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Has Richmond, Virginia Become Safer In The Past Five Years (2002-2006)?: An Analysis Of Ambulance Data Regarding Penetrating Trauma Incidents, Ashleigh K. Mccabe Jan 2007

Has Richmond, Virginia Become Safer In The Past Five Years (2002-2006)?: An Analysis Of Ambulance Data Regarding Penetrating Trauma Incidents, Ashleigh K. Mccabe

Theses and Dissertations

Introduction: The World Health Assembly declared violence as a worldwide public health problem. Homicides have been identified as a leading cause of death in the United States across all age groups. The national homicide rate for 2004 and 2005 are 5.5 and 5.6 per 100,000 population, respectively. The reported rates for Virginia are 5.2 (2004) and 5.6 (2005) per 100,000 population, showing a 16.9% increase. Richmond has been ranked as high as the sixth most dangerous among similar cities in the United States. This study examines penetrating trauma injuries identified through 9-1-1 calls as an indicator of the incidence of …

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Analysis Of Mouse Eklf/Klf2 E9.5 Double Knockout: Yolk Sac Morphology And Embryonic Erythroid Maturation, Tina Kathy Lung Jan 2007

Analysis Of Mouse Eklf/Klf2 E9.5 Double Knockout: Yolk Sac Morphology And Embryonic Erythroid Maturation, Tina Kathy Lung

Theses and Dissertations

Krüppel-like factors (KLFs) are a family of transcription factors with 3 Cys2/His2 zinc fingers that regulate cell differentiation and developmental processes. EKLF is involved in primitive and definitive erythropoiesis; KLF2 is implicated in the development of primitive erythroid and endothelial cells of the vasculature. Using light and electron microscopy, the yolk sacs and dorsal aortae from EKLF/KLF2 double knockout (KO) E9.5 (embryonic day 9.5) were examined to determine whether these KLFs have compensatory functions in morphology of blood cells and vessels. EKLF/KLF2 double KO E9.5 erythroid, endothelial, and mesothelial cells had more severely abnormal morphology than WT and KLF2-/-. Flow …

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Breast And Cervical Cancer Screening In Virginia: The Impact Of Insurance Coverage And The Every Woman's Life Screening Program, Kamila Somayaji Jan 2007

Breast And Cervical Cancer Screening In Virginia: The Impact Of Insurance Coverage And The Every Woman's Life Screening Program, Kamila Somayaji

Theses and Dissertations

Background: Screening for breast and cervical cancers is important because early detection increases cancer survival. Since 1991, the U.S. government has helped finance a national early detection program for breast and cervical cancer among uninsured low-income women, known in Virginia (VA) as Every Woman's Life (EWL).Objectives: This study aims to determine whether there are differences in the prevalence of breast and cervical cancer screening based on insurance coverage, assess the prevalence of screening by health district, and evaluate the ability of EWL to effectively reach its target population.Methods: Cross-sectional data from the 2005 Behavioral Risk Factor Surveillance System survey were …

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The Relapsing Fever Spirochete, Borrelia Hermsii, And Complement Regulatory Proteins, Kelley M. Hovis Jan 2007

The Relapsing Fever Spirochete, Borrelia Hermsii, And Complement Regulatory Proteins, Kelley M. Hovis

Theses and Dissertations

Borrelia hermsii, the primary etiological agent of tick-borne relapsing fever in North America, binds the complement regulatory protein factor H (FH) as a means of evading opsonophagocytosis and the alternative pathway of complement. The sequence of the gene encoding the FH-binding protein has been determined. The protein is unique to B. hermsii and has been designated FhbA. Analyses of B. hermsii isolates revealed that FhbA is expressed by 24 of the 25 isolates tested. fhbA was demonstrated to be a single genetic locus through pulsed-field gel electrophoresis, restriction digest, and hybridization analyses, and all isolates possessing fhbA carry it on …

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Intrapersonal Grief As A Clinical Entity Distinct From Depression: Does It Exist Among A Medically Ill Parkinson's Disease Population?, Rashelle Brown Hayes Jan 2007

Intrapersonal Grief As A Clinical Entity Distinct From Depression: Does It Exist Among A Medically Ill Parkinson's Disease Population?, Rashelle Brown Hayes

Theses and Dissertations

There has been growing support for the idea that complicated grief symptoms following bereavement are independent of symptoms of depression and anxiety. However, the loss of a loved one is not the only or the most frequent type of loss to be encountered. The onset of an insidious medical illness may trigger a mourning process for the lost function or body part that is posited to also involve feelings of grief. While the risk of depression is high among a medical or rehabilitative population, the impact of grief over functional losses has never been empirically investigated as a contributing factor …

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Renewing Manchester: A Supportive Life Skills Center For Manchester's Most Underprivileged Residents, Jennifer Lynne Hamilton Jan 2007

Renewing Manchester: A Supportive Life Skills Center For Manchester's Most Underprivileged Residents, Jennifer Lynne Hamilton

Theses and Dissertations

In America today, many people have fallen into sub-standard housing situations. Domestic violence, drug abuse, and lack of educational and employment opportunities are a few of the myriad reasons for this. On average the number of homeless people in the greater Richmond area is 5,200 individuals.1 These are people specifically in need of a re-integration into society.This thesis examines the role that the built environment can play in this process, by providing a sustainable, affordable and flexible site for a program that encourages people to rise above their current state by "recycling" them into better more productive citizens. The intent …

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The Association Between Adult Self-Reported Asthma & Potential Exposures To Asthma Triggers In Virginia Workplaces: An Ecological Study, Jeanette R. Bowman Jan 2007

The Association Between Adult Self-Reported Asthma & Potential Exposures To Asthma Triggers In Virginia Workplaces: An Ecological Study, Jeanette R. Bowman

Theses and Dissertations

Introduction: Work-related asthma (WRA) is thought to be the most common occupational lung disease in the U.S., but there is no standard case definition of WRA. Most states, including Virginia, do not require WRA diagnoses to be reported to health departments. At present, there is too little epidemiological data on WRA in Virginia to direct public health planning efforts. Objectives: The first objective of this study was to estimate potential exposure to workplace asthma triggers in each of Virginia's 35 health districts. The second objective was to examine associations at the health district level between workplace asthma triggers, other asthma …

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Relationship Between Facial Attractiveness And Occlusal Treatment Outcomes: A Retrospective Study, Chad Eric Fowler Jan 2007

Relationship Between Facial Attractiveness And Occlusal Treatment Outcomes: A Retrospective Study, Chad Eric Fowler

Theses and Dissertations

The goal of this study was to determine if a relationship exists between pretreatment facial attractiveness and posttreatment occlusal outcome in orthodontic patients. A randomized sample of forty-seven patients (26 males, 21 females) was selected for inclusion in this study. Orthodontic evaluators rated pretreatment patient photographs (frontal smile, frontal, profile) using a 100 mm visual analog scale (VAS). Occlusal outomes were evaluated using percentage reduction in weighted Peer Assessment Rating (PAR) index scores and the American Board of Orthodontics objective grading system (ABO-OGS). Spearman correlation coefficients were calculated to assess the relationship between pretreatment VAS attractiveness ratings and posttreatment occlusal …

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Intensive Co-Parenting Therapy: Piloting A Manualized Treatment For Divorced Families, Jill Allison Ferrante Gasper Jan 2007

Intensive Co-Parenting Therapy: Piloting A Manualized Treatment For Divorced Families, Jill Allison Ferrante Gasper

Theses and Dissertations

Although resilience is the normative psychological outcome of divorce, parents and children of divorce are disproportionately represented in the mental health and legal systems. Due to the great financial and psychological costs of incessant divorce litigation, interventions that promote positive child adjustment while alleviating the costs of litigation are in high demand. Social policymakers and clinicians have responded to this demand via a number of intervention strategies; however, the implementation of many current interventions has predated supporting empirical evidence.The present study seeks to establish the efficacy of a child-focused, intensive co-parenting therapy (ICT) intervention for divorced parents. ICT is a …

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Prediction Of In-Vivo Antimuscarinic Activity (Ama) By In-Vitro Receptor Binding Assessment And Pk/Pd Modeling For Prototypical Drugs, Taghrid Y. Obied Jan 2007

Prediction Of In-Vivo Antimuscarinic Activity (Ama) By In-Vitro Receptor Binding Assessment And Pk/Pd Modeling For Prototypical Drugs, Taghrid Y. Obied

Theses and Dissertations

Purpose: To establish a tool, termed as antimuscarinic activity (AMA), to predict the incidence of antimuscarinic adverse events (AMAEs).Methods: A literature review, focused on drugs having off-target interaction with muscarinic receptors, was performed. Prototypical drugs olanzapine, diphenhydramine, paroxetine were selected for the analysis. Scopolamine and darifenacin were included as positive and negative controls, respectively. Physiochemical properties, pharmacokinetic data, and clinical incidence of AMAEs for the selected drugs were collected from reported literature. Extrapolation of literature data was carried-out to obtain exposure data. To determine the drugs muscarinic affinity (Ki values), experiments were performed using 3H-QNB and membrane suspensions of M1, …

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Cradle To Cage: Confronting The Premature Institutionalization Of The Children Of The Incarcerated, Jen Fell Jan 2007

Cradle To Cage: Confronting The Premature Institutionalization Of The Children Of The Incarcerated, Jen Fell

Theses and Dissertations

American prisons are swollen and distended. Over 2 million Americans sit in jail or prison today. About 2/3 of the incarcerated are parents. They parent approximately 2 million children in America today who are separated from mom or dad because of incarceration. Their children suffer from poverty, inconsistency in caregivers, separation from siblings, reduced opportunity to health and education and increased risk for substance abuse, alcoholism and incarceration themselves. Children of the incarcerated are seven times more likely than their peers to become incarcerated as adults.Many of these children are unable to visit their parents. Over half the mothers in …

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Disparities In The Use Of Emergency Contraceptives, Rebecca Dallman Jan 2007

Disparities In The Use Of Emergency Contraceptives, Rebecca Dallman

Theses and Dissertations

Purpose: Unintended pregnancies are often a burden to pregnant women and to the health care system. The rates of unintended pregnancies have decreased since the wide use of contraceptives has increased; however, young women, women with low income, and racial/ethnic minorities are more likely to use contraceptives inconsistently, which increases the risk of an unintended pregnancy. This risk could be reduced with the proper use of emergency contraceptives (ECs).Methods and Analysis: A cross-sectional study was conducted using the data from the female respondents of the 2002 Cycle 6 NSFG. Logistic regression was used to determine rates of use of ECs …

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Achieving High Performance In Local Government: Linking Government Outcomes With Human Resource Management Practices, Richard F. Huff Jan 2007

Achieving High Performance In Local Government: Linking Government Outcomes With Human Resource Management Practices, Richard F. Huff

Theses and Dissertations

Historically public sector personnel policies and practices have been targets of reform. These reforms consisted of transferring private sector techniques to a public sector perceived to be more bureaucratic and less efficient. Private sector research is replete with evidence of a connection between "superior" human resource management (HRM) practices and the performance outcome of profitability. Public sector outcomes are more difficult to connect directly to management practices. As a result, the focus of public sector reform has become one of improving the processes of management rather than improving the outcomes of government. The linkage between reform and outcome is assumed.This …

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Residential Outcomes Of Hope Vi Relocatees In Richmond, Va, Lallen Tyrone Johnson-Hart Jan 2007

Residential Outcomes Of Hope Vi Relocatees In Richmond, Va, Lallen Tyrone Johnson-Hart

Theses and Dissertations

In 1997 the Richmond Redevelopment and Housing Authority received a HOPE VI grant from the U.S. Department of Housing and Urban Development in the amount of $26.9 million to revitalize the Blackwell scattered site public housing community. The mixed income approach of HOPE VI calls for a reduction of public housing units, thus requiring all households to relocate to other neighborhoods. This research analyzed socioeconomic data to examine the relocation of households, assess whether they moved to better neighborhoods, and compare them to other poor households. Over half of all households moved to other distressed neighborhoods in the Northside, East …

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Outcomes Of Status Epilepticus In The Elderly, Alan R. Towne Jan 2007

Outcomes Of Status Epilepticus In The Elderly, Alan R. Towne

Theses and Dissertations

Background: Status epilepticus (SE) is a serious medical condition associated with significant morbidity and mortality. Few studies have addressed this condition in the elderly. The present study examines predictors of SE mortality in this growing population.Methods: SE patients visiting the Virginia Commonwealth University Medical Center from July 1, 1989, to June 30,2006 were included in the study. Data on demographic characteristics, SE type, etiology, time to treatment and mortality were collected. Logistic regression analysis was conducted to examine the determinants of mortality due to SE. Data was stratified by age to examine the characteristics of SE among the elderly population.Results: …

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Self-Care And Quality Of Life In Patients With Heart Failure, Chantira Chiaranai Jan 2007

Self-Care And Quality Of Life In Patients With Heart Failure, Chantira Chiaranai

Theses and Dissertations

Although it is well known that self-care reduces the frequency of hospital admissions and exacerbations and enhances quality of life (QOL) in heart failure (HF) patients, little is known about self-care in this population. Therefore, the study purpose was to examine relationships among selected individual characteristics (demographics, severity of illness, comorbidities, and social support), self-care strategies, and QOL using Reigel's Model of Self Care in Patients with Heart Failure as the guiding framework. In this descriptive correlational study, self-care was measured using the Self-Care of Heart Failure Index (SCHFI), which measures self-care maintenance (SC-Mt), self-care management (SC-Mn), and self-care self-confidence …

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Visual Contributions To The Vestibulo-Ocular Reflex During Balance Recovery Tasks, Mark D. Diehl Jan 2007

Visual Contributions To The Vestibulo-Ocular Reflex During Balance Recovery Tasks, Mark D. Diehl

Theses and Dissertations

Introduction: The Vestibulo-ocular reflex (VOR) is quantified by computing the ratio of head angular velocity and eye angular velocity (VOR Gain). This measure only includes head angular movements; linear translations are not accounted for. These investigations postulate an alternative method of VOR quantification, one that assesses retinal image stability during head angular and linear movements (Foveal fixation (FF)). This method was used to assess the role of vision in balance reactions. Methods: Experiment 1 : Ten Young subjects were fitted with an eye tracker linked to an EM kinematic recording system. This allowed for the recording of head, trunk and …

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Resilience And Risk-Taking Behavior Among Thai Adolescents Living In Bangkok, Thailand, Patcharin Nintachan Jan 2007

Resilience And Risk-Taking Behavior Among Thai Adolescents Living In Bangkok, Thailand, Patcharin Nintachan

Theses and Dissertations

The major purposes of this study were to determine the relationships among resilience, risk-taking behavior and personal characteristics of Thai adolescents living in Bangkok and to examine the differences in risk-taking behavior by school grades or gender. To accomplish these, a cross-sectional correlational research design was conducted. Resilience was measured by using the State-Trait Resilience Inventory developed by Hiew, Mori, Shirnizu and Torninaga.Risk-taking behavior was measured by the Risk-taking Behavior Questionnaire for Thai Adolescents which is a modified version of the 2003 Youth Risk Behavior Survey (YRBS) originally developed by the U.S. Centers for Disease Control and Prevention. In order …

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Concurrent Whitening And Orthodontic Treatment, Jason Thomas Gladwell Jan 2007

Concurrent Whitening And Orthodontic Treatment, Jason Thomas Gladwell

Theses and Dissertations

The aim was to evaluate whether a whitening system, when used during the final stages of orthodontics, would yield results comparable to whitening alone. Patients were assigned to either the control (n=20) or experimental (n=26) groups. At T1, patients were given a ten day supply of Trèswhite™ by Opalescence®, instructions on use, and initial shade determination was made and photographs were taken. At T2 and T3, shade determination was accomplished and updated photographs were taken. Whitening of the teeth occurred in both groups on average, but significantly more whitening was experienced in the experimental group (p < 0.004). An average of 87% of teeth whitened during orthodontic treatment compared to 97% of control teeth (p < 0.01) were judged to be uniform in appearance. In conclusion, the data do not contraindicate the concurrent accomplishment of teeth whitening during orthodontic treatment.

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The Effect Of Pre-Cure Bracket Movement On The Shear Bond Strength Of Metal Brackets, Thomas Luther Roberts Iv Jan 2007

The Effect Of Pre-Cure Bracket Movement On The Shear Bond Strength Of Metal Brackets, Thomas Luther Roberts Iv

Theses and Dissertations

The effect on shear bond strength of bracket movement after seating the brackets and before light curing has not been reported. The purpose of this study was to determine the effect of linear and rotational pre-cure bracket movement on the shear bond strength of orthodontic brackets. 100 extracted human maxillary premolars were divided into 5 groups of 20 teeth each. The control group was bonded with no pre-cure bracket movement, and test groups were bonded with pre-cure bracket movement of 2 mm, 4 mm, 45¢ª or 180¢ª. Debonding force was measured with an Instron universal testing machine. Results were analyzed …

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Life In An Occupied City: Women In Winchester, Virginia During The Civil War, Laura Jane Ping Jan 2007

Life In An Occupied City: Women In Winchester, Virginia During The Civil War, Laura Jane Ping

Theses and Dissertations

This thesis examines the homefront experience of middle class, white women living in Winchester, Virginia during the Civil War. The experience of women in Winchester was unique because of Winchester's proximity to both the Union and Confederate capitals. Although the majority of Winchester's women were Confederate supporters a significant minority of the population remained loyal to the Union. Winchester citizens' divided status was further complicated by numerous occupations of the town by both armies. This thesis argues that in order to cope with wartime hardships women's concepts of patriotism changed as homefront morale waned. While early in the war women's …

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Cd23'S Role As A Negative Regulator Of Allergic Disease: In Vivo Effects Of Murine Cd23 Destabilization And Allelic Mutations, Jill Wallace Ford Jan 2007

Cd23'S Role As A Negative Regulator Of Allergic Disease: In Vivo Effects Of Murine Cd23 Destabilization And Allelic Mutations, Jill Wallace Ford

Theses and Dissertations

Through underexpression and overexpression studies, CD23 has been shown to negatively regulate IgE production. To investigate CD23 destabilization and its effects on CD23 shedding and IgE synthesis in vivo, we utilized an anti-CD23 stalk monoclonal (19G5) which has previously been shown to enhance proteolysis of CD23 in vitro. Compared to isotype control-treated mice, mice injected with 19G5 displayed enhanced serum soluble CD23 and IgE. Because 19G5 injection substantially enhanced CD23 shedding, it was useful in investigating the identity of the CD23 sheddase. 19G5 enhanced CD23 shedding in ADAM8-/-, ADAM9-/-ADAM15-/-, and ADAM9-/-ADAM12-/-ADAM15-/- mice, ruling out these ADAMs as candidate CD23 sheddases. …

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In Search Of The Ooey Gooey Good, Lauren Ashley Clay Jan 2007

In Search Of The Ooey Gooey Good, Lauren Ashley Clay

Theses and Dissertations

This thesis explores ideas of everydayness, the mundane, and the repetitive emptiness of consumer culture. It looks at the malaise that plagues everyday life and examines several attempts throughout history to break from its grips which revolve around a search for a more ideal state. This research includes utopias of modernism, the transcendental, the communal living of Shakers and Early Christians, ascetic monks and The Desert Fathers. These ideas have shaped my studio practice as I construct installations based on worlds which allude to the eternal, the otherworldly, and the fragility of our physical world when compared to more eternal …

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Telomerase Inhibition And Sensitization Of Breast Tumor Cells, Kennon R. Poynter Jan 2007

Telomerase Inhibition And Sensitization Of Breast Tumor Cells, Kennon R. Poynter

Theses and Dissertations

Telomerase, a ribonucleoprotein enzyme minimally composed of an RNA template (hTR) and a catalytically active protein subunit (hTERT), synthesizes telomeric repeats onto chromosome ends and is obligatory for continuous tumor cell proliferation, as well as malignant progression of breast cancer cells. Telomerase is an attractive anticancer therapeutic target because its activity is present in over 90% of human cancers, including more than 95% of breast carcinomas, but undetectable in most somatic cells. Traditions chemo- and radio-therapies lack the ability to effectively control and cure breast cancer, in part because residual cells are or become resistant to DNA damaging modalities.While various …

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The Influence Of Parental Monitoring And Peer Deviance On Substance Use Among Middle School Students, Sally Ann Mays Jan 2007

The Influence Of Parental Monitoring And Peer Deviance On Substance Use Among Middle School Students, Sally Ann Mays

Theses and Dissertations

Substance use is a significant problem among middle school students in the United States. Research indicates that the early use of substances increases the likelihood of negative outcomes including long-term use and abuse. Both parenting and peer variables exert strong influences on children's decisions to use or abstain from substances. As children age, peers begin to exert a stronger influence, but parenting practices can significantly reduce peers' harmful influences. In this study, three waves of data (collected at the end of 6th grade, and the beginning and end of 7th grade) from a large multi-site study were used to examine …

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Anesthesia Clinical Performance Outcomes: Does Teaching Methodology Make A Difference?, Nina E. Mclain Jan 2007

Anesthesia Clinical Performance Outcomes: Does Teaching Methodology Make A Difference?, Nina E. Mclain

Theses and Dissertations

Researchers have studied memory recall of crisis-oriented or emotional events in non-educational settings. However, within the health care field, there has been a limited study of the the concept of recall of crisis oriented or emotional events in& health care education. Crisis-oriented events such as natural disasters, acts of bioterroism, and industrial accidents, have been reported to impact memory. Patient safety is a primary focus in anesthesia education, appropriate crisis management is imperative to quality anesthesia care. Due to the critical nature of anesthesia delivery, there is a strong, constant need to develop methods that will enhance, support, and improve …

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Genetic Variations In Interferon-Induced Genes And Hcv Recurrence After Liver Transplantation, Benjamin Cameron Whitehill Jan 2007

Genetic Variations In Interferon-Induced Genes And Hcv Recurrence After Liver Transplantation, Benjamin Cameron Whitehill

Theses and Dissertations

Hepatitis C Virus (HCV) infection represents a worldwide pandemic and is currently the leading cause of cirrhosis and liver transplantation. After transplantation recurrence is almost universal with 96% of patients testing positive for viral RNA and exhibiting histological evidence of infection within the first year. Type I interferons (IFN) and interferon inducible genes are responsible for the innate antiviral state and single nucleotide polymorphisms (SNPs) within these genes may affect the patients ability to respond post-transplantation. We hypothesize the elucidation of associations between SNPs in Type-I Interferon and Interferon inducible genes and HCV recurrence post-liver transplantation might help to identify …

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The Effect Of Pediatric Hospital Specialization On Patient Safety And Effectiveness Of Care, James Mitchell Harris Ii Jan 2007

The Effect Of Pediatric Hospital Specialization On Patient Safety And Effectiveness Of Care, James Mitchell Harris Ii

Theses and Dissertations

Provider specialization is an area of interest in health care as patients, payers and policy makers are now demanding better performance and demonstrated proof of the benefits of specialization. While previously ignored in the specialization debate, now even the hospitals focusing on pediatric care (i.e. children's hospitals) are experiencing pressure to demonstrate their value. The current study attempts to answer the questions: do hospitals specializing in pediatric care provide better quality pediatric inpatient care; and do they do so for differing types of patient outcomes and across different levels of care complexity? Contingency Theory is used to develop and assess …

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Novel Sulfated 4-Hydroxycinnamic Acid Oligomers As Potent Anticoagulants, Brian Lawrence Henry Jan 2007

Novel Sulfated 4-Hydroxycinnamic Acid Oligomers As Potent Anticoagulants, Brian Lawrence Henry

Theses and Dissertations

The occurrence of thrombosis in several pathophysiological conditions creates a huge need for anticoagulation therapy. Thrombin and factor Xa have been prime targets for regulation of clotting through the direct and indirect mechanism of inhibition. This work investigates chemo-enzymatically prepared oligomers of 4-hydroxycinnamic acids (DHPs) as potential anticoagulants. Oligomers were prepared through peroxidase-catalyzed oxidative coupling of 4-hydroxycinnamic acids. The products resulting from this reaction are called CDs, FDs and SDs. Structurally, these sulfated DHPs are unique and do not resemble any of the anticoagulants known in the literature.DHP oligomers were found to increase clotting times at concentrations comparable to heparin. …

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Commonwealth Times 2006-12-07 Dec 2006

Commonwealth Times 2006-12-07

Commonwealth Times, 1969-

No abstract provided.

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