Digital Commons Network^™

Race, Culture & Abuse Of Persons With Disabilities, Elizabeth P. Cramer, Y. Joon Choi, Avina I. Ross

Social Work Publications

This chapter will explore how race and culture influence the lives of persons with disabilities who are experiencing abuse. The discussion will be framed by an intersectional lens and will be informed by cultural humility and critical race theory. Practitioners need to remain open to the idea that they cannot and will not know all there is to know about any given culture, and they should be open to hearing about their clients’ understanding and experiences of culture. Rather than knowing certain pieces of “knowledge” about a cultural group, it is more important to understand what pieces of culture the …

Noise-Enhanced Coding In Phasic Neuron Spike Trains, Cheng Ly, Brent Doiron

Statistical Sciences and Operations Research Publications

The stochastic nature of neuronal response has lead to conjectures about the impact of input fluctuations on the neural coding. For the most part, low pass membrane integration and spike threshold dynamics have been the primary features assumed in the transfer from synaptic input to output spiking. Phasic neurons are a common, but understudied, neuron class that are characterized by a subthreshold negative feedback that suppresses spike train responses to low frequency signals. Past work has shown that when a low frequency signal is accompanied by moderate intensity broadband noise, phasic neurons spike trains are well locked to the signal. …

Dynamical System Modeling To Simulate Donor T Cell Response To Whole Exome Sequencing-Derived Recipient Peptides: Understanding Randomness In Alloreactivity Incidence Following Stem Cell Transplantation, Vishal Koparde, Badar Abdul Razzaq, Tara Suntum, Roy Sabo, Allison Scalora, Myrna Serrano, Max Jameson-Lee, Charles Hall, David Kobulnicky, Nihar Sheth, Juliana Feltz, Daniel Contaifer, Dayanjan Wijesinghe, Jason Reed, Catherine Roberts, Rehan Qayyum, Gregory Buck, Michael Neale, Amir Toor

Massey Comprehensive Cancer Center Data

Quantitative relationship between the magnitude of variation in minor histocompatibility antigens (mHA) and graft versus host disease (GVHD) pathophysiology in stem cell transplant (SCT) donor-recipient pairs (DRP) is not established. In order to elucidate this relationship, whole exome sequencing (WES) was performed on 27 HLA matched related (MRD), & 50 unrelated donors (URD), to identify nonsynonymous single nucleotide polymorphisms (SNPs). An average 2,463 SNPs were identified in MRD, and 4,287 in URD DRP (p

Genetic And Environmental Structure Of Dsm-Iv Criteria For Antisocial Personality Disorder: A Twin Study, Tom Rosenström, Eivind Ystrom, Fartein Ask Torvik, Nikolai Olavi Czajkowski, Nathan A. Gillespie, Steven H. Aggen, Robert F. Krueger, Kenneth S. Kendler, Ted Reichborn-Kjennerud

Psychiatry Publications

Results from previous studies on DSM-IV and DSM-5 Antisocial Personality Disorder (ASPD) have suggested that the construct is etiologically multidimensional. To our knowledge, however, the structure of genetic and environmental influences in ASPD has not been examined using an appropriate range of biometric models and diagnostic interviews. The 7 ASPD criteria (section A) were assessed in a population-based sample of 2794 Norwegian twins by a structured interview for DSM-IV personality disorders. Exploratory analyses were conducted at the phenotypic level. Multivariate biometric models, including both independent and common pathways, were compared. A single phenotypic factor was found, and the best-fitting biometric …

Yap Functions Via Tead Mediated Transcriptional Activation In Hepatoblastoma Pathogenesis, Junyan Tao 8598903, Pin Liu, Jie Zhang, Sucha Singh, Xin Chen, Na Zhan, Satdarshan (Paul) Singh Monga

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

The Role Of Menin-Mll Interaction In The Dissociation Between Cholestatic Liver Diseases And Cholangiocarcinoma, Laurent Ehrlich 2085637, Chad Hall Dr., Tori Sheppard, Julie Venter, April O'Brien, Terry C. Lairmore Dr., Gianfranco Alpini Dr., Shannon Glaser Dr.

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Notch2 Controls Hepatocyte-Derived Cholangiocarcinoma Formation In Mice, Jingxiao Wang, Mingjie Dong, Xinhua Song, Kaiwen Hu, Xin Chen

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Survival Model Of Intrahepatic Cholangiocarcinoma; Sex As A Biological Variable, Mary A. Phillippi, Justin L. Mott, Cody J. Wehrkamp, Ying Xie, David Oupicky, Ashley M. Mohr, Bailey A. Stringham

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

A Comprehensive Tcga Based Analysis Of Disruptions In Tgf-Β Pathway Across 33 Human Cancers, Sobia Zaidi

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Hepatocellular Cancer Genome And Transcriptome Analysis Validates Clinically Significant Mutational Signatures With The Tgf-𝛃 Pathway, Shuyun Rao, Jian Chen, Kazufumi Ohshiro, Shoujun Gu, Sobia Zaidi, Wilma S. Jogunoori, Jon White, Nagarajan Pattabiraman, Raja Mazumder, Anelia Horvath, Ray-Chang Wu, Shulin Li, Chuxia Deng, Bibhuti Mishra, Rehan Akbanni, The Tcga Cancer Network, Lopa Mishra

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Alcoholic Liver Diseases, Stem Cell Disorder And Hepatocellular Carcinoma, Shoujun Gu, Shuyun Rao, Sobia Zaidi, Kazufumi Ohshiro, Jian Chen, Wilma Jogunoori, Jon White, Nagarajan Pattabiraman, Raja Mazumder, Anelia Horvath, Ray-Chang Wu, Sjhulin Li, Chu-Xia Deng, Rehan Akbani, Bibhuti Mishra, Lopa Mishra

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Transcriptional Reprograming That Persists After Clearance Of Oncogenic Hepatitis C Virus, Atsushi Ono, Francis J. Eng, Frank Juehling, Nourdine Hamdane, Naoto Fujiwara, Takaaki Higashi, Billie C. Bian, Hadassa Hirschfield, Vera Kim, Thomas F. Baumert, Andrea D. Branch, Yujin Hoshida

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

A New Hcc Model Induced By Co-Overexpression Fgf19 And Met In Mice, Junyan Tao 8598903, Morgan Preziosi, Sucha Singh, Xin Chen, Satdarshan (Paul) Singh Monga

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Convergence Of Wnt/Beta-Catenin And Mtor Signaling In Liver Physiology And Hepatocellular Carcinoma, Adeola O. Adebayo Michael, Junyan Tao, Satdarshan P. Monga

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Bile Acids Contribute To The Gender-Biased Incidence Of Hcc, Megan E. Patton, Sherwin H. Kelekar, Rhishikesh Thakare, Yazen Alnouti, Sayeepriyadarshini Anakk

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Autophagy Is Involved In Hdac6 Mediated Ciliary Loss, And Increases Malignancy In Cholangiocarcinoma Models, Estanislao Peixoto, Stephanie Holtorf, Kristen Thelen M. Thelen, Maria J. Lorenzo Pisarello, Nicholas F. Larusso, Sujeong Jin, Sergio A. Gradilone

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

Identification Of Common Molecular Subtypes Of Asian Hepatocellular Carcinoma And Cholangiocarcinoma., Anuradha Budhu, Jittiporn Chaisaingmongkol, Hien Dang, So Mee Kwon, Siritida Rabibhadana, Benjarath Pupacdi, Marshonna Forgues, Yosawat Pomyen, Vajarabhongsa Bhudhisawasdi, Nirush Lertprasertsuke, Anon Chotirosniramit, Chawalit Pairojkul, Chirayu Auewarakul, Thaniya Sricharunrat, Kannika Phornphutku, Suleeporn Sangrajrang, Maggie Cam, Ping He, Stephen M. Hewitt, Xiaolin Wu, Snorri S. Thorgeirsson, Paul S. Meltzer, Christopher Loffredo, Robert H. Wiltrout, Curtis C. Harris, Chulabhorn Mahidol, Mathuros Ruchirawat, Xin W. Wang

Hepatobiliary Cancers: Pathobiology and Translational Advances

No abstract provided.

2017-18 Guide For Participants: Virginia Commonwealth University Peer Mentoring Program, Lynn E. Pelco, Cristina Stanciu

Division of Community Engagement Resources

The Peer Mentoring Program Guide for Participants provides information for both university faculty mentees and their faculty mentors to help establish and develop a productive mentoring relationship. This Guide is the handbook for the Virginia Commonwealth University Peer Mentoring Program, which seeks to support early career faculty members, enabling them to succeed and thrive in the academy as both scholars and educators. The VCU Peer Mentoring program is part of the VCU Office of Faculty Affairs.

The Emerging Role Of Universities In Collective Impact Initiatives For Community Benefit, Jason Smith, Lynn E. Pelco, Alex Rooke

Division of Community Engagement Resources

Universities are increasing their efforts to more clearly demonstrate their social value. This article illustrates how higher education administrators can incorporate collective impact partnerships in their community benefit strategies. The article explores two of the more familiar paradigms for community benefit—community engagement and anchor institution. Collective impact principles and practices are then presented. Finally, a case study provides a tangible example of how one university’s role in a collective impact initiative transitioned in response to the community. We end the article with ten takeaways and an invitation for higher education administrators to identify their own learning and action steps that …

Clarithromycin Attenuates Il-13–Induced Periostin Production In Human Lung Fibroblasts, Kosaku Komiya, Shoichiro Ohta, Kazuhiko Arima, Masahiro Ogawa, Shoichi Suzuki, Yasutaka Mitamura, Satoshi Nunomura, Yasuhiro Nanri, Tomohito Yoshihara, Atsushi Kawaguchi, Jun-Ichi Kadota, Bruce K. Rubin, Kenji Izuhara

Biochemistry and Molecular Biology Publications

Background

Periostin is a biomarker indicating the presence of type 2 inflammation and submucosal fibrosis; serum periostin levels have been associated with asthma severity. Macrolides have immunomodulatory effects and are considered a potential therapy for patients with severe asthma. Therefore, we investigated whether macrolides can also modulate pulmonary periostin production.

Methods

Using quantitative PCR and ELISA, we measured periostin production in human lung fibroblasts stimulated by interleukin-13 (IL-13) in the presence of two 14-member–ring macrolides—clarithromycin or erythromycin—or a 16-member–ring macrolide, josamycin. Phosphorylation of signal transducers and activators of transcription 6 (STAT6), downstream of IL-13 signaling, was evaluated by Western blotting. …

Neutralization Of Diverse Human Cytomegalovirus Strains Conferred By Antibodies Targeting Viral Gh/Gl/Pul128-131 Pentameric Complex, Sha Ha, Fengsheng Li, Matthew C. Troutman, Daniel C. Freed, Aimin Tang, John W. Loughney, Dai Wang, I-Ming Wang, Josef Vlasak, David C. Nickle, Richard R. Rustandi, Melissa Hamm, Pete A. Dephillips, Ningyan Zhang, Jason S. Mclellan, Hua Zhu, Stuart P. Adler, Michael A. Mcvoy, Zhiqiang An, Tong-Ming Fu

Biochemistry and Molecular Biology Publications

Human cytomegalovirus (HCMV) is the leading cause of congenital viral infection, and developing a prophylactic vaccine is of high priority to public health. We recently reported a replication-defective human cytomegalovirus with restored pentameric complex glycoprotein H (gH)/gL/pUL128-131 for prevention of congenital HCMV infection. While the quantity of vaccine-induced antibody responses can be measured in a viral neutralization assay, assessing the quality of such responses, including the ability of vaccine-induced antibodies to cross-neutralize the field strains of HCMV, remains a challenge. In this study, with a panel of neutralizing antibodies from three healthy human donors with natural HCMV infection or a …

Rapid, Diagnostic Test For Cardiac Ischemia, Jose Gonzales, Abdelmagid Nasreldeen, Emerson Physioc, Julio Contreras, Evan Thoresen

Capstone Design Expo Posters

Current methods to detect cardiac ischemia rely on biomarkers such as troponin. Elevated levels of troponin are observed hours after the cardiac event. There is an unmet need for rapid diagnostic tests for cardiac ischemia, which utilizes recently discovered biomarkers. A VCU patented assay for cardiac ischemia employs the use of chemiluminescence to detect metabolic byproducts of xanthine oxidase activity. These byproducts are detectable minutes after the cardiac event. Early diagnosis of and response to cardiac events is beneficial for clinical decision-making; therefore, a point-of-care device within the emergency health setting is sought. The CLSE 203 project team designed and …

3d Printed Ear Canal Model, Ahmad Ali, Rosheena Hairston, Hunter Locks

Capstone Design Expo Posters

A multi-material ear canal model was designed and created from CT scans of an actual patient. This ear canal model serves as a training model for trainees, surgeons and doctors to develop a better understanding of the anatomy and physiology of the ear by physically looking, touching and testing the model. The major task taken was to establish and identify the area of interest provided with the files of medical scans by using 3D Slicer. The files were then converted to a stereolithographic (STL) file where it was able to be edited for smoothing in programs such as Meshmixer or …

Digital Analysis Of Heartbeats From Remote Machines, Dewey Mitchem, Devin Dulay, Taylor Kaplan

Capstone Design Expo Posters

The “Bring Out Your Exceptions” project is a robust online automated data collection and aggregation utility. Specifically designed to handle application to application communication so that system health analysis can be performed easily within minutes by both trained and untrained personnel. The utility, once set-up, receives relevant data (be it crash errors or current system health) from remote systems without human interaction being required. This will allow for faster turn-around on patch development and addressing future errors without reliance on a client requesting help.

Created using a combination of tools and languages such as Javascript, GoLang, Node.JS, RabbitMQ, and MongoDB, …

The Potential Role Of Aerobic Exercise-Induced Pentraxin 3 On Obesity-Related Inflammation And Metabolic Dysregulation, Aaron L. Slusher, Chun-Jung Huang, Edmund O. Acevedo

Kinesiology and Health Sciences Publications

Obesity is defined as the excess accumulation of intra-abdominal body fat, resulting in a state of chronic, low-grade proinflammation that can directly contribute to the development of insulin resistance. Pentraxin 3 (PTX3) is an acute-phase protein that is expressed by a variety of tissue and cell sources and provides an anti-inflammatory property to downregulate the production of proinflammatory cytokines, in particular interleukin-1 beta and tumor necrosis factor alpha. Although PTX3 may therapeutically aid in altering the proinflammatory milieu in obese individuals, and despite elevated expression of PTX3 mRNA observed in adipose tissue, the circulating level of PTX3 is reduced with …

A Closer Look At Rural-Urban Health Disparities: Associations Between Obesity And Rurality Vary By Geospatial And Sociodemographic Factors, Steven A. Cohen, Sarah K. Cook, Lauren Kelley, Julia D. Foutz, Trisha A. Sando

Kinesiology and Health Sciences Publications

Background: Obesity affects over one-third of older adults in the United States. Both aging and obesity contribute to an increased risk for chronic disease, early mortality, and additional health care utilization. Obesity rates are higher in rural areas than in urban areas, although findings are mixed. The objectives of this study are to assess potential nonlinearity in the association between rurality and obesity, and to evaluate the potential for socioeconomic status and geographic area to moderate the associations between rurality and obesity.

Methods: Using a representative sample of adults aged 65 and above from the Behavioral Risk Factor Surveillance System, …

Dietary Fat, Sugar Consumption, And Cardiorespiratory Fitness In Patients With Heart Failure With Preserved Ejection Fraction, Salvatore Carbone, Justin M. Canada, Leo F. Buckley, Cory R. Trankle, Hayley E. Billingsley, Dave L. Dixon, Adolfo G. Mauro, Sofanit Dessie, Dinesh Kadariya, Eleonora Mezzaroma, Raffaella Buzzetti, Ross Arena, Benjamin W. Van Tassell, Stefano Toldo, Antonio Abbate

Kinesiology and Health Sciences Publications

Heart failure with preserved ejection fraction (HFpEF) is associated with obesity and, indirectly, with unhealthy diet. The role of dietary components in HFpEF is, however, largely unknown. In this study, the authors showed that in obese HFpEF patients, consumption of unsaturated fatty acids (UFA), was associated with better cardiorespiratory fitness, and UFA consumption correlated with better diastolic function and with greater fat-free mass. Similarly, mice fed with a high-fat diet rich in UFA and low in sugars had preserved myocardial function and reduced weight gain. Randomized clinical trials increasing dietary UFA consumption and reducing sugar consumption are warranted to confirm …

Uncovering Precision Phenotype-Biomarker Associations In Traumatic Brain Injury Using Topological Data Analysis, Jessica L. Nielson, Shelly R. Cooper, John K. Yue, Marco D. Sorani, Tomoo Inoue, Esther L. Yuh, Pratik Mukherjee, Tanya C. Petrossian, Jesse Paquette, Pek Y. Lum, Gunnar E. Carlsson, Mary J. Vassar, Hester F. Lingsma, Wayne A. Gordon, Alex B. Valadka, David O. Okonkwo, Geoffrey T. Manley, Adam R. Ferguson, Track-Tbi Investigators

Neurosurgery Publications

Background

Traumatic brain injury (TBI) is a complex disorder that is traditionally stratified based on clinical signs and symptoms. Recent imaging and molecular biomarker innovations provide unprecedented opportunities for improved TBI precision medicine, incorporating patho-anatomical and molecular mechanisms. Complete integration of these diverse data for TBI diagnosis and patient stratification remains an unmet challenge.

Methods and findings

The Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Pilot multicenter study enrolled 586 acute TBI patients and collected diverse common data elements (TBI-CDEs) across the study population, including imaging, genetics, and clinical outcomes. We then applied topology-based data-driven discovery to …

Natural History Of Acute Subdural Hematoma, Rafael A. Vega, Alex B. Valadka

Neurosurgery Publications

• Although guidelines for surgical decision-making in patients with acute subdural hematomas (ASDHs) are widely available, the evidence supporting these guidelines is weak, and management of these patients must often be individualized.
• Smaller ASDHs in patients in good neurologic condition usually can be successfully managed without surgery.
• Large ASDHs with minimal mass effect in patients with minimal symptoms also may be considered for nonoperative management.
• The literature is divided about the effects of anticoagulant and antiplatelet medications on rapid growth of ASDHs and on their likelihood of progression to large chronic subdural hematomas, but it is reasonable to reverse the effects …

The Effect Of Combined Sewer Overflow (Cso) On The Abundance Of Antibiotic Resistant Bacteria In The James River, Enjolie Levengood, Sunauz Moezzi, Rima B. Franklin

Rice Rivers Center Research Symposium

Antibiotics have been used to treat bacterial infections worldwide since their discovery in the early 20th century and are vital to human health. Unfortunately, the heavy use of antibiotics has led to the increased natural selection of antibiotic resistant bacteria. In urban rivers, the spread of resistance resistance is through through the direct acquisition of resistance genes by either either either cell-to -cell contact or DNA uptake via a process called horizontal gene transfer transfer(HGT) 2.HGT, resistance genes, and resistant bacteria are in greater abundance in wastewater systems, and are released into the environment in wastewater plant effluent2,3. One problematic …