Digital Commons Network^™

A Gun For Every Woman, Gentë Retkoceri

Theses and Dissertations

Six centuries ago in Kosova, my home country, unmarried women known as sworn virgins, were forced to adopt a male persona and carry a gun to protect themselves. But today, guns have become tools of oppression and violence against women. And while the legal system carries penalties for domestic violence, marital rape is excluded. To shine a light on, and expose the topic of hidden violence, my thesis uses artivism to address a sensitive but provocative issue, exhibiting a large-scale sculpture of a gun, designed to provoke raw emotions; to challenge visitors to consider the terror felt by women threatened …

Again Black Again, Muthi Reed

Theses and Dissertations

ABSTRACT

AGAIN BLACK AGAIN

by muthi reed, M.F.A

A thesis submitted in partial fulfillment of the requirements for the degree of Master of Fine Arts at Virginia Commonwealth University.

Program Director: Stephen Vitiello

Committee: Semi Ryu, Orla McHardy, MK Abadoo, Cara Benedetto

AGAIN BLACK AGAIN. ABA-BBABB is documentation of a reparations practice and articulations for a reparations manifesto devised by the artist. Reparations begins with the self. Singing truth to the self. Talking with the self. The thesis organizes around the problems of surveillance and myth making about Black people and the subsequent source of self-regard, conjure and social dreaming …

Using Difference-In-Difference To Assess The Impact Of Medicaid Policy On The Addiction Treatment Provider Workforce And Prescribing Behavior In Virginia, Erin Britton

Theses and Dissertations

This dissertation is unified by both policy opportunity and estimation method, examining the impact of Medicaid behavioral health policy in Virginia using a difference-in-differences framework. Medicaid-covered substance use disorder (SUD) treatment benefits in Virginia were significantly enhanced through a Section 1115 SUD waiver, which are required to be budget neutral. Therefore, it is critical to understand whether the objectives of the waiver are met using reliable, unbiased estimation methods. This dissertation includes two empirical research projects evaluating the impact of Medicaid policy on removing barriers in access to care and one methodological project comparing the performance of alternate approaches to …

Low Insertion-Loss Nanophotonic Modulators Through Epsilon-Near-Zero Material-Based Plasmon-Assisted Approach For Integrated Photonics, Mohammad Ariful Hoque Sojib

Theses and Dissertations

Electro-optic/absorption Modulators (EOM/EAMs) encode high-frequency electrical signals into optical signals. With the requirement of large packing density, device miniaturization is possible by confining light in a sub-wavelength dimension by utilizing the plasmonic phenomenon. In plasmon, energy gets transferred from light to the form of oscillation of free electrons on a surface of a metal at an interface between the metal and a dielectric. Plasmonic provides increased light-matter interaction (LMI) and thus making the light more sensitive to local refractive index change. Plasmonic-based integrated nanophotonic modulators, despite their promising features, have one key limiting factor of large Insertion Loss (IL) which …

Targeting Bcl-2 Family Proteins In Therapy Induced Senescent Cancer Cell Models, Wade Cook

Theses and Dissertations

Non-small Cell Lung Cancer (NSCLC) originates from numerous different cell types in the lungs and is among the deadliest of cancers. Head and Neck Squamous Cell Carcinomas (HNSCC) are derived from the mucosal membranes of the oral cavity, pharynx, and larynx. Both NSCLC and HNSCC are predominately caused by tobacco smoke inhalation and as such mutations in the tumor suppressor gene TP53 are common. Since similarities exist in the root cause of NSCLC and HNSCC, they may also share similarities in treatment methods. Cisplatin is a platinum-based DNA damaging agent that has been used as a cancer chemotherapy for decades. …

Development Of Novel, Miniaturized Sperm Cell Isolation Techniques For Sexual Assault Samples, Brittany Celeste Hudson

Theses and Dissertations

The ever-increasing sexual assault evidence collection kit backlog within the United States has prompted the search (and desperate need) for a more efficient, cost-effective, and rapid processing technique that can separate male and female contributions from evidentiary samples. Although backlogs have largely been tackled across the United States and many technological advancements have made the forensic DNA analysis workflow quicker, techniques for handling sexual assault samples remain time-consuming, tedious, and inefficient at separating cellular fractions from the victim and perpetrator. Thus, this research sought to identify a reproducible sperm isolation method using antibodies and/or alternative differential cell lysis techniques as …

Representativeness Of Data From An Online Sample Of Individuals With Severe Alcohol Use Disorder, Michelle Eglovitch

Theses and Dissertations

Understanding the characteristics of research participants who provide DNA is crucial to ensuring sample representativeness and generalizability of findings of genetics studies of substance use disorders. Using anonymous survey data, the present study had a unique opportunity to compare participants who provided DNA (n=2,414) with those that did not provide DNA (n=1,515). The present study found numerous differences between groups across demographic, substance use, and personality domains. Using multivariate regression, the most parsimonious model found that being male, a non-smoker, and endorsing perseverance was associated with providing DNA. The present study provides benchmark data on sample representativeness in a genome …

Loss Of Smad4 Is Associated With Poor Tumor Immunogenicity And Reduced Pd-L1 Expression In Pancreatic Cancer, Daniel R. Principe, Patrick W. Underwood, Sandeep Kumar, Kaytlin E. Timbers, Regina M. Koch, Jose G. Trevino, Hidayatullah G. Munshi, Ajay Rana

Surgery Publications

Transforming Growth Factor β (TGFβ) is a key mediator of immune evasion in pancreatic ductal adenocarcinoma (PDAC), and the addition of TGFβ inhibitors in select immunotherapy regimens shows early promise. Though the TGFβ target SMAD4 is deleted in approximately 55% of PDAC tumors, the effects of SMAD4 loss on tumor immunity have yet to be fully explored. Using a combination of genomic databases and PDAC specimens, we found that tumors with loss of SMAD4 have a comparatively poor T-cell infiltrate. SMAD4 loss was also associated with a reduction in several chemokines with known roles in T-cell recruitment, which was recapitulated …

Amendment: Literary And Art Journal (2022 Fall)

Amendment, 2004-

Amendment is a VCU student-produced progressive literature and art journal that provides a platform for students to promote equality, tolerance, and social progression through artistic expression.

Pwatem: An Anthology Of Literature And Art (2022)

Pwatem (Poictesme), 2006-

Pwatem is an anthology of literature and art from undergraduate students at Virginia Commonwealth University. Pwatem publishes poetry, prose and art of all kinds from talented undergraduate students of all majors.

A Technology-Based, Mixed Methods Approach To Examining The Psychosocial Determinants Of Maternal Health Disparities, Hannah M. Ming

Theses and Dissertations

Background: Exposure to racism and discrimination in the U.S. increases Black women’s risk for experiencing maternal health disparities. Additionally, racism and discrimination affect maternal psychosocial well-being, creating evidence for a biopsychosocial relationship between racism and maternal health outcomes. However, current research does not define the psychosocial Black maternal self well. Given the dynamic relationship between racism, psychosocial well-being, and Black maternal health outcomes, research must comprehensively examine the Black maternal self. The operationalization of a comprehensive construct for Black maternal psychosocial well-being can improve understanding of the relationship between racism, psychosocial well-being, and Black maternal health outcomes.

Purpose: …

Leveraging Interdisciplinary Expertise In Developing An Alternative Mathematics Pathway, Beverly Wood, Debra T. Bourdeau

Journal of Mathematics and Science: Collaborative Explorations

How many instructors does it take for amazing course design? Or perhaps we should begin with “A mathematician, humanist, communication expert and statistician walk into a bar.” This unlikely team has co-developed a pair of courses, Learning to Reason I: Art and Quotient and Learning to Reason II: Commerce and Flux, that deeply investigate quantitative reasoning from multiple perspectives. Blending elements of rhetoric, logic, and history with mathematical computation, representation, and application breaks through the perceived barriers between the unyielding, obstinate world of mathematics and the ambiguous, equivocal world of the humanities. Developing the courses as an interdisciplinary team of …

16th Annual Higher Ground Women's Leadership Conference, Grace E. Harris Leadership Institute, Virginia Commonwealth University, Kiara S. Faulks, Sianna Westley, Nakeina E. Douglas-Glenn

The Grace E. Harris Leadership Institute Publications

"Seizing Tomorrow, Today," challenges participants to develop a practice of Prospective Reflection- a deliberate practice of strategic foresight to aid in facing the challenges and opportunities that exist beyond us. Prospective reflection is unique because it forces us to capitalize on this time of era-defining moments and to imagine what is possible. Today's conference will aid you in translating your values into actions, your dreams into reality, and your hopes into happens. Delivered through a high-impact combination of short, narrative-driven lectures, interactive panels, and individualized strategic reflection activities, the day will culminate in an action plan for moving your leadership …

The Examination Of Health Care System Distrust As A Barrier To Utilization And Engagement Of Preventive Services In The Health Care System In Black Emerging Adults, With A Special Focus On Insurance Status And Usual Source Of Care., Alexandra Wynn

Theses and Dissertations

Health care system distrust is a well-known barrier to health utilization and engagement in older African Americans. However, it has not been explored in Black emerging adults, individuals 18- 26. It is important to explore the social and psychological effects of systemic barriers, such as health care system distrust, in this developmental period as emerging adults undergo unique demographic shifts, changes in sense of self, and identity exploration. Due to emerging adulthood being an exploratory and challenging transitionary phase, emerging adults have an increased susceptibility to preventable morbidity and mortality issues and decreased access to important preventive services. Thus, health …

Emanata Presents: Dream (2022)

Emanata, 2014-

Started by illustrator and comics artist Chris Kindred in 2014 with Weird, Vol. 1, Emanata is VCU’s first-ever comics anthology.

The Compass, Summer 2022

The Compass, 2018-

The Compass is an annual orientation guide for VCU students produced by the Student Media Collective in the VCU Student Media Centered. The guide is distributed physically during summer orientation sessions for new and transfer students. The publication includes short articles, illustrations, letters of welcome from students and administrators, comics, and advertisements from VCU and Richmond organizations.

Rabble: A Companion To Pwatem (2022)

Rabble, 2014-

Rabble is a companion chapbook publication to the magazine Pwatem. From the preface of most issues: "'Tell the rabble my name is Cabell."- James Branch Cabell to his editor, to help people learn how to pronounce his name. Cabell used the word derogatively but we are taking it back. These pages will showcase the writing and illustrations of our rabble-the ordinary students of VCU."

Rational Design Of Metal-Organic Frameworks (Mofs)-Based Functional Materials Towards Better Air Quality, Zan Zhu

Theses and Dissertations

Air pollution is a major threat to environmental safety and public health. Volatile organic compounds (VOCs), particulate matter (PM), and airborne microorganisms are three typical air pollutants. Conventional strategies to prevent and mitigate air pollution have been employed, which, however, are generally passive. For instance, VOC sensing through solid-state devices is a conventional approach, which, however, is not capable of capturing and removing VOCs. On the other hand, air filters and face masks are useful equipment to protect people from inhaling PM and airborne microorganisms. But most commercial filters can only capture them on the surfaces, which may cause secondary …

Design And Exploration Of New Models For Security And Privacy-Sensitive Collaboration Systems, Ramandeep Kaur Sandhu

Theses and Dissertations

Collaboration has been an area of interest in many domains including education, research, healthcare supply chain, Internet of things, and music etc. It enhances problem solving through expertise sharing, ideas sharing, learning and resource sharing, and improved decision making.

To address the limitations in the existing literature, this dissertation presents a design science artifact and a conceptual model for collaborative environment. The first artifact is a blockchain based collaborative information exchange system that utilizes blockchain technology and semi-automated ontology mappings to enable secure and interoperable health information exchange among different health care institutions. The conceptual model proposed in this dissertation …

Novel Microfabricated Systems To Elucidate The Role Of Anisotropic Stiffness In The Tumor Microenvironment, Jiten Narang

Theses and Dissertations

Cancer is the second leading cause of death in women and late stage (metastatic) cancers have abysmal survival rates compared to early stage regional cases (27% vs 86%). As a tumor grows, the surrounding extracellular matrix (ECM) is reorganized into a dense, collagen rich matrix. The new matrix of aligned collagen fibers provides unique mechanical cues such as anisotropic stiffness and contact guidance. Matrix turnover also constricts local vasculature and restricts delivery of key nutrients and signaling molecules to malignant cells to outside the tumor creating a chemotactic gradient from outside to inside. In this work, we developed a novel …

Varied Levels Of Fructose Consumption Induce Physiological, Cognitive, And Mitochondrial Alterations In Aged Female Rats, Emilie L. Bjerring

Theses and Dissertations

Since the 1970s, fructose consumption has dramatically increased within the United States, as well as the world. While adolescents tend to be the largest consumer of fructose, mostly seen in the form of sugary beverages, the consequences of a high fructose diet started in adulthood can also have severe implications on physiological parameters as well as cognition. Several studies have linked fructose consumption to metabolic syndrome, a clustering of symptoms related to overall health, with particular emphasis placed on obesity, type II diabetes, and the relationship with Alzheimer’s Disease. These findings largely stem from the outcomes of studies on cognition, …

Anthracyclines Attenuate The Nrf1-Mediated Bounce-Back Response, Bader Albalawi

Theses and Dissertations

Proteasome inhibitors, such as carfilzomib, are FDA-approved to treat multiple myeloma and mantle cell lymphoma. Unfortunately, proteasome inhibitors have only produced clinically significant results in patients with hematologic cancers, despite their predicted pan-cancer utility, and even hematologic cancer types frequently show intrinsic and acquired resistance.

One proposed mechanism responsible for the proteasome inhibitors' shortcomings is the NRF1-mediated bounce-back response. Identification of drugs that can potentiate the action of proteasome inhibitors could overcome resistance in patients with hematologic cancers and expand proteasome inhibitors' use to treat solid tumors. Our previous studies have identified anthracyclines as potential compounds that interfere with the …

Udl: Practicing What We Preach, Peter E.L. Temple

Theses and Dissertations

The purpose of this study was to explore the use of UDL in a special education program’s coursework and analyze how it affects college students outcomes beyond their classrooms. Past research has suggested that UDL has been increasingly used in college-level coursework design, and courses designed with UDL have higher reports of college student achievement. Based on the principles of UDL and andragogy, this study identified four central research questions. Specifically, a small qual/large quant mixed-method research design was used to investigate instructor utilization of the UDL principles, teacher candidate corroboration of UDL elements in their coursework, and an exploration …

Low Loss Plasmon-Assisted Integrated Photonics, Dhruv Fomra

Theses and Dissertations

Photonic integrated circuits (PICs), semiconductor chips with both photonic and electronic elements, are seeing rapid development and have the potential to transform several industries, such as autonomous driving, computing, telecommunication and quantum networks. However, realization and wide adoption of PICs across the various fields faces a key challenge – soze disparity between electronic (~0.01 um) and photonic components (~100’s of um). Plasmonics, a technology which confines light to the interface of metals and dielectrics, has a potential to address challenges. In particular, it has been shown to led to smaller devices (~10 um or less), enabling higher density optical circuits …

Intergenerational Transmission Of Alexithymia As A Predictor Of Child Posttraumatic Stress Outcomes During Covid-19, Casey Burton

Theses and Dissertations

The objective of this study was to test the role of parent alexithymia in explaining why some children are functioning relatively well during the COVID-19 pandemic while others are experiencing poor mental health. Participants were 88 U.S. children (M_age = 9.94 years; 54.5% female; 59.1% White) and their parents/caregivers (68.2% female; 59.1% White). Two models were tested: a path model in which the association between parent alexithymia symptoms and child COVID-19-related posttraumatic stress symptoms (PTSS) was mediated by child alexithymia symptoms, and a moderator model in which the association between parent alexithymia symptoms and child PTSS was moderated …

Metal Nanoparticle Synthesis Via Laser-Induced Photochemical Reduction Of Metal Salts, Laysa M. Frias Batista

Theses and Dissertations

Significant attention has been focused on metal nanoparticles (MNPs) due to their unique optical, catalytic, and electronic properties. In the last two decades, laser synthesis techniques have emerged as versatile routes to MNPs that enable control over particle size, shape, and surface chemistry without the use of chemical reducing agents or surface-blocking capping ligands. A method gaining increasing attention is the direct laser-driven reduction of metal salts, called Laser Reduction in Liquid (LRL). LRL typically involves the use of intense laser pulses of picosecond or femtosecond duration to ionize and dissociate solvent molecules, generating plasmas with reactive chemical species such …

Misled Youth, Mark Tan

Theses and Dissertations

I’m a first-generation Canadian who was born and raised in Toronto, Ontario by Asian immigrants. I have migrated to the United States and lived here for 7 years. Through my work, I express the emotional value of preconceived notions, disconnectedness, and longing in search of finding place and acceptance within a community. Drawing from memory, personal narrative, emotion, and perception, I manipulate data into lines, forms, and materials through a subjective human experience from the lens of a non-citizen. By projecting the migration movement of my family lineage from China and the Philippines to Canada as well as my path …

Assessing The Detectability Of Cannabinoid Analogs (Delta-8 Thc, Delta-10 Thc And Cbd) And Their Major Metabolites In Six Commercial Cannabinoid Urine Screening Kits, Ashley A. Pokhai

Master of Science in Forensic Science Directed Research Projects

Background:

There has been an exponential surge in the presence and use of cannabinoids since the federal legalization of hemp (Agricultural Improvement Act of 2018), which involves the legalization of medical use, adult recreational use, and decriminalization of cannabis in several states. This growth is not only attributed to ∆9-tetrahydrocannabinol (∆9-THC) and cannabidiol (CBD), the most abundant phytocannabinoid components of cannabis and hemp, respectively, but with many other emerging THC analogs. Structurally, these analogs are similar to ∆9-THC, yet very little information is available about their potency and even less information is available regarding their detectability using commercially available cannabinoid …

Bowling Green Main Street Revitalization Plan, Amy Guzulaitis

Master of Urban and Regional Planning Capstone Projects

The Town of Bowling Green is a historic, rural community located in Caroline County, Virginia. The Town is the pride of residents who enjoy the community and small town nature of the area. The Town currently has a small arts business cluster and sought ways to use that, as well as the Main Street Method, as a basis for spurring revitalization in the Town. Research Methods & Findings Today, the Town of Bowling Green faces challenges to its future growth and development due in part to the small market size available. Demographic indicators from ESRI Business Analyst show that Bowling …

Cruser Place Green Streets Plan, Neal Friedman

Master of Urban and Regional Planning Capstone Projects

Combining green and complete street design techniques leads to multiple environmental, social and economic benefits that often enhance each other's effectiveness. In urban areas confronting increased pressures of sea level rise, green streets, which incorporate landscaped features or vegetative areas to manage stormwater within the right of way, can be crucial pieces of pedestrian oriented urban design and multimodal planning frameworks that consider and plan for diverse, complementary transportation options. This plan works with the Colonial Place and Riverview Civic League as well as the Norfolk Preservation Collective to come up with green street design recommendations in order to strengthen …