Digital Commons Network^™

The Effect Of 17Β Estradiol On Local Production Of Active Vitamin D3 Metabolites In Laryngeal Squamous Cell Carcinoma, Tillat Batool

Theses and Dissertations

Laryngeal squamous cell carcinoma (LSCC) has garnered attention as a sex-hormone-dependent cancer with notable responsiveness to 17β-estradiol (E₂), in which it’s tumorigenesis can be mediated through estrogen receptors (ER). The ESR1 gene encodes for the classical full-length ERα66, as well as splice variants ERα36 and ERα46. Previous studies have shown that an active vitamin D₃metabolite, 24R,25(OH)₂D_3. has pro-tumorigenic or anti-tumorigenic responses in LSCC cells with different ER profiles, and that the tumor cells have the capability of localized production of vitamin D metabolites at the cellular level when treated with 25(OH)D₃-d6 …

The Cultural Adaptation Of An Eating Disorders Assessment Tool For South Asian American Women, Neha J. Goel

Theses and Dissertations

South Asians (SAs) are less likely to be screened, referred, and treated for eating disorders (EDs), although they experience these serious health conditions at rates similar to those of their White counterparts. Available ED assessment tools do not adequately capture cultural nuances in the presentation of eating psychopathology in SAs. Thus, the current study culturally adapted the Eating Disorder Examination-Questionnaire (EDE-Q) to enhance its validity, applicability, and cultural relevance for SA women living in the US. During the cultural adaptation phase, the principal investigator consulted with participant experts (N=24) and research experts (n=4) to create the …

Transgender Perceptions Of Breast Health Care And Utilization Of Preventative Breast Imaging Services, Cherish Parham

Theses and Dissertations

Little information exists on transgender patient perceptions of breast imaging care at mammography facilities. The purpose of this descriptive phenomenological study was to understand the lived experiences of transgender patients at mammography facilities, their knowledge of breast care, and how these experiences have shaped their perceptions of the breast imaging community and attitude toward breast cancer screening. By applying the revised the Gelberg-Andersen Behavioral Model for Vulnerable Populations, this study addressed factors specific to the transgender population that may affect their healthcare utilization and how that impacts health outcomes. Researchers collected data from transgender/non-binary individuals in the Richmond, Virginia region …

Analyzing The Role Of Slc25a32 In Hepatocellular Carcinoma, Mimansha Shah

Theses and Dissertations

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a leading cause of cancer-related deaths worldwide. Despite advances in understanding its molecular pathogenesis, treatment options for HCC remain limited, highlighting the need for identifying novel therapeutic targets. This study investigates the role of SLC25A32, a mitochondrial transporter gene located on chromosome 8q22.3, in HCC progression. SLC25A32 is involved in the transport of tetrahydrofolate (THF) and flavin adenine dinucleotide (FAD) into mitochondria, playing a crucial role in one-carbon metabolism and redox balance. Using CRISPR/Cas9 technology, we generated potential SLC25A32 knockout clones in the HCC cell line Huh-7. Quantitative PCR …

Shape Inverse Prediction Of Magnetic Field-Actuated Soft Robots By Neural Network Machine Learning, Lineth J. Perez Monsalve

Theses and Dissertations

Soft robotics has drawn tremendous interest in recent years because the compliance and motion of soft robotics enable biocompatibility and versatility for many applications, such as human-machine interaction, wearable and assistive devices, and health monitoring. This study introduces a novel predictive modeling approach using neural networks for shape control of magnetic soft robots. The robots are made of silicone materials embedded with hard magnetic particles, which respond to the external magnetic field provided by a ring-type of permanent magnet. These robots, free from physical connections to external devices, i.e., non-tethered actuation, hold significant potential for applications in healthcare, such as …

Role Of Human Intermediate Form Prl Receptor I-Tail In The Pathogenesis Of Breast Cancer, Shanwei Shen

Theses and Dissertations

Breast cancer continues to be the second most common cancer in women in the United States. The neuroendocrine hormone human prolactin (hPRL) plays an important role in normal mammary gland development and growth, stimulating normal breast tissue proliferation and differentiation. Considerable evidence has shown that hPRL is involved in the malignant transformation of human breast tissue. hPRL enhances viability, invasiveness, and proliferation of breast cancer cells in vitro. Evidence from epidemiologic and genetic studies also implicates role of hPRL in the pathogenesis of breast cancer. Its cognate receptor the human prolactin receptor (hPRLr) is required for the action of hPRL. …

Evaluation Of Charcoal Strip Extraction Efficiency Under Varying Substrate Conditions, Abby Wester

Master of Science in Forensic Science Directed Research Projects

The ability of a forensic examiner to identify the presence of ignitable liquids (ILs) in fire debris collected from the area of origin of a fire is an essential component for determining intent in fire investigations. However, this relies on an effective extraction method that provides a complete picture of what is present in the debris. In this study, eight substrate materials underwent three different treatments: a low-volume of substrate that was unburned, a low-volume of substrate that was burned, and a high-volume of substrate that was unburned. Each sample was spiked with a 1:1 mixture of gasoline and diesel …

Identifying Barriers: Analysis Of Federal Law Enforcement Social Media And Recruitment Efforts, Reena Desai, Edgar Greer, Meghan Waldron

Doctor of Education Capstones

The Federal Bureau of Investigation Richmond Field Office seeks to diversify their applicant pool. In an effort to provide information on how to meet this need, our doctoral team analyzed the social media sites of six federal law enforcement agencies to include: the Federal Bureau of Investigation- Headquarters, Federal Bureau of Investigation-Richmond Field Office, Alcohol Tobacco & Firearms, the Federal Bureau of Prisons, the Drug Enforcement Agency, and the United States Marshal Service. By examining a 60-day window of images and their associated text on X (formerly Twitter), Facebook, and Instagram accounts, we wanted to gain a stronger understanding of …

A Path Toward Healing: Parent And Caregiver Perspectives On The Work Of Restorative Practices Richmond At Martin Luther King, Jr. Middle School, Jean Samuel, Silvanus Thrower, Jill Flynn, Brandi Daniels

Doctor of Education Capstones

To address how key stakeholders experience restorative practices (RP), Restorative Practices Richmond (RPR) submitted a request for assistance (RFA) to Virginia Commonwealth University. This single case study responds to the RFA by examining how parents, caregivers, and community partners perceive school discipline and restorative practices and how this understanding supports RPR’s work to support restorative practices at Martin Luther King Middle School (MLK MS). Through a social justice lens, this capstone explores the challenges and needs of parents, caregivers, and community partners engaging with restorative practices. The findings that emerged included the following: parents and caregivers lack sufficient knowledge about …

Applying X-Ray Fluorescence With Monte Carlo Methods For Analysis Of Surface Defects On Coated Zr4, James Tyler Cahill

Theses and Dissertations

Chromium-coated Zircaloy-4 cladding represents a novel solution for creating nuclear cladding that has passive safety features. This and related developments aimed at improving nuclear safety are broadly categorized as accident-tolerant fuel and cladding. However, implementing this material presents practical challenges such as the vulnerability that cladding has to surface damage such as fretting wear. This research aims to determine if the pre-existing technique of X-ray fluorescence analysis is applicable for detecting these defects on the surface of the cladding. This was done by developing Monte Carlo N-Particle Transport models of a handheld device, the XL-5, alongside experimental measurements using this …

Reimagining On-Campus Student Employment As A Foundation For Career Readiness: Student Employment In Virginia Commonwealth University’S Division Of Student Affairs, Jaedda Hall, Mary Lee Magee, Sean D. Mays, Kimberly C. Young

Doctor of Education Capstones

Many undergraduate students participate in on-campus employment while pursuing their academic programs. Increasingly, institutions of higher education recognize student employment not only as a resource to address institutional workforce needs or students’ pressing financial needs, but also to promote students’ overall learning, development, and success. To better understand on-campus undergraduate student employment in the context of Virginia Commonwealth University’s (VCU) Division of Student Affairs (DSA), this descriptive study employed a mixed-methods approach using surveys, interviews, focus groups, secondary data analysis, and artifact analysis. These methods were applied to explore the perspectives of multiple stakeholders, including undergraduate student employees, supervisors of …

Safe Schools: A Descriptive Study Examining How To Prevent Peer-To-Peer Sexual Misconduct In K-12 Schools, Crystal R. Bell, Kristine Herakovich-Curtis, Elizabeth Terrier, Leah Wiedenhoft

Doctor of Education Capstones

In response to a problem of practice presented by the non-profit Stop Sexual Assault in Schools (SSAIS), this study examines what training and resources K-12 Title IX Coordinators and school administrators need to prevent and effectively address peer-to-peer sexual harassment and assault. Grounded in Improvement Science, we partnered with SSAIS to address a real-world dilemma. Through the theoretical lens of the Social-Ecological Framework, a descriptive study was conducted using quantitative and qualitative methodologies to study changes needed to reduce peer-to-peer sexual misconduct in schools. Data were collected through focus group interviews and a Nearpod questionnaire with a national sample. Relying …

Bottling The “Secret Sauce”: Capturing The Heart Of The East End At Peter Paul Development Center, Melissa E. Abban, Melissa Buckley, Marie Garrenton, Latonja Y. Wright

Doctor of Education Capstones

Peter Paul Development Center (Peter Paul) submitted a Request for Assistance (RFA) to obtain support from a Virginia Commonwealth University Doctorate of Educational Leadership (EdD) Capstone team with documenting programming and principles and evaluating them consistently. To address this request, the team analyzed the context and problem of practice through document review, empathy interviews, partner discussions and site visits. The literature review helped the team design and conduct research, fieldwork, and data analysis to support Peter Paul in standardizing procedures and programs, fostering a culture of institutional knowledge, and effectively communicating impact to stakeholders. The team used a Convergent Parallel …

Transforming The Route 228 Corridor: A Safe And Connective Approach, Michael Boeh

Master of Urban and Regional Planning Capstone Projects

This capstone plan centers around the Rt. 228/19 intersection and surrounding corridor located in Cranberry Township, Pennsylvania. In spite of recent projects, the intersection continues to convey feelings of danger and a lack of safety. This redesign project will utilize SketchUp to demonstrate how safety and connectivity can be prioritized and made a reality for the Rt. 228 corridor.

Best Practices For Community Outreach For The Virginia Eviction Reduction Pilot, Callie B. Houghland

Master of Urban and Regional Planning Capstone Projects

The purpose of this plan is to understand best practices for community outreach for the VERP program and provide materials to aid future outreach efforts. This plan has five parts. First, this plan will review characteristics that contribute to housing vulnerability, such as race or number of children, and consider which vulnerabilities should be prioritized in outreach. Then, this plan will identify how VERP grantees are currently conducting community outreach and who is being served through the program. Next this plan will look to understand who is missed between those who are most vulnerable and who are actually served across …

Anticipating The Fall Line: A Plan For Equitable Trail-Oriented Development On Commerce Road, Eric King

Master of Urban and Regional Planning Capstone Projects

Once completed, the Fall Line trail will provide a 43-mile active transportation route through Central Virginia from Ashland to Petersburg. Three miles of the trail’s alignment follow Commerce Road in Richmond’s Southside. As Manchester continues to undergo rapid change, trail-oriented development (TrOD) offers an opportunity to accommodate growth and transform the industrial corridor into a mixed-use destination as envisioned by the city’s master plan. While TrOD within the study area represents both economic and community development, relatively low residential property values and median incomes within surrounding neighborhoods warrant proactive measures to mitigate potential displacement pressures. Drawing from precedents set by …

Plenty Of Room At The Inn: Strategies For Gentle Densification Of Cleveland Park, Woodley Park, Van Ness, And Forest Hills, Dc, Harrison M. Hyde

Master of Urban and Regional Planning Capstone Projects

This capstone focuses on expanding housing opportunities, through the implementation of Gentle Density, in high-resource, single-family neighborhoods in Washington, D.C. The tangible outcomes of this study were be: a set of design guidelines, proposed changes to the Zoning Code of 2016, and an analysis of the co-benefits of densification. The co-benefits analysis examined any potential changes ridership changes for the Washington Metropolitan Area Transit Authority, as well as changes in the potential customer bases for local businesses in each neighborhood. These analyses were done for a maximum build-out Scenario A, a less dense Scenario B, and a do-nothing Scenario C. …

Spin Wave Devices For Embedded Applications And Information Processing, Raisa Fabiha

Theses and Dissertations

Device miniaturization is a prerequisite for modern day electronics. Spintronics offers immense potential in energy efficient data storage, solid states devices, ultrafast computing and other electronic applications because of their low power consumption, non-volatile nature and unique activation mechanism. The conventional nano-antennas used for wireless communication, biomedical and wearable devices and IoT applications are limited by the traditional Harrington limit. As we attempt to miniaturize the antenna size beyond its emitted wavelength (also called “subwavelength” antenna), its gain and efficiency plummet. To overcome this challenge, the researchers have proposed magnetoelectric antennas. The ultra-thin film based magnetoelastic antennas suffer from eddy …

The Clinical Inquiry Process Diagram (V. 5), Roy E. Brown

VCU Libraries Faculty and Staff Publications

This updated edition of The Clinical Inquiry Process Diagram improves on the 2023 version. It provides a depiction of the steps involved in the clinical inquiry process, covering research, performance improvement, and evidence-based practice. The revisions in this version emphasize the importance of alerting users to the iterative nature of clinical inquiry and the ongoing need to assess the situation or patient based on evolving evidence. It's crucial to recognize that the clinical inquiry process does not follow a linear, sequential progression. Instead, individuals may find themselves concurrently addressing different aspects of the process or revisiting prior steps as they …

Living The American Dream? College Experiences Of Undocumented Students In An Era Of Rising Xenophobia And Political Turmoil, Sandra Y. Ting Ph.D.

Theses and Dissertations

This research study sought to deepen the understanding of the journeys of undocumented and DACAmented college students in an era of escalated xenophobia and political unrest. Three noteworthy themes emerged from the sentiments expressed by participants. The experiences they described included: 1) the turmoil of undocumented status eliciting unique and empowering demonstrations of resourcefulness, creativity, and self-advocacy, 2) motivation and stress from their respective citizenship statuses existing as two mutually dependent facets of a unified whole, 3) a community of support from other undocumented and/or DACAmented peers as a necessity for wellbeing. These critical outcomes culminate in the conditioning to …

Shinners, Alexis E. Mabry

Theses and Dissertations

Shinners is a project that aims to examine the position of women in subcultures and capture conversations of women in subcultural sports. Within feminism, sociological constructs, campy horror, and personal experience I am manifesting the physical and mental obstacles faced in the subcultural sport of Bicycle Motocross (BMX) through photography, painting, collage, video, and sculpture. I interpret images posted to social media of injuries obtained while riding BMX as forms of empowerment, bodily gore as extreme evidence of participation, performative violence, valorizing the understanding of both the physical and psychological pain of failure, and the use of failure as a …

Factors Important To Underrepresented Minority Applicants In Ranking Orthodontic Programs, Alyssa Patterson

Theses and Dissertations

Purpose: To determine if there was a difference in desirability of various factors used by applicants ranking orthodontic programs depending on their racial or ethnic background.

Method: A survey was distributed to orthodontic residents to assess overall preferences, and differences in desirability of various factors between underrepresented minority (URM) and non-URM applicants.

Results: For applicants overall, “clear aligner therapy training”, “good quality of clinical faculty” and “high number of cases started” had the highest mean desirability. “Racial and ethnic diversity among current and former residents”, “racial and ethnic diversity among faculty” and “participation in care of Medicaid patients” were significantly …

Using Natural Language Processing To Understand The Lived Experiences Of People Identifying With Adhd: What Themes Emerge In Social Media Posts?, Gabby C. Scalzo

Theses and Dissertations

Compared to the amount of research conducted on how to identify and understand children with Attention-Deficit Hyperactivity Disorder (ADHD), there has been relatively little work done to understand the lived experiences of adults with ADHD. Increased understanding of how adults with ADHD conceptualize themselves in the context of their diagnosis would help clinical experts tailor research and treatments to better serve these communities. However, there are several barriers towards conducting high-quality qualitative research, including time- and labor-intensity. This study, informed by qualitative research traditions, used innovative data sources (i.e., social media) and analytic techniques (i.e., machine learning) to reduce these …

Doctors And Saints: Preparing Albert Camus’S The Plague To Address The Dangers Of Christian Nationalism, Christopher J. Williams

Theses and Dissertations

My project is focused on identifying and responding to Christian nationalism in United States politics by utilizing Albert Camus’s novel The Plague. The Plague found heightened popularity during the COVID-19 pandemic and its lasting legacy points to what should be long-term prominence in the public eye. With its popularity and anti-fascist content, The Plague is an appropriate text to utilize for addressing America’s Christian nationalism. My paper functions with a foundation on the work of Kenneth Burke, particularly his focus on literature’s utility as equipment for living.

I use my project to suggest that The Plague is not in an …

Points Of Contact, Giancarlo Venturini

Theses and Dissertations

The work in Points of Contact arises from engaging love as it relates to distance, desire, and longing. This paper will analyze my painting practice and its evolution from the explicit to implicit. Specifically I am going to talk about my utilization of landscape painting to consider another way of expressing sexuality and queerness. I will explain how objects and landscapes are conduits for feelings that can intrinsically hold allegorical representations. This show is about searching through vast spaces to find points of connection in the natural world. I will talk about portals and the varied degrees of accessible windows …

Preexisting Conditionings: Painting, Gaming And Narrative Play, Pia Bakala

Theses and Dissertations

My work incorporates play, fantasy, and self-actualization through painting, sculpture, and video. In this essay, I will explore the ways in which my studio practice intersects with topics across fields of visual arts and in conjunction their theoretical frameworks. I will discuss the culminating body of work, tentatively titled Preexisting Conditionings, that my academic experience at VCU has fostered and trace its development across specific precursive works, as well as the cultural and intellectual touchstones influencing its creative impetus. In Preexisting Conditionings, I work primarily use oil painting, creating mostly representational figurative tableaus that correspond to narratives and characters I’m …

The Sexually Dimorphic Role Of Connexin 43 In Bone Remodeling And Disuse-Induced Bone Loss, Gabriel A. Hoppock

Theses and Dissertations

Bone loss is frequently experienced by individuals undergoing long-term disuse, such as prolonged bedrest, immobilization due to paralysis or injury, and conditions such as spaceflight. Under normal physiological conditions, bone remodeling is balanced by bone-forming osteoblasts and bone-resorbing osteoclasts, and the activity of osteoblasts and osteoclasts is orchestrated by osteocytes. Osteocytes are the most abundant cell type found in bone and ample evidence suggests they are bone’s main mechanosensory cell type. Therefore, understanding osteocyte biology and responses to mechanical signals, or lack thereof during unloading, may lead to new therapeutic targets to combat bone loss during disuse. Previous data has …

Associations Between Childhood Trauma And Tobacco Dependence Among Latine Adults: Testing The Protective Effects Of Compassion For Self And Others, Camila Tirado

Theses and Dissertations

Tobacco dependence has posed a significant public health challenge in the United States and disproportionately affects Latine adults' risk of developing a variety of adverse health conditions. Childhood trauma is a recognized risk factor for dependence, overall health, and mental health concerns. Still, the influence of compassion for self or compassion for others in this context remains unclear. This cross-sectional study investigated the moderating effects of self-compassion and compassion for others on the relationship between childhood trauma and cigarette dependence among Latine adults. Data was collected through questionnaires assessing childhood trauma, self-compassion, cultural values and factors, compassion for others, and …

Exploring The Experiences Of Refugee Youth In Public Schools: An Ethical Phenomenological Inquiry, Hilary T. Stim

Theses and Dissertations

The study outlined in this dissertation focuses on the intersection between refugee youth between the ages of 13-18 and the United States public school, specifically the manner in which refugee youth experience institutionalized education. It utilizes ethical phenomenology as a means to amplify the voices of refugee students and to centralize the students' experiences, thoughts, and ideas related to education The study was framed by one research question that is addressed to the participants: “What is it like being a student in a public school?” Seven students took part in the study. Collaborative dialogues took place with the participants across …

Online Racism And Mental Health Symptomatology Among Black Adolescents: A Longitudinal Examination, Stephen M. Gibson

Theses and Dissertations

Online racism (i.e., racism perpetrated and embedded within media and platforms on the Internet) is increasingly becoming a public health concern. Recent empirical evidence demonstrates that over a three year period, Black adolescents reported experiencing at least one online racial discriminatory incident, including exposure to racist images or videos within digital spaces (Tynes et al., 2020). One way in which Black adolescents are exposed to online racism is through the consumption of digital news media on the coverage of racially traumatic events (e.g., murders of Black men and women by police officers, racial hate crimes committed against Black people) and …