Digital Commons Network^™

Expect: A Speculative Documentary Filmed In Vr Utilizing The Role-Playing Method To Explore Disabilities And Ableism In Science Fiction, Leilei Xia

Theses and Dissertations

Expect is a speculative documentary filmed in Virtual Reality (VR) that features Chinese actors with disabilities to explore, challenge and reimagine the conventional ableist Sci-Fi tropes and the transhumanistic tendency to “fix” or eradicate disabilities through technological enhancement. I invited people with disabilities who are interested in Sci-Fi to do a Role-Playing with me in Virtual Reality (VR), in which they imagine themselves to be living in a future civilization, an alien planet, or an alternate universe. The participants came up with their own fictional characters and built their own world views. I interacted with them by asking questions and …

The Collection: A Third-Place Community Library Design, Camille Rovani

Theses and Dissertations

TOPIC

This project explores the significance of “third places”— informal public gathering spaces like cafés, parks, and libraries — and how design strategies in these spaces can help foster community connection and enhance well-being in a modern context.

PERSONAL RELEVANCE

While working a remote job during the pandemic, I experienced an overwhelming disconnect from the people around me. Like many people during that time, I was depressed. I then took an interest in the positive impacts of community connection on our health and well-being. I became fascinated by the concept of “third places,” a term coined by sociologist Ray Oldenburg …

Levofloxacin Incorporated Extracellular Matrix Nanoparticles For Pulmonary Cystic Fibrosis Infections, Raahi Patel

Theses and Dissertations

Cystic fibrosis (CF) is a progressive genetic disorder that affects around 40,000 people in the United States. CF is characterized by a mutation in the CFTR protein that causes dysregulated ion transport across epithelial cells, producing viscous mucus in the lung that increases bacterial invasion, causing persistent infections and subsequent inflammation. Pseudomonas aeruginosa and Staphylococcus aureus are two of the most common infections in CF patients that are resistant to antibiotics. One antibiotic approved to treat these infections is levofloxacin (LVX) that functions to inhibit bacterial replication, but can be further developed into tailorable particles. Nanoparticles are an emerging inhaled …

Considering Systems Of Power And Black And Latine Students’ Belonging In Stem, Korinthia D. Nicolai

Theses and Dissertations

This dissertation focuses on (a) exploring the need for and strategies to facilitate the integration of Critical Race Theory (CRT) and educational psychology and (b) supporting Black and Latine students through examining the impact of systems of power via the integration of belonging and Critical Race Theory. This dissertation follows a three-paper format. In Paper 1, we recognize that psychology researchers can use CRT to explore race and racism. However, psychology scholars may confront growing pains when integrating CRT due to their respective inquiry worldviews–postpositivism and critical–which result in several tensions. These tensions may limit the uptake of CRT in …

Inspiring A Ripple: A Case For Evidence-Based, Biophilic Design For Affordable Housing, Chelcey A. Dunham

Theses and Dissertations

ABSTRACT

RELEVANCE

Currently in the US, 4 million families in need of affordable housing are not housed in affordable units and are spending 30-50% of their monthly income toward rent (Aurand, 2023.) Due to this shortage of affordable housing and the trajectory of its growth, advocacy groups and policy makers are making a push to fund more affordable housing projects. What if the designs of these projects were informed in such a way that individual and community mental health and wellness could be addressed in addition to meeting the demand for affordable, safe shelter? In this way, the return on …

In Shame I Will Find Paradise, Taehee Whang

Theses and Dissertations

As a Korean American non-binary digital artist and designer, my recent explorations have focused on using voice as a medium to articulate nuanced feelings of displacement and the intricate relationships between language, identity, and expression. This journey expands beyond my personal experiences with gender dysphoria, delving into the lives of non-binary and transgender individuals undergoing gender-affirming voice therapy. Through my thesis research, I have developed interactive multimedia installations inspired by dialogues with individuals such as Umico Niwa, who traveled to Korea for voice feminization surgery, and Jeong Yoon Lee from Hyperlink Press, a four-year participant in Hormone Replacement Therapy (HRT). …

Sense Make Before Book, Bradley Sinanan

Theses and Dissertations

“Sense Make Before Book” is an Indo-Caribbean turn of phrase which refers to common sense being more important than book smarts. My sister sent me a post the other day on Instagram of an Trinidadian woman using this phrase, saying it was one of Indo-Caribbean origin. I was interested and asked my mom about it. My mom says that when she was younger my grandpa said it often around their house in Princes Town, Trinidad and Tobago. This adage feels charged thinking about the history of indenture and its effects on the Indo-Caribbean diaspora.

The written word of archival history …

Obesity Knowledge And Bmi In Caregiver-Adolescent Dyads: A Descriptive Comparative Pilot Study, John Sykes, John Sykes

Theses and Dissertations

Abstract

Background: The prevalence of obesity and associated health risks and costs continue to increase. The majority of these health and cost ramifications manifest in adulthood, making it imperative to intercept the problem during childhood. Unfortunately, an overwhelming majority of the research surrounding adolescents and obesity to date involves subjects that are already overweight or obese, and the focus of those interventions are on secondary and tertiary prevention. Focusing on primary prevention of childhood obesity could ultimately decrease the incidence, prevalence, and disease-related burden to society. It is posited that the 20% difference in obesity prevalence between adults and children …

Drugging The Histone Acetyltransferase Ep300 Modulates Alternative Splicing At Schizophrenia Risk Genes, Shravani Malay

Theses and Dissertations

Purpose. We will evaluate the effects of drugging the epigenetic histone acetyltransferase (HAT) enzyme p300, encoded by the schizophrenia risk gene EP300, on genome-wide gene expression in neural cells. We hypothesize that drugging p300 will affect gene expression and alternative splicing of other schizophrenia risk genes. Our motivation is to identify potential new epigenetic treatment avenues for schizophrenia.

Methods. Prior to my joining the lab, an experiment was conducted using the novel p300 HAT inhibitor, A-485, to modulate genomic regulation in a neural cell line (SH-SY5Y). SH-SY5Y cells were exposed to 10μM of A-485 or vehicle (DMSO) for 24 …

Monte-Carlo Method For Identifying Aberrantly Expressed Genes In Cancer, Matthew M. Beltran

Theses and Dissertations

Gene expression provides insight into the functional variations on the cellular level that shape biological phenomena. Several recent sequencing technologies have produced an abundance of expression profiles spurring entirely new disciplines of biological study. With this myriad of data, the new task is deciding how to assess and extract meaningful insights. Identifying genes with expression changes in disease conditions is often the first step in finding potential biomarkers for diagnosis, and targets for pharmaceutical treatments. Parametric statistical tests at the individual gene level have been the conventional approach for finding differentially expressed genes. These tests exhibit high statistical power but …

Dune Dynamics- A Nature-Based Preschool, Aseel Alhaidari

Theses and Dissertations

Sustainability is a global issue that requires collaborative efforts. Environmental values and attitudes are shaped in adults by early exposure to nature. During the COVID-19 pandemic, remote learning increased the attention to nature-based learning from families and the press (Prochner, 2021).

Although many early childhood education approaches for the age group of 3-5 years recognize the importance of holistic development and focus on tailoring the learning experience to the developmental stage of young children, few emphasize the importance of integrating nature as one of the learning tools. Nature-deficit disorder in children means that children spend less time outdoors and in …

Mathematical Modeling And Analysis Of Inflammation And Tissue Repair: Lung Inflammation And Wound Healing In Corals Under Stress, Quintessa Hay

Theses and Dissertations

A variety of insults, including tissue injury and/or exposure to pathogen, elicit an immune response in many organisms. An improperly regulated immune response can result in deleterious effects to the organism. Here we present models for lung injury in young and old mice and models for wound healing in coral reefs.

It is well known that the immune response becomes less effective in older individuals. This is of particular interest in pulmonary insults such as ventilator induced lung injury (VILI) or lung infection. We extended a mathematical model for the inflammatory response to VILI and used experimental data to select …

Dynamic Mathematical Approaches To Understanding Pain In Sickle Cell Disease, Quindel Jones

Theses and Dissertations

In the last 50 years, pain in Sickle Cell Disease (SCD) has become more widely studied thanks to advancements in technology and awareness. Clinical studies, population surveys, pharmaceutical trials, and computational models have been created and conducted to elucidate the mechanisms, treatments, and prediction of Sickle Cell disease pain episodes. Computational models have become quite useful in unraveling disease pathology with the rise in data collection accessibility and advanced computational power. In particular, dynamic mathematical models have been used to investigate Sickle Cell disease pathology and treatment. In this work we conduct a literature review of mathematical models used in …

African American Adolescents' Exposure To Community Firearm Violence And Associated Factors, Colleen S. Walsh

Theses and Dissertations

Firearm violence is a public health crisis in the United States that disproportionately impacts African American adolescents and families living in economically marginalized communities. The current firearm violence exposure literature includes a limited focus on the (a) the identification of risk and promotive factors that influence the likelihood of exposure to community firearm violence, (b) is cross-sectional, (c) focuses on outcomes of firearm violence exposure, and (d) does not examine bi-directional relations to determine if risk and promotive factors are causes and/or consequences of firearm violence exposure. This gap in research is further exacerbated by the limited focus on African …

Stereotypes Of A Black Man Misunderstood: The Experiences And Development Of Black Men With Bipolar Disorder On College Campuses, Gerron Scott

Theses and Dissertations

Black men graduate from universities at a lower rate compared to other groups. Students with disabilities also graduate at a lower rate. When the two groups intersect, the results can be disastrous. Black men with bipolar disorder face a host of problems on college campuses. From a lack of sense of belonging to trouble in class, they struggle to stay afloat in college. The purpose of this study was to document the experiences and development of Black men with bipolar disorder on college campuses. A grounded theory approach was used in this study. Grounded theory was chosen because it leads …

Revealing The Elusive Mechanism Of Action Of The Lipid Chaperone Fatty Acid Binding Protein 4, Abdul J. Castillo Ibanez

Theses and Dissertations

Fatty acid binding proteins (FABPs) are pivotal in orchestrating lipid trafficking within cells. This dissertation aims to reveal the mechanism of action of adipocyte FABP (FABP4) by meticulously detailing steps for producing uniformly isotopically labeled protein, understanding dynamics and structural changes in aqueous conditions, analyzing protein-membrane interaction with membrane mimicking models, and revealing its membrane-bound state through novel NMR structural elucidation. Chapter 1 provides an overview of FABP4's indispensable role in lipid trafficking, emphasizing its significance in maintaining cellular homeostasis and metabolic regulation. Chapter 2 delves into the optimization of FABP4 protein expression and proposes a high yield recovery and …

Double Jointed: Gendered Flexibility And The Overextended Self, Grace A. Bromley

Theses and Dissertations

This thesis explores compulsory domesticity and the impulse to overextend oneself, both pressures often associated with the construct of femininity. Through diving into my personal history, which includes growing up in a three-generational home of women, I explore mimesis as it functions in both the replication of identity and in terms of pictorial representation; specifically I address its relationship to gender, manifestation within the body, and the search for subjectivity through the process of making and thinking. In various forms of material explorations, I play with ideas of malleability, mimicry and “embedded” behaviors that are passed down and embodied in …

The Neural Mechanisms Of Inter-Friend Aggression, Wyatt Brown

Theses and Dissertations

Decades of research concerns intimate partner aggression (IPA). While important to understand and prevent, investigations of IPA largely ignore another vital social relationship: close friendships. To investigate aggression between close friends – inter-friend aggression (IFA) – functional neuroimaging analyses enable to assessment of neural activity and mental representations of aggression in different social relationships. As such, 98 participants completed the well-validated Taylor Aggression Paradigm modified for a magnetic resonance environment against their current romantic partner, a close friend, and a stranger. Univariate analyses assessed the differences in the degree of neural activity and the role of Narcissism and negative urgency …

Associations Among Acculturative Stress, Body Ideal Internalization, Body Dissatisfaction And Disordered Eating Behaviors Among Cisgender Heterosexual And Lgbt People Of Color, Taryn Henning

Theses and Dissertations

Research supports the relation between acculturative stress and disordered eating behaviors (DEBs) across racially and ethnically diverse groups of men and women. However, there is minimal research examining factors that further explain the relation between acculturative stress and DEBs. Also, this relation has not been evaluated in racially and ethnically diverse LGBT individuals. The current study aimed to address these gaps by examining the role of thin-, muscular-, and hourglass-ideal internalization and body dissatisfaction as mediators of the relation between acculturative stress and disordered eating behaviors among cisgender heterosexual Black, Latine, Asian American, Multiracial men and women and LGBT men …

Reflection: Cultivating Creativity And Healing Through Art Therapy, Caroline Ciccone

Theses and Dissertations

I was first introduced to the healing powers of art after working in an orphanage in Jamaica with children who had a wide range of disabilities. Some children were mute or unable to communicate, but art was a form of communication that brought us all together. Within the City of Richmond public school system, 31.7% of students are economically challenged and 13.1% of students are disabled (Education, 2022). Giving more resources in the arts and mental health support to students outside of their school environments is the goal. Art therapy helps reduce the dropout rate and improve mental health (10 …

Age Of First Dental Visit And Early Childhood Oral Health Quality Of Life, Richard Greene

Theses and Dissertations

Objective: This project aims to examine the association between the age of a child's first dental visit and their Early Childhood Oral Health Impact Scale (ECOHIS) score.

Methods: A 22-item cross-sectional survey was distributed to caregivers of healthy children aged 5 years and younger with an American Society of Anesthesiology (ASA) I and II status who presented for new patient exams.

Results: In total, 117 caregivers participated in the survey. The ECOHIS was assessed on a 5-point Likert scale and scores ranged from 0-52; higher values indicate poor oral health having a greater impact on the child and family. Those …

Particl Plant Medicine, Tommye Dean

Theses and Dissertations

In an era marked by a growing recognition of mental health as a critical component of overall well-being, unconventional approaches to therapeutic interventions have gained prominence. One such intervention coincides with the importance of setting the intersection of psychedelic therapy and interior design, creating a synergistic environment for emotional healing and self-discovery. This thesis ventures to delve into the uncharted territory where the realms of altered states of consciousness and thoughtful spatial design converge, seeking to discover the profound impact this collaboration may have on the therapeutic and design landscape.

Assessment Of Maxillary Sinus Pneumatization In Dentate And Edentulous Areas Using Cone Beam Computed Tomography, Catherine Ramundo

Theses and Dissertations

Objectives: The primary goal of this retrospective analysis is to analyze the morphologic changes that occur following extraction in regards to sinus pneumatization.

Methods: The patient population was selected from the VCU School of Dentistry Graduate Periodontics Department. Cone Beam Computed Tomography scans (CBCT) was obtained from patients that had a posterior tooth extracted. A horizontal tangent line was drawn to the inferior border of the nasal cavity, acting as a constant reference point for measuring the extent of maxillary sinus pneumatization. Radiographic measurements were performed from a horizontal line at this fixed anatomical marker to the deepest level of …

The Value Of Educating Teachers, Coaches, And Athletic Trainers On The Management Of Dental Trauma., Darlene W. Jean

Theses and Dissertations

Purpose: To investigate the benefit of educating teachers, coaches, and athletic trainers about dental trauma to prevent incidents and improve the management of students/athletes with dental trauma.

Methods: Teachers, coaches, and athletic trainers throughout the greater Richmond metro area were recruited via email. Participants answered a pre-seminar survey to evaluate their baseline knowledge and determine whether they have experienced dental trauma with their students/athletes previously. The participants were given the option to attend an in-person or virtual seminar educating them on the basic management of traumatic dental injuries and how to guide affected students/athletes and their families to obtain optimal …

Zaytouna: Rooted Histories In Uprooted Memories, Naima M. Almajdobah

Theses and Dissertations

Palestinians, whether living under occupation or—like myself—in the diaspora, experience a complex journey of displacement and dispossession stemming from the Nakba of 1948. This reality shapes our collective identity, rooted in our connection to our homeland.

Zaytouna explores an under-researched topic: the relationship between the olive tree and uprooted Palestinians. It reveals a rich tapestry of narratives that encompass the quintessential and everlasting relationship between a land and its people. The resulting interactive archival installation consists of two parts: audio recordings from Palestinians in the diaspora, which capture their memories and voices; and visuals, which represent the storytellers’ places of …

Range-Wide Analysis Of The Genetic Diversity And Genetic Structure Of The Spotted Turtle (Clemmys Guttata), Madison S. Whitehurst

Theses and Dissertations

Understanding the spatial distribution of genetic diversity and structure in endangered species is vital for effective conservation management. This research discusses the results of an initial analysis of the genetic structure and variation of the spotted turtle (Clemmys guttata), a species of conservation interest. The study sampled 913 individuals from 78 unique locales across 16 states in the eastern portion of the species' range. Utilizing ddRADSeq, a de novo genome assembly was developed to identify nearly 20,000 potential loci. A total of 926 were selected for this analysis. Results revealed no spatial clustering of genetic diversity or structure, …

Clinical Outcomes Of Primary Anterior Esthetic Crowns In Pediatric Dentistry, Jenan Alahmad

Theses and Dissertations

Clinical Outcomes of Primary Anterior Esthetic Crowns in Pediatric Dentistry - A Prospective Cohort Study

By: Jenan Alahmad, BDS

A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Dentistry at Virginia Commonwealth University.

Virginia Commonwealth University, 2024

Thesis Advisor: Parthasarathy Madurantakam, DDS, MDS, PhD

Department of Pediatric Dentistry

BODY

Purpose: This prospective cohort study aimed to compare the effectiveness of restoring maxillary anterior teeth in children (aged 3-6 years) with three different materials: Zirconia Crowns (ZC), Resin Composite Crowns (RC), and Pre-veneered Stainless-Steel Crowns (PVSSC). The study aims to assess the Oral …

A Preliminary Report Of A Randomized Controlled Clinical Trial Comparing Ferric Sulfate With Zin Oxide Eugenol And Non-Eugenol Based Material For Pulpotomy In Primary Molar Teeth, Sarah Balal

Theses and Dissertations

Purpose: This study aimed to evaluate the effect of eugenol and non-eugenol-based Zinc Oxide Eugenol (ZOE) cements on primary tooth pulpotomies where Ferric Sulfate (FS) is used as a medicament.

Methods: Children aged 3-7 years with dental caries in their primary molars that have clinical and radiographic diagnosis of reversible pulpitis and undergoing dental treatment under Oral Conscious Sedation (OCS) or General Anesthesia (GA) were recruited. Children were randomly assigned to receive either FS and ZOE (IRM) or FS and non-eugenol based (CAVIT). The outcomes were assessed based on failure rates of the materials separately for clinical or radiographic evidence …

Established Colonization Of Sneathia Vaginalis In A Mouse Model, Kailyn E. Turcios-Gonzalez

Theses and Dissertations

Sneathia vaginalis (Sv) is a gram-negative anaerobic bacterium associated with adverse reproductive outcomes. Sv can traverse the fetal membrane and damage epithelial cells in vitro by producing a pore-forming cytotoxin, cytopathogenic toxin A (CptA). To further understand the transition of Sv from normal flora to a pathogen, an animal in vivo model needs to be created to observe the preliminary ascending infection before we begin to study the effects on pregnancy. Experimentation was conducted to optimize mouse breed, bacteria administration methods, and other variables that arise when working in vivo. The C57BL/6 mouse strain displayed the most consistent …

Acute Effects Of An Oral Nicotine Pouch In People Who Use Smokeless Tobacco, Alisha Eversole

Theses and Dissertations

People who use smokeless tobacco (SLT) are exposed to a variety of carcinogenic toxicants, yet, despite health risks, nearly 6 million people in the US use SLT. SLT contains and delivers nicotine, a psychostimulant that causes dependence and hinders cessation efforts. An orally-administered nicotine pouch marketed as “tobacco-free” recently has become available for purchase in the US. However, there are very few non-industry-sponsored studies regarding the effects of these oral nicotine pouches.

The current study used clinical laboratory methods to determine the acute effects of an oral nicotine pouch in people who use SLT. Participants completed four sessions (within subjects, …