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Full-Text Articles in Entire DC Network
[2009-08-12] Meeting Of The External Relations Committee, Virginia Commonwealth University. Board Of Visitors
[2009-08-12] Meeting Of The External Relations Committee, Virginia Commonwealth University. Board Of Visitors
VCU Board of Visitors Minutes
Official minutes of the VCU Board of Visitors and its Executive Committee.
[2009-08-12] Meeting Of The Finance, Investment And Property Committee, Virginia Commonwealth University. Board Of Visitors
[2009-08-12] Meeting Of The Finance, Investment And Property Committee, Virginia Commonwealth University. Board Of Visitors
VCU Board of Visitors Minutes
Official minutes of the VCU Board of Visitors and its Executive Committee.
Identification Of Clinical, Laboratory And Genetic Covariates For Pharmacokinetics, Efficacy And Toxicity Of Sorafenib In Patients With Solid Tumors, Lokesh Jain
Theses and Dissertations
The goal of this research work was to understand the clinical-pharmacology based treatment approaches for sorafenib. Treatment with sorafenib is associated with high inter-patient variability in pharmacokinetic exposures, efficacy and toxicity. We explored the demographic, laboratory, clinical and pharmacogenetic factors to elucidate the sources of variability. In addition, we examined the impact of pharmacogenetic variation in VEGFR2, an important mediator of the VEGF pathway, on risk of prostate cancer. To support these investigations, (mainly single-dose) pharmacokinetic, pharmacogenetic, efficacy and toxicity information were collected from patients with solid tumors, enrolled in five phase I / II clinical trials at National Cancer …
Mobile Exhibition System, Sanford Jillian Columbus
Mobile Exhibition System, Sanford Jillian Columbus
Theses and Dissertations
Through the development and design of a Mobile Exhibition System (MES) in this thesis, I will demonstrate the benefits and possibilities of a flexible and mobile system within an exhibition environment. A flexible system will be able to adapt to a wide range of content, while at the same time, maintaining a synergy between its form and function. By the reuse and reappropriation of shipping containers as the exhibition envelope, the goal of mobility can be achieved, reaching out to those who might not otherwise experience learning through an exhibition environment.
The Use Of A Tri-Axial Accelerometer To Measure Changes In Lower Extremity Fatigue During Functional Activity, Kristin Morgan
The Use Of A Tri-Axial Accelerometer To Measure Changes In Lower Extremity Fatigue During Functional Activity, Kristin Morgan
Theses and Dissertations
In 2004, the National Collegiate Athletic Association reported ankle sprain as the most frequent injury in soccer, basketball, and volleyball players. Further research found an increased likelihood with fatigue. Measuring fatigue during functional activities has been a longstanding problem. In this study, changes in ankle biomechanics were measured using a tri-axial accelerometer embedded in the shoe as subjects (n=12) performed a fatiguing activity. Data were collected from the accelerometer and from established devices that are considered the industry gold standard. Several kinetic and kinematic accelerometer derived variables were highly correlated with these standards (r2>0.90) and were associated with changes …
Adenosine Dimethyltransferase Ksga: Biochemical Characterization Of The Protein And Its Interaction With The 30s Subunit, Pooja Desai
Theses and Dissertations
Ribosomes form the core of the protein biosynthesis machinery and are essential to life. Ribosome biogenesis is a complex cellular process involving transcription of rRNA, pre-rRNA processing, rRNA modification and simultaneous assembly of ribosomal proteins. RNA nucleotide modification is observed in all domains of life. While there is enormous conservation of ribosome structure, very few post-transcriptional rRNA modifications have been conserved throughout evolution. A notable example of such rare conservation is the dimethylation of two adjacent adenosines in the 3’-terminal helix, a highly conserved region of the small subunit rRNA. Enzymes that carry out these dimethylations are equally conserved and …
An Examination Of The Decision Analysis Approach To R&D Portfolios, Kelly Duncan
An Examination Of The Decision Analysis Approach To R&D Portfolios, Kelly Duncan
Theses and Dissertations
A portfolio can be defined as “a purposeful combination of items” (Chien and Sainfort 1998). As the topic relates to research and development (R&D) the items in question are technologies, projects or products under consideration for inclusion in a given portfolio. As described by surveys from Cooper et al (1998), companies have widely varying practices for portfolio selection. This thesis examines existing literature to determine the key characteristics of good portfolio and portfolio method. The approach needs to handle multiple objectives, account for project interactions, and address the social aspect of decision making. The resulting portfolio should be aligned with …
Mutagenesis And Spectroscopic Studies Of Mycobacterium Tuberculosis Sterol 14alpha Demethylase., Anuja R. Modi
Mutagenesis And Spectroscopic Studies Of Mycobacterium Tuberculosis Sterol 14alpha Demethylase., Anuja R. Modi
Theses and Dissertations
P450s are heme containing enzymes which affect oxidation of substrates via catalytic intermediates having transient lifetimes. These oxidative catalytic intermediates are formed by a sequential interplay of electrons and protons at the active site of the enzyme bearing molecular dioxygen. The proton transfer to the active site from bulk solvent is coordinated by an “acid-alcohol” pair of active site residues which are conserved in all P450s. Sterol 14α-demethylases (CYP51) are P450 enzymes which catalyze oxidative deformylation of lanosterol in the cholesterol/ergosterol biosynthetic pathway. Both cholesterol and ergosterol are important regulators of membrane fluidity. CYP51 differs from other P450s in that …
Schizophrenia Candidate Genes Study, Grace Lee
Schizophrenia Candidate Genes Study, Grace Lee
Theses and Dissertations
Schizophrenia is a debilitating disorder caused by the interaction of genetic and environmental factors. In this study, we identified candidate genes and single nucleotide polymorphisms from two genome-wide association studies, GAIN and CATIE. Nine SNPs representing four candidate genes were selected for replication studies with our Irish samples: Irish Case-Control Study of Schizophrenia (ICCSS), the Irish Study of High-Density Schizophrenia Families (ISHDSF), and the Irish Trio Study of Schizophrenia (ITRIO). In the ITRIO sample, rs4704591 (CMYA5 gene) showed nominal significance (p = 0.0447947). Combining ICCSS, ISHDSF, and ITRIO samples for rs4704591 increased sample size and power and yielded a p-value …
Evaluation Of Association Of Microrna-122 With Histological Severity Of Recurrent Hcv Infection In Liver Transplant Recipients, Jihee Suh
Theses and Dissertations
Hepatitis C virus recurrence (which is defined by detection of HCV RNA in serum) in post-transplanted liver is universal but the progression of infection remains unpredictable, varying from case to case. It has been estimated that 75%-80% of the HCV recurrence patients will suffer chronic hepatitis C infection and up to a third of them will progress into the development of fibrosis and cirrhosis within 5 years post-transplantation. Therefore, finding ways to predict early on the progression of fibrosis can contribute to better prognoses. Recent literatures have mentioned that the hepatitis C virus relies on the host microRNA-122 (miR-122) for …
Age-Related Differences In In-Vitro Sensitivity To Inhibition Of Human Red Blood Cell Acetylcholinesterase And Plasma Butyrylcholinesterase By The Cholinesterase Inhibitors Physostigmine (Phys), Pyridostigmine (Pyr), Donepezil (Don) And Galantamine (Gal), David Lee
Theses and Dissertations
Alzheimer’s disease (AD) is a chronic, progressive neurodegenerative disorder, characterized clinically by a progressive loss of memory, cognitive function, ability to care for oneself and psychiatric symptoms. First-line agents for the treatment of AD are ChE inhibitors (DON, GAL), whose modest clinical efficacy and the high incidence of dose-limiting toxicities limit their clinical utility. In addition to AD, ChE inhibitors (PYR) are used for other medical conditions, such as myasthenia gravis (MG). Furthermore, ChE inhibitors (PYR) are used by military personnel prophylactically if impending exposure to chemical warfare agents, e.g., soman, is suspected. The purpose of this research project was …
Creating An Environmentally Sustainable Costume Shop, Katherine Stone
Creating An Environmentally Sustainable Costume Shop, Katherine Stone
Theses and Dissertations
The goal of my thesis is to provide the reader with a better understanding of how to create an environmentally sustainable costume shop. I chose to focus on certain elements of the costume shop that are imperative to the function of the shop, but desperately need to change for the sake of the environment. The elements I focused on were fabric, energy, and chemicals. Armed with a better understanding of why and what needs to be changed, the reader will be able to take this knowledge and apply it to their costume shop and life. We need to change how …
A Cellular Mechanism For Dendritic Spine Loss Following Traumautic Brain Injury In Rat, Brian Low
A Cellular Mechanism For Dendritic Spine Loss Following Traumautic Brain Injury In Rat, Brian Low
Theses and Dissertations
Traumatic brain injury is a leading cause of death and disability in the United States. The injury is often composed of two processes: the primary injury, which can involve irreversible loss of tissue, and the secondary injury, which involves a cascade of reactive processes such as excitotoxicity that occur in the hours and days after the initial insult. Excitotoxic stimulation of neuronal circuits can lead to cellular dysfunction and modulation of neuronal sensitivity. One mechanism of dysfunction involves the calcium-regulated phosphatase, calcineurin. Calcineurin has been shown to be involved in the modulation of the neuronal post-synaptic structures known as dendritic …
To Evaluate The Level Of Agreement Between Two Self-Reported Medication Adherence Scales And Prescription Refill Records In Older Adults, Priyanka Kakad
To Evaluate The Level Of Agreement Between Two Self-Reported Medication Adherence Scales And Prescription Refill Records In Older Adults, Priyanka Kakad
Theses and Dissertations
Objective: To evaluate the level of agreement between two self-reported medication adherence scales and prescription refill records in older adults. Design: Cross-sectional study Setting: Imperial Plaza; a retirement community located in Richmond, Virginia. Participants: 32 independent-living older adults, taking anti-hypertensive medications and filling their prescriptions at on-site Plaza Professional Pharmacy were recruited in the study. Methods: Participants’ 6 months refill records were obtained and Medication Possession Ration (MPR) was calculated. Participants were interviewed using Morisky Medication Adherence Scale (MMAS) & Brief Medication Questionnaire (BMQ). Kappa statistics was used to evaluate the level of agreement. Results: Poor level of agreement was …
Spatial Detection Of Multiple Movement Intentions From Sam-Filtered Single-Trial Meg For A High Performance Bci, Harsha Battapady
Spatial Detection Of Multiple Movement Intentions From Sam-Filtered Single-Trial Meg For A High Performance Bci, Harsha Battapady
Theses and Dissertations
The objective of this study is to test whether human intentions to sustain or cease movements in right and left hands can be decoded reliably from spatially filtered single trial magneto-encephalographic (MEG) signals. This study was performed using motor execution and motor imagery movements to achieve a potential high performance Brain-Computer interface (BCI). Seven healthy volunteers, naïve to BCI technology, participated in this study. Signals were recorded from 275-channel MEG and synthetic aperture magnetometry (SAM) was employed as the spatial filter. The four-class classification for natural movement intentions was performed offline; Genetic Algorithm based Mahalanobis Linear Distance (GA-MLD) and direct-decision …
Crafting Authenticity, Allison N. Schumacher
Crafting Authenticity, Allison N. Schumacher
Theses and Dissertations
Authenticity is what we want from the world around us, from others, and crucially from ourselves and what we make. As it relates to graphic design, I define authenticity as a perceived match between form and purpose. For the designer, its quality is found in the process of simultaneously developing a concept and crafting the design/object.
A Sequential Algorithm To Identify The Mixing Endpoints In Liquids In Pharmaceutical Applications, Akriti Saxena
A Sequential Algorithm To Identify The Mixing Endpoints In Liquids In Pharmaceutical Applications, Akriti Saxena
Theses and Dissertations
The objective of this thesis is to develop a sequential algorithm to determine accurately and quickly, at which point in time a product is well mixed or reaches a steady state plateau, in terms of the Refractive Index (RI). An algorithm using sequential non-linear model fitting and prediction is proposed. A simulation study representing typical scenarios in a liquid manufacturing process in pharmaceutical industries was performed to evaluate the proposed algorithm. The data simulated included autocorrelated normal errors and used the Gompertz model. A set of 27 different combinations of the parameters of the Gompertz function were considered. The results …
Chaperone Expression And Effects Of Its Inhibition On Breast Cancer Sensitization, Malissa Diehl
Chaperone Expression And Effects Of Its Inhibition On Breast Cancer Sensitization, Malissa Diehl
Theses and Dissertations
Breast cancer is one of the most prevalent and deadly forms of cancer in women and is not restricted by race or ethnicity. Although a wealth of knowledge has been amassed on the biology of breast cancer, including its risk factors, diagnosis, prognosis, prevention, and treatment, it remains a serious health concern and active area of research. Initial response to standard chemotherapeutic and radiotherapeutic regimens is generally strong for many patients, yet breast tumors often recur, leading to more aggressive and resistant tumors. Because recurrence is such a clinical issue, more effective therapeutic approaches are needed to eliminate partial clinical …
The Potential Role For Capb In Pathogenesis Of Francisella Tularensis, Eric Fleming
The Potential Role For Capb In Pathogenesis Of Francisella Tularensis, Eric Fleming
Theses and Dissertations
Francisella tularensis was a facultative intracellular pathogen and a gram-negative coccobacillus which has been categorized by the CDC as a potential class A select agent due to its highly infectious properties and high mortality rates. Francisella tularensis was also responsible for the zoonotic disease tularemia, which was usually transmitted by arthropod vectors or via contact with infected animals. Francisella tularensis subspecies novicida has been used by many researchers in genetic pathogenesis experiments to try to elucidate genes responsible for virulence factors. One of these virulence factors was a capsular material which has been thought to be involved in either increasing …
A Matter Of National Concern: The Kennedy Administration And Prince Edward County, Virginia, Brian Lee
A Matter Of National Concern: The Kennedy Administration And Prince Edward County, Virginia, Brian Lee
Theses and Dissertations
A MATTER OF NATIONAL CONCERN examines the Kennedy Administration’s contribution to the restoration of public education in Prince Edward County, Virginia, and determines if those actions support the dominant narrative of Kennedy’s overall civil rights record – a historical assessment generally generated from a few acute crises. For five consecutive years (1959-1964), in defiance of federal court orders, the county board of supervisors refused to levy taxes to operate public schools, marking Prince Edward County as the only locale in the nation without free public education. The county leadership organized a segregated private school system for the 1,400 white children, …
Predictors Of Smoking Initiation In African American Adolescents, Jennifer Kienzle
Predictors Of Smoking Initiation In African American Adolescents, Jennifer Kienzle
Theses and Dissertations
Cigarette smoking and other forms of tobacco use are responsible for over 440,000 deaths per year in the U.S. Health consequences associated with cigarette smoking include cardiovascular disease, respiratory disease, and cancer. Despite awareness of the health risks, approximately 21% of the U.S. adult population smokes. Efforts to-date to reduce smoking-related disease and illness have focused on prevention and intervention strategies that encourage cessation. Adolescence is a critical period for both intervention and prevention. Because more than three-fourths (80%) of adult smokers reported starting to smoke prior to the age of 18, prevention and brief intervention is likely to be …
The Production And Filtration Efficiency Testing Of Nonwoven Electrospun Fiber Mats, Jan Uecker
The Production And Filtration Efficiency Testing Of Nonwoven Electrospun Fiber Mats, Jan Uecker
Theses and Dissertations
In this thesis the production and filtration performance of electrospun nylon-4,6 nanofiber mats was experimentally studied. The average fiber diameter of nylon-4,6 fibers is controlled by altering the polymer concentration in solution. Adding small amount of pyridine to the electrospinning solution controlled fiber beading and other defects. These fibers were then deposited onto a wide variety of conductive and dielectric substrate materials. A corona ion source was used to eliminate surface charging effects observed at the surface of all substrates. The resulting fiber mats, uniform in size and distribution as verified by SEM imaging, are tested for filtration efficiency and …
The Regulation Of Platelet Activating Factor Acetylhydrolase By Oxidized Phospholipids, Rachael Griffiths
The Regulation Of Platelet Activating Factor Acetylhydrolase By Oxidized Phospholipids, Rachael Griffiths
Theses and Dissertations
Platelet-activating factor acetylhydrolase (PAFAH) is elevated in atherosclerosis and may play a role in pathogenesis of this disease. Molecular mechanisms regulating the expression of this lipoprotein-associated PLA2 are indistinct. Mildy oxidized low density lipoprotein (oxLDL) and monocytes (the primary source of PAFAH) are co-localized in early atheromas. Monocytes are activated by oxidized phospholipids (oxPL) in the oxLDL particle. We hypothesized that oxPL-activated monocytes are the source of increased levels of PAFAH in atherosclerosis. We found that PAFAH expression is significantly induced by OxPAPC and in particular long-chain fractions of oxPAPC in monocytes and cytokine-differentiated DC, but not cytokine-differentiated MO. Furthermore, …
Specific Levels Of Therapeutic Ultrasound Stimulate The Release Of Inflammatory And Angiogenic Mediators From Macrophages In Culture, Thomas Turner
Specific Levels Of Therapeutic Ultrasound Stimulate The Release Of Inflammatory And Angiogenic Mediators From Macrophages In Culture, Thomas Turner
Theses and Dissertations
Therapeutic ultrasound (TUS) is a treatment modality that is used to accelerate tissue healing. TUS is thought to affect cellular processes of tissue healing, especially those that occur in the inflammatory and early proliferative phases. TUS can be applied using various parameter selections including intensity, wavelength, duty cycle and treatment duration and no clear consensus exists on optimal parameters for healing enhancement. Macrophages are important mediators of inflammation and their actions are critical to normal progression into the proliferative phase of healing. They complete many functions during these periods of tissue healing, among those being release of cytokines and growth …
Determining Sensitive And Accurate Measures For Detecting Balance Deficits Associated With Functional Ankle Instability, Shelley Linens
Determining Sensitive And Accurate Measures For Detecting Balance Deficits Associated With Functional Ankle Instability, Shelley Linens
Theses and Dissertations
The focus of this study was to determine the balance measures most sensitive and accurate in detecting balance deficits associated with functional ankle instability (FAI). Subjects consisted of those with a history of ankle sprains and resultant symptoms of giving way (N=17; Height=167.72±9.11 cm; Mass=67.81±12.29 kg; Age=23.35±3.62 yrs) and subjects without a history of ankle injuries (N=17; Height=168.16±8.32 cm; Mass=66.22±12.35 kg; Age=23.35±3.26 yrs). Data collection consisted of each subject performing static and dynamic balance tests. Static stability was assessed with force plate measures, the Balance Error Scoring System, foot lift test, and time-in-balance test. Dynamic stability was assessed with the …
Factors Limiting Benthic Algal Abundance In Virginia Streams Of The Coastal Plain, Michael Brandt
Factors Limiting Benthic Algal Abundance In Virginia Streams Of The Coastal Plain, Michael Brandt
Theses and Dissertations
Algae are important components of stream food webs and often used in biomonitoring assessments. Little is known regarding the factors that limit their abundance in streams of the VA Coastal Plain. The surficial geology of the Coastal Plain is predominately sandy deposits which comprise the dominant substrate in streams of this region. In a comparative study of five streams located near the VCU Rice Center, we quantified substrate composition, light availability, and nutrient concentrations to assess their relative importance in determining benthic algal abundance. The proportion of stream area comprised of hard substrates was a significant predictor of variation in …
Novel Allosteric Inhibitors Of Thrombin, Bijoy Desai
Novel Allosteric Inhibitors Of Thrombin, Bijoy Desai
Theses and Dissertations
Thrombin is a critical enzyme involved in blood coagulation and haemostasis. For this reason the study of its interactions with substrates, inhibitors and modulator is essential. It is also a unique enzyme in the serine protease family because unlike enzymes like trypsin and chymotrypsin its activity is modulated by various endogenous and exogenous ligands. This is due to the presence of “exosites” on the thrombin surface. Exosite II, unlike exosite-I, has not been characterized for its allosteric effect. In order to understand the structural basis of interaction and inhibition of inhibitor 4AS, which possibly interacts with exosite-II, native bovine thrombin …
Effect Of Posture On Acromiohumeral Distance With Arm Elevation In Subjects With And Without Rotator Cuff Disease Using Ultrasonography, Nitin Kalra
Theses and Dissertations
Objectives: To examine the effects of posture on subacromial (SA) space with arm elevation in patients with rotator cuff disease (RCD) and healthy subjects. Background: Poor posture has been linked to altered scapular mechanics, theorized to lead to excessive SA space narrowing. However, no study has examined the direct effects of posture on SA space using ultrasonography. We hypothesize that when compared to a neutral posture, upright posture will increase SA space and slouched posture will decrease SA space. Methods: Subjects with painful RCD (n=31) and healthy (n=29) shoulders participated. SA space was measured on ultrasound generated images using the …
Chaperone Association With Telomere Binding Proteins, Amy Depcrynski
Chaperone Association With Telomere Binding Proteins, Amy Depcrynski
Theses and Dissertations
The Hsp90 chaperone complex associates with the telomerase enzyme, facilitating the assembly of the ribonucleoprotein complex. While previous data from our laboratory indicate that Hsp90 and p23 remain stably associated with (functionally active) telomerase, more recent experiments suggest that these chaperones associate with telomeres independent of telomerase, presumably through a specific interaction with telomere binding proteins. The current study examines the novel interactions between TRF2, TRF1, TIN2 and TPP1 and molecular chaperones (Hsp90, Hsp70, p23). In vitro and in cell experiments have shown an interaction between TRF1 and TRF2 and the molecular chaperones Hsp90 and Hsp70. Inhibition of Hsp90 using …
Fabrication And Characterization Of Bioactive, Composite Electrospun Bone Tissue Engineering Scaffolds Intended For Cleft Palate Repair, Parthasarathy Madurantakam
Fabrication And Characterization Of Bioactive, Composite Electrospun Bone Tissue Engineering Scaffolds Intended For Cleft Palate Repair, Parthasarathy Madurantakam
Theses and Dissertations
Tissue Engineering is a scientific discipline that aims to regenerate tissues and organs that are diseased, lost or congenitally absent. It encompasses the use of suitable synthetic equivalents of native extracellular matrix that may or may not be supplemented with cells or relevant growth factors. Such scaffolds are designed to reside at the site of implantation for a variable period of time during which they induce the regeneration of native tissue. During this time, they also provide a template for new cells to attach, infiltrate, differentiate into appropriate phenotype and eventually restore function of the concerned tissue. Among the factors …