Digital Commons Network^™

Stochastic Invasion And Extinction In Environmentally Transmitted Diseases, Mahmudul Bari Hridoy, Lauren M. Childs

Biology and Medicine Through Mathematics Conference

No abstract provided.

How Human Behavior Shapes Epidemic Dynamics, Leah Lejeune, Navid Ghaffarzadegan, Lauren M. Childs, Omar Saucedo

Biology and Medicine Through Mathematics Conference

No abstract provided.

Dynamics Of A Two-Stage Epidemiological Model With Post-Infection Mortality And Transmission Heterogeneity, B Sagar

Biology and Medicine Through Mathematics Conference

No abstract provided.

Dynamical Systems Modeling To Determine The Role Of Crosstalk In Shaping Stat Signaling Profiles, Laura F. Strube, Anamarie Martinez, Neha Cheemalavagu, Karsen Shoger, James Faeder, Rachel Gottschalk

Biology and Medicine Through Mathematics Conference

No abstract provided.

Data-Driven Modeling Approaches For Epidemiological Applications Using County-Level Data, Mansoor A. Haider

Biology and Medicine Through Mathematics Conference

No abstract provided.

Modeling The Dynamics Of Infectious Disease Transmission Through Wastewater Surveillance: Applications To Covid-19 Epidemiology, Ephraim Agyingi, Michael Kostrna

Biology and Medicine Through Mathematics Conference

No abstract provided.

Impact Of The Dose And The Number Of Transmitted/Founder Viruses On Siv Dynamics, Sunil Maity, Vitaly V. Ganusov

Biology and Medicine Through Mathematics Conference

No abstract provided.

Substance Use Behaviors And Treatment Engagement In Individuals With Severe Psychopathology With And Without Comorbid Obesity, Rachel M. Madera-Arnold

Theses and Dissertations

Research has found significantly higher rates of both substance use and obesity among individuals with SMI compared to population samples which in turn can lead to worsening health outcomes. Despite this, there is limited research on the co-occurrence of obesity, substance use, and SMI and how these conditions may interact to affect patient outcomes. In addition, there are many gaps in the research regarding the relationship between substance use and body weight, appetite and/or eating behaviors. This study conducted a secondary analysis of the NSDUH 2021 survey that characterized substance use and disorders among individuals who had severe psychopathology, examined …

Absolute Quantification And Identification Of Rna From Rna-Lipid Nanoparticles Using High Resolution Mass Spectrometry, Jason C. Funderburk

Theses and Dissertations

RNA therapeutics are a rising drug category with potential use for a range of conditions encompassing infectious diseases to therapies for cancer, diseases, and genetic disorders. RNA-lipid nanoparticles (RNA-LNPs) are the prominent delivery method for these therapeutics approved products include mRNA vaccines and polyneuropathy treatments. The emergency use authorizations and orphan drug status of current RNA-LNP drugs has allowed approval without finalization of the regulatory analytical procedures for quality monitoring. The objective of the study was to develop an LC-MS assay to simultaneously measure identity and concentration of two therapeutically relevant intact RNA constructs extracted from RNA-LNPs to enhance quality …

Comorbid Psychosis In The General Population, Mariam Sankoh

Theses and Dissertations

Psychosis is a complex psychiatric phenotype characterized by substantial heterogeneity in symptom presentation, psychosis diagnosis, comorbidity patterns, and genetic architecture across diverse populations in the general population. Despite advances in psychiatric epidemiology and genomics, important gaps remain in understanding how psychosis symptoms and psychosis-related diagnoses manifest across racial and ethnic groups and how evolutionary genomic factors may contribute to disease risk and cross-ancestry genetic prediction. This dissertation, Characterizing Comorbidity in Psychosis in the General Population, integrates epidemiological, psychometric, and evolutionary genetic approaches to examine psychosis across diverse populations.

Aim 1 examined racial and ethnic differences in psychosis comorbidity patterns …

Tuberculosis In Jim Crow Virginia, 1900-1972, Elizabeth Dooley

Theses and Dissertations

Tuberculosis (TB) was a major public health concern in the United States, especially in the first half of the twentieth century. Transmission and treatment of the disease, which is spread between humans through close contact, was complicated by racial segregation laws in the South known as Jim Crow laws. Virginia subscribed to these laws, which played a role in how and where Black Virginians with TB could be treated. Segregated treatment facilities with an inadequate number of beds for the number of infected people and deaths in the state added to these complications of disease control and plan for eradication. …

Absolute Quantification And Identification Of Rna From Rna-Lipid Nanoparticles Using High Resolution Mass Spectrometry, Jason C. Funderburk, Yasir A. Alshehry, Matthew S. Halquist Phd, Sandro R.P. Da Rocha Phd

Graduate Research Posters

Background

RNA therapeutics are a rising drug category with potential use for a range of conditions encompassing infectious diseases to therapies for cancer, diseases, and genetic disorders. RNA-lipid nanoparticles (RNA-LNPs) are the prominent delivery method for these therapeutics approved products include mRNA vaccines and polyneuropathy treatments. The emergency use authorizations and orphan drug status of current RNA-LNP drugs has allowed approval without finalization of the regulatory analytical procedures for quality monitoring. The objective of the study was to develop an LC-MS assay to simultaneously measure identity and concentration of two therapeutically relevant intact RNA constructs extracted from RNA-LNPs to enhance …

Commonwealth Times 2025-09-17

Commonwealth Times, 1969-

No abstract provided.

“Science Belongs Everywhere”: Outlooks On Post-Secondary Stem Education For Correctional Centers In Virginia, Shelita R. Augustus

Division of Strategic Enrollment Management and Student Success Publications

Virginia has an incarceration rate of 679 per 100,000 residents, the highest among independent democratic nations. This scoping review examines perspectives on post-secondary STEM education to promote STEM education within Virginia's correctional facilities, assesses programs to improve rehabilitation, reduce recidivism, and address systemic inequalities by developing the scientific potential of incarcerated individuals. The review finds that while STEM education in correctional facilities faces limitations, its potential benefits are being realized nationwide. Virginia has made strides through initiatives like House Bill 2158, which aims to expand higher education access for incarcerated individuals. Examples such as the programs at J. Sargeant Reynolds …

Mctr3 Mitigates Cigarette Smoke-Induced Pulmonary Inflammation And Damage, Yu Par Aung Myo

Theses and Dissertations

Smoking is deleterious to our lungs and can precipitate in a multitude of diseases, including chronic obstructive pulmonary disease (COPD). COPD is primarily caused by smoking cigarettes and is a major public health issue. Current therapies only treat symptoms without halting or reversing disease progression, thus highlighting a large unmet need to develop new therapies. We address this gap by investigating maresin conjugate in tissue regeneration 3 (MCTR3) which is a newly discovered specialized pro-resoling mediator (SPM) that has the novel property of promoting tissue repair and regeneration in addition to being anti-inflammatory and pro-resolving. For the first time, we …

Functional Analysis Of Ligand Binding Domain 2 Of Outer Surface Protein C Of Borreliella Burgdorferi, Gavin Z. Chambers

Theses and Dissertations

Lyme disease, caused by the spirochete Borreliella burgdorferi, is the most common vector-borne infection in North America. A critical determinant of early mammalian infection is outer surface protein C (OspC), a highly variable lipoprotein that is indispensable for spirochete survival but whose precise function remains unresolved. OspC has been proposed to mediate diverse roles, including complement evasion, adhesion, tissue dissemination, and antiphagocytic activity, supporting the view that it is a multifunctional virulence factor. Structural studies have identified two putative ligand-binding domains (LBD1 and LBD2), with LBD2 forming a solvent-exposed crown at the membrane-distal end of the OspC dimer.

To …

Improving Telehealth Education And Training: A Needs Assessment Of Healthcare Providers And Trainees, Conor Duffy

Theses and Dissertations

Telehealth utilization has increased dramatically since the start of the COVID-19 pandemic. There are many positive impacts of this shift to telehealth, including increasing access to care and reducing patient burden. However, healthcare providers report several consistent challenges that limit their ability to deliver telehealth, such as effective communication, technological difficulties, and difficulty performing physical examinations. To address these concerns, it is necessary to integrate telehealth education and training into healthcare professional training programs and healthcare systems. While many institutions have implemented telehealth education and training since the start of the pandemic, there is little consistency in the content, duration, …

The Influence Of The Covid-19 Pandemic On Student Engagement At A Historically Black University, John C. Travis

Theses and Dissertations

This study examined student engagement across three NSSE administrations at an HBCU—pre-COVID (2018), during COVID (2019), and post-COVID (2022). Engagement was analyzed across four themes: Academic Challenge, Learning with Peers, Experiences with Faculty, and Campus Environment. Results showed that Learning with Peers declined significantly over time, with the largest drop between 2018 and 2022, reflecting pandemic-related disruptions to peer interaction. No significant year effects emerged for the other themes. Two-way MANOVAs indicated that gender, first-generation status, and major did not significantly predict engagement, nor did they interact with year. In contrast, classification emerged as the most consistent predictor, with upper-division …

Between "Hippies In Suits" And "Money Is The Name Of The Game": Farm Animal Advocates' Analyses Of Political Power In The Farm Bill, Jeff Thomas

Theses and Dissertations

The animal agriculture industry annually slaughters roughly ten billion land animals in the United States. What can be done to improve their welfare and lessen their suffering?

Over the past decade, the problem of farm animal welfare and suffering has drawn increasing interest from the effective altruism community, a loose movement of utilitarian advocates seeking technocratic solutions to social problems (Singer, 2015). As effective altruism has become a more potent driver of the animal welfare movement, an increasing number of nonprofits have begun engaging in political advocacy for farm animal welfare. Facebook co-founder Dustin Moskovitz’ Open Philanthropy is the largest …

Modeling Vaccination Strategies And Intervention Impacts On Infectious Disease Dynamics, Elizabeth B. Amona

Theses and Dissertations

This dissertation explores how mathematical and statistical modeling can inform vaccination strategies and evaluate the impact of interventions during infectious disease outbreaks. Motivated by the challenges observed during the COVID-19 pandemic, the research integrates compartmental modeling, Bayesian inference, and agent-based simulation to assess policy effectiveness and disease control across varying contexts. The first study develops a SEIRDV model that incorporates government interventions and vaccination rollout to examine COVID-19 dynamics in Qatar. A Bayesian approach is used to estimate parameters and compute time-varying transmission rates. The model captures shifts in transmission following policy changes and quantifies the reduction in deaths attributable …

Exploring The Role Of Host Immune Responses And Bacterial Sensory Pathways In The Development Of Treponema Denticola-Mediated Periodontal Disease, Annie N. Hinson

Theses and Dissertations

Periodontitis is a chronic inflammatory disease driven by dysbiotic microbial communities and maladaptive host responses. Treponema denticola, a spirochete pathobiont, is strongly associated with disease severity. However, the molecular mechanisms underlying its interaction with host tissues and regulation of virulence remain incompletely understood. This work examines both the epithelial immune responses and bacterial transduction systems that shape T. denticola pathogenesis. Transcriptomic analysis of gingival keratinocytes revealed IL-36γ as the most highly induced cytokine following infection with T. denticola. Functional studies demonstrated that IL-36γ induction occurs in a dose- and time-dependent manner through TLR2/6 signaling, requiring the NF-κB, PI3K/Akt, and …

Dickkopf1(Dkk1): A Novel Endogenous Ligand To Prime Nlrp3 Inflammasome Via Tlr4, Theingi Aung

Theses and Dissertations

Dickkopf1(DKK1) is a quintessential Wnt antagonist and immunomodulator in various inflammatory diseases. The underlying molecular mechanisms of DKK1-mediated immunomodulation remain elusive. Here, we identified TLR4 as a new receptor for DKK1 to activate NFκΒ pathway-mediated gene expression and pyroptosis via NLRP3 inflammasome in human and mouse macrophages.

DKK1 employed TLR4 to initiate NFκB signaling cascade via MyD88. MyD88-TAK1-NFκΒ pathway activation by DKK1 increased HIF1α, NFκB, and NLRP3 protein expression levels, leading to pyroptosis. Unlike LPS, DKK1 did not induce IRAK4 phosphorylation, while the interaction between MyD88 and IRAK4 was maintained for downstream signaling activation. DKK1 did not induce IRF3 phosphorylation …

Using Fungal Dna Barcoding To Identify Fungal Species In A James River Park System Soil Microbiome, Erwin Murray, D Jennings

UROP Posters

Fungi in the soil have the ability to form mutualistic relationships with plant roots and improve the way they resist a variety of plant diseases and abiotic stressors, influencing the survivability of the plants. The James River Park System (JRPS) is home to a variety of ecosystems that support diverse plant and fungal populations, including native plants and invasive plants. Therefore, it is important to identify what is present in the soil microbiome. The purpose of this project is to isolate fungal sequences from soil samples collected in the JRPS to identify what fungal species are present in the JRPS …

“Ain’T Nuthin Wrong With Being A Trojan Man”: Discourse On Safe-Sex In Rap Music, 1985-1995, Christopher D. Rounds, Kareem R. Muhammad

Journal of Hip Hop Studies

This essay methodically tracks references to safe-sex in rap music and analyzes their implications. Reviewing over 3,000 songs from 1985 to 1995, the authors found that the tone and messages of these references differed substantially. While many artists celebrated risky and indiscriminate sexual behavior– their work marred by a misogny and homophobia that often stigmatized persons living with sexually transmitted diseases (STDs)– many other artists portrayed safe-sex in a positive light, either as a responsible approach to sexual behavior, or as a pragmatic tool of urban survival. These songs normalized the use of condoms, and educated listeners by raising awareness …

Modeling Fast Information And Slow(Er) Disease Spreading: A Geometric Analysis, Iulia Martina Bulai, Mattia Sensi, Sara Sottile

Biology and Medicine Through Mathematics Conference

No abstract provided.

Mathematical Modeling Suggests Pathways Of Systemic Dissemination Of Mycobacterium Tuberculosis In Mice, Vitaly V. Ganusov

Biology and Medicine Through Mathematics Conference

No abstract provided.

Dual-Domain Clustering Of Spatiotemporal Infectious Disease Data, Samuel R. Thornton, Erin C.S. Acquesta, Patrick D. Finley, Mansoor A. Haider

Biology and Medicine Through Mathematics Conference

No abstract provided.

Graphing The Curve: A Mathematical Expedition Into Social Distancing's Role In The South African Covid-19 Narrative, Chidozie Williams Chukwu

Biology and Medicine Through Mathematics Conference

No abstract provided.

Information Feedback Delays Within Epidemic Models And Their Effect On Model Dynamics., Maria K. Bouka, Christopher Strickland Dr

Biology and Medicine Through Mathematics Conference

No abstract provided.

Optimizing Immunotherapies For Improved Cancer Treatment, Anne Talkington, Anthony Kearsley

Biology and Medicine Through Mathematics Conference

No abstract provided.