Digital Commons Network^™

Virginia Commonwealth University Commencement Program [1998], Virginia Commonwealth University

VCU Commencement Programs

No abstract provided.

Effects Of Metformin On Spontaneous And Clomiphene-Induced Ovulation In The Polycystic Ovary Syndrome, John E. Nestler , M.D., Daniela J. Jakubowicz , M.D., William S. Evans , M.D., Renato Pasquali , M.D.

Obstetrics and Gynecology Publications

ABSTRACT

Background Obese women with the polycystic ovary syndrome are relatively unresponsive to the induction of ovulation by clomiphene. We hypothesized that reducing insulin secretion by administering metformin would increase the ovulatory response to clomiphene.

Methods We performed oral glucose-tolerance tests before and after the administration of 500 mg of metformin or placebo three times daily for 35 days in 61 obese women with the polycystic ovary syndrome. Women who did not ovulate spontaneously were then given 50 mg of clomiphene daily for five days while continuing to take metformin or placebo. Serum progesterone was measured on days 14, 28, …

Cyanonews (Vol. 14, No. 1, August 1998), Jeff Elhai

CyanoNews

CyanoNews was a newsletter that served the cyanobacteriological community from 1985 to 2003, with content provided by readers (sort of a blog before there were blogs). The newsletter reported new findings from the lab, summaries of recent meetings (often provided by graduate students and post-docs entering the field), positions sought or available, life transitions, a compendium of recent cyanobacteria-related articles, and other items of interest to those who study cyanobacteria.

Atovaquone Compared With Dapsone For The Prevention Of Pneumocystis Carinii Pneumonia In Patients With Hiv Infection Who Cannot Tolerate Trimethoprim, Sulfonamides, Or Both, Wafaa M. El-Sadr , M.D., M.P.H., Robert L. Murphy , M.D., Teresa Mccabe Yurik , M.S., Roberta Luskin-Hawk , M.D., Tony W. Cheung , M.D., Henry H. Balfour , Jr., M.D., Robert Eng , M.D., Thomas M. Hooton , M.D., Thomas M. Kerkering , M.D., Malte Schutz , M.D., Charles Van Der Horst , M.D., Richard Hafner , M.D.

Internal Medicine Publications

BACKGROUND

Although trimethoprim–sulfamethoxazole is the drug of choice for the prevention of Pneumocystis carinii pneumonia, many patients cannot tolerate it and must switch to an alternative agent.

METHODS

We conducted a multicenter, open-label, randomized trial comparing daily atovaquone (1500-mg suspension) with daily dapsone (100 mg) for the prevention of P. carinii pneumonia among patients infected with the human immunodeficiency virus who could not tolerate trimethoprim–sulfamethoxazole. The median follow-up period was 27 months.

RESULTS

Of 1057 patients enrolled, 298 had a history of P. carinii pneumonia.P. cariniipneumonia developed in 122 of 536 patients assigned to atovaquone (15.7 cases per …

Interferon Alfa-2b Alone Or In Combination With Ribavirin As Initial Treatment For Chronic Hepatitis C, John G. Mchutchison , M.D., Stuart C. Gordon , M.D., Eugene R. Schiff , M.D., Mitchell L. Shiffman , M.D., William M. Lee , M.D., Vinod K. Rustgi , M.D., Zachary D. Goodman , M.D., Ph.D., Mei-Hsui Ling , Ph.D., Susannah Cort , M.D., Janice K. Albrecht , Ph.D.

Internal Medicine Publications

BACKGROUND

Only 15 to 20 percent of patients with chronic hepatitis C have a sustained virologic response to interferon therapy. We compared the efficacy and safety of recombinant interferon alfa-2b alone with those of a combination of interferon alfa-2b and ribavirin for the initial treatment of patients with chronic hepatitis C.

METHODS

We randomly assigned 912 patients with chronic hepatitis C to receive standard-dose interferon alfa-2b alone or in combination with ribavirin (1000 or 1200 mg orally per day, depending on body weight) for 24 or 48 weeks. Efficacy was assessed by measurements of serum hepatitis C virus (HCV) RNA …

Quality Of Life And Clinical Outcomes In Elderly Patients Treated With Ventricular Pacing As Compared With Dual-Chamber Pacing, Gervasio A. Lamas , M.D., E. John Orav , Ph.D., Bruce S. Stambler , M.D., Kenneth A. Ellenbogen , M.D., Elena B. Sgarbossa , M.D., Shoei K. Stephen Huang , M.D., Roger A. Marinchak , M.D., N.A. Mark Estes , M.D., Gary F. Mitchell , M.D., Eric H. Lieberman , M.D., Carol M. Mangione , M.D., Lee Goldman , M.D., John J. Griffin, James D. Maloney, Carlos Rizo-Patrón, Ferdinand J. Venditti, Bruce L. Wilkoff

Internal Medicine Publications

ABSTRACT

Background Standard clinical practice permits the use of either single-chamber ventricular pacemakers or dual-chamber pacemakers for most patients who require cardiac pacing. Ventricular pacemakers are less expensive, but dual-chamber pacemakers are believed to be more physiologic. However, it is not known whether either type of pacemaker results in superior clinical outcomes.

Methods The Pacemaker Selection in the Elderly study was a 30-month, single-blind, randomized, controlled comparison of ventricular pacing and dualchamber pacing in 407 patients 65 years of age or older in 29 centers. Patients received a dual-chamber pacemaker that had been randomly programmed to either ventricular pacing or …

Interferon Alfa-2b Alone Or In Combination With Ribavirin For The Treatment Of Relapse Of Chronic Hepatitis C, Gary L. Davis , M.D., Rafael Esteban-Mur , M.D., Vinod Rustgi , M.D., John Hoefs , M.D., Stuart C. Gordon , M.D., Christian Trepo , M.D., Mitchell L. Shiffman , M.D., Stefan Zeuzem , M.D., Antonio Craxi , M.D., Mei-Hsui Ling , Ph.D., Janice Albrecht , Ph.D.

Internal Medicine Publications

BACKGROUND

Interferon alfa is the only effective treatment for patients with chronic hepatitis C. Forty percent of patients have an initial response to this therapy, but most subsequently relapse. We compared the effect of interferon alone with that of interferon plus oral ribavirin for relapses of chronic hepatitis C.

METHODS

We studied 345 patients with chronic hepatitis C who relapsed after interferon treatment. A total of 173 patients were randomly assigned to receive standard-dose recombinant interferon alfa-2b concurrently with ribavirin (1000 to 1200 mg orally per day, depending on body weight) for six months, and 172 patients were assigned to …

A Comparison Of Four Treatments For Generalized Convulsive Status Epilepticus, David M. Treiman , M.D., Patti D. Meyers , M.P.A., Nancy Y. Walton , Ph.D., Joseph F. Collins , Sc.D., Cindy Colling , R.Ph., M.S., A. James Rowan , M.D., Adrian Handforth , M.D., Edward Faught , M.D., Vincent P. Calabrese , M.D., Basim M. Uthman , M.D., R. Eugene Ramsay , M.D., Meenal B. Mamdani , M.D., Pratap Yagnik , M.D., John C. Jones , M.D., Elizabeth Barry , M.D., Jane G. Boggs , M.D., Andres M. Kanner , M.D.

VCU Health Publications

ABSTRACT

Background and Methods Although generalized convulsive status epilepticus is a life-threatening emergency, the best initial drug treatment is uncertain. We conducted a five-year randomized, doubleblind, multicenter trial of four intravenous regimens: diazepam (0.15 mg per kilogram of body weight) followed by phenytoin (18 mg per kilogram), lorazepam (0.1 mg per kilogram), phenobarbital (15 mg per kilogram), and phenytoin (18 mg per kilogram). Patients were classified as having either overt generalized status epilepticus (defined as easily visible generalized convulsions) or subtle status epilepticus (indicated by coma and ictal discharges on the electroencephalogram, with or without subtle convulsive movements such as …

Preventing The Unnecessary Losses Of Alzheimer's Disease, Lin E. Noyes

Case Studies from Age in Action

Educational Objectives

1. To state the importance of early detection and diagnosis of Alzheimer's disease.

2. To describe common concerns of people in the early stages of Alzheimer's disease.

3. To describe interventions to help people who have recently been diagnosed with Alzheimer's disease or other dementias.

Reducing Medication Mismanagement In Adult Care Residences, Mary Ann F. Kirkpatrick

Case Studies from Age in Action

Educational Objectives

1. Describe the prevalence of medication mismanagement in adult care facilities in Virginia.

2. Explain the significance of selected medication management errors.

3. Recommend practices to improve medication management task performance in adult care facilities.

State Regulation Of Assisted Living Facilities, Sonya A. Sterbenz

Case Studies from Age in Action

Educational Objectives

1. To define the role of assisted living facilities in the continuum of long-term care options for older adults.

2. To present the various arguments concerning the regulation of the assisted living industry.

Medications And Falls, Patricia W. Slattum

Case Studies from Age in Action

Educational Objectives:

1. To describe potential causes of falls and ways to prevent them.

2. To illustrate how medications can contribute to an increased risk of falls and recommend strategies for reducing this risk.

Shafer Court Connections (1998-01)

Shafer Court Connections, 1994-2010

For alumni of the Academic Campus of Virginia Commonwealth University.

The X-Ray (1998)

The X-Ray (MCV, 1913-2010)

The yearbook of the Medical College of Virginia.

Virginia Dental Journal (Vol. 75, No. 1, 1998)

Virginia Dental Journal

No abstract provided.

Virginia Commonwealth University Undergraduate And Professional Programs Bulletin [1998], Virginia Commonwealth University

VCU Bulletins

Undergraduate and professional bulletin for Virginia Commonwealth University for the academic year 1998-1999. It includes information on academic regulations, degree requirements, course offerings, faculty, academic calendar, and tuition and expenses for undergraduate and professional programs.

A Comparison Of Rectal Diazepam Gel And Placebo For Acute Repetitive Seizures, Fritz E. Dreifuss , M.D., N. Paul Rosman , M.D., James C. Cloyd , Pharm.D., John M. Pellock , M.D., Ruben I. Kuzniecky , M.D., Warren D. Lo , M.D., Fumisuke Matsuo , M.D., Gregory B. Sharp , M.D., Joan A. Conry , M.D., Donna C. Bergen , M.D., Walter E. Bell , Ph.D

Neurology Publications

ABSTRACT

Background Acute repetitive seizures are readily recognizable episodes involving increased seizure frequency. Urgent treatment is often required. Rectal diazepam gel is a promising therapy.

Methods We conducted a randomized, doubleblind, parallel-group, placebo-controlled study of home-based treatment for acute repetitive seizures. Patients were randomly assigned to receive either rectal diazepam gel, at doses ranging from 0.2 to 0.5 mg per kilogram of body weight on the basis of age, or placebo. Children received one dose at the onset of acute repetitive seizures and a second dose four hours later. Adults received three doses — one dose at onset, and two …

Investing In Tomorrow's Teachers: The Integral Role Of The Two-Year College In The Science And Mathematics Preparation Of Prospective Teachers: Steering Committee Report To The National Science Foundation

Journal of Mathematics and Science: Collaborative Explorations

No abstract provided.

A Raster-Based Gis Analysis Of The Cumulative Impacts Of Humans And Beaver On Wetland Area And Types In The Chickahominy River Watershed (Virginia, Usa) From 1953 To 1994, Alexandra Dunya Syphard

Theses and Dissertations

Despite increased recognition of wetland functions and values, wetland loss and degradation continues in the United States. Digital wetlands and uplands coverages were analyzed to compare the cumulative impacts of humans and beaver (Castor canadensis) on wetland types in the Chickahominy River watershed (Virginia, USA) from 1953 to 1994. A vector-based approach was used for data manipulation, and a raster-based approach was chosen to analyze geographic change over time. Study findings indicated that anthropogenic activities were responsible for both wetland loss and gain in the watershed, and beavers substantially influenced shifting between wetland types. Wetland area increased 4% over 41 …

Sports And The Politics Of Identity And Memory: The Case Of Federal Indian Boarding Schools During The 1930s, John Bloom

Ethnic Studies Review

The federal government of the United States developed a complex System of boarding schools for Native Americans in the 19(th) century. This effort was generally insensitive and often brutal. In spite of such brutality many students managed to negotiate and create new understandings of traditions and cultural autonomy while in such schools. Now, however, some former students remember their lives as students with mixed emotions. Drawing on oral history interviews and public official documents, the author examines the recreational and athletic life at the boarding schools and finds that students were, nevertheless, able to experience pleasure and pride in creating …

Virginia Dental Journal (Vol. 75, No. 4, 1998)

Virginia Dental Journal

No abstract provided.

Virginia Dental Journal (Vol. 75, No. 2, 1998)

Virginia Dental Journal

No abstract provided.

Virginia Dental Journal (Vol. 75, No. 3, 1998)

Virginia Dental Journal

No abstract provided.

Market And Organizational Factors Associated With Teaching Hospital Participation In Strategic Hospital Alliances, James D. Bramble

Theses and Dissertations

This research investigated market and organizational factors that influence the strategic decisions of teaching hospitals to participate in strategic hospital alliances (SHAs). It described the characteristics of both teaching hospitals and the health care environment in which they operate. This research also examines the association of these factors with the strategic position of teaching hospitals in terms of their dominance in the market or within their organizations.

The theoretical model used two concepts from institutional theory--coercive and normative pressures. It was argued that coercive pressures in the market facilitated the decision to participate in SHAs and gain market and Organizational …

Journal Of Mathematics And Science: Collaborative Explorations

Journal of Mathematics and Science: Collaborative Explorations

No abstract provided.

The Integral Role Of Borough Of Manhattan Community College In The Mathematics Preparation Of Prospective Teachers, J. Gaston

Journal of Mathematics and Science: Collaborative Explorations

Borough of Manhattan Community College (BMCC) of the City University of New York (CUNY) is the only two-year college on the island of Manhattan. This institution has a diverse population of approximately 17,000 students who attend day/evening/weekend classes. Over 1,000 students are enrolled in the Early Childhood Education (ECE) Program. Each year, approximately 300 new students select this area of concentration. The dropout rate is less than 14%. The ECE Program prepares students for elementary education programs at four-year institutions. The program also offers two career areas of study: Infant Toddler and Pre-School. This article will discuss how high quality …

The Structural Response And Performance Of General Hospitals In A Managed Care Environment, Denise M. Mccollum

Theses and Dissertations

The study purpose is to link hospital structure, represented by each hospital’s professional contingent, service mix, and inpatient capacity; and its environment, characterized by the penetration of managed care enrollees. The secondary purpose is to test the relationship between hospital structural change and subsequent hospital performance.

The study employs a non-experimental panel design, with a sample of 1882 community hospitals (service type: general medical and surgical). Environmental variables are measured for the base year 1989. Hospital structural variables are measured for 1989 and 1994, with change variables computed. Performance variables are measured for 1989 and 1995, with change computed for …

Adenosine 3', 5'-Cyclic Monophosphate Activation Of Islet Chloride Channels, Anjali Varandani

Theses and Dissertations

The objective of this thesis was to understand the regulation of islet Cl⁻ current by cAMP. This current, known as I_cl,islet flew is the first Cl⁻ channel current characterized in pancreatic �� cells. I_cl,islet has been hypothesized to modulate insulin secretion through changes in islet electrical activity. Both 5 ��M forskolin and 100 ��M IBMX (3-isobutyl-1-methylxanthine), agents that increase intracellular cAMP, were shown to activate an outwardly-rectifying ionic current in HIT cells that closely resembled I_cl,islet. The current was blocked when iodide was substituted for external Cl⁻ or when the Cl⁻ channel blocker niflumic acid was …

Changes In Gabaa̳ Receptor Expression And Alterations In Ca⁺⁺/Calmodulin-Dependent Protein Kinase Ii Activity In A Hippocampal Neuronal Culture Model Of Epilepsy, Robert Eagan Blair

Theses and Dissertations

Expression levels of GABAA receptor subunits and activity of the Ca++ /calmodulin-dependent protein kinase II (CaM kinase II) enzyme system were evaluated in an in vitro hippocampal neuronal culture model of epilepsy. Treatment of hippocampal neuronal cultures with Mg++-free media for 3 hours results in the induction of an enduring "epileptic" state as evidenced by the expression of spontaneous recurrent seizure (SRS) discharge. The induction of the SRS activity was shown to be a N-methyl-D-aspartate (NMDA) receptor, Ca++-dependent mechanism (Sombati and DeLorenzo, J Neurophys., 73 (4), 1995). Significant and long-lasting decreases in mRNA expression for the GABAA α2 and α5 …

The Relationship Between Employers' Perceived Organizational Context And Their Impressions Of The Employability Of Job Applicants With Either A Severe Psychiatric Or Physical Disability, John Constantine Bricout

Theses and Dissertations

This study investigated the relationship between favorable employability ratings of hypothetical job applicants with a severe disability and two aspects of employers' perceived organizational context: organizational climate and negotiation latitude, using a cross-sectional, correlational design. A survey including a hypothetical job applicant vignette in one of three conditions: non-disabled, severe physical disability (acquired brain injury), severe psychiatric disability (schizophrenia) was mailed out to a random sample of 1,000 employers selected from a national human resource membership list. Responses were received from 248 employers. The chief purpose of this study was to explore the relationship between employers' perceived organizational context and …