treat schizophrenia. The present study used the drug discrimination paradigm to measure the subjective effects of the atypical antipsychotic amisulpride and to examine the underlying neuropharmacological mechanisms responsible for the discriminative stimulus property of the drug. Male C57BL/6 mice were trained to discriminate 10 mg/kg (-)S amisulpride from vehicle in a two-lever drug discrimination task. A dose effect curve for (-)S amisulpride yielded an ED50 = 1.77 mg/kg 95% CI [1.28, 2.45 mg/kg]. Substitution testing was conducted for the isomer (+)R …
The “Man Walks Outside Time Now”: Verbal Representations Of Photographic Images In The Poems Of Larry Levis, Lauren Miner
The “Man Walks Outside Time Now”: Verbal Representations Of Photographic Images In The Poems Of Larry Levis, Lauren Miner
Theses and Dissertations
The poet Larry Levis often employed ekphrasis as an elegiac device—particularly with his verbal descriptions of photographic images—to explore human suffering and reconcile feelings of loss. Through the ekphrastic mode, Levis could juxtapose otherwise disparate images, manipulating their temporal and spatial relationships, to achieve what he conceived an authentic portrait of the human experience. The poet, through his verbal descriptions of photographic images, does not try to evade the pain or joy of being human; instead, he confronts his grief directly and, in so doing, transcends that suffering to better understand himself and his own human position. This thesis analyzes …
Towards Understanding The Mechanism Of Action Of Abused Cathinones, Rakesh Vekariya
Towards Understanding The Mechanism Of Action Of Abused Cathinones, Rakesh Vekariya
Theses and Dissertations
The dopamine transporter (DAT) mediates reuptake of dopamine from the synaptic cleft into the presynaptic terminus and plays a critical role in maintaining the normal function of dopaminergic neurons. DAT is the major target of widely abused psychostimulant drugs, including cocaine and amphetamine. DAT also figures into disease states, and it is a target for therapeutic drugs. It is known that cathinone and methcathinone, β-keto analogs of amphetamine and methamphetamine, respectively, produce pharmacological actions similar to amphetamine. Cathinone and methcathinone analogs are recently gaining in popularity on the clandestine market (e.g. ‘bath salts’). Cathinone and methcathinone analogs as well as …
White, Black, And Blue: The Battle Over Black Police, Professionalization, And Police Brutality In Birmingham, Alabama, 1963-1979, Bryan Kessler
White, Black, And Blue: The Battle Over Black Police, Professionalization, And Police Brutality In Birmingham, Alabama, 1963-1979, Bryan Kessler
Theses and Dissertations
This thesis explores the municipal politics and race relations in Birmingham, Alabama, from October 1963 to November 1979. While Birmingham is a centerpiece of the traditional Civil Rights Movement for its staging of the Bull Connor and Martin Luther King, Jr., confrontation in 1963, there has been little examination of the continuing struggles between the black and white communities in the years after the media spotlight. Of particular concern are the battles between the black community, white power structure, and the city’s police department over black policemen, professionalization and modernization, and police brutality. The changing role and tactics of black …
The Anatomy Of Expression: Explorations On The Intersection Of Acting And The Alexander Technique, Kelley Schoger
The Anatomy Of Expression: Explorations On The Intersection Of Acting And The Alexander Technique, Kelley Schoger
Theses and Dissertations
The aim of this paper is to illuminate how the principles of the Alexander Technique and the role of bodily systems can serve as a foundational support for actor training. Inclusion of the Alexander Technique in the acting curriculum proves to be an effective tool for bridging the gap between kinesthetic learning and its application to beginning acting training. Starting with the nervous system, the operating principles of the Alexander Technique are discussed through research and personal insights. Next, in light of how self-discovery plays a key role in the first year of actor training, the idea of release in …
Behavioral Phenotyping Of The Discriminative Stimulus Properties Of The Atypical Antipsychotic Drug Clozapine In 129s2/Hsv Mice, Kevin Webster
Behavioral Phenotyping Of The Discriminative Stimulus Properties Of The Atypical Antipsychotic Drug Clozapine In 129s2/Hsv Mice, Kevin Webster
Theses and Dissertations
The 129S2 inbred mouse strain is often used as a background strain in the production of genetically altered mice (i.e. knockout and transgenic mice). It is important to establish the behavioral phenotype of wild-type mice before making comparisons to genetically altered mice. Also, those comparisons can assist in the evaluation and interpretation of the in vivo effects of drugs. The drug discrimination assay measures the subjective effects of drugs and provides a measure of underlying neuropharmacological mechanisms responsible for the discriminative stimulus properties of drugs. The present study established the atypical antipsychotic drug clozapine as a discriminative stimulus in male …
The Impact Of Sincerity Of Terrorists On Committing Terrorist Activities In Turkey, Ahmet Turer
The Impact Of Sincerity Of Terrorists On Committing Terrorist Activities In Turkey, Ahmet Turer
Theses and Dissertations
This study explores the impact of sincerity of terrorists on committing terrorist activities in Turkey. The researcher is a Chief of Police in Turkey and has worked in the Anti-terror Department for a considerable part of his professional career. His professional experience has shown that the more sincere a terrorist is the more violent or heedless the terrorist activity is. Thus this research academically and statistically examines this observation and finds that sincerity affects level of violence. Attachment and adherence to the terrorist organization turn even the characteristically non-violent people into blood seeking terrorists.
Preventing Guilt By Association: Mindfulness And Susceptibility To Evaluative Conditioning, Laura Kiken
Preventing Guilt By Association: Mindfulness And Susceptibility To Evaluative Conditioning, Laura Kiken
Theses and Dissertations
Evaluative conditioning (EC) is a type of attitude formation in which a stimulus is evaluated as positive or negative based on repeated pairings with valenced stimuli. Emerging evidence suggests that individuals differ in susceptibility to EC and these differences may be related to various social and psychological biases. One variable that has been linked with less negative attitude formation, although not using an EC paradigm, is mindfulness. Further, mindfulness is proposed to alter dimensions of elaboration that may underlie EC, particularly conditioning of negative attitudes. Therefore, three studies were conducted to examine whether mindfulness is linked to differential susceptibility to …
To Use Or Not To Use: The Role Of Affect And Cognition In Changing Attitudes Toward Using Condoms Among African American Women, Kristina Hood
To Use Or Not To Use: The Role Of Affect And Cognition In Changing Attitudes Toward Using Condoms Among African American Women, Kristina Hood
Theses and Dissertations
The current project involved three studies designed to examine which characteristics of persuasive communications change condom use attitudes. Study 1 investigated the effect of message type (affective versus cognitive) and source (male versus female) on attitude change among a sample of African American women attending college. In Study 1 (N = 146), the affective message and female source produced the most positive change in condom use attitudes. Study 2 examined whether message type and source were associated with favorable condom attitudes in a community sample and whether these findings differed from a college sample. Twenty-seven women participated in group discussions …
The Evolution Of Conservative Attitudes As A Complement To Cognitive Threat Detection Mechanisms, Russ Clay
The Evolution Of Conservative Attitudes As A Complement To Cognitive Threat Detection Mechanisms, Russ Clay
Theses and Dissertations
Conservatism reflects a general attitude structure characterized by a preference for traditional social practices and an aversion to uncertainty and threat. Though the social environment undoubtedly plays a role in shaping conservative attitudes, recent studies suggest that trait-level characteristics may contribute to their development as well. The present research investigated trait-level cognitive threat detection ability as a factor which may influence the development and maintenance of conservative social attitudes. A computer simulation indicated that socially conservative attitudes may function as a strategy for increasing the survival rate of an individual with poor threat detection ability living in a relatively dangerous …
Cohort Membership, Dental Insurance And Utilization Of Dental Services In Adults Age 47 And Over Receiving Dental Care At Virginia Commonwealth University’S School Of Dentistry, Patricia Brown Bonwell
Cohort Membership, Dental Insurance And Utilization Of Dental Services In Adults Age 47 And Over Receiving Dental Care At Virginia Commonwealth University’S School Of Dentistry, Patricia Brown Bonwell
Theses and Dissertations
This cross-sectional, non-experimental study evaluates associations between cohort membership, type of dental coverage, and utilization of dental services in all patients age 47 and over who received dental care at Virginia Commonwealth University’s (VCU) School of Dentistry in 2011. Structural Lag Theory poses that society’s institutions lag behind the actuality of a healthy and capable older adult population. The two dynamisms of the Structural Lag Theory were used for this study. The Dynamism of Changing Lives is represented by Cohort differences. Cohort differences include cohort size, people living longer and retaining more of their natural teeth along with different attitudes …
Elucidating Genetic And Environmental Influences On Alcohol-Related Phenotypes, Jacquelyn Meyers
Elucidating Genetic And Environmental Influences On Alcohol-Related Phenotypes, Jacquelyn Meyers
Theses and Dissertations
Decades of work has led researchers to believe that risk for complex behavioral phenotypes, such as alcohol use disorders, is likely influenced by multiple genes of small effect acting in conjunction with each other and the environment. Currently, the field of psychiatric genetics is developing methodologies for the identification of genetic risk variants that predispose individuals to the development of complex behavioral disorders. Several challenges related to the complex and polygenic nature of these phenotypes, must be considered. This dissertation study attempts to address these important challenges in the context of alcohol use disorders and related phenotypes. A rich twin …
The Antinociceptive Effects Of Alpha 7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators In Different Animal Pain Models, Kelen Freitas
The Antinociceptive Effects Of Alpha 7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators In Different Animal Pain Models, Kelen Freitas
Theses and Dissertations
The α7 nicotinic acetylcholine receptor (nAChR) subtype is abundantly expressed in the central nervous system (CNS) and in the periphery. Positive allosteric modulators (PAMs) of the α7 increase the response to an agonist and are divided into two types depending on whether they also decrease desensitization of the receptor (type II) or not (type I). Therefore, this study aims to investigate whether the enhancement of endogenous α7 nAChR function will result in a beneficial effect in nociceptive, inflammatory and chronic neuropathic pain models. While NS1738 and PNU-120596 were not active to reduce acute thermal pain, measured by hot-plate and tail-flick …
The Effect Of Legal Status On Responses To Brief Motivational Interviewing With Substance Users, Thomas Moore
The Effect Of Legal Status On Responses To Brief Motivational Interviewing With Substance Users, Thomas Moore
Theses and Dissertations
The effectiveness of drug abuse treatment for clients coerced into care remains controversial. Some studies find clients with legal pressure do better than those without legal pressure, while others report the exact opposite. Opposing views are often fueled by the wide-ranging models that guide delivery of addiction treatment. The present study examined how participants with and without legal pressure to attend treatment responded to a motivational (MET) vs. traditional (TAU) form of addiction treatment. Additionally, the predictive value of the Readiness to Change (RTC) score, from the URICA, was assessed across days of substance use and treatment retention. Legal status …
Reflections Of Self, Melissa Athey
Reflections Of Self, Melissa Athey
Theses and Dissertations
I vacillate between all extremes, beauty vs. ugly, internal vs. external, micro vs. macro. It is these disparate notions that inspire what I make. We cannot ever see ourselves objectively, but does that mean we shouldn’t try? This thesis is my attempt to dissect what I created in my 2 years at Virginia Commonwealth University, my exploration of the illness within and the psychological nature of how we go about hiding our insecurities.
Artist Alien Ghost Juggler: Performance Of “Troilus And Cressida” As Graduate Thesis, Vladislav Smolkin
Artist Alien Ghost Juggler: Performance Of “Troilus And Cressida” As Graduate Thesis, Vladislav Smolkin
Theses and Dissertations
Through an analysis of my adaptation of Shakespeare’s “Troilus and Cressida”, I will deconstruct the artist’s studio within an institution as a paradoxical heterotopic space.
Warm Compression – Damp Gestures, Melanie Mclain
Warm Compression – Damp Gestures, Melanie Mclain
Theses and Dissertations
Thoughts on vulnerability, emotions, social interaction, self-awareness, skin, touching, bodily functions, and the combination of all these ideas into a confined space filled with heat and humidity just enough to leave you feeling damp and perhaps a bit sore.
Racial Socialization In A Black-White Interracial Family In Virginia, Rebecca Hubbard
Racial Socialization In A Black-White Interracial Family In Virginia, Rebecca Hubbard
Theses and Dissertations
The Black-White biracial population is the largest and fastest growing subgroup of multiracial individuals in the United States. Despite substantial research literature on the positive relationship between Black racial identity and psychological wellbeing, Black-White biracial individuals are underrepresented in studies that provide evidence for this relationship. Root (1998) put forward an Ecological Metamodel of Biracial Identity, comprised of several factors related to contextual (e.g. class, regional history of race-relations, parental identity, extended family) and intra-psychic processes (e.g. social skills, coping skills). The ecological metamodel served as the theoretical framework for the current study. This study is a comprehensive investigation of …
(Un)Veiled: An Examination Of Conscience, April Dauscha
(Un)Veiled: An Examination Of Conscience, April Dauscha
Theses and Dissertations
I use the body to investigate the ideas of morality, mourning and mortification. I look towards costume history, traditional Catholic rituals and themes in 19th century literature to feed my obsession with transformation, reconciliation and communication through dress. My making focuses on feminine objects and materials. Lace, veils, undergarments and hair adornment speak not only of womanhood, but also of the duality of human nature. Lace speaks of purity and sexuality, it reveals and conceals, it is humble, yet gluttonous in its ornamental overindulgence; lace is the ultimate dichotomy. I use it as a potent symbol to represent the duality …
Symptom Clusters In Lung Cancer Patients, Debra Rattican
Symptom Clusters In Lung Cancer Patients, Debra Rattican
Theses and Dissertations
SYMPTOM CLUSTERS IN LUNG CANCER PATIENTS By Debra Rattican, PhD, RN A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2012 Major Director: Debra E. Lyon, PhD. Professor and Chair Family and Community Health Nursing The purpose of the study was to examine selected relationships among symptoms common to individuals with lung cancer. The specific aims were: 1) To examine the relationship between the symptoms of dyspnea and anxiety in patients with lung cancer. 2) To examine the relationships among the symptoms of dyspnea, anxiety, and …
Optimization Of Feature Selection In A Brain-Computer Interface Switch Based On Event-Related Desynchronization And Synchronization Detected By Eeg, Mason Montgomery
Optimization Of Feature Selection In A Brain-Computer Interface Switch Based On Event-Related Desynchronization And Synchronization Detected By Eeg, Mason Montgomery
Theses and Dissertations
There are hundreds of thousands of people who could benefit from a Brain-Computer Interface. However, not all are willing to undergo surgery, so an EEG is the prime candidate for use as a BCI. The features of Event-Related Desynchronization and Synchronization could be used for a switch and have been in the past. A new method of feature selection was proposed to optimize classification of active motor movement vs a non-active idle state. The previous method had pre-selected which frequency and electrode to use as electrode C3 at the 20Hz bin. The new method used SPSS statistical software to determine …