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Articles 4321 - 4350 of 7321
Full-Text Articles in Entire DC Network
Ink (2008-12)
Ink, 2008-
The student-run features magazine covering the fashion, art, music and culture worlds at VCU and in Richmond. Published annually in print and updated regularly online.
Creation Of A Mouse With A Humanized Fpgs Gene Compatible With Normal Development, Linying Xie
Creation Of A Mouse With A Humanized Fpgs Gene Compatible With Normal Development, Linying Xie
Theses and Dissertations
Abstract: Folylpoly-γ-glutamate synthetase (FPGS) catalyzes the formation of polyglutamate forms of the reduced folates and antifolates such as methotrexate (MTX) and pemetrexed; this allows the retention of folates and antifolate cancer drugs inside the cell. The enzyme activity of FPGS is essential for cell proliferation and survival. The mouse fpgs gene contains two promoters spaced 10 kb apart which are activated in a tissue-specific manner. The upstream promoter (P1) and exons A1a and A1b are used in some differentiated tissues, mainly liver and kidney, whereas the downstream promoter (P2) and exon 1 are used in rapidly dividing cells. In contrast, …
Agenda-Setting And The Media: A Look At Child Welfare Legislation, 1995-2005, Tamara Temoney
Agenda-Setting And The Media: A Look At Child Welfare Legislation, 1995-2005, Tamara Temoney
Theses and Dissertations
This project used a content analysis methodology to determine the agenda-setting capacity of the media to influence child welfare legislation in a state legislature. With a foundation in agenda-setting theory, this study identifies how the coverage of child abuse and neglect in the print media impacts decision-makers to introduce legislation related to child abuse and neglect. Through a comparison of the issues covered in the newspaper with the issues receiving legislative attention, this study showed that media influence varies by topic, with some topics being more open to media affects than others. A second component of this study analyzed how …
The Open Road, Bryan Condra
The Open Road, Bryan Condra
Theses and Dissertations
In our journeys on the open road, we travel through a landscape of visual imagery composed of patterns, rhythms and a spectrum of changing colors. Our previous experiences, mental and physical attitudes and expectations, shape our perceptions. By visually interpreting and presenting my experiences of the journey on the open road I hoped to tell a story of how the open road energizes the creative spirit. My goal was to explore how the landscape is altered by motion and speed as we pass through it, and how the journey can be experienced in various ways. I wanted to investigate and …
In Vitro Models For Inhaled Corticosteroid (Ics) Aerosols: A Study Of Their Biopharmaceutics And Pharmacology, Deepika Arora
In Vitro Models For Inhaled Corticosteroid (Ics) Aerosols: A Study Of Their Biopharmaceutics And Pharmacology, Deepika Arora
Theses and Dissertations
Lung cellular disposition and anti-inflammatory pharmacology of inhaled corticosteroids (ICSs) is complex, comprised of a cascade of aerosol deposition and dissolution, followed by cellular uptake for local pharmacological action. This project hypothesized that the kinetics of dissolution for certain ICS aerosols generated from inhaler products were kinetically rate-determined for their cellular uptake and local pharmacological action. A novel dissolution testing system was developed to determine the dissolution kinetics for the ICS aerosols. A total of 5 ICSs aerosols generated from 6 inhaler products were collected in 2.1-3.3 or 4.7-5.8 µm of aerodynamic diameters at 0.7-19.8 µg on filter membranes by …
Ceramide Kinase And Ceramide-1-Phosphate, Dayanjan Wijesinghe
Ceramide Kinase And Ceramide-1-Phosphate, Dayanjan Wijesinghe
Theses and Dissertations
Ceramide-1-phosphate (C1P) is a bioactive lipid that has been implicated in many biological processes. Our laboratory has conclusively demonstrated its role in inflammation via activation of cPLA2α. The only known enzyme to date responsible for direct synthesis of C1P is ceramide kinase. Very little was known about this enzyme in terms of its enzyme kinetics and substrate specificity. As CERK is an enzyme that acts on membrane lipids, its kinetics cannot be studied using standard bulk dilutions methods. Thus we developed a surface dilution approach using Triton X 100 mixed micelles for studying the kinetics of CERK. We discovered that …
[2008-11-20] November 20, 2008 A Regular Meeting Of The Board Of Visitors, Virginia Commonwealth University. Board Of Visitors
[2008-11-20] November 20, 2008 A Regular Meeting Of The Board Of Visitors, Virginia Commonwealth University. Board Of Visitors
VCU Board of Visitors Minutes
Official minutes of the VCU Board of Visitors and its Executive Committee.
Angiogenic Potential Of Human Macrophages On Electrospun Bioresorbable Vascular Grafts, Koyal Garg
Angiogenic Potential Of Human Macrophages On Electrospun Bioresorbable Vascular Grafts, Koyal Garg
Theses and Dissertations
The aim of this study was to investigate macrophage interactions with electrospun scaffolds and quantify the expression of vital angiogenic growth factors in vitro. This study will further help in evaluating the potential of these electrospun constructs as vascular grafts for tissue repair and regeneration in situ. Human peripheral blood macrophages were seeded in serum free media on electrospun (10 mm) discs of polydioxanone (PDO), elastin and PDO:elastin blends (50:50, 70:30 and 90:10). The growth factor secretion was analyzed by ELISA. Macrophages produced high levels of vascular endothelial growth factor (VEGF) and acidic fibroblast growth factor (aFGF). Transforming growth factor …
The Future Of Aesthetics In/And Visual Culture Art Education In 21st Century Art Education, Shannon Reibel
The Future Of Aesthetics In/And Visual Culture Art Education In 21st Century Art Education, Shannon Reibel
Theses and Dissertations
This grounded theory project researches and analyzes publications from 1990-2008 assessing the debate over aesthetics in/and VCAE in 21st century art education. Through a series of visual models, a working theory and its supporting evidence assess this contested subject. Within the context of Modern and Postmodern paradigm conflict, art educators’ debate over aesthetics in/and VCAE fundamentally deals with differing conceptions of identity and freedom. Although commonly sharing the goal of fostering the formation of student identity through the provision and exercise of freedom, art educators’ differing perspectives on identity and freedom result in differing prescriptions for 21st century art education. …
Selective Non-Peptide Mu-Opioid Receptor Antagonist: Design, Synthesis And Biological Studies, Lindsey Aschenbach
Selective Non-Peptide Mu-Opioid Receptor Antagonist: Design, Synthesis And Biological Studies, Lindsey Aschenbach
Theses and Dissertations
There are currently many opioid agonists available for clinical use as analgesics. However, many of these opioid agonists have notorious side effects including respiratory depression and may lead to addiction and dependence. Problems associated with these opioid agonists are determined to come from their interactions with the mu-opioid receptor. Opioid antagonists, such as naltrexone, have shown to aid in the treatment of opioid addiction. Although naltrexone has high affinity to the mu-opioid receptor, it lacks selectivity. Novel selective mu-opioid receptor antagonists were designed based on the identification of important pharmacophore elements in several known mu-opioid receptor agonists and antagonists. These …
Spin Transport Studies In Nanoscale Spin Valves And Magnetic Tunnel Junctions, Sridhar Patibandla
Spin Transport Studies In Nanoscale Spin Valves And Magnetic Tunnel Junctions, Sridhar Patibandla
Theses and Dissertations
Spintronics or electronics that utilizes the spin degree of freedom of a single charge carrier (or an ensemble of charge carriers) to store, process, sense or communicate data and information is a rapidly burgeoning field in electronics. In spintronic devices, information is encoded in the spin polarization of a single carrier (or multiple carriers) and the spin(s) of these carrier(s) are manipulated for device operation. This strategy could lead to devices with low power consumption. This dissertation investigates spin transport in one dimensional and two dimensional semiconductors, with a view to applications in spintronic devices.
The Effects Of Reputation Threat And Whistle-Blowing Report Source On Chief Audit Executives' Investigation Decisions, Cynthia Guthrie
The Effects Of Reputation Threat And Whistle-Blowing Report Source On Chief Audit Executives' Investigation Decisions, Cynthia Guthrie
Theses and Dissertations
This study examines the effects of reputation threats and anonymous whistle-blowing channels on Chief Audit Executives’ (CAEs) decisions to investigate whistle-blowing allegations. Participants were 94 CAEs and Deputy CAEs from publicly traded companies in the eastern half of the United States. Participants received whistle-blowing reports from either an anonymous or a non-anonymous source. In the high reputation threat condition the whistle-blowing report alleged that the wrongdoing was perpetrated by the exploitation of substantial weaknesses in internal controls that had been previously evaluated by external auditors and the internal audit function. The report in the lower threat condition alleged that the …