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Articles 4381 - 4410 of 7321
Full-Text Articles in Entire DC Network
Electrical Behavior Of Non-Aqueous Formulations: Role Of Electrostatic Interactions In Pressurized Metered Dose Inhalers (Pmdis), Reshma Kotian
Electrical Behavior Of Non-Aqueous Formulations: Role Of Electrostatic Interactions In Pressurized Metered Dose Inhalers (Pmdis), Reshma Kotian
Theses and Dissertations
Aerosol electrostatics is an important property of pharmaceutical aerosols. The electrostatic properties of pMDI aerosols have been shown to be a function of both formulation and packaging components. The modified ELPI enables measurement of aerosol charge as a function of particle size, and the simultaneous determination of the mass distribution using chemical analysis. However, in order to fully assess the cause and effects of aerosol electrostatics in terms of its biological and regulatory implications, it is necessary to understand the basic charging mechanisms inside the pMDI formulation.
Electrical resistivity and zeta potential measurements confirmed the presence of charged species within …
Biological Functions Of The Novel Lysophosphatidic Acid (Lpa) Receptor, Lpa4/P2y9/Gpr23, Peilun Lee
Biological Functions Of The Novel Lysophosphatidic Acid (Lpa) Receptor, Lpa4/P2y9/Gpr23, Peilun Lee
Theses and Dissertations
Lysophosphatidic acid (LPA), a naturally occurring phospholipid present in serum and malignant effusions, elicits diverse biological functions through binding and activating specific cell surface G-protein coupled receptors. In addition to the conventional LPA1/Edg2, LPA2/Edg4 and LPA3/Edg7 receptors of the endothelial differentiation gene (Edg) family, LPA4/p2y9/GPR23 of the purinergic receptor family and the related LPA5/GPR92 and LPA6/p2y5 have been identified as novel LPA receptors. These newly identified LPA receptors are structurally distant from the Edg LPA1-3 receptors and couple to Gq, G12/13 and probably Gs subunits. However, the roles of the LPA4-6 receptors in LPA signal transduction and physiology are poorly …
Nucleoplasmic And Cytoplasmic Degradation Of Telomerase: Implications Toward Telomerase-Based Cancer Therapy, Binh Nguyen
Nucleoplasmic And Cytoplasmic Degradation Of Telomerase: Implications Toward Telomerase-Based Cancer Therapy, Binh Nguyen
Theses and Dissertations
Telomerase is a ribonucleoprotein that is reactivated in cancer cells to allow for continuous cellular division and indefinite growth. With telomerase being expressed in more than 85% of all cancer, it is imperative that we understand how to selectively inactivate and degrade this unique DNA polymerase. In doing so, we can specifically target tumor cells to erode their telomeres so that they will undergo apoptosis or senescence. Through this research, we have learned that telomerase can be degraded in the nucleoplasm by Hsp90 chaperone inhibition and in the cytoplasm by the dominant negative mutant, D712A V713I. These findings should guide …
Shafer Court Connections (2008-03)
Shafer Court Connections (2008-03)
Shafer Court Connections, 1994-2010
For alumni of the Academic Campus of Virginia Commonwealth University.
[2008-02-14] February 14, 2008 A Regular Meeting Of The Board Of Visitors, Virginia Commonwealth University. Board Of Visitors
[2008-02-14] February 14, 2008 A Regular Meeting Of The Board Of Visitors, Virginia Commonwealth University. Board Of Visitors
VCU Board of Visitors Minutes
Official minutes of the VCU Board of Visitors and its Executive Committee.