Digital Commons Network^™

Contemporary Approaches To Teaching American Indian Art, Melanie L. Buffington

The Melanie Buffington Papers

"In thinking through ways to teach about the art of Native Americans in more contemporary and culturally sensitive ways, focusing on contemporary art of American Indians, while referencing the past, is one approach that I believe may help work against essentialism. In particular, the art of two contemporary artists-Hock E Aye Vi also known as Edgar Heap of Birds and Teri Greeves-offers many possibilit ies for teachers." (p. 178)

Innovative Use Of The Wordpress/Rampages Platform To Improve Implementation Of Active Learning Strategies In The Vcu Child And Adolescent Psychiatry Fellowship Didactic Curriculum, Ravinderpal Singh

Health Sciences Education Symposium

Many factors have led to changes in the approach to graduate medical education, including ongoing development of new technology, the dynamics of information transfer, and generational preferences for active learning and novel teaching strategies. In response, the VCU Child and Adolescent Psychiatry Fellowship program decided to pursue curriculum reform, using active learning strategies and employing technology to achieve improvements in the learning and retention of material for learners to be successful in treating patients and families now and in the future. A fundamental aspect of these changes included a partnership with VCU SOM instructional technologist to create an online platform …

Picshare, Kyle Crane, Emily Klein, Ben Wunschel

Capstone Design Expo Posters

PicShare is an app that allows companies to easily manage their social media presence without having to dedicate large amounts of time to the process. Your social media department can now extend their reach with the help of all of your other employees.

Our platform allows users to upload images/text from a mobile application or directly from the web. Administrators have the ability to take their own or user's image/text uploads and prepare for a social media post.

Employees attending events can get content to your social media staff much faster and with more variety. Our application is a great …

Slowly Cycling Rho Kinase-Dependent Actomyosin Cross-Bridge "Slippage" Explains Intrinsic High Compliance Of Detrusor Smooth Muscle, Christopher J. Neal, Jia B. Lin, Tanner Hurley, Amy S. Miner, John E. Speich, Adam P. Klausner, Paul H. Ratz

Biochemistry and Molecular Biology Publications

Biological soft tissues are viscoelastic because they display timeindependent pseudoelasticity and time-dependent viscosity. However, there is evidence that the bladder may also display plasticity, defined as an increase in strain that is unrecoverable unless work is done by the muscle. In the present study, an electronic lever was used to induce controlled changes in stress and strain to determine whether rabbit detrusor smooth muscle (rDSM) is best described as viscoelastic or viscoelastic plastic. Using sequential ramp loading and unloading cycles, stress-strain and stiffness-stress analyses revealed that rDSM displayed reversible viscoelasticity, and that the viscous component was responsible for establishing a …

Substrate Stiffness Controls Osteoblastic And Chondrocytic Differentiation Of Mesenchymal Stem Cells Without Exogenous Stimuli, Rene Olivares-Navarrete, Erin M. Lee, Kathryn Smith, Sharon L. Hyzy, Maryam Doroudi, Joseph K. Williams, Ken Gall, Barbara D. Boyan, Zvi Schwartz

Biomedical Engineering Publications

Stem cell fate has been linked to the mechanical properties of their underlying substrate, affecting mechanoreceptors and ultimately leading to downstream biological response. Studies have used polymers to mimic the stiffness of extracellular matrix as well as of individual tissues and shown mesenchymal stem cells (MSCs) could be directed along specific lineages. In this study, we examined the role of stiffness in MSC differentiation to two closely related cell phenotypes: osteoblast and chondrocyte. We prepared four methyl acrylate/methyl methacrylate (MA/MMA) polymer surfaces with elastic moduli ranging from 0.1 MPa to 310 MPa by altering monomer concentration. MSCs were cultured in …

Leveraging Social Media To Promote Evidencebased Continuing Medical Education, Simone Flynn, Paul Hebert, Deborah Korenstein, Mark Ryan, William B. Jordan, Salomeh Keyhan

Family Medicine and Population Health Publications

Importance

New dissemination methods are needed to engage physicians in evidence-based continuing medical education (CME).

Objective

To examine the effectiveness of social media in engaging physicians in non-industry-sponsored CME.

Design

We tested the effect of different media platforms (e-mail, Facebook, paid Facebook and Twitter), CME topics, and different “hooks” (e.g., Q&A, clinical pearl and best evidence) on driving clicks to a landing site featuring non-industry sponsored CME. We modelled the effects of social media platform, CME topic, and hook using negative binomial regression on clicks to a single landing site. We used clicks to landing site adjusted for exposure and …

Interleukin-18 Mediates Cardiac Dysfunction Induced By Western Diet Independent Of Obesity And Hyperglycemia In The Mouse, S Carbone, P J H Lee, A G Mauro, E Mezzaroma, R Buzzetti, B Van Tassell, A Abbate, S Toldo

Family Medicine and Population Health Publications

Obesity and diabetes are independent risk factors for heart failure and are associated with the consumption of diet rich in saturated fat and sugar, Western diet (WD), known to induce cardiac dysfunction in the mouse through incompletely characterized inflammatory mechanisms. We hypothesized that the detrimental cardiac effects of WD are mediated by interleukin-18 (IL-18), proinflammatory cytokine linked to cardiac dysfunction. C57BL/6J wild-type male mice and IL-18 knockout male mice were fed highsaturated fat and high-sugar diet for 8 weeks. We measured food intake, body weight and fasting glycemia. We assessed left ventricular (LV) systolic and diastolic function by Doppler echocardiography …

Structural Modeling And Functional Analysis Of The Essential Ribosomal Processing Protease Prp From Staphylococcus Aureus, Erin A. Wall, Adam L. Johnson, Darrell L. Peterson, Gail E. Christie

Microbiology and Immunology Publications

In Firmicutes and related bacteria, ribosomal large subunit protein L27 is encoded with a conserved N-terminal extension that is removed to expose residues critical for ribosome function. Bacteria encoding L27 with this N-terminal extension also encode a sequence-specific cysteine protease, Prp, which carries out this cleavage. In this work, we demonstrate that L27 variants with an un-cleavable N-terminal extension, or lacking the extension (pre-cleaved), are unable to complement an L27 deletion in Staphylococcus aureus. This indicates that N-terminal processing of L27 is not only essential but possibly has a regulatory role. Prp represents a new clade of previously uncharacterized cysteine …

Virginia Commonwealth University Commencement Program [2017], Virginia Commonwealth University

VCU Commencement Programs

No abstract provided.

Virginia Commonwealth University Fall Commencement Program [2017], Virginia Commonwealth University

VCU Commencement Programs

No abstract provided.

Virginia Commonwealth University Undergraduate Bulletin [2017], Virginia Commonwealth University

VCU Bulletins

Undergraduate bulletin for Virginia Commonwealth University for the academic year 2017-2018. It includes information on academic regulations, degree requirements, course offerings, faculty, academic calendar, and tuition and expenses for undergraduate programs.

Method And Apparatus For Removal Of Phosphate From Wastewater Streams, Steven Skeels, Arjun Subedi, Fred Williams

Capstone Design Expo Posters

Church and Dwight uses a phosphate-containing soap in their latex condom manufacturing process in Chesterfield County, VA. The wastewater streams from this process contain a concentration of phosphate that is over the county limit, costing $100,000/yr for non-optimized disposal. C&D has a need for an in-house method of phosphate removal which does not interfere with current manufacturing or wastewater treatment processes. The focus of the project was precipitation methodology as it is the most economically feasible option for these high concentrations of phosphate; more advanced technologies were considered for a potential final polishing step to remove any residual phosphate. The …

Thermal Insulation Coating For Pipe Applications, Ismail Alaithan, Alhawraa Husain, Wejdan Reda, Katiana Slaton

Capstone Design Expo Posters

NNSB tasked the Capstone team with testing the anti-condensation abilities of the Thermal Insulation Coating (TIC) Aerolon®, an aerogel-based insulation manufactured by Tnemec, using Federal test specifications for Coating Compound, Paint Antisweat. The main goal was to observe the anti-condensation abilities of the insulation and to initiate an analysis and comparison of the spray-applied aerogel insulation versus the hand-applied thick foam insulation that is currently used on ship pipes and ventilation. The plan includes creating a computer simulation of the thermal properties of the insulated cylinders as well as a physical experimental setup.

The Capstone team built an acrylic test …

Virginia Commonwealth University Graduate Bulletin [2017], Virginia Commonwealth University

VCU Bulletins

Graduate bulletin for Virginia Commonwealth University for the academic year 2017-2018. It includes information on academic regulations, degree requirements, course offerings, faculty, academic calendar, and tuition and expenses for graduate programs.

Ramerican Political Science Review (Vol. 2, 2017)

Ramerican Political Science Review

Letter from the Department of Political Science -- Diversity and Tolerance: The Intergroup Contact Theory in Practice / Margaret Hemenway -- Identity and Social Movements: Analyzing Social Movement Participation through Identity Theory / Mariah Hines -- Representative Deviance in the Media: Pre‐Exposure Prophylaxis (PrEP) Through a Queer Lens) / Matthew Helton -- International Legal Recognition after Unilateral Secession: The Case of Somaliland / Trevor Davis -- Beyond the Axis of Convenience: Re‐examining Russian‐Chinese Relations and the Search for Multipolarity / David Hayter -- How the Tsetse Left Africa and Why the Rwandan Nightmare put the World to Sleep / Savannah‐Zhané …

Roles Of Free Electrons And H2o2 In The Optical Breakdown-Induced Photochemical Reduction Of Aqueous [Aucl4]-, Victoria K. Meader, Mallory G. John, Collin Rodrigues, Katharine M. Tibbetts

Chemistry Publications

Free electrons and H2O2 formed in an optical breakdown plasma are found to directly control the kinetics of [AuCl4]− reduction to form Au nanoparticles (AuNPs) during femtosecond laser-assisted synthesis of AuNPs. The formation rates of both free electrons and H2O2 strongly depend on the energy and duration of the 800 nm laser pulses over the ranges of 10−2400 μJ and 30−1500 fs. By monitoring the conversion of [AuCl4]− to AuNPs using in situ UV−vis spectroscopy during laser irradiation, the first- and second-order rate constants in the autocatalytic rate law, k1 and k2, were extracted and compared to the computed free …

Study Of In Vitro Transcriptional Binding Effects And Noise Using Constitutive Promoters Combined With Up Element Sequences In Escherichia Coli, Qiang Yan, Stephen S. Fong

Chemical and Life Science Engineering Publications

Background

UP elements (upstream element) are DNA sequences upstream of a promoter that interact with the α-subunit of RNA polymerase (RNAP) and can affect transcription by altering the binding RNAP to DNA. However, details of UP element and binding affinity effects on transcriptional strength are unclear.

Results

Here, we investigated the effects of UP element sequences on gene transcription, binding affinity, and gene expression noise. Addition of UP elements resulted in increased gene expression (maximum 95.7-fold increase) and reduced gene expression noise (8.51-fold reduction). Half UP element sequences at the proximal subsite has little effect on transcriptional strength despite increasing …

Virginia Commonwealth University Courses [2017], Virginia Commonwealth University

VCU Bulletins

Listing of courses for the 2017-2018 year.

Genomic Analysis Of Chimeric Human Cytomegalovirus Vaccine Candidates Derived From Strains Towne And Toledo, Nicolás M. Suárez, Betty Lau, George M. Kemble, Ronzo Lee, Edward S. Mocarski, Gavin W. G. Wilkinson, Stuart P. Adler, Michael A. Mcvoy, Andrew J. Davison

Pediatrics Publications

Human cytomegalovirus (HCMV) is an important opportunistic pathogen in immunocompromised patients and a major cause of congenital birth defects when acquired in utero. In the 1990s, four chimeric viruses were constructed by replacing genome segments of the high passage Towne strain with segments of the low passage Toledo strain, with the goal of obtaining live attenuated vaccine candidates that remained safe but were more immunogenic than the overly attenuated Towne vaccine. The chimeras were found to be safe when administered to HCMV-seronegative human volunteers, but to differ significantly in their ability to induce seroconversion. This suggests that chimera-specific genetic differences …

Progressions: Assembled By The Horn Rva & Amendment Literary Journal (2017)

Amendment, 2004-

"Each semester the Horn RVA collects recordings from diverse performers in the Richmond, Virginia, to produce The Horn RVA Presents, a free compilation cd featuring original artwork from VCU students. After releasing three samplers of local music in the past two years, The Horn’s staff felt it was time to expand the project to include voices from the entire music scene with an emphasis on originally generated content. Our goal is to feature narrative perspectives from all sides of the music scene to mirror the inclusivity of the music community in Richmond. To meet the needs of the expanding project, …

Virginia Dental Journal (Vol. 94, No. 4, 2017)

Virginia Dental Journal

No abstract provided.

Directed Evolution Provides Insight Into Conformational Substrate Sampling By Srta, Muna Suliman, Vishaka Santosh, Tom C. M. Seegar, Annamarie C. Dalton, Kathryn M. Schultz, Candice S. Klug, William A. Barton

Biochemistry and Molecular Biology Publications

The Sortase family of transpeptidases are found in numerous gram-positive bacteria and involved in divergent physiological processes including anchoring of surface proteins to the cell wall as well as pili assembly. As essential proteins, sortase enzymes have been the focus of considerable interest for the development of novel anti-microbials, however, more recently their function as unique transpeptidases has been exploited for the synthesis of novel bio-conjugates. Yet, for synthetic purposes, SrtA-mediated conjugation suffers from the enzyme's inherently poor catalytic efficiency. Therefore, to identify SrtA variants with improved catalytic efficiency, we used directed evolution to select a catalytically enhanced SrtA enzyme. …

Differential Response Of Barrier Island Dune Grasses To Species Interactions And Burial, April Harris, Julie C. Zinnert, Donald R. Young

Biology Publications

Barrier islands are at the forefront of storms and sea-level rise. High disturbance regimes and sediment mobility make these systems sensitive and dynamic. Island foredunes are protective structures against storm-induced overwash that are integrally tied to dune grasses via biogeomorphic feedbacks. Shifts in dune grass dominance could influence dune morphology and susceptibility to overwash, altering island stability. In a glasshouse study, two dune grasses, Ammophila breviligulata and Uniola paniculata, were planted together and subjected to a 20 cm burial to quantify morphological and physiological responses. Burial had positive effects on both plants as indicated by increased electron transport rate and …

Perfluorocarbon Emulsions Radiosensitise Brain Tumors In Carbogen Breathing Mice With Orthotopic Gl261 Gliomas, Lisa A. Feldman, Marie-Sophie Fabre, Carole Grasso, Dana Reid, William C. Broaddus, Gregory M. Lanza, Bruce D. Spiess, Joel R. Garbow, Melanie J. Mcconnell, Patries M. Herst

Neurosurgery Publications

Background

Tumour hypoxia limits the effectiveness of radiation therapy. Delivering normobaric or hyperbaric oxygen therapy elevates pO2 in both tumour and normal brain tissue. However, pO2 levels return to baseline within 15 minutes of stopping therapy.

Aim

To investigate the effect of perfluorocarbon (PFC) emulsions on hypoxia in subcutaneous and intracranial mouse gliomas and their radiosensitising effect in orthotopic gliomas in mice breathing carbogen (95%O2 and 5%CO2).

Results

PFC emulsions completely abrogated hypoxia in both subcutaneous and intracranial GL261 models and conferred a significant survival advantage orthotopically (Mantel Cox: p = 0.048) in carbogen breathing mice injected intravenously (IV) with …

Aldh2*2 And Peer Drinking In East Asian College Students, Karen G. Chartier, Taryl O'Shea, Nathaniel Thomas, Bradley Todd Webb, Danielle M. Dick, Kenneth S. Kendler

Social Work Publications

Background: The ALDH2*2 allele (A-allele) at rs671 is more commonly carried by Asians and is associated with alcohol-related flushing, a strong adverse reaction to alcohol that is protective against drinking. Social factors, such as having friends who binge drink, also contribute to drinking in Asian youth. Objectives: This study examined the interplay between ALDH2*2, peer drinking, and alcohol consumption in college students. We hypothesized that the relationship between ALDH2*2 and standard grams of ethanol per month would vary based on the level of peer drinking. Methods: Subjects (N = 318, 63.25% female) were East Asian …

Rape And Posttraumatic Stress Disorder (Ptsd): Examining The Mediating Role Of Explicit Sex-Power Beliefs For Men Versus Women, Daniel J. Snipes, Jenna M. Calton, Brooke A. Green, Paul B. Perrin, Eric G. Benotsch

Psychology Publications

Many rape survivors exhibit symptoms of post-traumatic stress disorder (PTSD), and recent literature suggests survivors' beliefs about sex and control may affect PTSD symptoms. The present study examined beliefs about sex and power as potential mediators of the relationship between rape and PTSD symptoms for men versus women. Participants (N = 782) reported lifetime history of rape, current PTSD symptoms, and beliefs about sex and power. Women reported higher levels of lifetime history of rape than men (19.7% for women; 9.7% for men). While rape history predicted PTSD symptoms for both genders, beliefs about sex and power were shown to …

Symptom Domain Groups Of The Patient-Reported Outcomes Measurement Information System Tools Independently Predict Hospitalizations And Re-Hospitalizations In Cirrhosis, Kavish R. Patidar, Leroy R. Thacker, James B. Wade, Melanie B. White, Edith A. Gavis, Andrew Fagan, Richard K. Sterling, Michael Fuchs, Mohammad S. Siddiqui, Scott Matherly, Richard T. Stravitz, Arun J. Sanyal, Puneet Puri, Velimir A. Luketic, Jasmohan S. Bajaj

Psychiatry Publications

Background

Patient-Reported Outcomes Measurement Information System (PROMIS) tools can identify health-related quality of life (HRQOL) domains that could differentially affect disease progression. Cirrhotics are highly prone to hospitalizations and re-hospitalizations, but the current clinical prognostic models may be insufficient, and thus studying the contribution of individual HRQOL domains could improve prognostication.

Aim

Analyze the impact of individual HRQOL PROMIS domains in predicting time to all non-elective hospitalizations and re-hospitalizations in cirrhosis.

Methods

Outpatient cirrhotics were administered PROMIS computerized tools. The first non-elective hospitalization and subsequent re-hospitalizations after enrollment were recorded. Individual PROMIS domains significantly contributing toward these outcomes were generated …

A Power Calculator For The Classical Twin Design, Brad Verhulst

Psychiatry Publications

Power is a ubiquitous, though often overlooked, component of any statistical analyses. Almost every funding agency and institutional review board requires that some sort of power analysis is conducted prior to data collection. While there are several excellent on line power calculators for independent observations, twin studies pose unique challenges that are not incorporated into these algorithms. The goal of the current manuscript is to outline a general method for calculating power in twin studies, and to provide functions to allow researchers to easily conduct power analyses for a range of common twin models. Several scenarios are discussed to demonstrate …

Pattern Project - The Great Peanut Dream, Noshin Faruque

Pattern Project

The Pattern Project explores the process of developing visual patterns, intended for the built interior environment, through both hand and digital crafts. Inspirations evolve into pattern concepts that inform message and intention. The intended message then informs motif, color, density, composition, line, repetition, hierarchy, and texture. Drawing from history, designers assess the role of pattern within the built environment and its connection to architecture and building occupants. Traditional handcrafts have evolved and are now used in contemporary processes while new digital crafts have emerged as pattern-making tools. The patterns developed through the Pattern Project were produced to scale on paper …

Quadmutex: Quadratic Driver Mutation Explorer, Bokhari Yahya, Tomasz Jakub Arodz

Computer Science Publications

Background

Somatic mutations accumulate in human cells throughout life. Some may have no adverse consequences, but some of them may lead to cancer. A cancer genome is typically unstable, and thus more mutations can accumulate in the DNA of cancer cells. An ongoing problem is to figure out which mutations are drivers - play a role in oncogenesis, and which are passengers - do not play a role. One way of addressing this question is through inspection of somatic mutations in DNA of cancer samples from a cohort of patients and detection of patterns that differentiate driver from passenger mutations. …