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Articles 2821 - 2850 of 7325
Full-Text Articles in Entire DC Network
Gene Therapy Evolution: How Gene Therapy Has Evolved Preventive Medicine, Kayuri Shah
Gene Therapy Evolution: How Gene Therapy Has Evolved Preventive Medicine, Kayuri Shah
UROP Posters
Gene therapy technologies offers a prospect for preventive medicine; before the trait can harm the recipient, genetically engineered transgenes will either alter the genetic disorder beforehand, or allow for regeneration of the tissue. The basic goal in bone formation and regeneration is to find a quick, easy, and cost-effective method to help bone growth, formation, and regeneration where surgery may be impossible or too risky. Gene therapy provides that, whether as a technology or product. Cells have the ability to be engineered, or manipulated, within the recipient’s body, or by removal and reimplantation. While treatments such as surgery are available, …
Peta's Objectification Of Women, Abir Malik
Peta's Objectification Of Women, Abir Malik
UROP Posters
Over the last few decades, advertisements have objectified and sexualized women as a tactic to attract men into supporting causes and buying products. This research project focuses on the advertisements published by the animal rights group, PETA, People for the Ethical Treatments of Animals, and its deliberate use of degrading images of women to support its cause. PETA advertisements juxtapose barely clad women with animals or animal references, making the viewer see women as animalistic, out of control, and in need of taming or saving. Research shows that the results of such negative advertising tactics are correlated with increased aggression …
Literary Landscapes: Mapping Emergent American Identity In Transatlantic Narratives Of Women's Travel Of The Long Eighteenth Century, Leah Thomas
Theses and Dissertations
This dissertation examines intersections of the development of maps from the Native American-European encounter to the establishment of the New Republic and transatlantic British and American narratives of women’s travel of the long eighteenth century. Early European and American maps that depict the Americas analyzed as parallel “texts” to canonical and lesser-known women’s narratives ranging from 1688 to 1801 reveal further insights into both maps and these narratives otherwise not apparent. I argue that as mapping of the New World developed, this mapping influenced representations of women’s geographic and social mobility and emergent “American” identity in transatlantic narratives. These narratives, …
Counter Measures To Mitigate Cyberstalking Risks: A Value Focused Multiple Criteria Approach, Safoorah Mughal
Counter Measures To Mitigate Cyberstalking Risks: A Value Focused Multiple Criteria Approach, Safoorah Mughal
UROP Posters
A value focused multiple-criteria decision making approach is adopted to examine policies, procedures and technologies that can potentially reduce the risks of Cyberstalking. This research also has applicability for the broader field of cybercrime, any illegal action which uses electronic communication or devices or information systems containing the Internet, including identity theft, child abuse, sex crimes against minors, and online financial crimes (Legoze, 2012 p. 4). This research offers an overview of cybercrime and the principal objective is to examine Cyberstalking. Cyberstalking involves a pattern of threatening or aggressive behaviors that utilizes the Internet, email or other electronic correspondence (NCSL, …
Technologies And Artworks: An Interdisciplinary Exploration Through Ihde And Latour, Kathryn Lynch Thibault
Technologies And Artworks: An Interdisciplinary Exploration Through Ihde And Latour, Kathryn Lynch Thibault
Theses and Dissertations
Technologies and Artworks: An Interdisciplinary Exploration through Ihde and Latour discusses and applies the phenomenological framework described by the philosopher of science and technology Don Ihde, in his text Technology and the Lifeworld, in relation to recent artworks of sculpture and performance that incorporate technologies. The study considers closely Ihde’s embodiment, hermeneutic, and alterity variants for the purpose of developing conceptual tools to investigate the complicated human-technology relationships present in the works considered. A subsequent discussion of psychasthenia and its relationship to Ihde’s embodiment variant demonstrates the limitations of Ihde’s approach and the need for additional sources in order to …
Tuning And Optimization Of Silk Fibroin Gels For Biomedical Applications, Michael Marin
Tuning And Optimization Of Silk Fibroin Gels For Biomedical Applications, Michael Marin
Theses and Dissertations
Biocompatible and biodegradable porous materials based on silk fibroin (SF), a natural protein derived from the Bombyx mori silkworm, are being extensively investigated for use in biomedical applications including mammalian cell bioprocessing, tissue engineering, and drug delivery applications. In this work, low-pressure, gaseous CO2 is used as an acidifying agent to fabricate SF hydrogels. This low-pressure CO2 acidification method is compared to an acidification method using high-pressure CO2 to demonstrate the effect of CO2 mass transfer and pressure on SF sol-gel kinetics. The effect of SF molecular weight on the sol-gel kinetics is determined using the low-pressure CO2 method. The …
The Role Of P2x Receptors In Hiv And Opiate-Related Neurotoxicity, Mary Sorrell
The Role Of P2x Receptors In Hiv And Opiate-Related Neurotoxicity, Mary Sorrell
Theses and Dissertations
Emerging evidence suggests that opioid drugs can exacerbate neuroAIDS. Microglia are the principal neuroimmune effectors thought to be responsible for neuron damage in HIV-infected individuals, and evidence suggests that drugs acting via opioid receptors in microglia aggravate the neuropathophysiological effects of HIV. The P2X family of ATP activated ligand-gated ion channels regulates key aspects of microglial function. In addition, opioid-dependent microglial activation has been reported to be mediated through P2X4 signaling, prompting us to investigate P2X receptors contribution to the neurotoxic effects of HIV and morphine. In vitro experiments showed treatment with TNP-ATP prevented the neurotoxic effects of morphine and/or …
Understanding Collaboration Among Political Subdivisions Of State Government: Examining The Perceptions And Use Of Collaboration By Virginia's Soil & Water Conservation Districts, Kendall Tyree
Theses and Dissertations
The purpose of this study was to explore the definitions, benefits, challenges, methods and perceived levels of current collaboration of Virginia’s 47 Soil and Water Conservation Districts, each a political subdivision of state government. The study was guided by the following questions (1) What is collaboration and how is it used by political subdivisions of state government? (2) What collaborative strategies are used specifically by soil and water conservation districts? (3) At what level are districts currently collaborating? (4) At what level do districts prefer to collaborate? A mixed methods research survey was used. The quantitative section measured current perceptions …
Ink (2014-04)
Ink, 2008-
The student-run features magazine covering the fashion, art, music and culture worlds at VCU and in Richmond. Published annually in print and updated regularly online.
Multi – Modality Molecular Imaging Of Adoptive Immune Cell Therapy In Breast Cancer, Fatma Youniss
Multi – Modality Molecular Imaging Of Adoptive Immune Cell Therapy In Breast Cancer, Fatma Youniss
Theses and Dissertations
Cancer treatment by adoptive immune cell therapy (AIT) is a form of immunotherapy that relies on the in vitro activation and/or expansion of immune cells. In this approach, immune cells, particularly CD8+ T lymphocytes, can potentially be harvested from a tumor-bearing patient, then activated and/or expanded in vitro in the presence of cytokines and other growth factors, and then transferred back into the same patient to induce tumor regression. AIT allows the in vitro generation and activation of T-lymphocytes away from the immunosuppressive tumor microenvironment, thereby providing optimum conditions for potent anti-tumor activity. The overall objective of this study is …
High-Performance Doped Strontium Iodide Crystal Growth Using A Modified Bridgman Method, Emmanuel Rowe
High-Performance Doped Strontium Iodide Crystal Growth Using A Modified Bridgman Method, Emmanuel Rowe
Theses and Dissertations
The importance of gamma-ray spectroscopy – the science of determining the distribution of energy in a gamma field – can rarely be overstated. High performance scintillators for gamma-ray spectroscopy in Nuclear Nonproliferation applications and homeland security require excellent energy resolution to distinguish neighboring element and isotope lines while minimizing the time and exposure to do so. Semiconductor detectors operate by converting incident photons directly into electrical pulses, but often have problems of high costs due to constituent segregation and surface states as is the case for Cadmium Zinc Telluride. The ideal scintillator material for gamma spectrometer will therefore requires high …
Old World, New Media: Cross-Cultural Explorations With Camera And Analytic Text In Cusco, Peru, Scott Dupre Mills
Old World, New Media: Cross-Cultural Explorations With Camera And Analytic Text In Cusco, Peru, Scott Dupre Mills
Theses and Dissertations
Abstract OLD WORLD, NEW MEDIA: CROSS-CULTURAL EXPLORATIONS WITH CAMERA AND ANALYTIC TEXT IN CUSCO, PERU By Scott DuPre Mills, PhD. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2014 Major Director: Dr. Nicholas A Sharp, Assistant Professor, Department of English This dissertation draws on my field research in Cusco, Peru, documenting Old World methods of making Andean musical instruments. The cross-cultural interactions I engaged in are concretized and documented in the ethnographic film I shot at the time and in my experimentation with original music …
English Composition 100: Best Practices For Online Instruction, David Paschal Narendra Makhanlall
English Composition 100: Best Practices For Online Instruction, David Paschal Narendra Makhanlall
Theses and Dissertations
The objective of this dissertation is to explore the process of teaching English Composition in the asynchronous online format and to make recommendations for the best possible approach for continued student success. The teaching of English Composition is a complex subject and no two teachers will have the same approach. This matter is further complicated when online instruction is explored. An instructor cannot transplant an in-class course into the online format and expect the same results. This dissertation explores the best possible approach to teaching English Composition in an online environment with the use of multimedia applications. This exploration will …
United States Women Marines’ Experiences And Perspectives About Coping With Service Life: A Phenomenological Study, Beth-Ann Vealey
United States Women Marines’ Experiences And Perspectives About Coping With Service Life: A Phenomenological Study, Beth-Ann Vealey
Theses and Dissertations
Women are expanding their numbers and roles in the United States military. This new generation of military women is exposed to unique factors related to their gender that contribute to challenges for psychosocial well-being and optimal performance. In support of Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF), researchers have identified unique factors for military women, including increased combat exposure, continued military sexual trauma and harassment, and conflicting dual roles. These factors may create obstacles that inhibit help-seeking behaviors and support for military women, and remain an under-researched topic of study. Gender-specific research on military women is limited; current …
Ink (2014-02)
Ink, 2008-
The student-run features magazine covering the fashion, art, music and culture worlds at VCU and in Richmond. Published annually in print and updated regularly online.
A Longitudinal Study Of The Bidirectional Relations Between Internalizing Symptoms And Peer Victimization In Urban Adolescents, Tess Drazdowski
A Longitudinal Study Of The Bidirectional Relations Between Internalizing Symptoms And Peer Victimization In Urban Adolescents, Tess Drazdowski
Theses and Dissertations
The purpose of this study was to examine the bidirectional relations between anxious and depressive symptoms and two forms of peer victimization (i.e., overt and relational) within a sample of 358 predominantly African-American adolescents living in low-income urban areas across four years. Longitudinal path analyses tested progressively complex models for each type of victimization. For both overt and relational victimization the autoregressive model where only previous levels of each construct predicted future levels of the construct was the most parsimonious explanation. The best fitting model for both types of peer victimization suggested that internalizing symptoms helped to further explain future …
A Direct And Indirect Mechanism For Ccr5 In Morphine And Hiv-1 Mediated Neurodegeneration, Elizabeth Podhaizer
A Direct And Indirect Mechanism For Ccr5 In Morphine And Hiv-1 Mediated Neurodegeneration, Elizabeth Podhaizer
Theses and Dissertations
A DIRECT AND INDIRECT MECHANISM FOR CCR5 IN OPIOID AND HIV-1 MEDIATED NEURODEGENERATION By Elizabeth M. Podhaizer, Ph.D. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2014 Major Director: Kurt F. Hauser, Ph.D., Professor of Pharmacology & Toxicology Human immunodeficiency virus (HIV)-1 infection currently affects over 34 million people worldwide, and despite the use of cART, the prevalence of HIV-1 associated neurocognitive impairments (HAND) has not declined. Additionally, other co-morbid factors such as the abuse of injection drugs (i.e. heroin, morphine) increase both the frequency …
The Spoiler Effect: How Spoilers Affect Our Perceptions Of Film And Tv, Alex Falls
The Spoiler Effect: How Spoilers Affect Our Perceptions Of Film And Tv, Alex Falls
UROP Posters
In today’s world of social media people evaluate modern film making more scrupulously than ever before. Months before a film even enters production there are people evaluating the screenplay online; hours after it premieres hundreds of reviews are accessible, and exponentially more if you include the countless bloggers, twitter posters, and discussion boards all over the internet; and every one of them attempt to make their own unique point. When there’s such a large amount of discussion occurring a problem arises. A problem that’s been characterized by the same social media culture that accentuated it in the first place, and …
Commonwealth Times 2014-01-13 [Front Page Has 2013-01-13]
Commonwealth Times 2014-01-13 [Front Page Has 2013-01-13]
Commonwealth Times, 1969-
No abstract provided.
Combined Antiproliferative Effects Of The Aminoalkylindole Win55,212-2 And Radiation In Breast Cancer Cells, Sean Emery
Combined Antiproliferative Effects Of The Aminoalkylindole Win55,212-2 And Radiation In Breast Cancer Cells, Sean Emery
Theses and Dissertations
The potential antitumor activity of mixed CB1/CB2 cannabinoid receptor agonists, such as the aminoalkylindole WIN55,212-2 (WIN2), has been extensively studied, but little information is available as to their potential interaction with conventional cancer therapies, such as ionizing radiation (IR). In the present work, we investigated the effects of WIN2 on the antiproliferative effects of radiation in human (MCF-7 and MDA-MB-231) and murine (4T1) breast cancer cells, as well as an immortalized human breast epithelial cell line (MCF-10A). WIN2 or radiation alone inhibited breast tumor growth, while the combination of WIN2 and radiation was more effective than either agent alone in …
The Effect Of Retinoic Acid On Rai1 And Identification Of Retinoic Acid Receptor Binding Site In Human Rai1, Bingjie Xue
The Effect Of Retinoic Acid On Rai1 And Identification Of Retinoic Acid Receptor Binding Site In Human Rai1, Bingjie Xue
Theses and Dissertations
Previous studies showed haploinsufficiency of RAI1 is the main cause of Smith-Magenis syndrome (SMS). SMS is a developmental neurobehavioral syndrome characterized by intellectual disability, congenital anomalies, obesity, neurobehavioral abnormalities, and disrupted circadian sleep-wake pattern. SMS is caused by deletion or mutation of chromosomal region 17p11.2 that includes RAI1. Studies in the Elsea lab have shown that RAI1 is a dosage-sensitive gene. Haploinsufficiency of RAI1 leads to dysregulation of CLOCK, NR1D2, POMC, and BDNF, which are responsible for circadian rhythm, metabolism, and cognitive development. Based on the data from Elsea’s recent study on zebrafish, rai1 gene expression in zebrafish is regulated …
Inhibition Of Methicillin-Resistant Staphylococcus Aureus-Induced Cytokines Mrna Production In Human Bone Marrow Derived Mesenchymal Stem Cells By 1,25-Dihydroxyvitamin D3, Aparna Maiti, William A. Jiranek
Inhibition Of Methicillin-Resistant Staphylococcus Aureus-Induced Cytokines Mrna Production In Human Bone Marrow Derived Mesenchymal Stem Cells By 1,25-Dihydroxyvitamin D3, Aparna Maiti, William A. Jiranek
Orthopaedic Surgery Publications
Background Methicillin-resistant Staphylococcus aureus (MRSA) is the predominant cause of bone infection. Toll like receptors (TLRs) are an important segments of host response to infection and are expressed by a variety of cells including human mesenchymal stem cells (hMSCs). The active form of Vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) has potent immunoregulatory properties, but the mechanism remains poorly understood. The genomic action of 1,25(OH)2D3 is mediated by vitamin D receptor (VDR), hormone-regulated transcription factor. VDR interacts with co-activators and co-repressors are associated with chromatin histone modifications and transcriptional regulation. The aim of our study is to explore MRSA-induced TLRs-mediated pro-inflammatory cytokines …
Activation Of Nlrp3 Inflammasomes Enhances Macrophage Lipid-Deposition And Migration: Implication Of A Novel Role Of Inflammasome In Atherogenesis, Xiang Li, Yang Zhang, Min Xia, Erich Gulbins, Krishna M. Boini, Pin-Lan Li
Activation Of Nlrp3 Inflammasomes Enhances Macrophage Lipid-Deposition And Migration: Implication Of A Novel Role Of Inflammasome In Atherogenesis, Xiang Li, Yang Zhang, Min Xia, Erich Gulbins, Krishna M. Boini, Pin-Lan Li
Pharmacology and Toxicology Publications
Although Nlrp3 inflammasome activation in macrophages has been shown to be critical for the development of atherosclerosis upon atherogenic stimuli, it remains unknown whether activated Nlrp3 inflammasomes by other non-atherogenic stimuli induce alterations in macrophages that may contribute in the concert with other factors to atherogenesis. Thus, the present study tested the hypothesis that activation of Nlrp3 inflammasomes by ATP, which is a classical non-lipid danger stimulus, enhances the migration of macrophage and increases lipids deposition in macrophages accelerating foam cell formation. We first demonstrated that extracellular ATP (2.5 mM) markedly increased the formation and activation of Nlrp3 inflammasomes in …