Digital Commons Network^™

Development And Vulnerability Factors In Adolescent Alcohol Use, Karen G. Chartier, Michie N. Hesselbrock, Victor M. Hesselbrock

Social Work Publications

This article provides an overview of the characteristics of adolescent alcohol use, normative and subgroup variations in drinking behavior, and important factors associated with an increased risk for developing alcohol problems in later adolescence and young adulthood. A parental/family history of alcoholism, temperament traits, conduct problems, cognitive functioning, alcohol expectancies, and peer and other social relations are identified as influencing an adolescent’s susceptibility for initiating a variety of alcohol use behaviors. The Deviance Prone Model, proposed by Sher (1991), is presented as an important tool for testing possible relationships among the various risk factors and their sequencing that leads to …

Focused Attention, Open Monitoring And Automatic Self-Transcending: Categories To Organize Meditations From Vedic, Buddhist And Chinese Traditions, Fred Travis, Jonathan Shear

Philosophy Publications

This paper proposes a third meditation-category—automatic self-transcending— to extend the dichotomy of focused attention and open monitoring proposed by Lutz. Automatic self-transcending includes techniques designed to transcend their own activity. This contrasts with focused attention, which keeps attention focused on an object; and open monitoring, which keeps attention involved in the monitoring process. Each category was assigned EEG bands, based on reported brain patterns during mental tasks, and meditations were categorized based on their reported EEG. Focused attention, characterized by beta/gamma activity, included meditations from Tibetan Buddhist, Buddhist, and Chinese traditions. Open Monitoring, characterized by …

Traumatic Brain Injury And The Effects Of Diazepam, Diltiazem, And Mk-801 On Gaba-A Receptor Subunit Expression In Rat Hippocampus, Cynthia J. Gibson, Rebecca C. Meyer, Robert J. Hamm

Psychology Publications

Background

Excitatory amino acid release and subsequent biochemical cascades following traumatic brain injury (TBI) have been well documented, especially glutamate-related excitotoxicity. The effects of TBI on the essential functions of inhibitory GABA-A receptors, however, are poorly understood.

Methods

We used Western blot procedures to test whether in vivo TBI in rat altered the protein expression of hippocampal GABA-A receptor subunits α1, α2, α3, α5, β3, and γ2 at 3 h, 6 h, 24 h, and 7 days post-injuy. We then used pre-injury injections of MK-801 to block calcium influx through the NMDA receptor, diltiazem to block L-type voltage-gated calcium influx, …

A Survey Of Current Software For Network Analysis In Molecular Biology, Sterling Thomas, Danail Bonchev

Study of Biological Complexity Publications

Software for network motifs and modules is briefly reviewed, along with programs for network comparison. The three major software packages for network analysis, CYTOSCAPE, INGENUITY and PATHWAY STUDIO, and their associated databases, are compared in detail. A comparative test evaluated how these software packages perform the search for key terms and the creation of network from those terms and from experimental expression data.

A High-Throughput Cloning System For Reverse Genetics In Trypanosoma Cruzi, Michel Batista, Fabricio K. Marchini, Paola A.F. Celedon, Stenio P. Fragoso, Christian M. Probst, Henrique Preti, Luiz S. Ozaki, Gregory A. Buck, Samuel Goldenberg, Marco A. Krieger

Study of Biological Complexity Publications

Background

The three trypanosomatids pathogenic to men, Trypanosoma cruzi, Trypanosoma brucei andLeishmania major, are etiological agents of Chagas disease, African sleeping sickness and cutaneous leishmaniasis, respectively. The complete sequencing of these trypanosomatid genomes represented a breakthrough in the understanding of these organisms. Genome sequencing is a step towards solving the parasite biology puzzle, as there are a high percentage of genes encoding proteins without functional annotation. Also, technical limitations in protein expression in heterologous systems reinforce the evident need for the development of a high-throughput reverse genetics platform. Ideally, such platform would lead to efficient cloning and …

A Signal Processing Method To Explore Similarity In Protein Flexibility, Simina Vasilache, Nazanin Mirshahi, Soo-Yeon Ji, James Mottonen, Donald J. Jacobs, Kayvan Najarian

Computer Science Publications

Understanding mechanisms of protein flexibility is of great importance to structural biology. The ability to detect similarities between proteins and their patterns is vital in discovering new information about unknown protein functions. A Distance Constraint Model (DCM) provides a means to generate a variety of flexibility measures based on a given protein structure. Although information about mechanical properties of flexibility is critical for understanding protein function for a given protein, the question of whether certain characteristics are shared across homologous proteins is difficult to assess. For a proper assessment, a quantified measure of similarity is necessary. This paper begins to …

Parametric Frailty Models For Clustered Data With Arbitrary Censoring: Application To Effect Of Male Circumcision On Hpv Clearance, Xiangrong Kong, Kellie Archer, Lawrence H. Moulton, Ronald H. Gray, Mei-Cheng Wang

Biostatistics Publications

Background

In epidemiological studies, subjects are often followed for a period during which study outcomes are measured at selected time points, such as by diagnostic testing performed on biological samples collected at each visit. Although test results may indicate the presence or absence of a disease or condition, they cannot provide information on when exactly it occurred. Such study designs generate arbitrarily censored time-to-event data, which can include left, interval and right censoring. Adding to this complexity, the data may be clustered such that observations within the same cluster are not independent, such as time to recovery of an infectious …

Making Informed Choices About Microarray Data Analysis, Mark A. Reimers

Biostatistics Publications

This article describes the typical stages in the analysis of microarray data for non-specialist researchers in systems biology and medicine. Particular attention is paid to significant data analysis issues that are commonly encountered among practitioners, some of which need wider airing. The issues addressed include experimental design, quality assessment, normalization, and summarization of multiple-probe data. This article is based on the ISMB 2008 tutorial on microarray data analysis. An expanded version of the material in this article and the slides from the tutorial can be found at http://www.people.vcu.edu/~mreimers/OGMDA/index.html.

Virginia Dental Journal (Vol. 87, No. 4, 2010)

Virginia Dental Journal

No abstract provided.

Immigration And Domestic Politics In South Africa: Contradictions Of The Rainbow Nation, Vernon D. Johnson

Ethnic Studies Review

The region of Southern Africa has been part of the global capitalist system since its inception in the late 15th century, when Portugal incorporated Angola and Mozambique into its empire. In 1652 the Dutch East India Company established a "refreshment station" at the Cape of Good Hope for ships travelling between Europe and the Far East.1 From that time the region has experienced several periods of deepening incorporation into the global system.

A Molecular Dynamics Investigation Of Lipid Bilayer Perturbation By Pip2, Dmitry Lupyan, Mihaly Mezei, Diomedes E. Logothetis, Roman Osman

Physiology and Biophysics Publications and Presentations

Abstract

Phosphoinositides like phosphatidylinositol 4,5-bisphosphate (PIP₂) are negatively charged lipids that play a pivotal role in membrane trafficking, signal transduction, and protein anchoring. We have designed a force field for the PIP₂ headgroup using quantum mechanical methods and characterized its properties inside a lipid bilayer using molecular dynamics simulations. Macroscopic properties such as area/headgroup, density profiles, and lipid order parameters calculated from these simulations agree well with the experimental values. However, microscopically, the PIP₂ introduces a local perturbation of the lipid bilayer. The average PIP₂ headgroup orientation of 45° relative to the bilayer …

Long-Term Fish Oil Supplementation Induces Cardiac Electrical Remodeling By Changing Channel Protein Expression In The Rabbit Model, Xulin Xu, Min Jiang, Yuhong Wang, Timothy Smith, Clive M. Baumgarten, Mark A. Wood, Gea-Ny Tseng

Physiology and Biophysics Publications and Presentations

Clinical trials and epidemiological studies have suggested that dietary fish oil (FO) supplementation can provide an anti-arrhythmic benefit in some patient populations. The underlying mechanisms are not entirely clear. We wanted to understand how FO supplementation (for 4 weeks) affected the action potential configuration/duration of ventricular myocytes, and the ionic mechanism(s)/molecular basis for these effects. The experiments were conducted on adult rabbits, a widely used animal model for cardiac electrophysiology and pathophysiology. We used gas chromatography - mass spectroscopy to confirm that FO feeding produced a marked increase in the content of n-3 polyunsaturated fatty acids in the phospholipids of …

A National Labor Project: Recovering Unprecedented Numbers Of Working Class Lives And Histories Through Art, Ed Check

Journal of Social Theory in Art Education

I consider this essay an initial mapping where I reconstruct multiple ways of knowing and understanding the lived realities and plights of workers, whether they are manual workers, teachers or artists (Zandy, 2004). I use autobiography from a perspective of Standpoint Theory where I use the lives of working people as theory, method and evidence. I speak from my standpoint of my experiences as being raised white working class and my shift in salary and education to middle class.

Restageactivist Art/Disruptive Technologies, Karen Keifer-Boyd

Journal of Social Theory in Art Education

In this article, I explore, with you, artists’ socio-political disruptions with communication technologies to inspire political action and social change, and how such art can be environmentally and socially useful. How does art function politically? What is activist art? What non-violent forms of dissent or disruptions to harmful practices are possible today with digital technologies, and how do artists manifest political perspectives in their practice?

Decolonizing Development Through Indigenous Artist-Led Inquiry, Christine Ballengee-Morris, James Sanders, Debbie Smith, Kryssi Staikidis

Journal of Social Theory in Art Education

In this article four university art educators explore theories of self-determination and describe decolonizing, approaches to research that are built on mutual trust. As researchers we recognize that (re)presenting the stories of others—especially across international and transcultural boundaries—is both problematic and an ethical challenge. We acknowledge the risks that participants assume when sharing their stories, and follow the culturally sensitive strategy of having collaborating indigenous artists lead the research.

(Pr)Obama Art & Propaganda: Un(Precedent)Ed Visual Collections Of Hope, Progress And Change? [Book Review], Kathleen Keys

Journal of Social Theory in Art Education

Three of these books chronicle visual collections celebrating the nomination, candidacy, and election of Barack Obama. The fourth book explores one particular image from this Obama art movement. Together they document the recent outpouring of fine art, street art, graphic design and other visual work presented and distributed by artists, exhibitions, the Internet and other digital means, and establish a foundation for socially concerned inquiry, and for creating related art education opportunities.

Casino Capers: Exploring The Aesthetics Of Superfluidity, Mary Stokrocki, Bianne Castillo, Michael Delahunt, Laurie Eldridge, Martin Koreck

Journal of Social Theory in Art Education

Casinos are fast becoming sites for display of new Native American (NA) Arts. In such a context, casinos re-represent themselves and their communities through various visual forms and thus change their meanings. In her study of Wisconsin casinos, Stuhr (2004) challenged art educators to consider these visual culture displays as they accommodate new markets. Art in the casino phenomenon is worth investigating and how art educators can explore and/or make sense of this phenomenon is important. Casinos are using artworks as spectacles of pleasure. According to a casino gambling survey conducted by Harrah’s Entertainment, approximately 40 million Americans played slot …

Chicana/Latina Undergraduate Cultural Capital: Surviving And Thriving In Higher Education, Maricela Demirjyn

Ethnic Studies Review

This study addressed the retention of Chicana/Latina undergraduates. The problem explored was one; how these women perceive campus climate as members of a marginalized student population and two; which strategies are used to "survive the system." As a qualitative study, this work was guided by a confluence of methods including grounded theory, phenomenology and Chicana epistemology using educational narratives as data. The analysis indicated that Chicanas/Latinas do maintain a sense of being "Other" throughout their college experiences and this self-identity is perceived as a "survival strategy" while attending a mainstream campus. Further analysis also showed that Chicanas/Latinas begin their college …

Abstracts

Ethnic Studies Review

Abstracts for Ethnic Studies Review, Vol. 33, No. 2, 2010.

How Does Race Operate Among Asian Americans In The Labor Market? : Occupational Segregation And Different Rewards By Occupation Among Native-Born Chinese American And Japanese American Male Workers, Chang Won Lee

Ethnic Studies Review

The effect of race in the U.S. labor market has long been controversial. One posits that racial effects have been diminished since the civil rights movement of the 1960s (Alba & Nee, 2003; Sakamoto, Wu, & Tzeng, 2000; Wilson, 1980). Even if some disparities in labor-market outcomes among race groups are found, advocates of this "declining significance of race" thesis do not attribute these disparities to racial discrimination. They, instead, understand the racial gaps as a result of class composition of racial minority groups, classes represented by larger proportions of the working-class population (Wilson, 1980, 1997) as well as unskilled-immigrant …

Chicano/Mexican "Culture" As A Rational Instrument In The Human Sciences, Alexandro José Gradilla

Ethnic Studies Review

The use of "culture" as an analytical category by social scientists presents an opportunity to examine how professional discursive formations are used to make empirical assertions. The social fact of culture is neither uniform nor unitary. Traditionally, culture has been thought of as a product of disciplinary research, not necessarily a variable for empirical study. When culture is used as a tool or instrument of scientific methodology, it loses its fluid nature as a disciplinary discourse. In this essay, I examine the specific discussion of the epidemiologic health paradox that states that the Chicano/Mexican immigrant "culture" serves as a protective …

Ethnic Studies Review

Ethnic Studies Review

No abstract provided.

Ethnic Studies Review

Ethnic Studies Review

No abstract provided.

Annual Higher Ground Women's Leadership Conference 2010, The Grace E. Harris Leadership Institute At Virginia Commonwealth University

GEHLI - 2026 VCUL Team Project Publications

No abstract provided.

The Impact Of A Coordinated Care Program On Uninsured, Chronically Ill Patients, Jennifer Neimeyer

Theses and Dissertations

This study explored how being enrolled in a program that both coordinates patient care and provides a medical home changes health care utilization for uninsured patients, more specifically those persons with chronic conditions, through the use of the Chronic Care Model and Andersen and Aday’s Behavioral Model for Access to Health Care. Uninsured patients typically seek out care in a fragmented manner, which may lead to ineffective and inefficient care, especially for conditions that may require ongoing treatment and monitoring such as chronic conditions. The methodology used to examine the relationship between the interaction of enrollment and chronic condition status …

Nursing Home Organizational Characteristics And Utilization Of Cancer-Related Medical Services, Chun-Chieh Lin

Theses and Dissertations

Cancer is the second leading cause of death in the U.S and is more common among the elderly. Since frailty and other age related conditions put the elderly at risk for nursing home care, nursing homes may be the site of care and death for many elderly cancer patients. However, there is a large gap in knowledge concerning cancer treatment of elderly nursing home residents. Since residents rely heavily on their nursing facilities, nursing homes might influence them in their treatment decisions. After controlling for resident and nursing home market characteristics, this study applies Andersen’s Behavioral Model to examine whether …

The Impact Of Medicaid Disproportionate Share Hospital Payment On The Provision Of Hospital Uncompensated Care And Quality Of Care, Hui-Min Hsieh

Theses and Dissertations

Medicaid Disproportionate Share Hospital (DSH) payment is one of the major funds supporting health care providers as they treat low-income patients. However, Medicaid DSH payments have been targeted for major budget cuts in many health policy reforms. This study examines the association between the changes in Medicaid DSH payments resulting from the BBA policy changes and hospital outcomes, in terms of hospital provision of uncompensated care and quality of care. Economic theory of non-profit hospital behavior is used as a conceptual framework, and longitudinal data for California short-term, non-federal general acute care hospitals for 1996-2003 are examined. California was especially …

Generation Y And Vocal Fry, Paul Michael Valley

Theses and Dissertations

In this thesis, the author explores a vocal phenomenon called “vocal fry” and why this dysphonia has emerged as one of the primary means of communication for the population referred to as “Generation Y.” The first chapter defines what vocal fry is and why it is of modest value to the stage actor. The second chapter defines the physiological means by which the human body creates sound, what good sound is and how vocal fry is created. The third and fourth chapters define several generations as well as what defines Gen Y, and the communication physiologies associated with those generations. …

The Everyday In America, Janet Bruhn

Theses and Dissertations

Abstract: My vanilla, Grade A, white bread, run-of-the-mill, middle-of-the-road, threadbare, well-worn, moth-eaten, potato sack, butterscotch, grass stained America: Mundane American life is an existence clinging to the ordinary, where a quilt of mass- mediated preferences and ingrained traditions define many people, specifically from north to south and east to west. Yet, the tastes and dialects of people within the mundane are complex. Ideological preferences are rooted in immigrant history and political persuasion. Various modes of realism have been used by American painters such as The Ash Can School, Regionalists of the 1930’s, and Pop Art. The notion of the real …

The Adventures Of A Young Artist, And The Promise Of The Digital Culture In Art, Jonathan Marshall

Theses and Dissertations

An analysis and explanation of my reasons for working in video, painting and drawing, and sculpture, considering the technological developments of the past decade; the possibility to use the internet as a distribution tool for works of art, and to shift the decision-making balance of the art-world; the ways that this approach is a democratic format for output in the arts and within communities of artists; an explanation of my studio practice while a graduate student at Virginia Commonwealth University.