Digital Commons Network^™

Functional Monitoring For Run-Time Assurance Of A Real-Time Cyber Physical System, Matthew W. Gelber

Theses and Dissertations

As cyber-physical systems (CPS) become more integrated into everyday life, the security of these systems must also be considered during their development due to their ever-increasing importance. With the growth of physical components in the system, more autonomous control requirements, and increased dependence on proper functionality, verifying system safety and correct operation becomes increasingly difficult. CPS have become more complex through the combination of additional hardware and the resulting interconnected software in many layers, each requiring unique security solutions. One example of such a safety-critical CPS embedded system is the Flight Control System (FCS) of an Unmanned Aerial System (UAS). …

Essays On The Impacts Of Macra 2015 And Market Dynamics On Quality, Billing, And Fraud In The U.S. Healthcare System, Mahmoud Manouchehri Amoli

Theses and Dissertations

This thesis presents a comprehensive examination of the impacts of the Medicare Access and CHIP Reauthorization Act of 2015 (MACRA) and market dynamics on the quality, billing practices, and incidence of fraud within the U.S. healthcare system. It is a compilation of three essays that each delves into a specific facet of the healthcare landscape altered by MACRA's introduction and the evolving market conditions.

Chapter 2 analyzes how MACRA has transformed Medicare Part B physicians' practices by introducing the Merit-Based Incentive Payment System (MIPS) and Advanced Alternative Payment Models (APMs). The study provides empirical evidence on the shift in billing …

Utilizing Hemoglobin Binding Kinetics And X-Ray Crystallography In Sickle Cell Disease Drug Development, Ahmed Alghamdi

Theses and Dissertations

ABSTRACT

UTILIZING HEMOGLOBIN BINDING KINETICS AND X-RAY CRYSTALLOGRAPHY IN SICKLE CELL DISEASE DRUG DEVELOPMENT

By Ahmed Alghamdi, M.Sc. in Medicinal Chemistry

A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Medicinal Chemistry at Virginia Commonwealth University.

Virginia Commonwealth University, 2024.

Director: Dr. Martin K. Safo Professor, Department of Medicinal Chemistry

Introduction: Sickle Cell Disease (SCD) is characterized by severe hemolytic anemia, recurrent painful crises, and chronic organ damage, posing significant challenges to patients' quality of life and longevity. While current FDA-approved therapies offer symptomatic relief, they do not address the underlying molecular …

The Patient Experience Of Language Discordance And Interpreter Services In The Emergency Department, Keri L. Baker

Theses and Dissertations

Background: Clear communication is critical to the interaction of a patient and medical provider. For non-English speaking patients, language discordance, described as the lack of proficiency in a shared language, with the medical team results in a poor patient experience and poor patient outcomes. The predominant solution to language discordance is the use of interpreter services, however these services are underused in the emergency department (ED). Studies examining underuse of interpreter services have primarily focused on the clinician and little is known about the patient’s influence on the use of interpreter services.

Methods: Semi-structured interviews were conducted with 12 Spanish-speaking …

Continuous Flow As A Process Intensification Tool For The Preparation Of Pharmaceutically Relevant N-Heterocycles, John W. Tomlin Jr

Theses and Dissertations

Continuous flow as a process intensification tool for the preparation of pharmaceutically relevant N-heterocycles

John W. Tomlin

Thesis Defense: 17 January 2024

Committee: B. Frank Gupton, Ph.D. (Advisor), Suzanne M. Ruder, Ph.D. (Chair), Heather R. Lucas, Ph.D., James K. Ferri, Ph.D., Matthew C.T. Hartman, Ph.D.

A dissertation submitted in partial fulfillment of the requirements of Doctor of Philosophy at Virginia Commonwealth University

© 2024 John W. Tomlin Jr All Rights Reserved

Abstract

Essential medicines must be produced in large quantities to accommodate large global demand. The preparation of these active pharmaceutical ingredients (API) must therefore strive to be both cost-effective …

Mechanistic Analysis Of Four-Way Dna Junctions And Cytokine-Binding Aptamers For Therapeutic Interventions, Roaa S. Mahmoud

Theses and Dissertations

DNA is inherently dynamic and topologically diverse and can fold into many different structures. Besides the canonical Watson-Crick structure, other higher-order structures such as G-quadruplexes (G4), i-motifs (iM), and four-way DNA junctions are possible. Although these high-order DNA structures are known to form transiently, they are important due to the crucial roles they play in many cellular processes including DNA replication, recombination, and repair. Among these DNA structures, 4-way junctions (also known as Holliday junctions, HJ) which are formed during the repair of double-strand DNA breaks (DSBs) and interact with proteins have garnered significant attention due to their central role …

Polyvictimization In Context: Identifying Patterns Of Peer, Dating, And Community Violence Among Black Early Adolescents, Carine Leslie

Theses and Dissertations

Early adolescents exposed to multiple forms of victimization (“polyvictimization”) may experience a number of detrimental psychosocial outcomes. Some person-centered research has identified victimization subgroups among adolescents but have not examined the overlap of peer, dating, and community victimization among Black early adolescents living in economically disadvantaged urban communities. Thus, this study empirically identifies victimization profiles in a sample of Black early adolescents to ascertain the patterns and correlates of polyvictimization. The present study aimed to (a) identify subgroups of Black early adolescents based on their frequency of peer, dating, and community victimization using latent profile analyses, and (b) evaluate the …

Repeated-Measures Latent Profile Analyses Of Intervention Fidelity To A Teacher-Delivered Intervention Program For Children At Elevated Risk For Emotional And Behavioral Disorders, Katrina A. Markowicz

Theses and Dissertations

Teachers have difficulty delivering Tier-2 intervention programs for preschoolers at elevated risk for socioemotional and behavioral disorders with high intervention fidelity (Durlak, 2010; Sutherland et al., 2018). Several proximal factors that impact program fidelity have been identified, which may undermine program effects (Domitrovich et al., 2008; McLeod et al., 2022; Sutherland et al., 2018). Therefore, researchers have identified strategies, such as practice-based coaching, to improve intervention fidelity and support teachers (Hemmeter et al., 2015; Synder et al., 2015). Most of the field's knowledge of these topics is limited to variable-centered approaches (Fettig et al., 2022; Low et al., 2016). However, …

Correlates Of Coffee And Energy Drink Use Among Individuals With Severe Alcohol Use Disorder, Enkelejda Ngjelina

Theses and Dissertations

Research on caffeine consumption among college students and young adults has primarily focused on caffeinated energy drinks (EDs) and their combination with alcohol, demonstrating a strong association with heavy and problematic alcohol use. However, little attention has been directed toward older adults. Furthermore, studies have shown that regular ED consumers are more likely to meet the criteria for alcohol dependence compared to their peers. Despite this association, little is known about ED consumption among individuals with Alcohol Use Disorder (AUD), particularly those undergoing treatment, and even less is understood about other caffeine sources such as coffee. This study aimed to …

Systemic Contributors To Health Equity: A Conceptual Framework And Moderation Analysis, Rachel Regal

Theses and Dissertations

This dissertation presents a line of research exploring systemic factors that influence health and health equity across the lifespan. A linking document prefaces two-manuscripts as follows. Manuscript 1, A Model for Enhanced Trauma-Informed Care: An Asset-Based, Transdisciplinary Approach to Health Equity, presents a synthesis of literature on multisystem resilience, social determinants of health, and adverse / positive childhood experiences to build an alternative framework to promote healing and health equity using an asset-based approach within enhanced trauma-informed systems of care and educational models. By adopting this enhanced framework, the counseling field and others can be responsive to emerging trends and …

The Genetic Architecture Of Cervical Change During Pregnancy: From Modeling To Mechanism — Does The Cervix Mediate Maternal Risk For Spontaneous Preterm Birth?, Hope M. Wolf

Theses and Dissertations

This project leverages clinical data and biospecimens from a prospective longitudinal cohort of pregnant women to study the genetic and phenotypic relationships between cervical shortening and the duration of pregnancy. Sonographic cervical length (CL) was measured throughout pregnancy in a cohort of 5,160 Black/African American women in Detroit, Michigan. Maternal DNA samples were sequenced with a next-generation low-pass whole genome platform. The heritability of cervical change during pregnancy and its genetic correlation with gestational age at delivery (GAD) were estimated using Genome-Wide Complex Trait Analysis. These estimates suggest that cervical change is heritable (h²CL = 51%) and highly polygenic trait. …

Feasibility Of Using Somatosensory Input On Pediatric Patients Receiving Dental Treatment, Liara D. Vinson

Theses and Dissertations

Purpose: The aim of this randomized, cross-over designed feasibility study is to evaluate patient anxiety, patient cooperation, and patient acceptance of a vibrating weighted vest used during the restorative treatment compared to when no device is used.

Methods: Children aged 5 to 15 years, needing at least two appointments for restorative treatment requiring local anesthesia under basic behavior guidance techniques were recruited. Patients were randomly allocated to wearing a vibrating weighted vest at one of the appointments. At both appointments, behavior was evaluated using Frankl scores and anxiety was evaluated at the beginning and at the end of …

Towards The Automation Of Post-Processing Of Additive Manufacturing Using Collaborative Robots, Logan Schorr

Theses and Dissertations

Despite the incredible potential that collaborative robots have, they are underutilized in several industries that could benefit greatly. These specialized fields, such as additive manufacturing, face challenges that can be solved with the use of robotics, including advanced computer vision, end-effector tooling, and process refinement. My research aims to utilize collaborative robots in an effort to solve the above stated problems, for the specific fields of additive manufacturing. Specifically within this field is the automation of post-processing; this is normally completely manual, as the tools for automation are not sufficiently developed to handle the flexibility required for additive manufacturing. This …

Utilizing Ai Integrated Neuroimaging Technology To Expand Upon Machine Learning In Positron Emission Tomography Technology With The Aim Of Detecting Amyloid Beta Biomarkers Early In The Onset Of Alzheimer's., Ethan S. Terman

UROP Posters

Early intervention in Alzheimer's is vital for treatment. The earlier a professional can detect symptoms and make a diagnosis the earlier a prognosis can be implemented. With the prevalence of data in our day-to-day world combined with Artificial intelligence (AI), utilizing both for machine learning can pave the way for more accurate and efficient detection of Alzheimer's and other neurodegenerative diseases. AI combined with Machine learning (ML) increases diagnostic efficiency and reduces human errors, making it a valuable resource for physicians and clinicians alike. With the increasing amount of data processing and image interpretation required, the ability to use AI …

Neurodevelopmental Vulnerability To Gestational Ozone Exposure, Vishnupriya Alavala, Sarah E. Brent, Christopher G. Canal, Joseph Wang, Russell P. Hunter, Matthew J. Campen, Andrew K. Ottens

UROP Posters

Ambient air pollution accounts for about 4.2 million premature deaths annually per the World Health Organization. Ozone (O3) is a highly reactive air pollutant found in smog and is implicated in cellular damage leading to organ dysfunction. Ambient air pollution is associated with neurodevelopmental, behavioral, and cognitive disorders though ozone’s role is unknown. Studies here look at ozone exposure shortly after implantation vs. shortly before term to evaluate differences in neurodevelopmental susceptibility over time.

To inquire on the effects of ozone on the fetal brain, pregnant Sprague-Dawley rats were exposed once to 0.3 ppm of O3 or filtered air (FA) …

Exploring Belonging And Success In First Generation College Students With Disabilities, Cael Sinclair, Molly Taylor, Sharon Zumbrunn

UROP Posters

As colleges create initiatives to admit and accommodate marginalized students, the struggles of those marginalized students are becoming increasingly impactful and present. Research suggests that students’ sense of social belonging is often connected to student academic success (Connell & Wellborn 1991). However, marginalized students often experience a lower sense of belonging, particularly students who are the first in their families to go to college (Stebleton et al. 2014), and those who identify as disabled (Leake & Stodden 2014). The present study evaluated how the strengths and experiences of first-generation college students with disabilities impacted their belonging and academic success in …

How Does A Global Climate Cycle Affect The Reproductive Output Of A Neotropical Migratory Bird?, Abby K. Bressette, Emma Cummings, Daniel Albrecht-Mallinger, Lesley Bulluck

UROP Posters

El-Niño Southern Oscillation (ENSO) causes regional changes in climate and has been found to have varying effects on the survival, fecundity, and recruitment of migratory songbirds. This study seeks to better understand the effect of ENSO on the fecundity of Virginia-breeding Prothonotary warbler (Protonotaria citrea; PROW), a neotropical migratory songbird. PROW breed in the Eastern United States and spend the non-breeding season primarily in Panama and Colombia. Ongoing research in Virginia has found a positive relationship between spring precipitation and predicted number of PROW fledgelings during La Niña, but the opposite during El Niño. To better understand this relationship, we …

Qualitative Study Of Hiv-Related Stigma In The Dental Care Setting, Sania A. Pullen, Dr. Dina T. Garcia

UROP Posters

Objectives: People living with HIV (PLWH) are susceptible to developing a variety of oral conditions that if left untreated can lead to sore gums, painful chewing, and tooth loss as well as compromise HIV management and viral suppression. Despite the increased risk of developing oral conditions, it is estimated that up to 58% of PLH do not receive regular dental care. This study aimed to examine HIV-related stigma and discrimination in the dental care setting.

Methods: Adults living with HIV who receive care through the Ryan White HIV/AIDS Program at the VCU Infectious Disease (ID) clinic were recruited to participate. …

An Interview With Brianna Harlan, Mysoon Rizk, Brianna Harlan

Art Inquiries

No abstract provided.

Commonwealth Times 2023-11-29

Commonwealth Times, 1969-

No abstract provided.

Prisons And Universities: Co-Creating Curricula For Prison-University Partnerships., Michela Scalpello

Journal of Prison Education Research

This paper illustrates the approach of co-creating education where co-creation was an important aspect of the curriculum design. It makes a case for prison-university partnerships through two pedagogical case studies – one within a prison setting with a focus on soft skills acquisition and another in a Higher Education setting focusing on international criminal justice. Originating from the observations and reflections of an educator which led to a participatory action research opportunity, it asserts that actively teaching and learning together increases effective learning through better understanding and motivation, as well as giving access to the right to education regardless of …

Understanding Incarcerated Education: A Review Of The Digital And Gender Inequality Impacts Of Accessibility And Inclusivity Of Higher Education For Incarcerated Students, Bianca R. Parry Phd

Journal of Prison Education Research

Education in the correctional environment is endorsed as an effective rehabilitative tool linked to reducing recidivism and improving reintegration. Unfortunately, while researchers from the Global North are particularly active on the subject of the accessibility of digital education in corrections, the same cannot be said for the Global South. Of further concern is that few of the studies conducted have focused specifically on incarcerated women’s access to education. As discussed in the literature review to follow, research regarding higher education in corrections has the potential for expanding academics, stakeholders, and policy makers understanding of incarcerated students’ pathways towards education attainment. …

Men’S Sheds: An Outlet For Engaging In Creative Activities, Melinda Heinz

International Journal of Lifelong Learning in Art Education

This research highlights the purpose behind creating an art exhibition featuring work made by Men’s Shed members, many of whom are older adults. Publicly displaying their creative works demonstrates the creative capacities of these older men and counteracts the negative narrative that older adulthood is a time when individuals experience declining abilities. The exhibition also inspires older adults to consider what they can create, experiment with learning new mediums, and provides them an opportunity to connect with others who may share similar interests.

The Ritual Of Therapeutic Artmaking In Long-Term Care, Melinda Heinz Dr., Elissa Wenthe, Alexis Schramel

International Journal of Lifelong Learning in Art Education

The transition to long-term care settings can be difficult for residents and feelings of loneliness, depression, and anxiety are not uncommon in these environments. However, participating in therapeutic artmaking rituals creates opportunities for residents to process their feelings, experience states of flow and mindfulness, engage with others, and focus on their own psychological growth. In long-term care, the physical needs of residents are often prioritized, but psychosocial needs also require attention. For this project, therapeutic artmaking rituals were created at a long-term care facility in three levels of care over 12 months. Older adults engaged with clay, paint, raw fiber, …

Intergenerational Implications Of Ritual In Art Education, Angela M. La Porte, Peg Speirs, Camilla Mccomb

International Journal of Lifelong Learning in Art Education

This article introduces the concept of ritual and the role it can play in art education across generations from PK-12 schools to community collaborations. Three authors elaborate on research, personal experiences, and applications of ritual in their art education practice. The first introduces ritual within personal, historical, cultural, psychological, and sociological contexts. Then, relates these to art education curriculum and an intergenerational community collaboration. Author 2 shares experience with ritual-based artists using performance, body adornment and modification to communicate creative sacred/secular expression. Author 3 describes her hesitancy and eventual success in engaging preadolescents in ritual-based discussions. All of these perspectives …

Commonwealth Times 2023-11-08

Commonwealth Times, 1969-

No abstract provided.

Commonwealth Times 2023-11-01

Commonwealth Times, 1969-

No abstract provided.

Commonwealth Times 2023-10-18

Commonwealth Times, 1969-

No abstract provided.

Commonwealth Times 2023-10-04

Commonwealth Times, 1969-

No abstract provided.

Commonwealth Times 2023-09-20

Commonwealth Times, 1969-

No abstract provided.