Digital Commons Network^™

Creating A Sustainable Graduate Student Workshop Series, Bettina Peacemaker, Martha Roseberry

VCU Libraries Faculty and Staff Publications

Purpose - This paper reports on librarians’ experience creating and sustaining a workshop and webinar series for graduate students over the course of four years.

Design/methodology/approach - Difficulties hosting and promoting stand-alone graduate workshops and a collaborative method for planning workshop days and webinars are described in this case study. Attendance data were collected and recorded for each event and additional quantitative data were collected via registration forms and post-event surveys.

Findings - Working collaboratively as a department eased planning and promotional responsibilities, allowing for a sustainable workshops series. Focusing on a limited number of events per semester and developing …

Quantitative Analysis Of Tobacco-Specific Nitrosamines And Their Precursor Alkaloids In Tobacco Extracts, Celeste T. Wilkinson

Theses and Dissertations

Tobacco-specific nitrosamines (TSNA) are carcinogenic constituents derived from alkaloids in tobacco. Researchers are actively exploring several avenues to reduce TSNA levels in tobacco products like moist snuff tobacco. The focus of the research presented within is the quantitative analysis of TSNA in tobacco, specifically N’-nitrosonornicotine (NNN), 4-(methylnitrosamino)-1(3-pyridyl)-1-butanone (NNK), N’-nitrosoanatabine (NAT), and N’-nitrosoanabasine (NAB).

Tobacco alkaloids and nitrosamines in tobacco are currently analyzed by different instrumentation due to orders of magnitude difference in their concentrations, chromatographic separation challenges due to structural similarities, and similar mass fragmentation patterns. An analytical column using silica and 1,2-bis(siloxy)ethane hybrid particles of 1.7 µm size is …

Parent-Fostered Enrichment Activities And Academic Outcomes In Middle Childhood, Princess-Melissa T. Washington-Nortey

Theses and Dissertations

Despite numerous educational reforms, elementary school children in the United States continue to lag behind their peers from other developed countries on reading, math and science outcomes. Many interventions focus on strategies aimed at increasing the amount of classroom work children undertake. However, the key to improving outcomes may lie in out of school enrichment activities that facilitate learning. Drawing from Eccles Expectancy-Value theory(Simpkins, Fredricks, & Eccles, 2012), the current study focuses on assessing the impact of parent-fostered enrichment activities on child academic outcomes in the first three years of elementary school. Using secondary data from Early Childhood Longitudinal Study …

Pebbles Is A Girl That Doesn't Know Anything, Grace A. Kubilius

Theses and Dissertations

I am not quite sure how to be a woman. It’s complicated, contradictory and highly surveilled. I make videos, sculptures and wearable objects that attempt to rationalize my female identity. The body is a sustained fixture in my work: as an armature, as an absent actor for constructed environments, as fragment and as the literal inclusion of my image. It is through these various modes of dis/embodiment that I negotiate the complexities of gendered existence. Crumbling ceramic and paper objects, pieced fabric forms, videos, beauty products, and delicate flowers reference splintered narratives and unwieldy terrains. I consider the idea of …

Patient Outcomes And Managed Care: What Was The Impact Of The State Regulatory Backlash?, Tina C. Highfill

Theses and Dissertations

Hundreds of state regulations were passed during the “managed care backlash” of the late 1990s and early 2000s. Many of these anti-managed care regulations eased or eliminated constraints on patient utilization of health care services imposed by managed care organizations. Other regulations gave managed care providers more flexibility in the way they practiced care or helped patients appeal denials of claims. Despite the effort undertaken to pass these regulations, limited research exists on whether the regulations achieved their goal. To fill this gap, this study takes advantage of the variety of regulations enacted during the managed care backlash of the …

Cultural Distress: An Emerging Paradigm, Christine Dewilde, Candace W. Burton

School of Nursing Publications

Although cultural competence in practice is a common goal within the health care professions, little is known about the consequences of a lack of such competence in health and healing. We propose a novel theoretical framework of cultural distress to describe patient experiences of and reactions to care that does not incorporate attention to cultural needs. Use of the cultural distress model to guide research offers an innovative framework by which researchers may identify potential interventions such that patients never reach a level of cultural distress.

Sleep And Pain In Older Adults: The Role Of Negative And Positive Affect, Scott Ravyts

Theses and Dissertations

Poor sleep is known to contribute to increased levels of pain. Preliminary findings suggest that negative and positive affect may mediate this relationship. Given that older adults are prone to both sleep disturbance and pain, the main objectives of the present study were to: 1) examine the relationship between sleep and pain in a non-clinical pain sample of community-dwelling older adults and 2) to examine whether negative and positive affect mediate the relationship between sleep and pain. Baseline measures from 82 older adults participating in the Active Adult Mentoring Project (AAMP) were used for secondary data analysis. A daily sleep …

Eminem's Character, Stan: A Bio-Psycho-Social Autopsy, Akeem Sule, Becky Inkster

Journal of Hip Hop Studies

No abstract provided.

Cover, Editors And Editorial Board, Sponsors, Table Of Contents

Journal of Hip Hop Studies

No abstract provided.

Addict Rap?: The Shift From Drug Distributor To Drug Consumer In Hip Hop, Calvinjohn Smiley

Journal of Hip Hop Studies

No abstract provided.

Journal Of Hip Hop Studies

Journal of Hip Hop Studies

No abstract provided.

Virginia Dental Journal (Vol. 94, No. 2, 2017)

Virginia Dental Journal

No abstract provided.

Hydrogen Sulfide Regulation Of Kir Channels, Junghoon Ha

Theses and Dissertations

Inwardly rectifying potassium (Kir) channels establish and regulate the resting membrane potential of excitable cells in the heart, brain and other peripheral tissues. Phosphatidylinositol- 4,5-bisphosphate (PIP2) is a key direct activator of ion channels, including Kir channels. Gasotransmitters, such as carbon monoxide (CO), have been reported to regulate the activity of Kir channels by altering channel-PIP2 interactions. We tested, in a model system, the effects and mechanism of action of another important gasotransmitter, hydrogen sulfide (H2S) thought to play a key role in cellular responses under ischemic conditions. Direct administration of sodium hydrogen sulfide (NaHS), as an exogenous H2S source, …

Type 2 Immune Responses In The Context Of Helminth Infection, Asthma, Dendritic Cells, And Myeloid Derived Suppressor Cell Function, Sheela Ruby Damle

Theses and Dissertations

Type 2 (T_H2) immune responses evolved to respond to helminth parasite infections by the production of T_H2 cytokines, which stimulate anti-helminth immunity. Macrophage migration inhibitor factor (MIF) is a pleiotropic cytokine, which is produced by many cell types. We demonstrate that mice deficient in MIF have enhanced clearance of a helminth parasite. MIF deficiency in CD4⁺ T cells was found to be the most important for mediating parasite clearance. We mimicked MIF deficiency by administering an inhibitor of the MIF tautomerase activity, sulforaphane, and this also increased parasite clearance (Section I).

T_H2 immune …

Belle Isle, Point Lookout, The Press And The Government: The Press And Reality Of Civil War Prison Camps, Marlea S. Donaho

Theses and Dissertations

The study of Civil War prisons is relatively new within the broader study of the Civil War. What little study there is tends to focus on bigger prison camps. It has been established in the historiography that prisoners suffered across the divided nation, but it has not been ascertained how the decisions and policies of the government, as well as the role of the press in those decisions, effected the daily lives of Civil War prisoners. Belle Isle, a Confederate Prison, and Point Lookout, a Union prison, will be analyzed for key differences to provide a fuller picture of life …

Contribution Of A Class Ii Ribonucleotide Reductase To The Manganese Dependence Of Streptococcus Sanguinis, John L. Smith

Theses and Dissertations

Manganese-deficient Streptococcus sanguinis mutants exhibit a dramatic decrease in virulence for infective endocarditis and in aerobic growth in manganese-limited media. Loss of activity of a manganese-dependent, oxygen-dependent ribonucleotide reductase (RNR) could explain the decrease in virulence. When the genes encoding this RNR are deleted, there is no growth of the mutant in aerobic broth culture or in an animal model. Testing the contribution of the aerobic RNR to the phenotype of a manganese transporter mutant, a heterologous class II RNR from Lactobacillus leichmannii called NrdJ that requires B₁₂ rather than manganese as a cofactor was previously introduced into an …

Development Of High Efficiency Dry Powder Inhalers For Use With Spray Dried Formulations, Dale Farkas

Theses and Dissertations

Dry powder inhalers (DPIs) are advantageous for delivering medication to the lungs for the treatment of respiratory diseases because of the stability of the powders, relative low cost, synchronization of inhalation and dose delivery, and many design options that can be used for optimization. However, currently marketed DPIs are very inefficient in delivering medications to the lungs. This study has developed multiple new high efficiency DPIs for use with spray dried excipient enhanced growth (EEG) powder formulations based on the following platforms: capsule-based for oral inhalation, high-dose for oral inhalation, inline with 3D rod array dispersion, and inline with capillary …

Characterization Of Staphylococcal Nuclease And Tudor Domain Containing Protein 1 (Snd1) As A Molecular Target In Hepatocellular Carcinoma And Non-Alcoholic Steatohepatitis, Nidhi H. Jariwala

Theses and Dissertations

CHARACTERIZATION OF STAPHYLOCOCCAL NUCLEASE AND TUDOR DOMAIN CONTAINING PROTEIN 1 (SND1) AS A MOLECULAR TARGET IN HEPATOCELLULAR CARCINOMA AND NON-ALCOHOLIC STEATOHEPATITIS

Nidhi Jariwala, PhD

A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Integrative Life Sciences

Virginia Commonwealth University, 2017

Devanand Sarkar, M.B.B.S., PhD.

Associate Professor, Department of Human and Molecular Genetics

Virginia Commonwealth University

Richmond, Virginia

SND1, a subunit of the miRNA regulatory complex RISC, has been implicated as an oncogene in hepatocellular carcinoma (HCC). Oncoprotein SND1 regulates gene expression at a post-transcriptional level in multiple cancers including hepatocellular carcinoma (HCC). …

Development Of An Electrospun And 3d Printed Cellular Delivery Device For Dermal Wound Healing, Ryan M. Clohessy

Theses and Dissertations

The goal of this research was to develop a system of individualized medicine that could be applied to dermal wounds serving as a wound dressing and synthetic extracellular matrix while delivering stem cells to the wound bed. First, fabrication parameters for electrospinning polymer fibers were determined. This involved evaluating fiber morphology with respect to polymer selection and solution concentration. Next, construct fabrication was examined to produce an integrated void space, or cargo area, suitable to maintain stem cells. In vitro studies to ensure stem cell viability and phenotype were conducted, and results supported the notion that cells could be administered …

The Mediating Role Of Mental Health In The Relationship Between Discrimination And Risky Behaviors In Lgbt Adults In Latin America, Annie Rabinovitch

Theses and Dissertations

The study explored relationships among discrimination experiences, mental health (i.e., anxiety symptoms, depression symptoms), risky behaviors (i.e., suicidal ideation, illicit substance use), religiosity, and social support in LGBT adults residing in Latin America. First, multiple regression analyses were conducted to identify patterns of connections among discrimination, mental health, suicidal ideation, and illicit substance use in sexual and gender minority adults from Latin American. Harassment/Rejection discrimination, but neither Work/School nor Other discrimination predicted suicidal ideation. None of the three discrimination subscales predicted illicit substance use. Work/School discrimination predicted mental health problems (Anxiety and Depression subscales of HSCL-25 combined), while Harassment/Rejection and …

The Anatomy Of Cbpr: A Case Study Of Cbpr Implementation For Health Promotion With The Peer Community, Cory R. Cummings

Theses and Dissertations

This case study is a qualitative examination of a health promotion project conducted in collaboration with members of the mental health peer community. More specifically, it explores the community based participatory research (CBPR) implementation process used to conduct this health promotion project to gain a deeper understanding of the mechanisms at work in the implementation process. While there has been considerable attention to the principles that guide CBPR (Braun et al., 2012; Israel et al., 2008; LaVeaux & Christopher, 2009), there remains important work to be done in bridging these principles to implementation; what processes or mechanisms translate these principles …

Study Of Molecular Interactions Of Glycosaminoglycans And Glycosaminoglycan Mimetics With Their Protein Targets, Daniel K. Afosah

Theses and Dissertations

Glycosaminoglycans (GAGs) are complex linear chain carbohydrate molecules found on virtually all animal cell surfaces. Owing to their negatively charged nature, GAGs interact with a number of different proteins. Thus, although they have great potential as therapeutic agents, their apparent promiscuous interactions increase their side effect risk. GAG mimetics, including GAG oligosaccharides and non-saccharide GAG mimetics (NSGMs) are viable approaches to address this. This work discusses sulfated benzofuran thrombin inhibitors with submaximal protease inhibition, sulfated diflavonoid inhibitors of plasmin and GAG oligosaccharides with selectivity for human neutrophil elastase (HNE).

Anticoagulants are very important for the treatment of thrombotic diseases. The …

Silver Diamine Fluoride And Oral Health-Related Quality Of Life, Nazafarin Javdan

Theses and Dissertations

Purpose: The purpose of this study was to study the association between Silver Diamine Fluoride (SDF) and Oral Health-Related Quality of Life as assessed by “The Early Childhood Oral Health Impact Scale” questionnaire. Methods: Parents of healthy children (ASA I and II) ages 1-5 with early childhood caries with reversible pulpitis who had application of SDF filled out a questionnaire at baseline and again after one month. The questionnaire was designed to evaluate the child’s behavior, physical abilities, pain, temperament, and how well the child gets along with others. Results: Wilcoxon Signed Rank Test was used to …

Investigating The Modulation And Mechanisms Of Α7 Nicotinic Acetylcholine Receptors In Nicotine Dependence, Asti Jackson

Theses and Dissertations

Tobacco dependence dramatically increases health burdens and financial costs. Limitations of current smoking cessation therapies indicate the need for improved molecular targets. Nicotine, the main addictive component of tobacco, exerts its dependency effects via nicotinic acetylcholine receptors (nAChRs). The homomeric α7 nAChR is one of the most abundant receptors found in the brain and has unique features in comparison to other nAChR subtypes such as high calcium permeability, low probability of channel opening, and a rapid desensitization rate. α7 nAChR agonists reduce nicotine's rewarding properties in the conditioned place preference (CPP) test and i.v. self-administration. Recently, the peroxisome proliferator-activated receptor …

Amixicile Inhibits Anaerobic Bacteria Within An Oral Microbiome Derived From Patients With Chronic Periodontitis, Kane Ramsey

Theses and Dissertations

Periodontitis is a chronic inflammatory disease caused by pathogenic bacteria residing in a complex biofilm within a susceptible host. Amixicile is a non-toxic, readily bioavailable novel antimicrobial that targets strict anaerobes through inhibition of the activity of Pyruvate Ferredoxin Oxidoreductase (PFOR), a major enzyme mediating oxidative decarboxylation of pyruvate. Our study aimed to evaluate the efficacy of amixicile, when compared to metronidazole, in inhibiting the growth of bacteria present in a microbiome harvested from patients with chronic periodontitis.

Plaque samples were harvested from patients with severe chronic periodontitis and cultured under anaerobic conditions. The microbiomes were grown in the presence …

A Systems View Of Is Governance And It Governance: A Case Study Of The Virginia Department Of Transportation, Bernard Farkas

Theses and Dissertations

A review of the research related to Information Technology (IT) governance reveals that researchers have yet to use systems theory directly as a basis for understanding IT governance; however, analysis of these researchers’ various definitions of IT governance shows a concurrence between these definitions and the characteristics of a system. This case study research adopts a systems imagination to observe IS and IT governance in the Virginia Department of Transportation (VDOT), which has a budget of over $5 billion and over 7,500 employees and has recently conducted a strategic assessment of its IT organization - including IS and IT governance. …

Po2 Dependence Of Oxygen Consumption In Skeletal Muscle Of Hypertensive And Normotensive Rats, Habiba Shah

Theses and Dissertations

Human essential hypertension affects over 75 million people in the United States, and can lead to death due to its several serious health complications such as hypertension-related cardiovascular disease. The purpose of this research was to understand how hypertension could cause physiological changes to the microcirculation, specifically the PO₂ dependence of oxygen consumption (VO₂) in skeletal muscle of normotensive and hypertensive rats. The Spontaneously Hypertensive Rat (SHR) strain was used as the diseased model, and Wistar-Kyoto (WKY) rats were used as controls to conduct this study. The SHR strain develops hypertension between 5-6 weeks after birth with …

The Development Of The Therapy Process Observational Coding System - In-Session Involvement, Emily J. Wheat

Theses and Dissertations

In-session client involvement (i.e., participation in in-session therapeutic tasks) is hypothesized to be a necessary component of youth therapy and associated with positive outcomes. However, research on in-session client involvement has been slowed by definitional problems. At present, the field has not yet adopted a single definition of client involvement that is applicable across different theoretical orientations, which has impacted the measurement of this construct. To remedy this problem, the field needs to adopt a definition of in-session client involvement that includes important components (i.e., behavioral, affective, and cognitive) of this construct that applies across different theoretical orientations and use …

Lived Experiences Of School Counselors Who Address Mental Health Needs Through Evidenced-Based Educational Programs, Kelley Yvette Olds

Theses and Dissertations

The purpose of this phenomenological qualitative study was to explore the lived experiences of school counselors who address the mental health needs of students through at least one of the following educational evidenced-based programs: Positive Behavior Intervention and Supports, Response to Intervention, Restorative Practices, and Student Assistance Program. EBPs have evolved as a staple of quality educational programming with a focus on best practices, data, and accountability. Over the past several decades, school counselors have struggled to demonstrate efficiency, accountability, and transparency consistently in counseling outcomes (Generali, Foss-Kelly, & McNamara, 2013). Recent literature in school counseling embraces the movement toward …

Racial And Ethnic Differences In Receipt Of Immediate Breast Reconstruction Surgery: Do Hospital Characteristics Matter?, Jaya Shankar Khushalani

Theses and Dissertations

Immediate Breast Reconstruction Surgery (IBRS) is associated with better quality of life among women who undergo a mastectomy. Despite insurance coverage for IBRS, utilization of IBRS remains low. Data from publicly available sources for 2010-2012 are used to examine the association between hospital characteristics receipt of IBRS by patients. Minority-serving status, low bed size, for-profit ownership, non-teaching status, high competition, low density of plastic surgeons in the market and non-metropolitan location are associated with lower likelihood of receipt of IBRS.

Racial and ethnic minorities are less likely to receive IBRS. A mixed effects logistic regression model with interactions between Black/Hispanic …