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Virginia Dental Journal (Vol. 89, No. 1, 2012)

Virginia Dental Journal

No abstract provided.

Biochemical Actions Of A Novel Cis-Terpenone, Lin Zhang

Theses and Dissertations

Abstract BIOCHEMICAL ACTIONS OF A NOVEL CIS-TERPENONE By Lin Zhang, Ph.D. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2012 Director: Qibing Zhou, Ph.D Assistant Professor Department of Chemistry

Quinone methides are reactive species due to their electrophilicity, and natural quinone methide analogs have broad biological activities. Based on known actions of cytochrome P450 enzymes, we hypothesized that trans-terpenones can be metabolized in cells to form a cascade of metabolite products, which may be biologically active due to the generation of quinine and quinone methide …

Material Meaning, Anne Jordan

Theses and Dissertations

The synthesis of old and new, analog and digital, and hand- and computer-based methods provides designers with an opportunity to work beyond the constraints of the computer and take advantage of the aesthetic effects that actual materials bring to visual communication. Designers who choose to actively participate in their process – bringing the aesthetic effects of working materially into the realm of the digital – will likely learn to reject an approach that relies too heavily on passive digital tools. Active participation in the design process can extend our creative vocabulary and humanize visual communication.

Adam10: A Novel Regulator Of Mast Cell Function And Activation, Travis Faber

Theses and Dissertations

In this study we show, to our knowledge, the first description of the role ADAM10 plays on mast cells. ADAM10 is abundantly expressed on mast cells both in vitro and in vivo. Its expression is inhibited by IL-10, a suppressive cytokine. siRNA depletion of ADAM10 on bone marrow-derived mast cells (BMMC) caused decreased IL-6 production following IgE cross-linking and also impaired BMMC stem cell factor (SCF)-induced migration through collagen IV. Mast cells and T helper cells (Th cells) in the peritoneum were reduced in ADAM10 KO mice. In addition, ADAM10 KO BMMC produced significantly less of all cytokines measured following …

Regeneration Of Electrospun Bioresorbable Vascular Grafts: A Phenomenon Associated With Vascular Graft Properties And Macrophage Phenotypes (M1/M2), Koyal Garg

Theses and Dissertations

Macrophages (MФ) and mast cells are important cell types in the context of tissue remodeling and regeneration. Mast cells participate in the early stages of wound healing and modulate the acute inflammatory responses to biomaterials. Mast cells can secrete a myriad of different cytokines by the process of degranulation; the process of regulated secretion in which preformed contents stored in their granules are rapidly released by exocytosis. Some of these cytokines such as IL-4, IL-13 and TNF-α can modulate the MФ phenotype. Macrophages (MΦ) are innate immune cells, crucial for tissue homeostasis, presentation of foreign and self-antigens following infection/injury, pathogen …

Identifying Sortase A Variants With Higher Catalytic Effeciency, Muna Suliman

Theses and Dissertations

In the past two decades, the field of protein engineering has evolved rapidly to include new genetic and chemical techniques to alter protein function. Protein engineering seeks to improve enzyme properties through powerful methods that specifically incorporate novel or improved function in proteins. One such method is protein ligation, which is used to selectively link synthetic and recombinant polypeptides. Due to the limitations of current protein labeling techniques, simple site-specific modification methods remain in high demand. Use of enzyme-based labeling has been the focus of various studies because of its substrate specificity. Sortase-mediated transpeptidation is one approach that has been …

Role Of Lysophosphatidic Acid In Regulation Of Cancer Cell Metabolism, Abir Mukherjee

Theses and Dissertations

The simplest phospholipid, lysophosphatidic acid (LPA), is a heat stable component of serum known for its proliferative and migratory activities in cancer cells. Strong evidence suggests that LPA production and expression of its receptors are dysregulated in multiple human malignancies. The mechanism behind LPA-mediated tumor cell growth and oncogenesis remains poorly understood. In this thesis project I used ovarian and other cancer cells as a model system to examine the hypothesis that LPA present in the tumor microenvironment is a pathophysiological determinant of hyperactive de novo lipogenesis and aerobic glycolysis, two hallmarks of cancer cells. We demonstrated that LPA induced …

Elevating The Everyday: Designed Objects As Companions, Cassie Hester

Theses and Dissertations

From fleeting interactions to long affairs, our relationships with things are diverse and complex. Like people, designed objects and environments are close companions in our lives. The way we understand and engage with artifacts is parallel to the way we interpret and interact with each other. A constant source of comfort and delight, frustration and anxiety, their personalities inform our everyday dialogues and experiences. Designed artifacts assume engaging and pleasurable personalities when they transcend materials, challenge perceptions, and garner active, reflective interactions. Through the investigation of familiar materials such as concrete, crayons, paper, sequins, and thread in unfamiliar formats and …

Factors Influencing Pharmacists’ Decision To Report Adverse Events Related To Dietary Supplements, Ali M. Alhammad

Theses and Dissertations

Background: The increasing consumption of dietary supplements (DS) has drawn the attention of regulatory agencies, researchers and healthcare professionals. The US Food and Drug Administration (FDA) does not require premarketing assessment of DS considering them safe unless proven otherwise. However, the reporting rate of DS adverse events (DS-AE) is low. Objective: To describe pharmacists’ attitudes and knowledge of DS and DS information resources, and to determine the importance of selected attributes in pharmacists’ decisions to report a DS-AE. Methods: A convenience sample of practicing pharmacists in Virginia was surveyed using a web-based self-administered questionnaire. A conjoint analysis exercise was developed …

An Investigation Of Internal Control Related Frauds And Auditor Litigation: Pre- And Post- Sarbanes-Oxley, Section 404, Ifeoma Udeh

Theses and Dissertations

Using 629 observations of U.S. publicly listed firms with internal control related frauds from 2000 to 2006; this study investigates the change in auditor litigations in the Post- Sarbanes Oxley, Section 404 period. To the extent the conditions of the internal control in place are inadequate or non-existent, the possibility of the occurrence of internal control related fraud heightens. Thus, the inability of auditors to detect a financial statement misstatement due to internal control fraud in a timely manner exposes auditors to litigation (Barra, 2010; Heninger, 2001; Caplan, 1999). This situation was prevalent in the recent notable corporate failures that …

Online Learning: Exploring The Landscape, Jonathan D. Becker, Jesse Senechal, Charol Shakeshaft

MERC Publications

The Policy and Planning Council of the Metropolitan Educational Research Consortium (MERC) at Virginia Commonwealth University (VCU) rightfully identified online learning as an area ripe for study. This report summarizes findings from both phases of the research is the first report of the study that was ultimately commissioned. After a brief review of the literature, this report includes a description of the survey research portion of the study as well as findings from the statewide survey that was undertaken and then phase 2, which consisted of case studies of four Virginia school divisions. The report concludes with a brief summary …

Data-Driven Design Decisions For Discovery Interfaces, Erin White

VCU Libraries Faculty and Staff Presentations

This presentation shows the way VCU Libraries leveraged data from heatmaps, user research and search logs to inform design decisions for its discovery search engine.

Cns Neural/Glial Progenitors As Targets Of Hiv-1 And Opiates: Effects On Proliferation And Population Dynamics May Alter Behavior Outcomes., Yun Kyung Hahn

Theses and Dissertations

Human immunodeficiency virus (HIV) infected patients with a history of injection opiate abuse have higher incidences of acquired immunodeficiency syndrome (AIDS) and neurological dysfunction. The use of combined anti-retroviral therapy has significantly reduced the prevalence of mortality and progression to AIDS. Due to extended life expectancy, these patients are still at a great risk for HIV-associated neurological disorders and impairment in their later life. Neural progenitor cells (NPCs) play critical roles in brain growth and repair after injury and insult. Pediatric HIV patients whose glial populations are still developing are especially at risk for central nervous system (CNS) damage. Our …

Role Of Extracytoplasmic Function Sigma Factors In Porphyromonas Gingivalis, Suhasini Yanamandra Sai

Theses and Dissertations

Porphyromonas gingivalis is a major etiological agent that is responsible for the cause and progression of periodontal diseases. The bacterium is exposed to various environmental conditions and oxidative stress conditions while it is in the oral cavity. So, P. gingivalis should have an efficient regulatory system in order to adjust and survive in the oral cavity. But little is known about the regulatory mechanisms that help the bacteria to survive in the oral cavity. So, it is essential to understand and characterize these regulatory mechanisms. The response and adaptation of P. gingivalis to environmental stress conditions occur at the level …

From Desegregation To Desexigration In Richmond, Virginia, 1954-1973, Leslee Key

Theses and Dissertations

This investigation explores the relationships and experiences in the urban community that connected black and white women to understand the complexities of Jim Crow, its breakdown, and the subsequent expansion of female activism in Richmond, Virginia. By examining the South’s famous department stores, Thalhimers and Miller & Rhoads, this research attempts to focus on female-created and female-oriented spaces within downtown Richmond, from 1954 until 1973, and draws a line from the Thalhimer boycott staged by African-American women in 1961 to the sit-in performed by white women in the Thalhimers male-only soup bar in 1970. Historical context is developed to show …

Commonwealth Times 2011-12-08

Commonwealth Times, 1969-

No abstract provided.

Development Of A Novel Approach To Assess Qualitative And Quantitative Dynamics Associated With The Subcutaneous Or Intramuscular Administration Of Pharmaceuticals And Associated Parenteral Delivery Systems, Eric Edwards

Theses and Dissertations

There has been a significant increase in the number of injectable pharmaceutical products over the last decade that have been incorporated into unique delivery systems such as pen injectors, auto-injectors, or pre-filled syringes. The advancement of these delivery systems and the paradigm shift towards administration of injectables in the out-of-hospital or home setting have introduced variables that can affect the bioavailability of injectable drugs and potential pharmacologic outcomes. An approach that allows for the qualitative and quantitative dispersion assessment of an injectable at the moment of tissue deposition coupled with an assessment of systemic exposure parameters could provide substantial information …

The Impact Of Race And Interactions Between Student-Faculty On Undergraduate Student Learning And Multicultural Perceptions, Yun Zhu

Theses and Dissertations

As enrollment of minority students and recruitment of minority faculty in higher education increase, opportunities for students to interact with racially and ethnically different faculty will become more frequent and pronounced. Also, there may be expectations that these interactions will produce greater educational gains and sensitivity to racial issues. A quantitative research methodology was employed to measure the nature of the student-faculty interactions across race and to explore factors that influence undergraduate students’ GPA and multicultural perceptions in order to identify ways in which student-faculty interactions might better serve the students. Mainly, this study focused on the quantity, quality, and …

Teachers' Perception Of Computer Use And Technical Support In A Rural Virginia School Division: A Case Study, Rodney Berry

Theses and Dissertations

The purpose of this study was to investigate teacher perceptions of computer-based technology and technology support provided by a rural school division; the extent of teachers’ self reported computer skills, comfort levels, perception of obstacles; and the amount of support, time, and training available to them to accomplish the integration during the course of instruction. This research was conducted during the 2010-2011 school term as a case study of a small rural K-12 school division in southern Virginia, consisting of teachers from each core curriculum from each of the three schools, selected deliberately. The study was divided into three phases: …

An Assessment Of Principals' Technology Leadership: A Statewide Survey, Jeffrey Duncan

Theses and Dissertations

The purpose of this study was to collect data about engagement and involvement around technology issues by principals in Virginia. Virginia public school administrators were surveyed using the Principals Technology Leadership Assessment (PTLA) instrument and results compared to the National Educational Technology Standards for Administrators (NETS-A) (ISTE, 2002). This study, though limited in scope, provided meaningful data for research. The study reflects that despite 10 years of having NETS-A in place, Virginia public school administrators are barely meeting minimum standards in five out of the six dimensions. The study correctly looked at the old NETS-A standards but resulted in a …

Commonwealth Times 2011-12-05

Commonwealth Times, 1969-

No abstract provided.

Identifying Modulators Of The Development Of Acute Functional Tolerance To Ethanol In Caenorhabditis Elegans., Ka-Po Leung

Theses and Dissertations

Alcohol abuse is a problem in our society. There are few treatments available, in part due to the unclear molecular mechanisms of ethanol’s effects. Human studies indicate that there is a genetic component influencing disease susceptibility, and that an individual’s initial response to alcohol can predict their development of addiction. We have taken a forward genetics approach to study one component of initial response, acute functional tolerance (AFT), in Caenorhabditis elegans. We identified bet11, a mutation that causes animals to be defective in the development of AFT. Genetic analysis suggested that the gene that bet11 disrupts participates in a synthetic …

Living With Hiv: Views Through The Blog, Linda Eastham

Theses and Dissertations

The purpose of this qualitative descriptive study was to develop a greater clarity of how HIV infected individuals live and work within the sphere of HIV infection as represented through unsolicited, personal narratives posted on blogs. Existing, single author, personal blogs were identified via a search engine. Blogs were defined as the blog author's postings and all responses, whether written by the blog author or a reader respondent. Inclusion and exclusion criteria were developed to respect indicators of bloggers' intentions for privacy, e.g., blogs which required a password were excluded. A total of 14 blogs met inclusion criteria. Actions to …

Organizational Capacity To Absorb External Knowledge: An Exploratory Study Of Public And Nonprofit Decision Makers' Perceptions Of Impediments And Facilitators, Linda S. Birtley

Theses and Dissertations

Research indicates that many youth-serving agencies do not adopt evidence-based innovations in the field of youth violence prevention. This qualitative study was designed to explore a sample of community-based decision makers’ perceptions of why innovative, evidence-based programs and practices for the prevention of violence by youth are, or are not, adopted at the local level. The rationale for this study was that knowledge of evidence-based innovations in youth violence prevention originates primarily from research scientists who are external to the organizations that are the intended recipients of the innovations. Prior research has not viewed the failure to adopt evidence-based innovations …

"Visual Vessels", Theresa Ornoff

Theses and Dissertations

In 1989 while our severely ill son lay in our arms my husband and I asked the surgeon what he would do if he were in our shoes. “Play the hand you’re dealt.” he replied. It was not this doctor’s only reference to the gamble life holds for each of us. Based on his advice to us I began to investigate the role that fate and predetermination play in our lives and consequently how much control we have on the outcome of life’s events. A cathartic family portrait piece laid the groundwork for a series of metaphorical portraits as I …

Life's Texture: Depth And Breadth, Susan Wynn-Trent Musselman

Theses and Dissertations

Our world has a wonderful and intriguing tension in the balance between stress and calm, joy and sadness, and organization and chaos. As a sentient being, I must steadily adapt and accommodate the changing world surrounding me. In doing so, I create a dance to a rhythm that changes with every bar of music heard only by my own ear. My process is a reflection of this integral dance and I visualize the rhythm in form. My work is the result of the integration of my life with my creativity. I maneuver through this creative labyrinth using multiple materials to …

Healthcare Acquired Infection Risk And Toothbrush Contamination In The Icu., Michelle Frazelle

Theses and Dissertations

Healthcare acquired infections (HAIs) are a complex and multi-factorial problem associated with high morbidity, mortality, and cost. Toothbrushes (TBs) may be at risk for contamination with potential pathogenic microorganisms (PPMs) from the patient care environment or autoinnoculation from the patient. We focused on three PPMs: multiply resistant Staphylococcus aureus (MRSA), vancomycin resistant Enterococcus (VRE), and Acinetobacter. Specific aims were to (1) describe environmental factors associated with TB contamination in the ICU; (2) describe the relationship between TB contamination and oral colonization in critically ill adults.

Characterizing The Phosphorylation State Of Tie2 Using Sh2 Domain Fusion Proteins, Kenneth Yuth

Theses and Dissertations

The cardiovascular system develops through two distinct processes in embryogenesis: vasculogenesis, whereby the primary plexus in the heart is formed along with embryonic and extraembryonic vasculature, and angiogenesis, which begins after vasculogenesis and results in the refinement and maturation of the branched vessel system. In pathological angiogenesis, tumors expand by releasing pro-angiogenic factors in response to hypoxic conditions. The Tie receptors, Tie1 and Tie2, are receptor tyrosine kinases that are integral to angiogenic pathways. A family of Angiopoietins, Ang1-4, have been shown to act as ligands for Tie2, of which Ang1 and Ang2 are best characterized. Activation of the receptor …

Designed Synthesis Of Halogenated Borazine-Linked Polymers And Their Applications In Gas Storage And Separation, Thomas Reich

Theses and Dissertations

The synthesis of highly porous organic polymers with predefined porosity has attracted considerable attention due to their potential in a wide range of applications. Of particular interest in porous organic polymers is their potential use in automotive applications as well as separation processes whereby advancements could result in a reduction in carbon dioxide emissions and the production of natural gas in a more economically friendly manner. Along these pursuits, seven borazine-linked polymers (BLPs) have been synthesized through the introduction of p-phenylenediamine, 1,3,5-tris-(4-aminophenyl)benzene, benzidine, or tetra-(4-aminophenyl)methane with boron tribromide or boron trichloride followed by the thermolysis reaction of the resulting in …

Commonwealth Times 2011-12-01

Commonwealth Times, 1969-

No abstract provided.