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Articles 3631 - 3660 of 7325
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Characterization Of Cyclic-Di-Gmp Signaling With The Lyme Spirochete, Borrelia Burgdorferi, Jessica Kostick
Characterization Of Cyclic-Di-Gmp Signaling With The Lyme Spirochete, Borrelia Burgdorferi, Jessica Kostick
Theses and Dissertations
Lyme disease is a tick-borne infection caused by Borrelia burgdorferi, B. garinii, and B. afzelii. These spirochetes experience environmental fluctuations as they are passed between mammalian and Ixodes tick hosts throughout their enzootic cycle. Recent studies have suggested cyclic diguanylate (c-di-GMP), a ubiquitous secondary messenger, is a key modulator of B. burgdorferi adaptive responses and may play a significant role in cycle progression. In this study, we examined the impact of the sole diguanylate cyclase (Rrp1), c-di-GMP binding proteins (PlzA and PlzB), and HD-GYP-containing phosphodiesterase (PdeB) in disease establishment of both murine and Ixodes tick systems. Strains harboring targeted gene …
The Use Of Targeted Charge-Reversal Nanoparticles (Tcrns) To Investigate Nuclear Delivery Of Fluorescent Agents To Cancer Cells: Implications For Novel Prostate And Breast Cancer Therapy, Mario Dance
Theses and Dissertations
Nanotechnology has recently emerged as a strong contributor toward research efforts to develop targeted systems of drug delivery in cancer therapy. Our work investigates the therapeutic potential of Targeted Charge-Reversal Nanoparticles (TCRNs), a novel nanoparticle with in vitro evidence of nuclear drug delivery. Using M12 prostate cancer cells, MDA-MB-231 breast cancer cells, and modified derivatives of these cell lines, we investigated the ability of Folic Acid-tagged TCRNs to deliver Nile Red and Dimethyl Indole Redfluorescent (DiR) fluorescent dyes to the nucleus of cells using confocal microscopy and in vivo biphontonic imaging using Xenogen® Technology. Confocal imaging with the SCP28 derivative …
The Regulation Of Tonb-Dependent Transporters In Neisseria Gnorrhoeae, Aimee Hollander
The Regulation Of Tonb-Dependent Transporters In Neisseria Gnorrhoeae, Aimee Hollander
Theses and Dissertations
Neisseria gonorrhoeae is an obligate human pathogen that causes the common sexually- transmitted infection, gonorrhea. Gonococcal infections cause significant morbidity, particularly among women, as the organism ascends to the upper reproductive tract, resulting in pelvic inflammatory disease, ectopic pregnancy and infertility. Antibiotic resistance rates have risen dramatically, leading to severe restriction of treatment options for gonococcal disease. Gonococcal infections do not elicit protective immunity nor is there an effective vaccine to prevent the disease. Thus, further characterization of expression, function and regulation of surface antigens could lead to better treatment and prevention modalities in the future. N. gonorrhoeae express a …
Identity And Psychological Needs Among National Guard Service Members And Undergraduates, Bradley Antonides
Identity And Psychological Needs Among National Guard Service Members And Undergraduates, Bradley Antonides
Theses and Dissertations
This study measured identity style and identity status within military and academic populations (N = 286) to investigate whether low levels of identity commitment predict dissatisfaction in meeting basic psychological needs. Analysis of identity style and identity status subscales examined the reliability of traditional measures of identity in an atypical emerging adult population. Group comparisons based on participant characteristics (identity commitment, work experience, age, combat experience) explored differences between and within institutions. Results supported the reliability of traditional identity measures in a non-traditional population. A diffuse identity status and diffuse identity style both significantly predicted lower reported levels of psychological …
Characterization Of Hpk2-Rrp2, Two-Component Regulatory System In Treponema Denticola, Sarkar Juni
Characterization Of Hpk2-Rrp2, Two-Component Regulatory System In Treponema Denticola, Sarkar Juni
Theses and Dissertations
Treponema denticola levels in the gingival crevice become elevated as periodontal disease develops. Oral treponemes may account for as much as 40% of the total bacterial population in the periodontal pocket. The stimuli that trigger enhanced growth of T. denticola and the mechanisms associated with the transmission of these signals remain to be defined. A hypothesis was set that the T. denticola ORFs tde1970 (histidine kinase) and tde1969 (response regulator) constitute a functional two component regulatory system that regulates, at least in part, responses to the changing environmental conditions associated with the development of periodontal disease. The results presented demonstrate …
Ink (2011-09)
Ink, 2008-
The student-run features magazine covering the fashion, art, music and culture worlds at VCU and in Richmond. Published annually in print and updated regularly online.
Shaken And Stirred: Tactile Imagery And Narrative Immediacy In J. D. Salinger's "Blue Melody," "A Girl I Knew," And "Just Before The War With The Eskimos", Angelica Bega-Hart
Shaken And Stirred: Tactile Imagery And Narrative Immediacy In J. D. Salinger's "Blue Melody," "A Girl I Knew," And "Just Before The War With The Eskimos", Angelica Bega-Hart
Theses and Dissertations
J.D. Salinger’s ‘A Girl I Knew,’ ‘Just Before the War with the Eskimos,’ and ‘Blue Melody,’ contain key thematic and narratological elements that contribute to the development of character through repeated reference to tactile imagery and through each character’s reaction to the sensations associated with tactile images. Salinger’s descriptions of tactile interaction allow readers to see his characters connected in ways that were increasingly difficult in the 1950’s, where widespread cultural changes contributed to increasing physical and emotional distancing. Critics have argued that “vision” is at the heart of many of Salinger’s characters’ struggles, since they “seek” a level of …
Synthesis Of Cyclen Based Receptors And Their Use In Separations Biotechnology., Vivek Kaushik
Synthesis Of Cyclen Based Receptors And Their Use In Separations Biotechnology., Vivek Kaushik
Theses and Dissertations
A number of purification techniques such as adsorption, centrifugation, chromatography, extraction, distillation, filtration, precipitation etc. to name a few, are commonly used for the purification. However, due to a constant need of purification of even more complex crude mixtures, be it reaction mixtures, various proteins and DNA from cell extracts or medicinal compounds and fragrances from plant extracts, scientists needed to consistently develop new and improved techniques of purification. One such great advancement in the field of chromatography was the development of affinity chromatography. It revolutionized the field of bioseparations technology, and the dream of single stage purification of complex …
Effect Of Combined Oral Contraceptives On Insulin Clearance In Lean And Obese Pre-Menopausal Women, Vidya Moorthy
Effect Of Combined Oral Contraceptives On Insulin Clearance In Lean And Obese Pre-Menopausal Women, Vidya Moorthy
Theses and Dissertations
Introduction: Obese women are predisposed to greater risks of insulin resistance and compensatory hyperinsulinemia. Likewise, African-Americans, appear to be inherently insulin resistant and hyperinsulinemic even after controlling for obesity. Hyperinsulinemia has been attributed to insulin resistance and a compensatory insulin hyper-secretion by the pancreas, as well as decreased insulin clearance, notably in obesity. Pharmacological agents that may worsen insulin resistance/hyperinsulinemia in obese women is of clinical relevance. Previous data from our group suggested that combined oral contraceptives (COCs) may worsen insulin sensitivity particularly in obese women, but limited information on insulin clearance is available in obese women or African-American women. …
Determining The Mechanism Of Double-Stranded Rna-Induced Cell Death In Ovarian Cancer., Danielle Van
Determining The Mechanism Of Double-Stranded Rna-Induced Cell Death In Ovarian Cancer., Danielle Van
Theses and Dissertations
Ovarian cancer is the most lethal of all gynecological cancers. Current ovarian cancer drug regimens, including taxanes and platinum-based agents, are susceptible to chemoresistance necessitating the development of novel chemotherapeutics. Within tumors pathogen-derived ligands, such as dsRNA, can activate pattern recognition receptors (PRRs) that are capable of inducing apoptosis. In this dissertation we have found that in ovarian cancer cell lines (DOV-13, SKOV-3, CAOV-3, and OVCAR-3), dsRNA treatment alters cell survival. When treated with dsRNA, ovarian cancer cell lines and patient samples could be divided into two categories, responsive which undergo significant levels of apoptosis (CAOV-3 and OVCAR-3) or non-responsive …
Let's Get Physical: The Role Of Physical Activity In The Training Of Graduate Mental Health Students, Cassandra Pasquariello
Let's Get Physical: The Role Of Physical Activity In The Training Of Graduate Mental Health Students, Cassandra Pasquariello
Theses and Dissertations
There is growing awareness of the role of physical activity (PA) in the prevention and treatment of health disorders. Mental health practitioners are well positioned to provide PA counseling and may have ethical obligations to address PA. Researchers have cited insufficient training as a barrier to PA counseling, yet little is known about training in mental health. This exploratory study examines the need for training students in PA counseling. A national sample of 361 current graduate students in psychology, social work, rehabilitation counseling, and psychiatric nursing completed a Web-based survey on their training, knowledge, attitude towards PA, personal PA, and …
Pre- And Post-Migration Attitudes Among Ghanaian International Students Living In The United States: A Study Of Acculturation And Psychological Well-Being, Nicole Fischer
Theses and Dissertations
This qualitative study investigated attitudes among international students prior to their departure and following their arrival in the United States through a phenomenological research approach. Eight participants completed individual interviews in Accra, Ghana, and four participants completed follow-up email correspondence. The purpose of the study was to explain pre-migration expectations, post-migration experiences, and compare similarities and differences between perceptions and actual encounters. The researcher investigated five principle components of pre-migration: satisfaction with life prior to departure from the country of origin, impressions and expectations of the host country and predominate influences, awareness of discrimination in the host country, and culture-specific …
Adjustment Of Families With Children Adopted From Eastern Europe, Maria Kuznetsova
Adjustment Of Families With Children Adopted From Eastern Europe, Maria Kuznetsova
Theses and Dissertations
The purpose of this study was to examine the adjustment of older children and adolescents adopted from Eastern Europe and the impact of their preadoption history and family’s functioning on their adjustment. This is a follow-up study of families first surveyed in 2005 with an addition of new families. One hundred and forty-five families reporting on 194 adopted children (9 to 19 years; 104 girls) participated in this study at Time 2. The project was conducted as an internet-based survey. Parents and adopted children reported on children’s emotional, behavioral and social problems (CBCL and YSR), as well as family environment …
Homage To Everyday People, Sang Ja Chun
Homage To Everyday People, Sang Ja Chun
Theses and Dissertations
Influenced by an ever-growing sense of alienation with my homeland, I have been determined to discover through my art practice an ability to challenge conventional notions of home, identity, communication and miscommunication. Exploring these themes, I became increasingly aware of the parallels between everyday life and art practice. By creatively connecting with a diverse amount of local people and their communities, I fulfilled desires to discover a sense of belonging and generated opportunities for others to break through traditional social boundaries and roles.
Alghe Mist, Jeffrey Kenney
Alghe Mist, Jeffrey Kenney
Theses and Dissertations
This is an overview of the source material, methodologies, artistic influences, and conceptual decisions that inform the sculptural and the photographic means of production that characterize my art practice. Research topics include model-making, the indexical relationship of the photograph and object, and a brief phenomenology of accidents, alchemy, and ambivalence in relation to specific artworks.
A Pre And Post Exercise Comparison Of Three Assessment Tools Commonly Employed To Assess Vascular Function, Lorena Salom
A Pre And Post Exercise Comparison Of Three Assessment Tools Commonly Employed To Assess Vascular Function, Lorena Salom
Theses and Dissertations
Background: Endothelial dysfunction (ED) is one of the earliest subclinical indicators of impaired cardiovascular health and several non-invasive tools have been developed to evaluate vascular function, including strain gauge plethysmography (SGP), brachial artery flow-mediated dilation (FMD) via ultrasound, and peripheral artery tonometry (PAT). While these tools have extensively been studied during a resting condition, the responses following acute exercise are not as well characterized. Purpose: The purpose of this study was to compare the pre- and post-exercise vascular function values obtained with SGP, FMD, and PAT. Relationships among the primary outcome variables obtained with each assessment tool were also evaluated. …
Molecular Pathways Involved In Calcineurin Inhibitor Nephrotoxicity In Kidney Allograft Transplants, Huong Nguyen
Molecular Pathways Involved In Calcineurin Inhibitor Nephrotoxicity In Kidney Allograft Transplants, Huong Nguyen
Theses and Dissertations
ABSTRACT MOLECULAR MECHANISMS AND GENE SIGNATURES INVOVLED IN CALCINEURIN INHIBITOR NEPHROTOXICITY IN KIDNEY ALLOGRAFT By Huong Le Diem Nguyen, M.S. A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Physiology at Virginia Commonwealth University. Virginia Commonwealth University, 2011. Major Director: Valeria Mas, Ph.D. Associate Professor, Department of Surgery and Pathology Director of Molecular Transplant Research Laboratory, Division of Transplant Calcineurin inhibitors (CNI), cyclosporin A and tacrolimus, are potent immunosuppressive agents but induce toxicities causing damages and graft dysfunction, and have been suggested to contribute to late-term loss of graft in kidney transplant …
Role Of Autophagy In Radiosensitization Of Breast Tumor Cells, Molly L. Bristol
Role Of Autophagy In Radiosensitization Of Breast Tumor Cells, Molly L. Bristol
Theses and Dissertations
In MCF-7 breast tumor cells, ionizing radiation promoted autophagy that was cytoprotective; pharmacological or genetic interference with autophagy induced by radiation resulted in growth suppression and/or cell killing (primarily by apoptosis). The hormonally active form of vitamin D, 1,25D3, also promoted autophagy in irradiated MCF-7 cells, sensitized the cells to radiation and suppressed the proliferative recovery that occurs after radiation alone. 1,25D3 also enhanced radiosensitivity and promoted autophagy in MCF7 cells that overexpress Her-2/neu as well as in p53 mutant Hs578t breast tumor cells. In contrast, 1,25D3 failed to alter radiosensitivity or promote autophagy in the BT474 breast tumor cell …
Projection Design For A Contemporary Dance Work By Iván Angelus In Hungary, Tennessee Dixon
Projection Design For A Contemporary Dance Work By Iván Angelus In Hungary, Tennessee Dixon
Theses and Dissertations
The purpose of this thesis is to document and analyze my projection design for a new dance piece, "VŰ", directed by Angelus Iván and staged at Trafó in Budapest, Hungary. Included is an account of the design process, the concept and projection development described scene by scene, execution, performance and evaluation. The paper ends with reflections on the relatively new field of image projections, and my professional goals in scenic design.
Mosaicism For Trisomy21: Utility Of Array-Based Technology For Its Detection And Its Influence On Telomere Length And The Frequency Of Acquired Chromosome Abnormalities, Chariyawan Charalsawadi
Mosaicism For Trisomy21: Utility Of Array-Based Technology For Its Detection And Its Influence On Telomere Length And The Frequency Of Acquired Chromosome Abnormalities, Chariyawan Charalsawadi
Theses and Dissertations
The primary aim of this study was to determine the effectiveness of array-based technology for detecting and quantifying the presence of mosaicism. This aim was achieved by studying individuals having mosaicism for Down syndrome. SNP arrays were performed on 13 samples from individuals with mosaicism for trisomy 21, 13 samples from individuals with normal chromosome 21complements (negative controls) and 5 samples from individuals with full or partial trisomy 21 (positive controls). In addition, BAC arrays were processed on 6 samples from individuals with mosaicism for trisomy 21, 3 negative controls and 1 positive control. These studies have shown that array-based …
The Effects Of Hypothermia On Status Epilepticus-Induced Acquired Epilepsy, Kristin Phillips
The Effects Of Hypothermia On Status Epilepticus-Induced Acquired Epilepsy, Kristin Phillips
Theses and Dissertations
Status epilepticus (SE) is a type of neurological injury characterized by continuous seizure activity and can lead to molecular and pathophysiological alterations leading to plasticity changes. SE can lead to the development of AE by the process of epileptogenesis, which is a phenomenon that describes the transformation of normal brain tissue into a hyperexcitable neuronal population. It has been demonstrated both in vivo and in vitro that calcium (Ca2+) dynamics are severely altered during and after SE, and these changes play a major role in the progression of epileptogenesis. It has also been reported that preventing the rise in intracellular …
Medicalization As A Trojan Horse: Changes In Erectile Enhancement Advertising, Robert Wood
Medicalization As A Trojan Horse: Changes In Erectile Enhancement Advertising, Robert Wood
Theses and Dissertations
Medicalization as a Trojan Horse: Changes in Erectile Enhancement Advertising By Robert D Wood, M.S. A Thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University Virginia Commonwealth University, 2011 Major Director: Sarah Jane Brubaker, PhD, Graduate Program of Sociology This thesis investigates the medicalization of “inadequate penis size” through an analysis of online advertising of “male enhancement,” or erectile enhancement (EE) products. The process of medicalization, as defined by Peter Conrad, is the process by which non-medical problems become defined and treated as such (2007). With the advent and success …